公开(公告)号：US09327062B2

公开(公告)日：2016-05-03

申请号：US14624063

申请日：2015-02-17

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F. A. Hossainy ,  O. Mikael Trollsas ,  Lothar W. Kleiner

IPC: A61L31/14 ,  A61L31/06 ,  A61L31/16 ,  A61L31/04 ,  A61L27/34 ,  A61L31/10 ,  A61L27/58 ,  A61L29/14 ,  A61L29/08 ,  A61F2/82 ,  C09D105/08 ,  C09D189/00 ,  C09D101/28 ,  C08L1/28 ,  C08L5/08 ,  C08L89/00

CPC classification number: A61L31/148 ,  A61F2/82 ,  A61L27/34 ,  A61L27/58 ,  A61L29/085 ,  A61L29/148 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  C08L1/286 ,  C08L5/08 ,  C08L89/00 ,  C09D101/286 ,  C09D105/08 ,  C09D189/00

Abstract: The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.

Abstract translation: 本发明提供了具有包含聚电解质和抗衡离子的生物可溶性涂层的可植入装置及其制备和使用方法。

公开(公告)号：US09821091B2

公开(公告)日：2017-11-21

申请号：US13953656

申请日：2013-07-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F. A. Hossainy ,  Fuh-Wei Tang ,  Lothar W. Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter E. Roorda ,  Stephen D. Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

IPC: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

公开(公告)号：US09610387B2

公开(公告)日：2017-04-04

申请号：US15170618

申请日：2016-06-01

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Syed F. A. Hossainy ,  Stephen D. Pacetti

IPC: C08G63/00 ,  A61L31/14 ,  A61L31/06 ,  C08J3/18 ,  C08K5/00 ,  B29C45/72 ,  C08G63/02 ,  B29K67/00 ,  B29L31/00

CPC classification number: A61L31/141 ,  A61L31/06 ,  A61L31/148 ,  A61L2400/00 ,  B29C45/0053 ,  B29C45/72 ,  B29C71/0009 ,  B29C71/02 ,  B29C2071/0027 ,  B29C2071/022 ,  B29K2033/04 ,  B29K2067/04 ,  B29L2031/753 ,  C08J3/18 ,  C08J9/00 ,  C08J2207/10 ,  C08J2300/16 ,  C08K5/0016

Abstract: Methods of making polymeric devices, such as stents, with one or more modifications such as addition of plasticizers, to improve processing, and the devices made by these methods.

公开(公告)号：US09387282B2

公开(公告)日：2016-07-12

申请号：US14182211

申请日：2014-02-17

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Lothar W. Kleiner ,  Syed F. A. Hossainy ,  Mikael Trollsas ,  Stephen D. Pacetti

IPC: A61F2/00 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/148 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2420/02 ,  A61L2420/08 ,  C08L67/04

Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.

Abstract translation: 本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。

公开(公告)号：US09375876B2

公开(公告)日：2016-06-28

申请号：US14928823

申请日：2015-10-30

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Jason Van Sciver ,  Syed F. A. Hossainy ,  Stephen Pacetti

IPC: A61F2/06 ,  B05D3/02 ,  B29C65/76 ,  A61F2/91 ,  B05D3/04 ,  B05D1/38 ,  A61F2/82 ,  A61F2/86 ,  B29C65/10 ,  A61L31/14 ,  B29K67/00 ,  B29K105/00 ,  B29L31/00

CPC classification number: B29C65/76 ,  A61F2/82 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00389 ,  A61L31/14 ,  A61L31/148 ,  A61L2420/02 ,  B05D1/38 ,  B05D3/0254 ,  B05D3/0473 ,  B29C65/10 ,  B29K2067/046 ,  B29K2105/258 ,  B29L2031/7534

Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

公开(公告)号：US09204981B2

公开(公告)日：2015-12-08

申请号：US14659276

申请日：2015-03-16

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yung-Ming Chen ,  Jason Van Sciver ,  Syed F. A. Hossainy ,  Stephen Pacetti

IPC: A61F2/06 ,  B05D3/02 ,  A61F2/82 ,  A61L31/14

CPC classification number: B29C65/76 ,  A61F2/82 ,  A61F2/86 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2310/00389 ,  A61L31/14 ,  A61L31/148 ,  A61L2420/02 ,  B05D1/38 ,  B05D3/0254 ,  B05D3/0473 ,  B29C65/10 ,  B29K2067/046 ,  B29K2105/258 ,  B29L2031/7534

Abstract: Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.

Abstract translation: 本文描述了用于涂覆支架的方法的各种实施例。 公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。 重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平​​。

公开(公告)号：US09067002B2

公开(公告)日：2015-06-30

申请号：US14185699

申请日：2014-02-20

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： O. Mikael Trollsas ,  Lothar W. Kleiner ,  Syed F. A. Hossainy

IPC: A61F2/00 ,  A61L31/10 ,  A61L27/34 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2400/18 ,  A61L2420/08 ,  C08L67/04

Abstract: An aliphatic polyester polymer for stent coating is described.

Abstract translation: 描述了用于支架涂层的脂族聚酯聚合物。

公开(公告)号：US09067001B2

公开(公告)日：2015-06-30

申请号：US14044693

申请日：2013-10-02

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Eugene T. Michal ,  Syed F. A. Hossainy ,  Ashok Shah

IPC: A61L31/10 ,  A61L31/16 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/56 ,  C08G18/62 ,  C08G18/71 ,  C09D151/00 ,  C09D151/06 ,  C09D151/08 ,  C09D175/04

CPC classification number: A61L31/10 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/56 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/606 ,  C08F8/00 ,  C08F8/30 ,  C08F8/32 ,  C08F2800/10 ,  C08F2810/50 ,  C08G18/6212 ,  C08G18/711 ,  C09D151/003 ,  C09D151/06 ,  C09D151/08 ,  C09D175/04 ,  C08L2666/02 ,  C08L2666/04 ,  C08L2666/14 ,  C08F216/06 ,  C08F8/34 ,  C08F210/02 ,  C08F8/14

Abstract: The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.

Abstract translation: 本申请教导了具有与聚合物缀合或混合的生物相容性化合物的涂层，其中所述聚合物包括至少一种烯烃衍生单元和至少一种衍生自乙烯醇，烯丙醇或其衍生物的单元 。

公开(公告)号：US20150174300A1

公开(公告)日：2015-06-25

申请号：US14580101

申请日：2014-12-22

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： O. Mikael Trollsas ,  Michael H. Ngo ,  Syed F. A. Hossainy ,  David J. Sherman

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/06 ,  A61L31/16 ,  A61L31/04

CPC classification number: A61L31/10 ,  A61L31/047 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  C08L71/02 ,  C08L67/04

Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

Abstract translation: 本发明提供了用于控制药物释放的可植入装置上的涂层的嵌段共聚物及其制备和使用方法。

公开(公告)号：US09060923B2

公开(公告)日：2015-06-23

申请号：US13668019

申请日：2012-11-02

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F. A. Hossainy

IPC: A61F2/00 ,  A61K9/00 ,  A61K31/56 ,  A61K31/573

CPC classification number: A61K9/00 ,  A61K31/56 ,  A61K31/573 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2420/08

Abstract: The present invention relates to the treatment of vascular disease in a diabetic patient using a drug-eluting implantable medical device that releases everolimus from three distinctly loaded drug reservoir layers wherein at least one of the layers comprises at least 200 μg/cm2 of everolimus and further wherein the everolimus is the only therapeutic agent in the layers or the layers or any combination thereof further comprise an anti-inflammatory agent or an RGD peptide or both.

Abstract translation: 本发明涉及使用药物洗脱可植入医疗装置治疗糖尿病患者的血管疾病，所述药物洗脱可植入医疗装置从三个明显负载的药物储存层释放依维莫司，其中至少一个层包含至少200μg/ cm 2的依维莫司 其中依维莫司是层或层中唯一的治疗剂或其任何组合进一步包含抗炎剂或RGD肽或两者。