公开(公告)号：US20060122556A1

公开(公告)日：2006-06-08

申请号：US11211562

申请日：2005-08-26

Applicant: Atul Kumar ,  Alkar Kumar

Inventor： Atul Kumar ,  Alkar Kumar

IPC: A61M31/00

CPC classification number: A61B1/015 ,  A61M1/0058 ,  A61M1/0072 ,  A61M3/0258 ,  A61M2205/3337

Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation by using two positive displacement pumps, such as peristaltic pumps, one pump on the inflow side and another pump on the outflow side, such that the amplitude of the pressure pulsations created by a the said positive displacement pumps inside the tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method of reducing the frequency of the said pressure pulsations. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.

Abstract translation: 本发明提供一种系统和方法，其通过使用两个容积式泵，例如蠕动泵，流入侧的一个泵和流出侧的另一个泵，通过连续流动冲洗来膨胀受试者的身体组织腔，使得 由组织空腔内的所述正位移泵产生的压力脉动的幅度基本上被抑制到几乎可忽略的水平。 本发明还提供一种降低所述压力脉动频率的方法。 本发明还提供了一种用于在任何内窥镜程序中精确地确定流体损失速率的方法，而不使用任何缺陷重量或流体体积计算，这通过使用两个流体流速传感器来实现。 本发明还提供了一种在任何期望的腔体流出速率下，在身体组织腔中产生和维持任何所需压力的系统。 上述本发明的系统和方法可用于需要连续流动灌洗的任何内窥镜程序中，这种内窥镜手术的例子是宫腔镜手术，关节镜手术，经皮穿刺手术，脑内窥镜手术和脊柱内窥镜手术 。

公开(公告)号：US08652089B2

公开(公告)日：2014-02-18

申请号：US10548950

申请日：2004-07-21

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61M1/00 ,  A61M31/00 ,  A61B1/00

CPC classification number: A61M3/0258 ,  A61M1/006 ,  A61M3/0216 ,  A61M3/0229 ,  A61M3/0262 ,  A61M2205/3337

Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation such that minimal or negligible fluid turbulence is present inside the cavity, such that any desired cavity pressure can be created and maintained for any desired outflow rate. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation or flow rate sensor. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.

Abstract translation: 本发明提供一种系统和方法，用于通过连续流动冲洗来膨胀受试者的身体组织腔，使得在腔内存在最小或可忽略的流体湍流，使得可以产生任何期望的腔压力并保持任何期望的流出 率。 本发明还提供了一种用于在任何内窥镜程序期间精确地确定流体损失进入受检者体内系统的方法，而不使用任何赤字重量或流体体积计算或流量传感器。 上述本发明的系统和方法可用于需要连续流动灌洗的任何内窥镜程序中，这种内窥镜手术的例子是宫腔镜手术，关节镜手术，经皮穿刺手术，脑内窥镜手术和脊柱内窥镜手术 。

公开(公告)号：US07427686B2

公开(公告)日：2008-09-23

申请号：US10677116

申请日：2003-09-30

Applicant: Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Suprabhat Ray ,  Girish Kumar Jain

Inventor： Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Suprabhat Ray ,  Girish Kumar Jain

IPC: C07D311/00

CPC classification number: C07D311/58

Abstract: The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 alkyl; C3-C7 cycloalkyl; R2 is phenyl, optionally substituted with 1 to 5 substituents independently selected from the group comprising OH, C1-C6-alkyl, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkoxy and phenyl, wherein R4 is C1-C6 alkyl; R3 is phenyl substituted with OR5 wherein R5 has the formula (II), (III) or (IV) wherein Y is chosen from NHR4, NR42, NHCOR4, NHSO2R4, CONHR4, CONR4, CONR42, COOH, COOR4, SO2R4, SOR4, SONHR4, SONR42, a C3-C7 heterocyclic ring, saturated or unsaturated, containing one or two heteroatoms independently selected from the group consisting of O, S and N, optionally being substituted with 1 to 3 substituents independently selected from the group comprising H, OH, halogen, nitro, cyano, SH, SR4, trihalo-C1-C6-alkyl, C1-C6-alkyl and C1-C6-alkoxy, preferably NHR4, NR24, or a nitrogen heterocycle, wherein R4 is as defined above, and the esters, ethers, and salts of the compounds of formula I, optionally along pharmaceutically acceptable excipients, a process for the preparation of the same, and a method of preventing and/or treating estrogen-related disease conditions in a subject using compounds of formula 1, or its salts, optionally along with pharmaceutically acceptable excipients.

公开(公告)号：US20080091061A1

公开(公告)日：2008-04-17

申请号：US11871051

申请日：2007-10-11

Applicant: Alka Kumar ,  Atul Kumar

Inventor： Alka Kumar ,  Atul Kumar

IPC: A61B1/015

CPC classification number: A61B1/015 ,  A61B1/00068 ,  A61B1/00071 ,  A61M1/0058 ,  A61M3/0258

Abstract: A continuous flow irrigation endoscope and a continuous flow irrigation fluid management system, both designed to be compatible to each other and meant to function as a single system. The endoscope and the fluid management system are synergistic to each other such that both enhance the efficiency of each other. The system allows a body tissue cavity to be distended by continuous flow irrigation so that the detached tissue pieces and waste fluid present inside a body tissue cavity are continuously automatically evacuated from the tissue cavity without causing the cavity to collapse at any stage and without the need of withdrawing the endoscope or a part of the endoscope from the tissue cavity.

Abstract translation: 连续流动灌溉内窥镜和连续流动灌溉流体管理系统，其被设计为彼此兼容并且意图用作单个系统。 内窥镜和流体管理系统彼此协同，从而提高彼此的效率。 该系统允许通过连续流动灌洗来扩张身体组织腔，使得存在于身体组织腔内的分离的组织片和废液不断地从组织腔排出，而不会导致腔在任何阶段崩溃，而不需要 从组织腔抽出内窥镜或内窥镜的一部分。

公开(公告)号：US20070244161A1

公开(公告)日：2007-10-18

申请号：US11812251

申请日：2007-06-15

Applicant: Sangita ,  Atul Kumar ,  Man Singh ,  Girish Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

Inventor： Sangita ,  Atul Kumar ,  Man Singh ,  Girish Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

IPC: A61K31/12 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61P19/08 ,  A61P25/28 ,  A61P35/00

CPC classification number: C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Abstract translation: 新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症 ，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：US07250446B2

公开(公告)日：2007-07-31

申请号：US10809845

申请日：2004-03-26

Applicant: Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Girish Kumar Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

Inventor： Sangita ,  Atul Kumar ,  Man Mohan Singh ,  Girish Kumar Jain ,  Puvvada Sri Ramanchandra Murthy ,  Suprabhat Ray

IPC: A61K31/18 ,  C07C313/00 ,  C07C315/00

CPC classification number: C07D295/088 ,  C07C317/22 ,  C07C317/24 ,  C07C323/19 ,  C07C323/22 ,  C07C323/25

Abstract: Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.

Abstract translation: 新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症 ，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

公开(公告)号：US07192645B2

公开(公告)日：2007-03-20

申请号：US10207652

申请日：2002-07-29

Applicant: Chung J. Lee ,  Atul Kumar

Inventor： Chung J. Lee ,  Atul Kumar

IPC: B32B27/28

CPC classification number: H01L23/5329 ,  B01J19/123 ,  B01J19/1887 ,  B01J2219/00153 ,  B01J2219/00159 ,  B01J2219/0879 ,  B05D1/007 ,  B05D1/60 ,  B05D3/0254 ,  B05D3/061 ,  B05D3/062 ,  B29C71/02 ,  B29C2071/022 ,  B29C2071/025 ,  B29C2071/027 ,  C08G61/02 ,  C08G61/025 ,  C08G2261/3424 ,  C08J5/18 ,  C08J2365/04 ,  C08L65/00 ,  C08L65/04 ,  C23C16/452 ,  F28D17/005 ,  H01L21/0212 ,  H01L21/02203 ,  H01L21/02263 ,  H01L21/312 ,  H01L21/3127 ,  H01L23/53238 ,  H01L2924/0002 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31855 ,  H01L2924/00

Abstract: Methods and products of Transport co-polymerization (“TCP”) that are useful for preparations of low Dielectric Constant (“ε”) thin films are disclosed. Transport co-polymerization (“TCP”) of reactive intermediates that are generated from a first precursor with a general structural formula (Z)m—Ar—(CX′X″Y)n (VI) with a second reactive intermediate that is generated from a cage compound (e.g. Fullerenes, Methylsilsesquioxane, Hydrosilsesquioxane, and Adamantanyl) or a cyclic-compounds (e.g. Cyclo-Siloxanes and 2,2-Paracyclophanes) results in co-polymer films that are useful for making porous low ε (≦2.0) thin films. The porous thin films of this invention consist of nano-pores with uniform pore distribution thus retain high rigidity thus are suitable for manufacturing of future ICs using copper as conductor. Preparation methods and stabilization processes for low k co-polymers that consist of sp2C—Z and HC-sp3Cα—X bonds are also revealed. A preparation method is achieved by controlling the substrate temperature and feed rate of the major precursors. One stabilization process includes a post annealing of as-deposited co-polymer films under the presence of hydrogen under high temperatures. The reductive annealing of these films is conducted at temperatures from −20° C. to −50° C. to +20° C. to +50° C. of their Reversible Crystal Transformation (“CRT”) temperatures, then quenching the resulting films to −20° C. to −50° C. below their “CRT” temperatures. The reductive annealing is conducted before the as-deposited film was removed from a deposition system and still under the vacuum. “Re-stabilization” processes of co-polymer surfaces that are exposed to reactive plasma etching are also disclosed; thus, further coating by barrier metal, cap layer or etch-stop layer can be safely applied.

公开(公告)号：US20060129099A1

公开(公告)日：2006-06-15

申请号：US11240393

申请日：2005-10-03

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61M1/00

CPC classification number: A61M3/0258 ,  A61M3/0216

Abstract: A system for distending body tissue cavities of subjects by continuous flow irrigation during endoscopic procedures, the system including: a fluid source reservoir containing a non viscous physiologic fluid meant for cavity distension; a fluid supply conduit tube connecting the fluid source reservoir to an inlet port of a variable speed positive displacement inflow pump and an outlet port of the said inflow pump being connectable to an inflow port of an endoscope instrument through an inflow tube for pumping the fluid at a controlled flow rate into the cavity, the flow rate of the said inflow pump being termed as the inflow rate; an inflow pressure transducer being located anywhere in the inflow tube between the outlet port of the inflow pump and the inflow port of the endoscope; an outflow port of the endoscope being connectable to a waste fluid collecting container via a waste fluid carrying tube, and characterized in that an active inflow pressure pulsation dampening means is connected to the inflow tube for dampening the pressure pulsations inside the cavity created by the positive displacement inflow pump.

Abstract translation: 一种用于在内窥镜程序期间通过连续流动灌注来增加受试者的身体组织腔的系统，所述系统包括：含有用于腔膨胀的非粘性生理液的流体源储存器; 将流体源储存器连接到变速正排量流入泵的入口和所述流入泵的出口的流体供应管道，其可通过流入管连接到内窥镜器械的流入口，用于将流体泵送 进入空腔的受控流速，所述流入泵的流量被称为流入速率; 流入压力传感器位于流入管的出口与内窥镜的流入口之间的流入管的任何地方; 所述内窥镜的流出口经由废液输送管可连接到废液收集容器，其特征在于，主动流入压力脉动阻尼装置连接到所述流入管，用于阻尼所述空腔内产生的压力脉动 排量流入泵。

公开(公告)号：US20060122557A1

公开(公告)日：2006-06-08

申请号：US11211571

申请日：2005-08-26

Applicant: Atul Kumar ,  Alka Kumar

Inventor： Atul Kumar ,  Alka Kumar

IPC: A61M31/00

CPC classification number: A61M3/0237 ,  A61B1/015 ,  A61M1/0058

Abstract: The present invention provides a system and a method for distending a body tissue cavity of a subject by continuous flow irrigation by using a positive displacement pump, such as a pneumatic pump, on the inflow side and a positive displacement pump, such as a peristaltic pump, on the outflow side, such that the amplitude of the pressure pulsations created by a the two positive displacement pump inside the said tissue cavity is substantially dampened to almost negligible levels. The present invention also provides a method for accurately determining the rate of fluid loss, into the subject's body system, during any endoscopic procedure without utilizing any deficit weight or fluid volume calculation, the same being accomplished by using two fluid flow rate sensors. The present invention also provides a system of creating and maintaining any desired pressure in a body tissue cavity for any desired cavity outflow rate. The system and the methods of the present invention described above can be used in any endoscopic procedure requiring continuous flow irrigation few examples of such endoscopic procedures being hysteroscopic surgery, arthroscopic surgery, trans uretheral surgery, endoscopic surgery of the brain and endoscopic surgery of the spine.

公开(公告)号：US20060051972A1

公开(公告)日：2006-03-09

申请号：US10936156

申请日：2004-09-07

Applicant: Chieh Chen ,  Atul Kumar ,  Yuri Pikovsky ,  Chung Lee

Inventor： Chieh Chen ,  Atul Kumar ,  Yuri Pikovsky ,  Chung Lee

IPC: H01L21/469 ,  C23C16/00

CPC classification number: H01L21/02271 ,  H01L21/02118 ,  H01L21/0212 ,  H01L21/02123 ,  H01L21/02126 ,  H01L21/02131 ,  H01L21/02164 ,  H01L21/022 ,  H01L21/312 ,  H01L21/316 ,  H01L21/76808 ,  H01L21/76811 ,  H01L21/76835 ,  Y10T29/41

Abstract: A method of forming a hybrid inorganic/organic dielectric layer on a substrate for use in an integrated circuit is provided, wherein the method includes forming a first dielectric layer on the substrate via chemical vapor deposition, and forming a second dielectric layer on the first dielectric layer via chemical vapor deposition, wherein one of the first dielectric layer and the second dielectric layer is formed from an organic dielectric material, and wherein the other of the first dielectric layer and the second dielectric layer is formed from an inorganic dielectric material.

Abstract translation: 提供了一种在用于集成电路的衬底上形成杂化无机/有机电介质层的方法，其中所述方法包括通过化学气相沉积在衬底上形成第一电介质层，并在第一电介质上形成第二电介质层 层，其中所述第一介电层和所述第二介电层中的一个由有机介电材料形成，并且其中所述第一介电层和所述第二介电层中的另一个由无机介电材料形成。