公开(公告)号：US09084671B2

公开(公告)日：2015-07-21

申请号：US13942474

申请日：2013-07-15

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Eugene T. Michal ,  Ashok A. Shah ,  Ni Ding

IPC: A61F2/06 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61F2/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/45

Abstract: A coating for an implantable device such as a stent is provided including micronized peptides. A method of making the same is also provided.

Abstract translation: 提供了用于诸如支架的可植入装置的涂层，其包括微粉化肽。 还提供了制造该方法的方法。

公开(公告)号：US20150134048A1

公开(公告)日：2015-05-14

申请号：US14602617

申请日：2015-01-22

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Ni Ding

IPC: A61L31/06 ,  A61K31/436 ,  A61F2/82 ,  C08G63/66

CPC classification number: A61L31/06 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/436 ,  C08G63/64 ,  C08G63/66 ,  C08G63/664 ,  C08G63/78

Abstract: The present invention is directed to polymeric materials comprising biodegradable, dioxanone-based copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The polymeric materials can also contain at least one additional biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.

Abstract translation: 本发明涉及包含由这些材料形成的可生物降解的二恶烷酮基共聚物和可植入装置（例如药物递送支架）的聚合物材料。 聚合物材料还可含有至少一种另外的生物相容性部分，至少一种非结垢部分，至少一种生物有益材料，至少一种生物活性剂或其组合。 聚合材料被设计成改善由其形成的可植入装置的机械，物理和生物学特性。

公开(公告)号：US20140330365A1

公开(公告)日：2014-11-06

申请号：US14267620

申请日：2014-05-01

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Ni Ding

IPC: A61L31/16 ,  B65B3/00 ,  A61F2/82

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L27/50 ,  A61L27/505 ,  A61L27/54 ,  A61L31/022 ,  A61L31/143 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/802 ,  B65B3/003 ,  Y10T29/49993

Abstract: A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.

Abstract translation: 用于装载到支架的结构元件中的组合物，其中所述结构元件由内腔和至少一个开口限定以进入所述内腔。 组合物可以包含治疗剂，螯合剂，沉淀剂或其组合。 还描述了填充有组合物的医疗装置，例如具有由内腔限定的结构元件和用于进入内腔的至少一个开口的支架。

公开(公告)号：US20140110885A1

公开(公告)日：2014-04-24

申请号：US14139740

申请日：2013-12-23

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yunbing Wang ,  Xiao Ma ,  Fuh-Wei Tang ,  Ni Ding

IPC: B29C35/02

CPC classification number: B29C71/02 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91583 ,  A61F2210/0004 ,  A61F2240/001 ,  A61L2/007 ,  A61L2/08 ,  A61L2/087 ,  A61L31/06 ,  A61L31/148 ,  A61L2202/21 ,  A61L2202/24 ,  A61L2400/18 ,  B29C35/02 ,  B29C2035/0877 ,  B29C2071/022 ,  B29L2031/753 ,  C08J7/08 ,  C08J7/123 ,  C08J2367/04 ,  C08L67/04

Abstract: Methods are disclosed for conditioning a polymeric stent after sterilization, and/or after crimping and before packaging, such that the properties of the polymeric stent fall within a narrower range of values. The stent is exposed to a controlled temperature at or above ambient for a period of time after radiation sterilization and/or after crimping and before sterilization. As a result, the polymeric stent properties, particularly radial strength and number-average molecular weight of the polymer of the polymeric stent, fall within a narrower range.

Abstract translation: 公开了用于在灭菌后和/或在卷曲之后和包装之前调节聚合物支架的方法，使得聚合物支架的性质落在较窄的值范围内。 在辐射灭菌后和/或在压接之后和灭菌之前将支架暴露于等于或高于环境的受控温度一段时间。 结果，聚合物支架的聚合物支架性质，特别是聚合物支架的聚合物的径向强度和数均分子量落在更窄的范围内。

公开(公告)号：US09993583B2

公开(公告)日：2018-06-12

申请号：US14636818

申请日：2015-03-03

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Ni Ding

IPC: A61L31/16 ,  A61F2/82 ,  A61K38/17 ,  A61L31/10

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61K38/1709 ,  A61L31/10 ,  A61L2300/252 ,  A61L2300/416

Abstract: Method are disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

公开(公告)号：US20150359647A1

公开(公告)日：2015-12-17

申请号：US14302295

申请日：2014-06-11

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Ni Ding

IPC: A61F2/90

CPC classification number: A61F2/90 ,  A61L31/06

Abstract: Methods of making polymeric devices, such as stents, using solvent based processes. More particularly, methods of making bioabsorbable stents.

Abstract translation: 使用基于溶剂的方法制造聚合物装置例如支架的方法。 更具体地，制备生物可吸收支架的方法。

公开(公告)号：US20150328375A1

公开(公告)日：2015-11-19

申请号：US14664554

申请日：2015-03-20

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Thierry Glauser ,  Stephen Dirk Pacetti ,  Syed Faiyaz Ahmed Hossainy ,  Ni Ding

IPC: A61L31/10 ,  A61L33/08 ,  A61L33/00 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/08 ,  A61L2300/40 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  C08L33/14

Abstract: A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含其上的包含聚合物和任选的生物活性剂的涂层的DES，以及使用该装置的方法 提供了人类疾病的治疗。

公开(公告)号：US20130317599A1

公开(公告)日：2013-11-28

申请号：US13942474

申请日：2013-07-15

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Eugene T. Michal ,  Ashok A. Shah ,  Ni Ding

IPC: A61F2/06

CPC classification number: A61F2/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/45

Abstract: A coating for an implantable device such as a stent is provided including micronized peptides. A method of making the same is also provided.

Abstract translation: 提供了用于诸如支架的可植入装置的涂层，其包括微粉化肽。 还提供了制造该方法的方法。

公开(公告)号：US20130150953A1

公开(公告)日：2013-06-13

申请号：US13759898

申请日：2013-02-05

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Ni Ding

IPC: A61F2/82 ,  B65D1/00

CPC classification number: A61F2/82 ,  A61L31/10 ,  A61L31/143 ,  B65B55/00 ,  B65D1/00 ,  B65D3/00 ,  B65D77/04 ,  C08K5/13

Abstract: Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

Abstract translation: 本发明描述了将抗氧化剂并入包括聚合物的医疗装置中的方法，以及包装医疗装置的方法。

公开(公告)号：US20240400756A1

公开(公告)日：2024-12-05

申请号：US18643271

申请日：2024-04-23

Applicant: Abbott Cardiovascular Systems, Inc.

Inventor： Xinhua Zong ,  Ni Ding ,  Mary Beth Kossuth ,  Erik David Eli

IPC: C08G64/18 ,  A61L17/00 ,  A61L17/12

Abstract: A block copolymer comprises an A block and a B block. The A block provides mechanical strength while the B block provides elasticity to the polymeric material. The block copolymer may be an ABA tri-block copolymer. The A block may include one or more of polyglycolide (PGA), polylactic acid (PLA), or copolymer thereof. The B block may include a random copolymer of (i) glycolide (GA) and/or lactide (LA), (ii) trimethylene carbonate (TMC), and (iii) ε-caprolactone (CL). The block copolymer may cover an implantable device which may be used in delivering immediate hemostasis at a puncture site in a wall of a blood vessel.