公开(公告)号：US20060194825A1

公开(公告)日：2006-08-31

申请号：US10539539

申请日：2003-12-19

Applicant: Soumitra Ghosh ,  Yazhong Pei ,  Xiao-Qing Tang ,  Spiros Liras ,  Michael Ahlijanian

Inventor： Soumitra Ghosh ,  Yazhong Pei ,  Xiao-Qing Tang ,  Spiros Liras ,  Michael Ahlijanian

IPC: A61K31/44 ,  A61K31/40 ,  A61K31/277 ,  A61K31/235 ,  A61K31/192 ,  A61K31/195

CPC classification number: C07D263/57 ,  A61K31/185 ,  C07C65/24 ,  C07C65/30 ,  C07C65/40 ,  C07C69/94 ,  C07D277/66 ,  C07D307/80 ,  C07D333/16 ,  C07D333/24 ,  C07D333/56 ,  C07D333/60

Abstract: Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

Abstract translation: 可用于治疗与改变的线粒体功能相关的病症的化合物。 具有结构（I）的化合物，包括立体异构体，前药和药学上可接受的盐，其中R 1，R 2，R 3， R 4，R 5和R 6如本文所定义。 还公开了含有结构（I）化合物的药物组合物，以及与其使用有关的方法。

公开(公告)号：US20060045953A1

公开(公告)日：2006-03-02

申请号：US11051567

申请日：2005-02-04

Applicant: Catherine Tachdjian ,  Andrew Patron ,  Ming Qi ,  Sara Adamski-Werner ,  Xiao-Qing Tang ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Chad Priest

Inventor： Catherine Tachdjian ,  Andrew Patron ,  Ming Qi ,  Sara Adamski-Werner ,  Xiao-Qing Tang ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Chad Priest

IPC: A23L1/22

CPC classification number: A23L27/2056 ,  A23L27/205

Abstract: The inventions disclosed herein relate to non-naturally occurring amide compounds that are capable, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, of serving as savory (“umami”) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for use in foods, beverages, and other comestible or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as monosodium glutamate or known natural and artificial sweeteners.

Abstract translation: 本文公开的本发明涉及非天然存在的酰胺化合物，当与可食食品或饮料或药物组合物以优选约100ppm或更低的量级的浓度接触时，其能够作为咸味（“鲜味”）或甜味 味道改良剂，咸味或甜味调味剂和咸味或甜味增味剂，用于食品，饮料和其他可食用或口服给药的药物或组合物中，任选在常规调味剂如谷氨酸钠或其混合物存在下或与之混合时， 已知的天然和人造甜味剂。

公开(公告)号：US20050084506A1

公开(公告)日：2005-04-21

申请号：US10913303

申请日：2004-08-06

Applicant: Catherine Tachdjian ,  Andrew Patron ,  Sara Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

Inventor： Catherine Tachdjian ,  Andrew Patron ,  Sara Adamski-Werner ,  Farid Bakir ,  Qing Chen ,  Vincent Darmohusodo ,  Stephen Hobson ,  Xiaodong Li ,  Ming Qi ,  Daniel Rogers ,  Marketa Rinnova ,  Guy Servant ,  Xiao-Qing Tang ,  Mark Zoller ,  David Wallace ,  Amy Xing ,  Klaus Gubernator

IPC: A23L1/226 ,  A61K9/00 ,  A61K47/00 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  G01N33/566 ,  G01N33/74

CPC classification number: G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

Abstract translation: 本发明涉及某些非天然存在的非肽酰胺化合物和酰胺衍生物，例如草酰胺，脲和丙烯酰胺，是有用的风味或调味剂，例如调味剂或调味剂和风味或味道 增强剂，更特别地，用于食品，饮料和其它可食用或口服给药的药物产品或组合物的美味（味道味道）或甜味调节剂，美味或甜味调味剂和咸味或甜味增味剂。

公开(公告)号：US09603848B2

公开(公告)日：2017-03-28

申请号：US11760592

申请日：2007-06-08

Applicant: Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

Inventor： Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

IPC: A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D285/15 ,  C07D487/04 ,  C07D491/04 ,  G01N33/74 ,  G06F19/16 ,  G06F19/18

CPC classification number: A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D285/15 ,  C07D487/04 ,  C07D491/04 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04 ,  G06F19/16 ,  G06F19/18

Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

公开(公告)号：US08815956B2

公开(公告)日：2014-08-26

申请号：US13572237

申请日：2012-08-10

Applicant: Catherine Tachdjian ,  Xiao-Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy James Davis ,  Vincent Darmohusodo ,  Melissa Sue Wong ,  Victor Selchau

Inventor： Catherine Tachdjian ,  Xiao-Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy James Davis ,  Vincent Darmohusodo ,  Melissa Sue Wong ,  Victor Selchau

IPC: A23L1/236

CPC classification number: C07D405/12 ,  A23L2/60 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  C07D215/42 ,  C07D215/54 ,  C07D401/12 ,  C07D451/06

Abstract: The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.

Abstract translation: 本发明包括具有结构式（I）的化合物或其盐或溶剂化物。 这些化合物可用作甜味调味剂。 本发明还包括包含本发明化合物的组合物和增强组合物甜味的方法。

公开(公告)号：US20110245494A1

公开(公告)日：2011-10-06

申请号：US13056843

申请日：2009-07-29

Applicant: Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

Inventor： Catherine Tachdjian ,  Donald S. Karanewsky ,  Xiao-Qing Tang ,  Qing Chen ,  Peter Leeming ,  Tayyab Rashid ,  Daniel Levin

IPC: C07D285/16 ,  C07C255/60 ,  C07C381/00 ,  C07C237/44 ,  C07C229/40 ,  C07C231/06 ,  C07C231/02 ,  C07C253/30 ,  C07C255/58

CPC classification number: C07D285/16 ,  C01B21/096 ,  C07C231/02 ,  C07C231/14 ,  C07C235/20 ,  C07C237/44 ,  C07C253/30 ,  C07C255/54 ,  C07C255/57 ,  C07C255/59 ,  C07C303/40 ,  C07C307/10

Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.

Abstract translation: 本发明包括用于制备具有结构式（I）的化合物的方法/方法和中间体：其中X是烷基，取代的烷基，烯基，取代的烯基，杂烷基，取代的杂烷基，杂烯基或取代的杂烯基。

公开(公告)号：US20080306093A1

公开(公告)日：2008-12-11

申请号：US11760592

申请日：2007-06-08

Applicant: Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

Inventor： Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Haitian Liu ,  Catherine Tachdjian ,  Xiao-Qing Tang ,  Sara Werner ,  Marketa Rinnova ,  Qing Chen ,  Albert Zlotnik ,  Mark Zoller ,  Boris Klebansky ,  Richard Fine ,  Xinshan Kang

IPC: A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  A61P27/00 ,  C07D487/00 ,  C12N5/06 ,  G01N33/53 ,  G06G7/48

CPC classification number: A61K31/495 ,  A61K31/517 ,  A61K31/519 ,  C07D239/80 ,  C07D239/95 ,  C07D239/96 ,  C07D285/15 ,  C07D487/04 ,  C07D491/04 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/04 ,  G06F19/16 ,  G06F19/18

Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

公开(公告)号：US20070003680A1

公开(公告)日：2007-01-04

申请号：US11455314

申请日：2006-06-15

Applicant: Catherine Tachdjian ,  Andrew Patron ,  Farid Bakir ,  Claudia Averbuj ,  Chad Priest ,  Sara Adamski-Werner ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Rachel Kimmich ,  Xiao-Qing Tang ,  Rhondi Shigemura

Inventor： Catherine Tachdjian ,  Andrew Patron ,  Farid Bakir ,  Claudia Averbuj ,  Chad Priest ,  Sara Adamski-Werner ,  Qing Chen ,  Vincent Darmohusodo ,  Marketa Lebl-Rinnova ,  Rachel Kimmich ,  Xiao-Qing Tang ,  Rhondi Shigemura

IPC: A23L1/236

CPC classification number: A23L2/39 ,  A23G3/36 ,  A23G9/32 ,  A23L7/122 ,  A23L27/204 ,  A23L27/205 ,  A23L27/30 ,  A23V2002/00 ,  C07C233/11 ,  C07C233/22 ,  C07C235/34 ,  C07C235/78 ,  C07C237/20 ,  C07C255/57 ,  C07C271/22 ,  C07D213/30 ,  C07D213/85 ,  C07D239/26 ,  C07D241/24 ,  C07D307/52 ,  C07D307/54 ,  C07D333/24 ,  A23V2200/16

Abstract: The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

Abstract translation: 本文公开的本发明涉及人造双芳族酰胺化合物，当与可食食品或饮料或药物组合物以优选约100ppm或更低的量级的浓度接触时，可用作甜味调味剂，甜味调味剂或 用于食品，饮料和其他可食用产品的甜味增味剂或任选在常规调味剂如已知天然糖甜味剂和先前已知的人造甜味剂存在下或与之混合的口服药物或组合物。