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公开(公告)号：US20150005279A1
公开(公告)日：2015-01-01
申请号：US14315504
申请日：2014-06-26
Applicant: ABBVIE INC.
Inventor： Dominique Bonafoux , Heather M. Davis , Kristine E. Frank , Michael M. Friedman , J. Martin Herold , Michael Z. Hoemann , Raymond Huntley , Augustine Osuma , George Sheppard , Gagandeep K. Somal , Jennifer Van Camp , Stacy A. Van Epps , Anil Vasudevan , Grier A. Wallace , Lu Wang , Lu Wang , Zhi Wang , Noel S. Wilson , Xiangdong Xu
IPC: C07D487/04 , C07D471/04 , C07D209/08 , C07D401/12 , C07D401/14 , C07D403/14 , C07D231/56 , C07D417/12 , C07D417/14
CPC classification number: C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20250122188A1
公开(公告)日：2025-04-17
申请号：US18648195
申请日：2024-04-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: C07D471/04 , A61P25/28 , C07C235/22 , C07C311/13 , C07C311/24 , C07C317/22 , C07D213/30 , C07D213/64 , C07D213/66 , C07D213/73 , C07D231/56 , C07D237/14 , C07D237/16 , C07D241/18 , C07D261/08 , C07D261/20 , C07D271/113 , C07D317/64 , C07D401/04 , C07D405/08
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20220106281A1
公开(公告)日：2022-04-07
申请号：US17108416
申请日：2020-12-01
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei Zhang , Yunsong Tong , Charles W. Hutchins , SeungWon Chung , Michael J. Dart
IPC: C07D307/82 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07D277/32 , C07D213/57 , C07D307/56 , C07C233/74 , C07D213/54 , C07C235/54 , C07C233/79 , C07C255/41 , C07C255/57 , C07C235/14
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210393599A1
公开(公告)日：2021-12-23
申请号：US16761388
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Kathleen J. Murauski
IPC: A61K31/44 , A61K45/06 , C07C237/24 , C07D213/40 , C07D241/12 , C07D261/08 , C07D277/28 , C07D213/64 , C07D263/32 , C07D231/12 , C07D213/71 , C07D307/52 , C07C323/40 , C07D213/85 , C07D213/75 , C07D271/06 , C07D405/12 , C07D401/12 , C07D239/47 , C07D233/64 , C07D333/20 , C07D471/04 , C07D237/14 , C07C311/46 , C07D235/14 , C07D239/34 , C07D471/08 , C07D493/08 , A61K31/165 , A61K31/4402 , A61K31/4965 , A61K31/426 , A61K31/42 , A61K31/4409 , A61K31/421 , A61K31/415 , A61K31/4406 , A61K31/341 , A61K31/4245 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/437 , A61K31/381 , A61K31/4045 , A61K31/4184 , A61K31/50 , A61K31/18 , A61K31/439 , A61K31/35 , A61P25/28
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20210205277A1
公开(公告)日：2021-07-08
申请号：US16761349
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Zhaoming Xiong , Michael J. Dart
IPC: A61K31/4245 , A61K45/06 , C07D271/10 , C07D207/33 , C07D263/32 , C07D271/06 , C07D233/64 , C07D231/12 , A61K31/40 , A61K31/4164 , C07D413/12 , A61K31/415 , A61P25/28
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Patent Agency Ranking
公开(公告)号：US20210179556A1
公开(公告)日：2021-06-17
申请号：US17173613
申请日：2021-02-11
Applicant: AbbVie Inc.
Inventor： Dominique Bonafoux , Heather Michele Davis , Kristine E. Frank , Michael M. Friedman , J. Martin Herold , Michael Z. Hoemann , Raymond Huntley , Augustine Osuma , George Sheppard , Gagandeep Kaur Somal , Jennifer Van Camp , Stacy Anne Van Epps , Anil Vasudevan , Grier Allan Wallace , Lu Wang , Lu Wang , Zhi Wang , Noel S. Wilson , Xiangdong Xu
IPC: C07D209/08 , C07D487/04 , C07D417/12 , C07D471/04 , C07D417/14 , C07D401/14 , C07D403/14 , C07D231/56 , C07D401/12 , A61P35/00 , C07D513/04 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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公开(公告)号：US20200347033A1
公开(公告)日：2020-11-05
申请号：US16761394
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , SeungWon Chung , Zhaoming Xiong , Kathleen J. Murauski , Qingwei I. Zhang , Brian S. Brown , Michael J. Dart
IPC: C07D403/12 , C07D207/273 , C07D401/04 , C07D401/12 , C07D239/88 , C07D413/12 , C07D263/22 , C07D265/10 , C07D209/48 , C07D405/14 , C07D405/10 , C07D209/46
Abstract: Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20190194135A1
公开(公告)日：2019-06-27
申请号：US16098946
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC: C07D213/42 , C07D261/08 , C07D231/12 , C07D241/12 , C07D213/89 , C07D271/10 , C07D307/36 , C07D277/28 , C07D471/04 , C07D333/20 , C07D209/14 , A61K31/44 , A61K31/42 , A61K31/415 , A61K31/4965 , A61K31/4245 , A61K31/341 , A61K31/426 , A61K31/4439 , A61K31/381 , A61K31/4045 , C07D263/32 , A61K31/421 , C07D235/00 , A61K31/417 , C07D239/34 , A61K31/505 , C07D237/08 , A61K31/50 , C07C235/22 , A61K31/197 , C07C311/16 , A61K31/18 , C07C323/09
CPC classification number: C07D213/42 , A61K31/18 , A61K31/197 , A61K31/341 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/44 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C235/22 , C07C311/16 , C07C323/09 , C07C2602/38 , C07C2602/40 , C07C2602/42 , C07C2602/44 , C07C2603/90 , C07D209/14 , C07D213/40 , C07D213/64 , C07D213/89 , C07D231/12 , C07D235/00 , C07D237/08 , C07D239/34 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/07 , C07D271/10 , C07D277/28 , C07D307/36 , C07D307/52 , C07D333/20 , C07D471/04
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20190135772A1
公开(公告)日：2019-05-09
申请号：US16098679
申请日：2017-05-05
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Lawrence A. Black , Xiangdong Xu , Ramzi Farah Sweis , Lei Shi , Qingwei I. Zhang , Yunsong Tong , Charles W. Hutchins , Seungwon Chung , Michael J. Dart
IPC: C07D307/82 , C07D307/56 , C07D277/32 , C07D261/08 , C07D241/44 , C07D241/12 , C07D237/10 , C07D231/14 , C07D213/74 , C07D213/57
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20250145594A1
公开(公告)日：2025-05-08
申请号：US18251079
申请日：2021-10-29
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Kathleen J. Murauski , John T. Randolph , Lei Shi , Russell C. Smith , Yunsong Tong , Xiangdong Xu , Hanae Benelkebir , Kamaldeep K. Chohan , Steven J. Edeson , Sebastian Schwenk , Kathryn A. Starbuck
IPC: C07D405/14 , A61K31/167 , A61K31/353 , A61K31/397 , A61K31/4025 , A61K31/403 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/538 , A61K31/695 , C07C235/22 , C07D213/65 , C07D231/18 , C07D271/10 , C07D311/66 , C07D403/04 , C07D405/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D493/08 , C07F7/10
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
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