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公开(公告)号：US20250115563A1
公开(公告)日：2025-04-10
申请号：US18647747
申请日：2024-04-26
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Yunsong Tong , Xiangdong Xu , Qingwei Zhang , Ramzi Farah Sweis , Michael J. Dart
IPC: C07D271/10 , A61K31/4245 , A61K31/4355 , A61K31/4439 , A61K45/06 , A61P25/28 , C07D233/96 , C07D271/06 , C07D401/12 , C07D413/12 , C07D491/048
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240018133A1
公开(公告)日：2024-01-18
申请号：US18462918
申请日：2023-09-07
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph , Hanae Benelkebir
IPC: C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08
CPC classification number: C07D413/12 , C07D209/08 , C07D265/36 , C07D307/83 , C07D307/85 , C07D311/24 , C07D317/68 , C07D319/20 , C07D405/12 , C07D405/14 , C07D417/12 , C07D493/04 , C07D493/08 , A61K45/06
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20210230195A1
公开(公告)日：2021-07-29
申请号：US17227071
申请日：2021-04-09
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC: C07F9/12
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20200345727A1
公开(公告)日：2020-11-05
申请号：US16761390
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Marina Pliushchev , Yunsong Tong , Lawrence A. Black , Xiangdong Xu , Lei Shi , Qingwei I. Zhang , SeungWon Chung , Ramzi Farah Sweis , Michael J. Dart , John T. Randolph , Kathleen J. Murauski
IPC: A61K31/4965 , A61K45/06 , C07D261/18 , C07D263/34 , C07D241/20 , A61K31/421 , A61K31/42 , A61K31/437 , C07D471/04 , C07D487/04 , C07D333/38 , C07D307/68 , A61K31/381 , A61K31/519 , A61K31/341 , A61K31/415 , A61K31/426 , A61K31/425 , C07D275/03 , C07D277/56 , C07D231/14 , C07D495/04 , A61K31/4985 , C07D237/20 , C07D413/04 , C07D285/06 , C07D317/46 , A61K31/36 , A61K31/4245 , A61K31/422 , A61K31/4196 , C07D249/10 , C07D217/26 , A61K31/472 , A61K31/196 , C07C233/62 , C07D401/04 , A61K31/4427 , A61K31/5355
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US10280184B2
公开(公告)日：2019-05-07
申请号：US15304131
申请日：2015-04-16
Applicant: AbbVie Inc.
Inventor： Michael M. Friedman , Philip Cox , Kristine E. Frank , Michael Z. Hoemann , Augustine Osuma , Noel S. Wilson , Xiangdong Xu , Kevin Cusack , Raymond Huntley , J. Martin Herold
IPC: C07D471/04 , C07D519/00 , A61K31/437 , C07D487/04 , C07D498/04
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
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Patent Agency Ranking
公开(公告)号：US09567339B2
公开(公告)日：2017-02-14
申请号：US14315504
申请日：2014-06-26
Applicant: AbbVie Inc.
Inventor： Dominique Bonafoux , Heather M. Davis , Kristine E. Frank , Michael M. Friedman , J. Martin Herold , Michael Z. Hoemann , Raymond Huntley , Augustine Osuma , George Sheppard , Gagandeep K. Somal , Jennifer Van Camp , Stacy A. Van Epps , Anil Vasudevan , Grier A. Wallace , Lu Wang , Lu Wang , Zhi Wang , Noel S. Wilson , Xiangdong Xu
IPC: C07D487/04 , C07D417/12 , C07D471/04 , C07D209/08 , C07D417/14 , C07D401/14 , C07D403/14 , C07D231/56 , C07D401/12
CPC classification number: C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: The invention provides compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Abstract translation: 本发明提供式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。
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公开(公告)号：US20240173307A1
公开(公告)日：2024-05-30
申请号：US18330171
申请日：2023-06-06
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Marina Pliushchev , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Qingwei Zhang , Zhaoming Xiong , Ramzi Farah Sweis , Michael J. Dart , Kathleen J. Murauski
IPC: A61K31/44 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/444 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K45/06 , A61P25/28 , C07C237/24 , C07C311/46 , C07C323/40 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/85 , C07D231/12 , C07D233/64 , C07D235/14 , C07D237/14 , C07D239/34 , C07D239/47 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D471/04 , C07D471/08 , C07D493/08
CPC classification number: A61K31/44 , A61K31/165 , A61K31/18 , A61K31/341 , A61K31/35 , A61K31/381 , A61K31/4045 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/437 , A61K31/439 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/443 , A61K31/444 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K45/06 , A61P25/28 , C07C237/24 , C07C311/46 , C07C323/40 , C07D213/40 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/85 , C07D231/12 , C07D233/64 , C07D235/14 , C07D237/14 , C07D239/34 , C07D239/47 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D471/04 , C07D471/08 , C07D493/08
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20240000792A1
公开(公告)日：2024-01-04
申请号：US18463183
申请日：2023-09-07
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , SeungWon Chung , Qingwei Zhang , Lei Shi , Kathleen J. Murauski , Michael J. Dart , John T. Randolph
IPC: A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
CPC classification number: A61K31/538 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/4045 , A61K31/472 , A61K45/06 , C07C235/22 , C07D209/08 , C07D209/42 , C07D217/16 , C07D265/36 , C07D307/85 , C07D311/66 , C07D317/46 , C07D319/20 , C07D405/12 , C07D413/06 , C07D413/12 , C07D493/04
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：US20230192712A1
公开(公告)日：2023-06-22
申请号：US16761369
申请日：2018-11-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Zhaoming Xiong
IPC: C07D487/10 , C07D205/04 , C07D211/32 , C07D207/09 , C07D209/44 , C07D295/185
CPC classification number: C07D487/10 , C07D205/04 , C07D211/32 , C07D207/09 , C07D209/44 , C07D295/185
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：US20220251123A1
公开(公告)日：2022-08-11
申请号：US17446807
申请日：2021-09-02
Applicant: Calico Life Sciences LLC , AbbVie Inc.
Inventor： Kathleen Ann Martin , Carmela Sidrauski , Michael J. Dart , Jennifer M. Frost , Yunsong Tong , Xiangdong Xu , Lei Shi , Kathleen Murauski , Marina Pliushchev , Brian S. Brown , Eric Voight , John T. Randolph
IPC: C07F9/12
Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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