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    AUTOMATIC INJECTION DEVICE FOR MICROARRAY CHIP AND AUTOMATIC INJECTION HYBRIDIZATION MICROARRAY CHIP
    22.
    发明申请
    AUTOMATIC INJECTION DEVICE FOR MICROARRAY CHIP AND AUTOMATIC INJECTION HYBRIDIZATION MICROARRAY CHIP 有权
    微胶囊自动注射装置和自动注射微胶囊芯片

    公开(公告)号：US20140011703A1

    公开(公告)日：2014-01-09

    申请号：US14006488

    申请日：2012-02-10

    Applicant: Jiaming Ye ,  Pinhong Wang ,  Guoqing Wang ,  Wanli Xing

    Inventor： Jiaming Ye ,  Pinhong Wang ,  Guoqing Wang ,  Wanli Xing

    IPC: G01N1/10

    CPC classification number: G01N1/10 ,  C12Q1/6813 ,  C40B30/04 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  G01N33/543 ,  G01N33/68 ,  G01N35/1095

    Abstract: An automatic injection device comprises at least an injection unit (1). The said injection unit (1) is formed by sealing a cover plate layer (3) with hydrophilic surfaces and a microfluid layer (4). The said cover plate layer (3) is provided with at least two through holes (5). he said microfluid layer (4) is provided with a hollow-out hybridization chamber (7) and at least two hollow-out microfluid channels (6). One end of each channel (6) is connected with the hybridization chamber (7), and the other end is connected with a through hole (5) of the cover plate layer (3) respectively. Taking advantage of the hydrophilicity of the cover plate, the automatic injection device makes a solution automatically enter and fill the hybridization chamber (7) and the microfluid channels (6) by the driving force of liquid surface tension. The flow uniformity of sample solution in microarray chip is achieved by the structural design of the hybridization chamber (7) and the microfluid channels (6). The automatic injection device has advantages of simple manufacture, easy operation, high hybridization efficiency, low sample cost, and automatic quantificational injection.

    Abstract translation: 自动注射装置至少包括注射单元（1）。 所述注射单元（1）通过密封具有亲水表面的盖板层（3）和微流体层（4）而形成。 所述盖板层（3）设置有至少两个通孔（5）。 他表示微流体层（4）设置有中空杂交室（7）和至少两个中空的微流体通道（6）。 每个通道（6）的一端与杂交室（7）连接，另一端分别与盖板层（3）的通孔（5）连接。 利用盖板的亲水性，自动注射装置通过液面张力的驱动力使溶液自动进入并填充杂交室（7）和微流体通道（6）。 微阵列芯片中样品溶液的流动均匀性通过杂交室（7）和微流体通道（6）的结构设计来实现。 自动注射装置制造简单，操作简便，杂交效率高，样品成本低，自动定量注射等优点。

    Microelectrode Arrays
    23.
    发明申请
    Microelectrode Arrays 有权
    微电极阵列

    公开(公告)号：US20090322309A1

    公开(公告)日：2009-12-31

    申请号：US12424955

    申请日：2009-04-16

    Applicant: Jing Zhu ,  Zhongyao Yu ,  Xueling Quan ,  Guangxin Xiang ,  Yuming Hu ,  Wanli Xing ,  Jing Cheng

    Inventor： Jing Zhu ,  Zhongyao Yu ,  Xueling Quan ,  Guangxin Xiang ,  Yuming Hu ,  Wanli Xing ,  Jing Cheng

    IPC: G01N27/00 ,  H05K1/16

    CPC classification number: G01N33/4836

    Abstract: Among others things, techniques, systems, and apparatus are disclosed for recording electrophysiological signals. In one aspect, a microelectrode sensing device includes a printed circuit board (PCB), a chip unit electrically connected to the PCB, and a cell culture chamber positioned over the chip unit and sealed to the PCB with the chip unit between the PCB and the cell culture chamber. The chip unit includes a substrate; a conductive layer positioned over the substrate that includes one or more recording electrodes; an insulation layer positioned over the conductive layer; another conductive layer positioned over the insulation layer that includes positioning electrodes; and another insulation layer positioned over the other conductive layer. The recording and positioning electrodes are electrically independent so as to independently receive a stimulus signal at each recording electrode and positioning electrode and independently detect a sensed signal at each recording electrode.

    Abstract translation: 公开了用于记录电生理信号的技术，系统和装置。 在一个方面，微电极感测装置包括印刷电路板（PCB），与PCB电连接的芯片单元和位于芯片单元上方并且密封到PCB的细胞培养室，芯片单元位于PCB和PCB之间 细胞培养室。 芯片单元包括基板; 位于所述基板上方的包括一个或多个记录电极的导电层; 位于导电层上的绝缘层; 位于包括定位电极的绝缘层之上的另一个导电层; 以及位于另一导电层上的另一绝缘层。 记录和定位电极是电独立的，以便在每个记录电极和定位电极处独立地接收刺激信号，并独立地检测每个记录电极处的感测信号。

    MICROARRAY-BASED ASSAY INTEGRATED WITH PARTICLES FOR ANALYZING MOLECULAR INTERACTIONS
    27.
    发明申请
    MICROARRAY-BASED ASSAY INTEGRATED WITH PARTICLES FOR ANALYZING MOLECULAR INTERACTIONS 有权
    用于分析分子相互作用的基于微阵列的测定

    公开(公告)号：US20130217584A1

    公开(公告)日：2013-08-22

    申请号：US13814213

    申请日：2010-08-06

    Applicant: Guanbin Zhang ,  Guangxin Xiang ,  Wanli Xing ,  Jing Cheng

    Inventor： Guanbin Zhang ,  Guangxin Xiang ,  Wanli Xing ,  Jing Cheng

    IPC: C12Q1/68

    CPC classification number: C12Q1/6837 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2563/155

    Abstract: A microarray-based assay is provided, which is used for analyzing molecular interactions, including polynucleotides, polypeptides, antibodies, small molecule compounds, peptides and carbohydrates. Such method comprises coupling a target molecule to a particle and then binding to a probe molecule on microarray. In particular, multiplexed genetic analysis of nucleic acid fragments can be implemented. Specific genes, single nucleotide polymorphisms or gene mutations, such as deletions, insertions, and indels, can be identified. Coupled with microarray, the particles, themselves or further modified, facilitate the detection of results with non-expensive devices or even naked eyes. This technology enables the detection and interpretation of molecular interactions in an efficient and cost effective way.

    Abstract translation: 提供基于微阵列的测定法，其用于分析分子相互作用，包括多核苷酸，多肽，抗体，小分子化合物，肽和碳水化合物。 这种方法包括将靶分子偶联到颗粒上，然后与微阵列上的探针分子结合。 特别地，可以实现核酸片段的多重遗传分析。 可以鉴定特异性基因，单核苷酸多态性或基因突变，例如缺失，插入和插入。 与微阵列结合，颗粒本身或进一步修饰，有助于使用非昂贵装置甚至肉眼检测结果。 该技术能够以有效和成本有效的方式检测和解释分子相互作用。

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