公开(公告)号：US09155453B2

公开(公告)日：2015-10-13

申请号：US11869470

申请日：2007-10-09

Applicant: Alka Kumar ,  Atul Kumar

Inventor： Alka Kumar ,  Atul Kumar

IPC: A61B1/00 ,  A61B1/012 ,  A61B17/32 ,  A61B19/00 ,  A61M1/00

CPC classification number: A61B17/32002 ,  A61B1/00071 ,  A61B1/012 ,  A61B1/126 ,  A61B17/320016 ,  A61B2017/320024 ,  A61B2090/3614 ,  A61B2217/005 ,  A61B2217/007 ,  A61M1/0058

Abstract: A user friendly, safe and efficient continuous flow irrigation endoscope having only a single housing sheath without an inner sheath. The exclusion of the inner sheath increases the effective lumen of the endoscope. A long hollow cylindrical tube, capable of performing a to and fro and rotary motion, is placed inside the housing sheath to function as an endoscopic instrument, but also to serve as a conduit for evacuating waste fluid and detached tissue pieces present inside a tissue cavity. A single inflow port located at the proximal end of the single housing sheath allows the irrigation fluid to enter the tissue cavity via the lumen of the said housing sheath. The invented endoscope system has a single inflow port, a single outflow port, without an inner sheath so that all waste fluid and tissue debris present inside cavity are evacuated via the same single outflow port. No type of feedback mechanism, such as mechanical or electrical feedback mechanism, is incorporated in the endoscope to facilitate the removal of detached tissue pieces or waste fluid.

Abstract translation: 用户友好，安全和有效的连续流动灌溉内窥镜，其仅具有没有内护套的单个外壳护套。 内护套的排除增加了内窥镜的有效内腔。 能够进行往复和旋转运动的长的中空圆柱形管被放置在壳体护套内部以用作内窥镜器械，而且还用作用于排出存在于组织腔内的废液和分离的组织片的导管 。 位于单个壳体护套的近端的单个流入口允许冲洗流体经由所述壳体护套的内腔进入组​​织腔。 本发明的内窥镜系统具有单个流入口，单个流出口，没有内护套，使得存在于腔内的所有废液和组织碎片经由相同的单个流出口排出。 没有类型的反馈机构，例如机械或电气反馈机构，被并入内窥镜中以便于去除分离的组织片或废液。

公开(公告)号：US09028398B2

公开(公告)日：2015-05-12

申请号：US11870267

申请日：2007-10-10

Applicant: Alka Kumar ,  Atul Kumar

Inventor： Alka Kumar ,  Atul Kumar

IPC: A61B1/12 ,  A61B1/00 ,  A61B1/04 ,  A61B1/015 ,  A61M1/00 ,  A61M3/02 ,  F04B43/12

CPC classification number: A61B1/015 ,  A61B1/00068 ,  A61B1/00071 ,  A61B1/00094 ,  A61M1/0031 ,  A61M1/0058 ,  A61M3/0258 ,  A61M2205/3337 ,  F04B43/1253

Abstract: A continuous flow irrigation endoscope and a continuous flow irrigation fluid management system, both designed to be compatible to each other and to function as a single system. The endoscope and the fluid management system are synergistic to each other such that both enhance the efficiency of each other. The invented system allows a body tissue cavity to be distended by continuous flow irrigation so that detached tissue pieces and waste fluid present inside a body tissue cavity are continuously automatically evacuated from the tissue cavity without causing the cavity to collapse at any stage and without the need of withdrawing the endoscope of a part of the endoscope from the tissue cavity. No type of feedback mechanism, such as mechanical or electrical, or valve or valve like systems, are incorporated in the endoscope to influence or facilitate the removal of detached tissue pieces or waste fluid in any manner.

Abstract translation: 连续流动灌溉内窥镜和连续流动灌溉流体管理系统，均被设计为彼此兼容并用作单个系统。 内窥镜和流体管理系统彼此协同，从而提高彼此的效率。 本发明的系统允许身体组织腔通过连续流动灌洗来扩张，使得存在于身体组织腔内的分离的组织片和废液不断地从组织腔排出，而不会导致腔在任何阶段崩溃，而不需要 从所述组织腔抽出所述内窥镜的一部分的内窥镜。 没有类型的反馈机构，例如机械或电气，或阀或阀门系统，并入内窥镜中以影响或便于以任何方式去除分离的组织片或废液。

公开(公告)号：US08226549B2

公开(公告)日：2012-07-24

申请号：US11871051

申请日：2007-10-11

Applicant: Alka Kumar ,  Atul Kumar

Inventor： Alka Kumar ,  Atul Kumar

IPC: A61B1/12

CPC classification number: A61B1/015 ,  A61B1/00068 ,  A61B1/00071 ,  A61M1/0058 ,  A61M3/0258

Abstract: A continuous flow irrigation endoscope and a continuous flow irrigation fluid management system, both designed to be compatible to each other and meant to function as a single system. The endoscope and the fluid management system are synergistic to each other such that both enhance the efficiency of each other. The system allows a body tissue cavity to be distended by continuous flow irrigation so that the detached tissue pieces and waste fluid present inside a body tissue cavity are continuously automatically evacuated from the tissue cavity without causing the cavity to collapse at any stage and without the need of withdrawing the endoscope or a part of the endoscope from the tissue cavity.

Abstract translation: 连续流动灌溉内窥镜和连续流动灌溉流体管理系统，其被设计为彼此兼容并且意图用作单个系统。 内窥镜和流体管理系统彼此协同，从而提高彼此的效率。 该系统允许通过连续流动灌洗来扩张身体组织腔，使得存在于身体组织腔内的分离的组织片和废液不断地从组织腔排出，而不会导致腔在任何阶段崩溃，而不需要 从组织腔抽出内窥镜或内窥镜的一部分。

公开(公告)号：US20060264701A1

公开(公告)日：2006-11-23

申请号：US11280734

申请日：2005-11-17

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61B1/00

CPC classification number: A61B17/3423 ,  A61B17/3421 ,  A61B17/3431

Abstract: A system for minimizing leakage of fluid distending media by the sides of the endoscopic instrument in endoscopic procedures such as arthroscopy, hysteroscopy or laparoscopy. A double-wall flexible tubular sheath having walls containing pressurized fluid is mounted over an endoscopic instrument. The double-wall flexible tubular sheath moves in and out of a natural opening of a tissue cavity or through an incision made in the cavity wall.

公开(公告)号：US20060052666A1

公开(公告)日：2006-03-09

申请号：US11216170

申请日：2005-09-01

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61B1/12

CPC classification number: A61M31/00 ,  A61B1/015 ,  A61M1/0058 ,  A61M3/0216 ,  A61M3/0258 ,  A61M29/00 ,  A61M2205/3334

Abstract: A system to minimize fluid turbulence inside a tissue cavity during endoscopic procedures. A body tissue cavity of a subject is distended by continuous flow irrigation using a solenoid operated pump on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by the outflow positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss into the subject's body system during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate.

Abstract translation: 一种在内窥镜手术期间使组织腔内的流体湍流最小化的系统。 受试者的身体组织腔通过流入侧的电磁操作泵和流出侧上的诸如蠕动泵的容积式泵，通过连续流动灌流来扩张，使得由流体侧产生的压力脉动的振幅 所述组织腔内的流出正位移泵基本上被抑制到几乎可忽略的水平。 本发明还提供了一种用于在任何内窥镜程序中精确地确定进入受试者身体系统的流体速率的方法，而不使用任何缺陷重量或流体体积计算，这通过使用两个流体流速传感器来实现。 本发明还提供了一种在任何期望的腔体流出速率下，在身体组织腔中产生和维持任何所需压力的系统。

公开(公告)号：US07427686B2

公开(公告)日：2008-09-23

申请号：US10677116

申请日：2003-09-30

Applicant: Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Suprabhat Ray ,  Girish Kumar Jain

Inventor： Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Suprabhat Ray ,  Girish Kumar Jain

IPC: C07D311/00

CPC classification number: C07D311/58

Abstract: The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 alkyl; C3-C7 cycloalkyl; R2 is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6-alkyl, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkoxy and phenyl, wherein R4 is C1-C6 alkyl; R3 is phenyl substituted with OR5 wherein R5 has the formula (II), (III) or (IV) wherein Y is chosen from NHR4, NR42, NHCOR4, NHSO2R4, CONHR4, CONR4, CONR42, COOH, COOR4, SO2R4, SOR4, SONHR4, SONR42, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR4, NR24, or a nitrogen heterocycle, wherein R4 is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.

公开(公告)号：US20070244161A1

公开(公告)日：2007-10-18

申请号：US11812251

申请日：2007-06-15

Applicant: Sangita ,  Atul Kumar ,  Man Singh ,  Girish Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

Inventor： Sangita ,  Atul Kumar ,  Man Singh ,  Girish Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

IPC: A61K31/12 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61P19/08 ,  A61P25/28 ,  A61P35/00

CPC classification number: C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Abstract translation: 新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症 ，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：US07250446B2

公开(公告)日：2007-07-31

申请号：US10809845

申请日：2004-03-26

Applicant: Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Girish Kumar Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

Inventor： Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Girish Kumar Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

IPC: A61K31/18 ,  C07C313/00 ,  C07C315/00

CPC classification number: C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Abstract translation: 新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症 ，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：US07192645B2

公开(公告)日：2007-03-20

申请号：US10207652

申请日：2002-07-29

Applicant: Chung J. Lee ,  Atul Kumar

Inventor： Chung J. Lee ,  Atul Kumar

IPC: B32B27/28

CPC classification number: H01L23/5329 ,  B01J19/123 ,  B01J19/1887 ,  B01J2219/00153 ,  B01J2219/00159 ,  B01J2219/0879 ,  B05D1/007 ,  B05D1/60 ,  B05D3/0254 ,  B05D3/061 ,  B05D3/062 ,  B29C71/02 ,  B29C2071/022 ,  B29C2071/025 ,  B29C2071/027 ,  C08G61/02 ,  C08G61/025 ,  C08G2261/3424 ,  C08J5/18 ,  C08J2365/04 ,  C08L65/00 ,  C08L65/04 ,  C23C16/452 ,  F28D17/005 ,  H01L21/0212 ,  H01L21/02203 ,  H01L21/02263 ,  H01L21/312 ,  H01L21/3127 ,  H01L23/53238 ,  H01L2924/0002 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31855 ,  H01L2924/00

Abstract: Methods and products of Transport co-polymerization (“TCP”) that are useful for preparations of low Dielectric Constant (“ε”) thin films are disclosed. Transport co-polymerization (“TCP”) of reactive intermediates that are generated from a first precursor with a general structural formula (Z)m—Ar—(CX′X″Y)n (VI) with a second reactive intermediate that is generated from a cage compound (e.g. Fullerenes, Methylsilsesquioxane, Hydrosilsesquioxane, and Adamantanyl) or a cyclic-compounds (e.g. Cyclo-Siloxanes and 2,2-Paracyclophanes) results in co-polymer films that are useful for making porous low ε (≦2.0) thin films. The porous thin films of this invention consist of nano-pores with uniform pore distribution thus retain high rigidity thus are suitable for manufacturing of future ICs using copper as conductor. Preparation methods and stabilization processes for low k co-polymers that consist of sp2C—Z and HC-sp3Cα—X bonds are also revealed. A preparation method is achieved by controlling the substrate temperature and feed rate of the major precursors. One stabilization process includes a post annealing of as-deposited co-polymer films under the presence of hydrogen under high temperatures. The reductive annealing of these films is conducted at temperatures from −20° C. to −50° C. to +20° C. to +50° C. of their Reversible Crystal Transformation (“CRT”) temperatures, then quenching the resulting films to −20° C. to −50° C. below their “CRT” temperatures. The reductive annealing is conducted before the as-deposited film was removed from a deposition system and still under the vacuum. “Re-stabilization” processes of co-polymer surfaces that are exposed to reactive plasma etching are also disclosed; thus, further coating by barrier metal, cap layer or etch-stop layer can be safely applied.

公开(公告)号：US20060122556A1

公开(公告)日：2006-06-08

申请号：US11211562

申请日：2005-08-26

Applicant: Atul Kumar ,  Alkar Kumar

Inventor： Atul Kumar ,  Alkar Kumar

IPC: A61M31/00

CPC classification number: A61B1/015 ,  A61M1/0058 ,  A61M1/0072 ,  A61M3/0258 ,  A61M2205/3337

Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation by using two positive displacement pumps, such as peristaltic pumps, one pump on the inflow side and another pump on the outflow side, such that the amplitude of the pressure pulsations created by a the said positive displacement pumps inside the tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method of reducing the frequency of the said pressure pulsations. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.

Abstract translation: 本发明提供一种系统和方法，其通过使用两个容积式泵，例如蠕动泵，流入侧的一个泵和流出侧的另一个泵，通过连续流动冲洗来膨胀受试者的身体组织腔，使得 由组织空腔内的所述正位移泵产生的压力脉动的幅度基本上被抑制到几乎可忽略的水平。 本发明还提供一种降低所述压力脉动频率的方法。 本发明还提供了一种用于在任何内窥镜程序中精确地确定流体损失速率的方法，而不使用任何缺陷重量或流体体积计算，这通过使用两个流体流速传感器来实现。 本发明还提供了一种在任何期望的腔体流出速率下，在身体组织腔中产生和维持任何所需压力的系统。 上述本发明的系统和方法可用于需要连续流动灌洗的任何内窥镜程序中，这种内窥镜手术的例子是宫腔镜手术，关节镜手术，经皮穿刺手术，脑内窥镜手术和脊柱内窥镜手术 。