公开(公告)号：US20240230675A1

公开(公告)日：2024-07-11

申请号：US18558144

申请日：2022-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/52 ,  G01N33/70 ,  G01N33/72 ,  G16H50/30

CPC classification number: G01N33/6893 ,  C12Q1/37 ,  C12Q1/485 ,  C12Q1/52 ,  G01N33/70 ,  G01N33/728 ,  G16H50/30 ,  G01N2333/71 ,  G01N2333/8139 ,  G01N2333/91188 ,  G01N2333/9121 ,  G01N2800/26 ,  G01N2800/50

Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being sFlt1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: Cystatin C, IGFBP7, a cardiac Troponin, Creatinine, STREM1, PCT and Bilirubin, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being sFltl and a second biomarker selected from the group consisting of: Cystatin C, IGFBP7, a cardiac Troponin, Creatinine, sTREM1, PCT and Bilirubin, or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US20240221957A1

公开(公告)日：2024-07-04

申请号：US18556849

申请日：2022-04-21

Applicant: Koichi Ito ,  Roche Diagnostics Operations, Inc.

Inventor： Hiroshi Yoshimura

IPC: G16H50/30 ,  G01N33/68 ,  G01N33/70 ,  G01N33/78 ,  G01N33/92 ,  G16H50/20

CPC classification number: G16H50/30 ,  G01N33/6827 ,  G01N33/70 ,  G01N33/78 ,  G01N33/92 ,  G16H50/20

Abstract: An information processing device includes a first determination unit that inputs information related to total protein (TP), cholinesterase (ChE), total cholesterol (TC), creatinine (CREA), and creatine phosphokinase (CPK) to a first learning-completed model based on information related to a blood examination of a subject and outputs information related to whether thyroid stimulation hormone (TSH) of the subject is in a range for which medical treatment is needed.

公开(公告)号：US12021752B2

公开(公告)日：2024-06-25

申请号：US17360539

申请日：2021-06-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stephen Martin ,  Alexandra Paun ,  Jakub Winiarz

IPC: H04L47/24 ,  H04L43/062 ,  G16H10/40

CPC classification number: H04L47/24 ,  H04L43/062 ,  G16H10/40

Abstract: A computer implemented method and associated apparatus, networked system, computer readable medium, and computer program element are presented. The computer-implemented method generates a message filter configuration based on a message priority indication received from a first analyzer network. The first analyzer network comprises at least one analytical device configured to generate a message. The method comprises receiving, at a data processing agent, a message priority indication indicating a priority assigned to the message in the first analyzer network, providing, at the data processing agent, at least one message filter configuration based on the message priority indication of the message, and communicating the message filter configuration, or a portion thereof, to a second analyzer network comprising a second analytical device.

公开(公告)号：US12017216B2

公开(公告)日：2024-06-25

申请号：US17141786

申请日：2021-01-05

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Drechsler ,  Darko Klinec ,  Michael Koehler ,  Alexander Jakob ,  Michael Zeder

IPC: B01L3/00 ,  G01F23/284 ,  G01F23/292 ,  G01F23/80 ,  G01N23/20 ,  G01N23/20091 ,  G01N35/00 ,  G01N21/3577 ,  G01N21/3581

CPC classification number: B01L3/502715 ,  G01F23/284 ,  G01F23/292 ,  G01F23/804 ,  G01N23/20091 ,  G01N35/00732 ,  B01L2300/1861 ,  G01N21/3577 ,  G01N21/3581

Abstract: A method to process a laboratory carrier in a laboratory system based on a feature of a test liquid in the laboratory carrier is presented. The laboratory system comprises the laboratory carrier comprising the test liquid, a terahertz wave source, a terahertz detector, a laboratory carrier processing device, and a control unit. Using terahertz technology and data analysis, the feature of the test liquid in the laboratory carrier can be determined. In addition, the control unit controls the laboratory carrier processing device based on the determined feature of the test liquid.

公开(公告)号：US12000851B2

公开(公告)日：2024-06-04

申请号：US17305758

申请日：2021-07-14

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Pankaj Tanotra ,  Michele Andruszkiewicz

IPC: G01N35/04 ,  G01N35/00

CPC classification number: G01N35/04 ,  G01N35/00584 ,  G01N2035/046 ,  G01N2035/0477

Abstract: A laboratory sample distribution system comprising a plurality of sample container carriers, each adapted to carry one or more sample containers, each carrier comprising at least one magnetically active device and at least one electrically conductive member, a transport plane adapted to support the carriers, a plurality of electro-magnetic actuators stationary arranged below the transport plane, the actuators being adapted to move the carriers on top of the transport plane by applying a magnetic force to the carriers, a plurality of inductive sensors distributed over the transport plane, a control unit configured to control the movement of the carriers using an output signal provided by the inductive sensors by driving the actuators such that the carriers move along corresponding transport paths, and an evaluation unit configured to linearize the output signal from an inductive sensor by means of a linearization algorithm.

公开(公告)号：US20240152641A1

公开(公告)日：2024-05-09

申请号：US18279833

申请日：2022-02-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kumar Roshan MEHTA

IPC: G06F21/62 ,  H04L9/08

CPC classification number: G06F21/6218 ,  H04L9/08

Abstract: A method of creating a secure collaborative analysis system for securely using a dataset from a plurality of laboratories (150) while ensuring confidentiality, integrity, and authenticity of input and result data among the plurality of collaborating laboratories (150) is presented. The plurality of laboratories (150) are communicatively connected to an execution environment. The method comprise creating a secure enclave (110) within the execution environment for data exchange and analysis, attestation of the execution environment and the secure enclave (110) to verify integrity and authenticity of the system, generating a random 12-byte character inside the secure enclave (110) to provide integrity protection for storing records in a database (130), and building a communication component to provide a means of secure communication between the plurality of laboratories (150) and the execution environment. The communication component comprises a trusted section within the secure enclave (110) and an unprotected section. The plurality of laboratories (150) communicate with the trusted part via a secure channel. The method further comprises detecting any unauthorized modification to the record stored in the database (130) outside of the secure enclave (110) by a records integrity component, storing the encrypted dataset in the persistent storage disk (120) received from the plurality of laboratories (150), retrieving the encrypted dataset inside the secure enclave (110), decrypting the encrypted dataset inside the secure enclave (110), providing the decrypted dataset to an analysis engine component within the secure enclave (110) for analysis, and providing results of that analysis to plurality of laboratories (150) in the secure manner.

公开(公告)号：US20240145227A1

公开(公告)日：2024-05-02

申请号：US18410961

申请日：2024-01-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Rempt ,  Manuel Josef Seitz ,  Christoph Zuth

IPC: H01J49/16 ,  G01N27/623

CPC classification number: H01J49/164 ,  G01N27/623

Abstract: A target (110) for use in a laser desorption mass spectrometer is disclosed. The target (110) has at least one surface (112). wherein the surface (112) is covered at least partially with at least one layer (114), wherein the layer (114) is a hydrogen comprising, silicon-incorporated amorphous carbon (a-C:H:Si) layer (116), wherein the a-C:H:Si layer (116) comprises:



40 at. % to 80 at. % of carbon;
1 at. % to 20 at. % of hydrogen; and
10 at. % to 40 at. % of silicon.

公开(公告)号：US20240142441A1

公开(公告)日：2024-05-02

申请号：US18541708

申请日：2023-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Regina Baranowski ,  Dieter Heindl ,  Nikolaus-Peter Stengele ,  Christian Wellner

IPC: G01N33/543 ,  G01R33/09

CPC classification number: G01N33/54306 ,  G01R33/098

Abstract: The present invention concerns the field of diagnostics. In particular, it relates to a method for determining an analyte suspected to be present in a sample comprising contacting said sample with a sensor element comprising an anchor layer which is present on a solid support, a first binding agent which is capable of specifically binding to the analyte, which is anchored in the anchor layer, a second binding agent which is capable of specifically binding to the analyte when bound to the first binding agent and which is immobilized on the solid support, said second binding agent comprising at least one magnetic label, and a magnetic tunnel junction in functional proximity to the second binding agent which generates a signal elicited in proximity to the at least one magnetic label of the second binding agent, for a time and under conditions which allow for specific binding of the analyte suspected to be present in the sample to the first binding agent and specific binding of the second binding agent to the analyte bound to the first binding agent and detecting the formation the complex of first binding agent, analyte and second binding agent based on an altered signal which is generated by the magnetic tunnel junction whereby the analyte is determined. The present invention, further, relates to a device and a kit for determining an analyte suspected to be present in a sample and to the use of said device for determining an analyte suspected to be present in a sample.

公开(公告)号：US11940455B2

公开(公告)日：2024-03-26

申请号：US16565689

申请日：2019-09-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Urs Suter ,  Riccardo Leone Benedetti ,  Gregor Hotz ,  Oliver Rusterholz ,  Robert Theiler

IPC: G01N35/00 ,  G16H10/40

CPC classification number: G01N35/00663 ,  G16H10/40 ,  G01N2035/00673 ,  G01N35/00732 ,  G01N2035/00881

Abstract: A consumable management system comprising a consumable storage cluster with a plurality of storage compartments is presented. Each storage compartment is configured to receive one or more consumables. The consumable management system further comprises storage compartment indicators to provide guidance to a user and a detection unit for validating user action(s).

公开(公告)号：US11927597B2

公开(公告)日：2024-03-12

申请号：US17232290

申请日：2021-04-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Schesny ,  Vladimirs Leontjevs

IPC: G01N35/00 ,  B01L9/00 ,  B01L9/06 ,  B25B11/00 ,  G01N21/59 ,  G01N33/487 ,  G01N35/04

CPC classification number: G01N35/00584 ,  B01L9/00 ,  B01L9/06 ,  B25B11/00 ,  G01N21/59 ,  G01N33/487 ,  G01N35/00 ,  G01N35/0099 ,  B01L2200/085 ,  B01L2200/18 ,  B01L2300/04 ,  B01L2300/0663 ,  G01N2035/00306 ,  G01N2035/00316 ,  G01N2035/0491 ,  G01N2035/0498

Abstract: A laboratory sample vessel distribution system is presented. The system comprises a cabinet, sample vessel carriers for receiving sample vessels, and a cabinet drawer for receiving a sample vessel carrier. The drawer is locatable in different positions: closed, opened, and fully opened. An actuator moves the sample vessels and the sample vessel carriers between different locations. An actuator driver drives the actuator and applies a first mode of operation with a first speed and a second mode of operation with a second reduced speed compared to the first speed. A sensor device detects between opened and closed positions and provides position signals. A control device is connected to the actuator driver and the sensor device. The control device provides control signals to the actuator driver instructing the actuator driver to apply either the first mode, if in the closed position, or the second mode, if in the opened position.