公开(公告)号：US09078801B2

公开(公告)日：2015-07-14

申请号：US13784573

申请日：2013-03-04

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/00 ,  A61H39/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/362 ,  A61N1/375 ,  A61N1/18 ,  A61N1/378

CPC classification number: A61F5/41 ,  A61F2005/418 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61H2205/087 ,  A61N1/18 ,  A61N1/36107 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加施加在穴位BL52，BL23或GV4中的至少一个穴位下方或附近的目标组织位置处的刺激脉冲来治疗患者的勃起功能障碍状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US08954143B2

公开(公告)日：2015-02-10

申请号：US13777901

申请日：2013-02-26

Applicant: Valencia Technologies Corporation

Inventor： Chuladatta H. Thenuwara ,  David K. L. Peterson

IPC: A61N1/18 ,  A61N1/375

CPC classification number: A61N1/375 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3754 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats a disease or medical condition of a patient through application of stimulation pulses applied at a specified acupoint or other target tissue location. In a preferred implementation, the IEAD is an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在特定穴位或其他目标组织位置施加的刺激脉冲来治疗患者的疾病或医学状况。 在优选的实施方案中，IEAD是可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214128A1

公开(公告)日：2014-07-31

申请号：US13769699

申请日：2013-02-18

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson ,  Jeffrey H. Greiner

IPC: A61N1/378

CPC classification number: A61N1/378 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

Abstract: An implantable electroacupuncture device (IEAD) treats a disease or medical condition of a patient through application of stimulation pulses applied at a specified acupoint or other target tissue location. In a preferred implementation, the IEAD is an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在特定穴位或其他目标组织位置施加的刺激脉冲来治疗患者的疾病或医学状况。 在优选的实施方案中，IEAD是可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US20140214117A1

公开(公告)日：2014-07-31

申请号：US13630322

申请日：2012-09-28

Applicant: VALENCIA TECHNOLOGIES CORPORATION

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61N1/36

CPC classification number: A61H39/002 ,  A61N1/36096 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3782 ,  Y10T29/49002

Abstract: An implantable electroacupuncture device (IEAD) treats depression, bipolar disorder or Anxiety through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.

Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3处施加的刺激脉冲来治疗抑郁症，双相情感障碍或焦虑症。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。

公开(公告)号：US10820864B2

公开(公告)日：2020-11-03

申请号：US15057106

申请日：2016-02-29

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson

IPC: A61B5/00 ,  A61B5/021 ,  A61N1/36 ,  A61N1/05 ,  G16H50/30 ,  G16H20/40 ,  G16H20/10

Abstract: An exemplary method includes determining a variability of a plurality of measurements of a cardiovascular parameter of a patient suffering from hypertension, the plurality of measurements recorded one at a time over a predetermined time period. The method further includes comparing the determined variability with a predetermined reference value. If the comparing indicates that the determined variability is less than the predetermined reference value, the method includes designating the patient to be within a first class of patients representative of patients that are likely to be responsive to subcutaneous neuromodulation therapy as a treatment for hypertension. If the comparing indicates that the determined variability is greater than the predetermined reference value, the method includes designating the patient to be within a second class of patients representative of patients that are likely to be unresponsive to subcutaneous neuromodulation therapy as a treatment for hypertension. Corresponding systems and methods are also described.

公开(公告)号：US20190290541A1

公开(公告)日：2019-09-26

申请号：US16392378

申请日：2019-04-23

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara ,  Stacy O. Greiner

IPC: A61H39/00 ,  A61N1/372 ,  A61N1/36 ,  A61N1/375

Abstract: A method of treating a mental disorder of a patient includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a tissue location associated with the mental disorder. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US20190247274A1

公开(公告)日：2019-08-15

申请号：US16394902

申请日：2019-04-25

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Chuladatta Thenuwara

IPC: A61H39/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/375

CPC classification number: A61H39/002 ,  A61H39/00 ,  A61H2201/01 ,  A61N1/3606 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/3756 ,  A61N1/3782 ,  A61N1/3787 ,  Y10T29/49002

Abstract: A method of treating cardiovascular disease in a patient includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a tissue location associated with the cardiovascular disease. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

公开(公告)号：US10071252B2

公开(公告)日：2018-09-11

申请号：US15246489

申请日：2016-08-24

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson

IPC: A61N1/37 ,  A61N1/372 ,  H04W52/02 ,  H04W48/10 ,  A61H39/00 ,  A61N1/05 ,  A61H23/02 ,  H05K3/32

CPC classification number: A61N1/37223 ,  A61H23/0218 ,  A61H39/002 ,  A61H2039/005 ,  A61H2201/0157 ,  A61H2201/1207 ,  A61H2201/165 ,  A61H2201/5012 ,  A61H2201/5033 ,  A61H2201/5038 ,  A61H2201/5043 ,  A61H2201/5058 ,  A61H2201/5066 ,  A61H2201/5097 ,  A61N1/0551 ,  A61N1/3606 ,  A61N1/37205 ,  A61N1/37247 ,  A61N1/37252 ,  A61N1/37276 ,  H04W48/10 ,  H04W52/0235 ,  H05K3/325 ,  H05K2201/09027 ,  H05K2201/10037 ,  Y02D70/00

Abstract: An exemplary subcutaneous medical device implanted within a patient uses a coil-less magnetic field sensor included within the subcutaneous medical device to detect a toggling sequence between a presence and an absence of an externally-generated static magnetic field. The toggling sequence is representative of a digital data stream according to a digital wireless communication protocol. The subcutaneous medical device identifies, based on the detected toggling sequence and in accordance with the digital wireless communication protocol, a multi-bit command encoded within the digital data stream represented by the toggling sequence. The subcutaneous medical device further performs, in response to the identifying of the multi-bit command, an action associated with the multi-bit command. Corresponding methods and a corresponding external controller are also disclosed.

公开(公告)号：US20180056069A1

公开(公告)日：2018-03-01

申请号：US15690804

申请日：2017-08-30

Applicant: Valencia Technologies Corporation

Inventor： Jeffrey H. Greiner ,  David K. L. Peterson ,  Stacy Greiner Chambliss

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  A61N1/375 ,  A61N1/378 ,  A61H39/00

CPC classification number: A61N1/36071 ,  A61H39/002 ,  A61N1/0504 ,  A61N1/0551 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/36192 ,  A61N1/36196 ,  A61N1/37235 ,  A61N1/3756 ,  A61N1/378

Abstract: An exemplary electroacupuncture device may be implanted beneath a skin surface of a patient at a location corresponding to a joint affected by osteoarthritis and may perform methods for treating the osteoarthritis. In some implementations, the electroacupuncture device is powered by a primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms and a capacity of less than 60 milliamp-hours (mAh).

公开(公告)号：US09827428B2

公开(公告)日：2017-11-28

申请号：US14805336

申请日：2015-07-21

Applicant: Valencia Technologies Corporation

Inventor： David K. L. Peterson ,  Jeffrey H. Greiner

IPC: A61N1/36 ,  A61N1/378 ,  A61N1/375 ,  A61H39/00 ,  A61N1/372

CPC classification number: A61N1/378 ,  A61H39/002 ,  A61H2201/5005 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5097 ,  A61N1/36117 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3758 ,  A61N1/3782

Abstract: An implantable electroacupuncture device (IEAD) treats a specified medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied substantially at or near a specified acupoint, its underlying nerves, or other target tissue location. The IEAD includes an IEAD housing having an electrode configuration thereon that includes at least two electrodes, and pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes. The pulse generation circuitry is adapted to deliver stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, the stimulation regimen requiring that the stimulation session have a duration of T3 minutes and a rate of occurrence of once every T4 minutes, and wherein a ratio of T3/T4 is no greater than 0.05.