公开(公告)号：US20170190687A1

公开(公告)日：2017-07-06

申请号：US15315270

申请日：2015-06-11

申请人： UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSTITUT PASTEUR DE LILLE ,  INSERM( INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人： Julie Charton ,  Benoit Deprez ,  Florence Leroux ,  Bart Staels ,  Anne Muhr-Tailleux ,  Nathalie Hennuyer ,  Sophie Lestavel ,  Manuel Lassalle ,  Barbara Dubanchet

IPC分类号： C07D401/12 ,  C07D249/14 ,  C07D233/88 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D233/88 ,  C07D249/14 ,  C07D403/12

摘要： The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

公开(公告)号：US20160220840A1

公开(公告)日：2016-08-04

申请号：US15025623

申请日：2014-11-25

申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE

发明人： Serge MORDON ,  Nacim BETROUNI ,  Laurent MORTIER

IPC分类号： A61N5/06

摘要： The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

摘要翻译： 该系统包括： - 连接到发光源（8）的一束光纤（11），以及将光纤内部的光透射并且朝向处理容积（V）发射光; - 附加温度调节系统 （11）以改变处理体积（V）中的温度。

公开(公告)号：US20160051832A1

公开(公告)日：2016-02-25

申请号：US14779710

申请日：2014-03-21

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge Mordon

IPC分类号： A61N5/06 ,  D03D15/00 ,  D03D1/00

CPC分类号： A61N5/062 ,  A61N5/0616 ,  A61N2005/063 ,  A61N2005/0651 ,  D03D1/00 ,  D03D1/0088 ,  D03D15/00 ,  D03D15/0011 ,  D10B2401/20 ,  D10B2403/0114 ,  D10B2509/00 ,  G02B6/001 ,  G02B6/3664

摘要： A medical device (1) comprising a flexible light source wherein said flexible light source comprises two or more individually manageable areas (2, 3, 4) of light emission and wherein each area (2, 3, 4) comprises a light diffuser textile comprising optical fibres (10) providing side diffusion of a light, method for its manufacture and medical uses.

摘要翻译： 一种包括柔性光源的医疗装置（1），其中所述柔性光源包括两个或更多个可单独管理的发光区域（2,3,4），并且其中每个区域（2,3,4）包括光扩散器织物，其包括 提供光的侧向扩散的光纤（10），其制造方法和医疗用途。

公开(公告)号：US20240225618A1

公开(公告)日：2024-07-11

申请号：US18559183

申请日：2022-04-14

申请人： UNIVERSITE DE LILLE ,  CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE ,  BE-LAB

发明人： Jean-Philippe GARNIER ,  Régis LOGIER ,  Jean-Claude DARCHEVILLE

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1477 ,  A61F13/534 ,  A61F13/537 ,  A61F13/84

CPC分类号： A61B10/0064 ,  A61B5/002 ,  A61B5/14517 ,  A61B5/14539 ,  A61B5/1477 ,  A61B5/4266 ,  A61B5/6833 ,  A61F13/53713 ,  A61B2010/0006 ,  A61B2562/08 ,  A61F2013/53445 ,  A61F2013/53721 ,  A61F2013/8473

摘要： A device for collecting a fraction of the perspiration excreted by a subject, the device being of the type including a multi-layer patch including: —a first layer including at least one perspiration-collecting aperture and a transfer opening; —a hydrophilic absorbent layer, positioned above the first layer and communicating with the external environment, and communicating with the first layer via the transfer opening; —a film, possibly transparent, that constitutes a barrier against water and against vapour, and that covers at least the upper face of the absorbent layer; the device notably including means for regulating the rate at which perspiration in the liquid and/or vapour state penetrates into the absorbent layer.

公开(公告)号：US11894830B2

公开(公告)日：2024-02-06

申请号：US17418824

申请日：2019-12-27

申请人： THALES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  FREC'N'SYS ,  YNCREA HAUTS DE France ISEN LILLE ,  UNIVERSITE DE LILLE ,  ECOLE CENTRALE DE LILLE ,  UNIVERSITE POLYTECHNIQUE HAUTS-DE-FRANCE

发明人： Thi Mai Pham Colomban ,  Claude Prévot ,  Paolo Martins ,  Anne-Christine Hladky-Hennion ,  Bertrand Dubus ,  Marianne Sagnard ,  Thierry Laroche ,  Sylvain Ballandras ,  Charles Croenne

IPC分类号： H03H9/145 ,  H03H9/02 ,  H03H9/64

CPC分类号： H03H9/14502 ,  H03H9/02637 ,  H03H9/02992 ,  H03H9/64

摘要： A surface acoustic wave device includes at least one transducer; two acoustic reflectors disposed on either side of the at least one transducer so as to form a cavity, each acoustic reflector comprising an array of electrodes in the form of lines parallel with each other, each array comprising a subset of electrodes connected to a reference potential denoted mass defining a first connection type, and a subset of electrodes that are not connected to any potential, i.e. that have a floating connection defining a second connection type; at least one switching circuit configured to modify the distribution of the connections of at least one part of the electrodes of each array between the different connection types.

公开(公告)号：US20240011155A1

公开(公告)日：2024-01-11

申请号：US18247432

申请日：2021-09-30

申请人： Centre National de la Recherche Scientifique ,  Universite de Lille ,  Centrale Lille Institut ,  Universite Polytechnique Hauts de France ,  Universite d'Artois ,  Nantes Universite

发明人： Christophe LETHIEN ,  Maxime HALLOT ,  Pascal ROUSSEL ,  Thierry BROUSSE

IPC分类号： C23C16/455 ,  C23C16/18 ,  C23C8/12

CPC分类号： C23C16/45553 ,  C23C16/45555 ,  C23C16/18 ,  C23C8/12

摘要： The invention relates to a manufacturing method for manufacturing a positive electrode layer based on a lithiated material suitable for three-dimensional batteries, or 3D batteries, so as to obtain a lithiated material on a substrate, the lithiated material comprising several thin layers, i.e. layers that have thicknesses between 1 nm and 1 μm, are made up of electrochemically active complex materials, and are, inter alia, homogeneous and suitable for conforming to the raised patterns of greater or lesser complexity of the surface of the substrate on which the lithiated material is deposited.

公开(公告)号：US20230148181A1

公开(公告)日：2023-05-11

申请号：US17910937

申请日：2021-03-12

申请人： UNIVERSITE DE LORRAINE ,  UNIVERSITE DE LILLE ,  CELLENGO

发明人： Frédéric Jean BOURGAUD ,  Sissi MIGUEL ,  Aleksander SALWINSKI ,  Cindy SIGNE ,  Alain HEHN ,  Jean-Louis HILBERT ,  David GAGNEUL ,  Guillaume LEGRAND

IPC分类号： C12P7/62 ,  C12N9/18 ,  C12N15/81 ,  C12N15/82

CPC分类号： C12P7/62 ,  C12N9/18 ,  C12N15/815 ,  C12N15/8243

摘要： A protein capable of converting chlorogenic acid into isochlorogenic acid. The protein includes or is an amino acid sequence SEQ ID No. 1, a sequence having at least 80% identity with this sequence or a fragment of this sequence. Also, a process for producing isochlorogenic acid from chlorogenic acid, which includes producing the protein and bringing it into contact with chlorogenic acid.

公开(公告)号：US20230130668A1

公开(公告)日：2023-04-27

申请号：US18088158

申请日：2022-12-23

申请人： Julien PAYEN ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE ,  UNIVERSITE DE LILLE

发明人： Pierre-Marie DANZE ,  Philippe MARCHETTI ,  Pierre GUERRESCHI ,  Julien PAYEN

IPC分类号： A61F2/12 ,  A61F2/00

摘要： A device to be implanted in a subject's body to form an implant for replacing and/or increasing a volume of soft tissue, the device being of the type including a three-dimensional frame which defines an inner space in the frame. The frame is typically bio-absorbable and includes two side apertures forming a transverse passage for inserting a vascular pedicle. The device further has at least two bio-absorbable textile sheets that can be stacked on each other in the inner space of the frame.

公开(公告)号：US11635372B2

公开(公告)日：2023-04-25

申请号：US16618605

申请日：2018-06-01

申请人： Universite De Lille ,  Centre National De La Recherche Scientifique ,  Institut National De La Recherche Agronomique ,  Institut National Des Sciences Appliquees De Toulouse

发明人： Vincent Senez ,  Alexis Vlandas ,  Sebastien Lamant ,  Bernard Cathala ,  Celine Moreau ,  Gabrielle Veronese ,  Sophie Bozonnet ,  Elisabeth Laville ,  Megane Cleret

IPC分类号： G01N21/45 ,  G01N21/77 ,  G01N21/17

摘要： A process for detecting the sensitivity of one or more polymers and/or of one or more mixtures of polymers to a compound, including the steps of exposing a plurality of individualized micro-deposits including the polymer(s) and/or the mixture(s) of polymers to the compound, and detecting, by interferometry, a variation in appearance of an assembly of micro-deposits exposed to the compound and/or a variation in the dimensions and/or refractive index of at least one of the micro-deposits exposed to the compound, linked to an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.

公开(公告)号：US20230032690A1

公开(公告)日：2023-02-02

申请号：US17818481

申请日：2022-08-09

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Luc BUEE ,  Malika HAMDANE ,  David BLUM ,  Maxime DERISBOURG ,  Coline LEGHAY ,  Giovanni CHIAPPETTA ,  Joelle VINH ,  Yann VERDIER

IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/68

摘要： The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated. The invention also relates to antibody that specifically binds this new tau species, a method of detection of this new Tau species and a method of diagnosis of Tauopathy disorder.