公开(公告)号：US07351531B2

公开(公告)日：2008-04-01

申请号：US10333152

申请日：2001-07-17

申请人： Isao Saito ,  Kazuhiko Nakatani ,  Shinsuke Sando

发明人： Isao Saito ,  Kazuhiko Nakatani ,  Shinsuke Sando

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07H21/02

CPC分类号： C07D519/00 ,  A61K31/4375

摘要： A method of forming a self-connective structure (a hairpin structure, a four-stranded structure, etc.) of a single-stranded oligonucleotide chain by forming a mimetic base pair of a mismatch base pair failing to form any normal base pair among base pairs of the single-stranded oligonucleotide chain with the use of a compounds represented by the following general formula (I): A-L-B (I) wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair failing to form any normal base pair; B represents a chemical structural moiety capable of forming a pair with the other base of the base pair failing to form any normal base pair; and L represents a linker structure by which the chemical structures A and B are linked to each other; and a method of inhibiting the activity of enzyme according to the previous method.

摘要翻译： 通过形成不能在碱基中形成任何正常碱基对的错配碱基对的模拟碱基对，形成单链寡核苷酸链的自连接结构（发夹结构，四链结构等）的方法 使用由以下通式（I）表示的化合物的单链寡核苷酸链对：ALB（I）其中A表示能够与未成形的碱基对的一个碱基形成一对的化学结构部分 任何正常的碱基对; B表示能够与碱基对的另一个碱基形成一对而不能形成任何正常碱基对的化学结构部分; L表示化学结构A和B彼此连接的连接体结构; 以及根据前述方法抑制酶的活性的方法。

公开(公告)号：US20070037841A1

公开(公告)日：2007-02-15

申请号：US10547234

申请日：2004-02-26

申请人： Kazuhiko Nakatani ,  Souta Horie ,  Isao Saito ,  Shinya Hagihara ,  Yuki Goto ,  Akio Kobori

发明人： Kazuhiko Nakatani ,  Souta Horie ,  Isao Saito ,  Shinya Hagihara ,  Yuki Goto ,  Akio Kobori

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： An inhibitor contains naphthyridine dimer, a naphthyridine-azaquinolone hybrid, a trinaphthyridine-azaquinolone hybrid, or a trinaphthyridine-azaquinolone hybrid derivative. In order to inhibit binding of 100 nM of RRE to 100 nM of Rev protein, for example, an inhibitor containing naphthyridine dimer is used at a molarity of 1.2 μM to 12 μM, an inhibitor containing the naphthyridine-azaquinolone hybrid is used at a molarity of 2 μM to 20 μM, or an inhibitor containing the trinaphthyridine-azaquinolone hybrid derivative is used at a molarity of 200 nM to 2 μM. This makes it possible to effectively inhibit binding of RRE to Rev protein.

摘要翻译： 抑制剂含有萘啶二聚体，萘啶 - 氮杂喹诺酮杂环，三萘啶 - 氮杂喹诺酮杂环或三萘并氮杂喹啉酮杂合衍生物。 为了抑制100nM的RRE与100nM的Rev蛋白的结合，例如，使用含有萘啶二聚体的抑制剂，摩尔浓度为1.2μM至12μM，含有萘啶 - 氮杂喹诺酮杂化物的抑制剂的摩尔浓度 或者含有三萘并氮杂喹啉酮杂化衍生物的抑制剂的摩尔浓度为200nM至2μM。 这使得有可能有​​效地抑制RRE与Rev蛋白的结合。

公开(公告)号：US06919476B2

公开(公告)日：2005-07-19

申请号：US10398621

申请日：2001-09-05

申请人： Hisafumi Ikeda ,  Isao Saito ,  Yushin Nakamura

发明人： Hisafumi Ikeda ,  Isao Saito ,  Yushin Nakamura

IPC分类号： B01D15/36 ,  B01J39/04 ,  B01J39/26 ,  C07C235/38 ,  C07C255/60 ,  C07C269/06 ,  C07C271/20 ,  C07K1/06 ,  C07C261/00

CPC分类号： C07C255/60 ,  B01D15/362 ,  B01J39/04 ,  B01J39/26 ,  C07C235/38 ,  C07C269/06 ,  C07C271/20 ,  C07K1/062

摘要： A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II): (wherein R1 has the same meaning as described above, and R2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.

公开(公告)号：US06607890B1

公开(公告)日：2003-08-19

申请号：US09889976

申请日：2001-07-24

申请人： Kazuhiko Nakatani ,  Isao Saito ,  Shinsuke Sando

发明人： Kazuhiko Nakatani ,  Isao Saito ,  Shinsuke Sando

IPC分类号： C12Q168

CPC分类号： C12Q1/6832 ,  C12Q2527/125 ,  C12Q2527/107

摘要： A method whereby a mismatched base pair in a nucleic acid such as DNA or RNA can be conveniently and highly sensitively detected; and detection reagents therefor. A method comprising, in a base pair failing to form a normal base pair, forming a mimetic base pair with the use of a mismatch-recognizing molecule represented by the following general formula (I): A—L—B (I) wherein A represents a chemical structure moiety capable of forming a pair with one of the bases of the base pair failing to form a normal base pair; B represents a chemical structure moiety capable of forming a pair with the other of the bases of the base pair failing to form a normal base pair; and L represents a linker structure whereby the chemical structure moieties A and B are linked to each other; and measuring the formation of the above-described mimetic base pair to thereby detect and identify the base pair failing to form a normal base pair; kits therefor; reagents for detecting a mismatch; and a method of detecting an abnormality in the base sequence of a gene.

摘要翻译： 可以方便，高度敏感地检测核酸如DNA或RNA中的错配碱基对的方法; 及其检测试剂。 在不能形成正常碱基对的碱基对中，使用由以下通式（I）表示的错配识别分子形成模拟碱基对：ALB（I）其中A表示化学结构 能够与碱基对的碱基之一形成一对的部分未能形成正常的碱基对; B表示能够与碱基对的另一个碱基形成正常碱基对的化学结构部分; L表示连接结构，其中化学结构部分A和B彼此连接; 并测量上述模拟碱基对的形成，从而检测和鉴定不能形成正常碱基对的碱基对; 套装; 用于检测错配的试剂; 以及检测基因的碱基序列异常的方法。

公开(公告)号：US5726702A

公开(公告)日：1998-03-10

申请号：US393335

申请日：1995-02-23

申请人： Masakazu Hamaguchi ,  Hiroaki Takahashi ,  Takashi Takeuchi ,  Toshiyuki Oda ,  Tomochika Yamashita ,  Hitoshi Akiyama ,  Isao Saito

发明人： Masakazu Hamaguchi ,  Hiroaki Takahashi ,  Takashi Takeuchi ,  Toshiyuki Oda ,  Tomochika Yamashita ,  Hitoshi Akiyama ,  Isao Saito

IPC分类号： H04N5/445 ,  H04N5/765 ,  H04N5/775

CPC分类号： H04N21/47214 ,  H04N5/44543 ,  H04N5/765 ,  H04N21/4104 ,  H04N21/42204 ,  H04N21/4316 ,  H04N21/47 ,  H04N21/488 ,  H04N5/775

摘要： A television signal receiving apparatus which can read program information relevant to a television program from an optical disk medium, interlocked with the television program and can reproduce and display the read program information. Program information (broadcasting information including program names, broadcasting channel names and broadcasting dates and times and appendant information relevant to the contents of the programs) relevant to the television programs to be displayed by the television receiver/display is recorded in the optical disk medium. When a user instructs a display of the program information by the selection and decision input unit, the television control unit transmits the display request and time information from the clock apparatus to the control unit of the optical disk unit. The control unit makes the appendant information to be reproduced from the optical disk medium, by using the broadcasting channel name and the time information as retrieval information. The appendant information is sent to the television receiver/display through the interface and is displayed in a picture and sound.

摘要翻译： 一种电视信号接收装置，其能够从光盘介质读取与电视节目相关的节目信息，与电视节目互锁，并且可以再现和显示所读取的节目信息。 与电视接收机/显示器显示的电视节目相关的节目信息（包括节目名称，广播频道名称，广播日期和时间以及与节目内容相关的附属信息）被记录在光盘媒体中。 当用户通过选择和决定输入单元指示节目信息的显示时，电视控制单元将来自时钟设备的显示请求和时间信息发送到光盘单元的控制单元。 控制单元通过使用广播频道名称和时间信息作为检索信息，使从光盘介质再生的附加信息。 该附加信息通过接口发送到电视接收机/显示器，并以图像和声音的形式显示。

公开(公告)号：US4598553A

公开(公告)日：1986-07-08

申请号：US375582

申请日：1982-05-06

申请人： Isao Saito ,  Yoji Ishibashi ,  Takashi Ohmori ,  Yoshimitsu Minakawa ,  Michio Kuroda

发明人： Isao Saito ,  Yoji Ishibashi ,  Takashi Ohmori ,  Yoshimitsu Minakawa ,  Michio Kuroda

IPC分类号： F23R3/14 ,  F23R3/28 ,  F23R3/30 ,  F23R3/34 ,  F02C1/00 ,  F02G3/00

CPC分类号： F23R3/14 ,  F23R3/34

摘要： A gas turbine combustor comprises an inner cylinder provided with louvers in an outer periphery thereof, defines a head combustion chamber and a main combustion chamber located downstream of and greater in diameter than the head combustion. An outer cylinder surrounds the inner cylinder and defines an air passage therebetween. A first burner communicates with the head combustion chamber and supplies air with gaseous fuel, and a second burner being disposed in the air passage near the head combustion chamber and supplying air and gaseous fuel into the main combustion chamber. The second burner is formed with a plurality of air inlets by a plurality of vanes which are disposed in an annular passage and which swirl the air, and with gaseous fuel jet ports near the inner peripheries of the air inlets. When the flow rate of the supplied fuel is small, the fuel flows along an inner-peripheral surface of the second burner, and when the flow rate is large, the fuel from the air inlets moves from the inner-peripheral surface toward the outer-peripheral surface of the second burner so as to be mixed well with the air supplied into the main combustion chamber. Thus, the production of NO.sub.x, CO, HC etc. can be decreased over the whole operating range of the turbine.

摘要翻译： 燃气轮机燃烧器包括在其外周设置有百叶窗的内筒，限定头部燃烧室和主燃烧室，该主燃烧室和主燃烧室位于头部燃烧的直径以下。 外筒围绕内筒并在其间形成空气通道。 第一燃烧器与头部燃烧室连通并且向空气供应气体燃料，第二燃烧器设置在靠近头部燃烧室的空气通道中并将空气和气体燃料供应到主燃烧室中。 第二燃烧器由多个叶片形成有多个空气入口，多个叶片设置在环形通道中并使空气旋转，并且在空气入口的内周边附近具有气体燃料喷射口。 当供给的燃料的流量小时，燃料沿着第二燃烧器的内周面流动，并且当流量大时，来自空气入口的燃料从内周面朝向外侧面移动， 第二燃烧器的周面，以便与供给主燃烧室的空气充分混合。 因此，可以在涡轮机的整个工作范围内降低NOx，CO，HC等的生产。

公开(公告)号：US4556580A

公开(公告)日：1985-12-03

申请号：US685285

申请日：1984-12-24

申请人： Takashi Kamuro ,  Hisao Ootsuga ,  Isao Saito ,  Motoyuki Koga

发明人： Takashi Kamuro ,  Hisao Ootsuga ,  Isao Saito ,  Motoyuki Koga

IPC分类号： F16L55/16 ,  B05D7/22 ,  F16L55/10 ,  F16L55/1645 ,  F16L55/18 ,  F16L58/10 ,  G01M3/28 ,  B05D1/42

CPC分类号： G01M3/2853 ,  F16L55/10 ,  F16L55/1645 ,  F16L55/18

摘要： A method for repairing pipes laid underground, such as gas pipes, consisting of a main supply pipe from which numerous distribution pipes branch off to supply the individual users, the method using resin to repair the main supply pipe and the distribution pipes from the inside while in their buried state.The repair method of this invention is characterized by the fact that, having repaired the main supply pipe and the distribution pipe in successive operations, whether the repairs to the main supply pipe and the distribution pipes have been done properly or not can be confirmed on completion of the repairs by carrying out sealage tests on the distribution pipes and the main supply pipe.

摘要翻译： 一种用于修理地下管道的方法，例如气体管道，由主要供应管道组成，多个分配管从该主管道分流出来供应个体用户，使用树脂从内部维修主供应管道和分配管道的方法， 在他们的埋葬状态。 本发明的修理方法的特征在于，在连续操作中维修主供水管和分配管的情况下，是否已经完成了对主供水管和配水管的修理是否已经完成。 对配水管和主供水管进行密封试验。