公开(公告)号：US08730031B2

公开(公告)日：2014-05-20

申请号：US13180539

申请日：2011-07-11

申请人： Todd Thompson ,  Mark Zdeblick ,  Yashar Behzadi ,  Benedict Costello ,  Timothy Robertson ,  Hooman Hafezi ,  George Savage

发明人： Todd Thompson ,  Mark Zdeblick ,  Yashar Behzadi ,  Benedict Costello ,  Timothy Robertson ,  Hooman Hafezi ,  George Savage

IPC分类号： H04Q5/22

CPC分类号： A61B5/076 ,  A61B5/0028 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/4839 ,  A61B2560/0214 ,  A61J3/007 ,  A61N1/37288 ,  G06F19/00 ,  G06F19/3418 ,  H01Q1/273

摘要： The system of the present invention includes an implantable device that can detect high and low frequency current signature. The implantable device can communicate with a communication device that includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, the communication device is activated.

摘要翻译： 本发明的系统包括可以检测高频和低频电流签名的可植入装置。 可植入装置可以与包括导电元件，电子部件和不同材料形式的部分电源的通信装置通信。 当与导电流体接触时，通信装置被激活。

公开(公告)号：US09883819B2

公开(公告)日：2018-02-06

申请号：US13141048

申请日：2010-01-06

申请人： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

发明人： Marc Jensen ,  Robert Leichner ,  Patrick Beaulieu ,  Kit Yee Au-Yeung ,  Lawrence Arne ,  Mark Zdeblick ,  Andrew Thompson ,  George Savage ,  Timothy Robertson ,  Yashar Behzadi

IPC分类号： A61B5/07 ,  A61B5/00 ,  G06F19/00 ,  H04B13/00 ,  A61B5/021 ,  A61B5/024 ,  A61B5/11

CPC分类号： A61B5/073 ,  A61B5/0002 ,  A61B5/021 ,  A61B5/024 ,  A61B5/1112 ,  A61B5/486 ,  A61B5/6833 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G16H10/60 ,  G16H20/00 ,  G16H20/10 ,  H04B13/005

摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.

公开(公告)号：US09149423B2

公开(公告)日：2015-10-06

申请号：US13319977

申请日：2010-05-10

申请人： Robert Duck ,  George Savage ,  Patricia Johnson ,  Mark Zdeblick ,  Benedict Costello ,  Kityee Au-Yeung ,  Timothy Robertson ,  Hooman Hafezi

发明人： Robert Duck ,  George Savage ,  Patricia Johnson ,  Mark Zdeblick ,  Benedict Costello ,  Kityee Au-Yeung ,  Timothy Robertson ,  Hooman Hafezi

IPC分类号： A61K9/00 ,  A61K9/48 ,  A61K49/00 ,  A61B5/07 ,  A61M31/00 ,  A61B5/1473 ,  A61J3/07

CPC分类号： A61K9/0004 ,  A61B5/073 ,  A61B5/1473 ,  A61J3/07 ,  A61K9/4808 ,  A61K49/00 ,  A61M31/002

摘要： Ingestible event markers comprising an identifier and an ingestible component are provided. The ingestible component may vary, where ingestible components of interest include osmotic ingestible components, liquid capsules, tablets, multi-layered ingestible component and multi-compartment ingestible components. In some instances, the identifier is mechanically stably associated with the ingestible component. Also provided are systems that include the ingestible event markers, as well as methods of using the ingestible event markers.

摘要翻译： 提供包含标识符和可摄入成分的可摄入事件标记。 可摄取组分可以变化，其中感兴趣的摄入成分包括渗透性可摄取组分，液体胶囊，片剂，多层可摄取组分和多室摄入组分。 在一些情况下，标识符与可摄入组分机械稳定地相关联。 还提供了包括可摄入事件标记的系统，以及使用可摄取事件标记的方法。

公开(公告)号：US08469921B2

公开(公告)日：2013-06-25

申请号：US13336956

申请日：2011-12-23

申请人： Timothy Robertson ,  Fataneh Omidvar ,  Yashar Behzadi ,  Lawrence Arne ,  Kenneth Rowberry ,  James Hutchison ,  Robert Leichner ,  George Savage ,  Andrew Thompson ,  Mark Zdeblick ,  Marc Kreidler ,  Hooman Hafezi ,  Robert Duck

发明人： Timothy Robertson ,  Fataneh Omidvar ,  Yashar Behzadi ,  Lawrence Arne ,  Kenneth Rowberry ,  James Hutchison ,  Robert Leichner ,  George Savage ,  Andrew Thompson ,  Mark Zdeblick ,  Marc Kreidler ,  Hooman Hafezi ,  Robert Duck

IPC分类号： A61M5/16

摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.

公开(公告)号：US20120059257A1

公开(公告)日：2012-03-08

申请号：US13319977

申请日：2010-05-10

申请人： Robert Duck ,  George Savage ,  Patricia Johnson ,  Mark Zdeblick ,  Benedict Costelo ,  Kityee Au-yeung ,  Timothy Robertson ,  Hooman Hafesi

发明人： Robert Duck ,  George Savage ,  Patricia Johnson ,  Mark Zdeblick ,  Benedict Costelo ,  Kityee Au-yeung ,  Timothy Robertson ,  Hooman Hafesi

IPC分类号： A61B6/00

CPC分类号： A61K9/0004 ,  A61B5/073 ,  A61B5/1473 ,  A61J3/07 ,  A61K9/4808 ,  A61K49/00 ,  A61M31/002

摘要： Ingestible event markers comprising an identifier and an ingestible component are provided. The ingestible component may vary, where ingestible components of interest include osmotic ingestible components, liquid capsules, tablets, multi-layered ingestible component and multi-compartment ingestible components. In some instances, the identifier is mechanically stably associated with the ingestible component. Also provided are systems that include the ingestible event markers, as well as methods of using the ingestible event markers.

摘要翻译： 提供包含标识符和可摄入成分的可摄入事件标记。 可摄取组分可以变化，其中感兴趣的摄入成分包括渗透性可摄取组分，液体胶囊，片剂，多层可摄取组分和多室摄入组分。 在一些情况下，标识符与可摄入组分机械稳定地相关联。 还提供了包括可摄入事件标记的系统，以及使用可摄取事件标记的方法。

公开(公告)号：US20100312188A1

公开(公告)日：2010-12-09

申请号：US12673326

申请日：2009-12-15

申请人： Timothy Robertson ,  Fataneh Omidvar ,  Yashar Behzadi ,  Lawrence Arne ,  Kenneth Rowberry ,  James Hutchison ,  Robert Leichner ,  George Savage ,  Andrew Thompson ,  Mark Zdeblick ,  Marc Kreidler ,  Hooman Hafezi ,  Robert Duck

发明人： Timothy Robertson ,  Fataneh Omidvar ,  Yashar Behzadi ,  Lawrence Arne ,  Kenneth Rowberry ,  James Hutchison ,  Robert Leichner ,  George Savage ,  Andrew Thompson ,  Mark Zdeblick ,  Marc Kreidler ,  Hooman Hafezi ,  Robert Duck

IPC分类号： A61M5/20 ,  A61B5/00

CPC分类号： A61M5/1723 ,  A61B5/0006 ,  A61B5/0028 ,  A61B5/02055 ,  A61B5/0404 ,  A61B5/04085 ,  A61B5/0428 ,  A61B5/053 ,  A61B5/11 ,  A61B5/1112 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/4094 ,  A61B2560/0209 ,  A61B2560/0412 ,  A61B2560/0468 ,  A61B2562/0219 ,  A61M5/1452 ,  A61M5/172 ,  G06F19/34 ,  G06F19/3418 ,  H04B13/005

摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.

摘要翻译： 提供可能是外部或可植入的接收器。 本发明的接收机的方面包括存在一个或多个：高功率低功率模块; 中介模块; 电源模块，被配置为激活和去激活一个或多个电源给高功率处理块; 连接主站和从站的串行外设接口总线; 和多用途连接器。 本发明的接收机可以被配置为接收电传送的信号。 还提供了包括接收器的系统，以及使用它们的方法。 另外公开了使用接收器来配合给药系统的系统和方法。

公开(公告)号：US20100228312A1

公开(公告)日：2010-09-09

申请号：US12772044

申请日：2010-04-30

申请人： Robert White ,  George Savage ,  Mark Zdeblick

发明人： Robert White ,  George Savage ,  Mark Zdeblick

IPC分类号： A61N1/378

CPC分类号： H01L41/1136 ,  A61N1/30 ,  A61N1/32 ,  A61N1/3785

摘要： Implantable cardiac motion powered piezoelectric energy sources are provided. Aspects of the subject implantable energy sources they include a piezoelectric transducer that converts cardiac mechanical energy to electrical energy. The subject energy sources find use in a variety of applications, including providing power to a wide range of implantable devices.

摘要翻译： 提供了植入式心脏运动动力压电能源。 目标可植入能源的方面，它们包括将心脏机械能转化为电能的压电换能器。 主题能源可用于各种应用，包括向广泛的可植入装置提供动力。

公开(公告)号：US20080077186A1

公开(公告)日：2008-03-27

申请号：US11734617

申请日：2007-04-12

申请人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

发明人： Todd Thompson ,  Mark Zdeblick ,  Olivier Colliou ,  Benedict Costello ,  Marc Jensen ,  George Savage

IPC分类号： A61N1/00

CPC分类号： A61N1/3627

摘要： Methods of highly selective cardiac tissue stimulation and devices for practicing the same, e.g., implantable segmented electrode devices, are provided. The methods and devices provide a previously unavailable high phrenic nerve capture voltage paired with a low pacing capture voltage threshold. The subject methods and devices provide a number of benefits. For example, patients who previously would have been required to have their resynchronization device turned off due to phrenic nerve capture will now be able to reap the benefits of resynchronization therapy.

摘要翻译： 提供了高选择性心脏组织刺激的方法和用于实施该方法的装置，例如可植入分段的电极装置。 这些方法和装置提供了与低起搏捕获电压阈值配对的先前不可用的高膈神经捕获电压。 主题方法和设备提供了许多好处。 例如，以前由于膈神经捕获而被关闭的再同步装置的患者现在将能够获得再同步治疗的好处。

公开(公告)号：US09198608B2

公开(公告)日：2015-12-01

申请号：US13304274

申请日：2011-11-23

申请人： Hooman Hafezi ,  David O'Reilly ,  Patricia Johnson ,  Zahedeh Hatamkhany ,  Timothy Robertson ,  Mark Zdeblick

发明人： Hooman Hafezi ,  David O'Reilly ,  Patricia Johnson ,  Zahedeh Hatamkhany ,  Timothy Robertson ,  Mark Zdeblick

IPC分类号： G08B13/14 ,  A61B5/145 ,  A61B5/07 ,  A61J3/00 ,  H01Q1/27 ,  A61B5/01 ,  A61B5/03 ,  A61B5/1473 ,  A61B5/00 ,  H04B1/3888 ,  H04B1/38

CPC分类号： G08B21/18 ,  A61B5/01 ,  A61B5/036 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4839 ,  A61B2562/0214 ,  A61J3/007 ,  B65D41/02 ,  H01Q1/273 ,  H04B1/3888 ,  H04B2001/3894

摘要： The system of the present invention includes a container and an electronic component with a partial power source in the form of dissimilar materials. The container includes a liquid. Upon contact with the liquid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature.

摘要翻译： 本发明的系统包括容器和具有不同材料形式的部分动力源的电子部件。 容器包括液体。 当与液体接触时，产生电压电位并且电源完成，这激活了系统。 电子部件控制不同材料之间的电导，以产生独特的当前签名。

公开(公告)号：US20120299723A1

公开(公告)日：2012-11-29

申请号：US13304274

申请日：2011-11-23

申请人： Hooman Hafezi ,  David O'Reilly ,  Patricia Johnson ,  Zahedeh Hatamkhany ,  Timothy Robertson ,  Mark Zdeblick

发明人： Hooman Hafezi ,  David O'Reilly ,  Patricia Johnson ,  Zahedeh Hatamkhany ,  Timothy Robertson ,  Mark Zdeblick

IPC分类号： G08B1/08

CPC分类号： G08B21/18 ,  A61B5/01 ,  A61B5/036 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/4839 ,  A61B2562/0214 ,  A61J3/007 ,  B65D41/02 ,  H01Q1/273 ,  H04B1/3888 ,  H04B2001/3894

摘要： The system of the present invention includes a container and an electronic component with a partial power source in the form of dissimilar materials. The container includes a liquid. Upon contact with the liquid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature.

摘要翻译： 本发明的系统包括容器和具有不同材料形式的部分动力源的电子部件。 容器包括液体。 当与液体接触时，产生电压电位并且电源完成，这激活了系统。 电子部件控制不同材料之间的电导，以产生独特的当前签名。