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公开(公告)号：US10254562B2
公开(公告)日：2019-04-09
申请号：US15068396
申请日：2016-03-11
Applicant: Battelle Memorial Institute
Inventor： Herbert S. Bresler , Erik Edwards , Amy M. Heintz , John S. Laudo , Alexander C. Morrow , Steven M. Risser
Abstract: Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.
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公开(公告)号：US10211489B2
公开(公告)日：2019-02-19
申请号：US14620600
申请日：2015-02-12
Applicant: Battelle Memorial Institute
Inventor： C. Alexander Morrow , Steven M. Risser , James H. Saunders
Abstract: Light is transmitted from a light source through or from a separator of a battery cell and received by one or more light detectors. The light that is normally transmitted through the separator is scattered, absorbed, wavelength-shifted or otherwise distorted by an impending fault in the vicinity of or within the separator. The change in light due to the impending fault is measured by a detector and a signal from the detector is processed to identify the impending fault so that a warning can be generated indicative of the impending fault. In particular, one or both of the light source and detector are enclosed within a battery cell housing.
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公开(公告)号：US09884179B2
公开(公告)日：2018-02-06
申请号：US14728512
申请日：2015-06-02
Applicant: Battelle Memorial Institute
Inventor： Chad E. Bouton , Jeffrey Friend , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Alexander Morrow , Raymond Richard Zaborski , George Naegele Brand , Matthew Edward Mowrer
CPC classification number: A61N1/0484 , A61N1/0456 , A61N1/36003 , G06F3/015 , G06F3/017
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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24.发明授权Optical waveguide methods for detecting internal faults in operating batteries 有权用于检测工作电池内部故障的光波导方法公开(公告)号：US09570781B2
公开(公告)日：2017-02-14
申请号：US14620568
申请日：2015-02-12
Applicant: Battelle Memorial Institute
Inventor： James H. Saunders , C. Alexander Morrow , Steven M. Risser , Kevin B. Spahr
IPC: G01N27/416 , H01M10/48 , H01M2/16 , H01M10/42
CPC classification number: H01M10/48 , H01M2/164 , H01M2/1686 , H01M10/4285
Abstract: Light is transmitted from a light source through or from a separator of a battery cell and received by one or more light detectors. The light that is normally transmitted through the separator is scattered, absorbed, wavelength-shifted or otherwise distorted by an impending fault in the vicinity of or within the separator. The change in light due to the impending fault is measured by a detector and a signal from the detector is processed to identify the impending fault so that a warning can be generated indicative of the impending fault. In particular, the separator and a battery cell electrolyte can be selected to provide waveguide properties.
Abstract translation: 光从光源通过电池单元的隔板传送，并由一个或多个光检测器接收。 通常通过分离器传播的光被分离器附近或内部即将发生的故障散射，吸收，波长偏移或以其它方式扭曲。 由于即将发生的故障引起的光的变化由检测器测量，并且来自检测器的信号被处理以识别即将发生的故障，使得可以产生指示即将发生的故障的警告。 特别地，可以选择分离器和电池单体电解质以提供波导特性。
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公开(公告)号：US20160221283A1
公开(公告)日：2016-08-04
申请号：US15021652
申请日：2014-09-10
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Herbert S. Bresler , Erik Edwards , Amy M. Heintz , John S. Laudo , Alexander C. Morrow , Steven M. Risser
CPC classification number: B29D11/00461 , A61F2/1627 , A61F2/1635 , B29D11/00153 , B29D11/023 , G02B1/041 , G02C7/022 , G02C7/04 , G02C7/108 , C08L33/08 , C08L101/14 , C08L83/04
Abstract: Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.
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Patent Agency Ranking
公开(公告)号：US20160195735A1
公开(公告)日：2016-07-07
申请号：US15068396
申请日：2016-03-11
Applicant: Battelle Memorial Institute
Inventor： Herbert S. Bresler , Erik Edwards , Amy M. Heintz , John S. Laudo , Alexander C. Morrow , Steven M. Risser
CPC classification number: G02C7/022 , A61F2/1627 , A61F2/1635 , A61F2/1659 , A61F2002/16965 , G02B1/043 , G02C7/04
Abstract: Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.
Abstract translation: 公开了用于改变诸如人工晶状体的透镜的功率的方法和装置。 在一种方法中，透镜包含含有可交联侧基的单一聚合物基质，其中当交联时聚合物基体的体积增加。 镜头不含有游离单体。 当暴露于紫外线辐射时，交联使得透镜的暴露部分体积增加，导致折射率增加。 在另一种方法中，透镜包含含有可光漂白的发色团的聚合物基质。 在紫外线照射下，光漂白导致曝光部分的折射率降低，透镜厚度没有变化。 这些方法避免了等待发生扩散以改变透镜形状的需要，并且避免了第二次暴露于辐射以锁定透镜变化的需要。
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27.发明申请OPTICAL WAVEGUIDE METHODS FOR DETECTING INTERNAL FAULTS IN OPERATING BATTERIES 有权用于检测操作电池内部故障的光波导方法公开(公告)号：US20150270584A1
公开(公告)日：2015-09-24
申请号：US14620568
申请日：2015-02-12
Applicant: Battelle Memorial Institute
Inventor： James H. Saunders , C. Alexander Morrow , Steven M. Risser , Kevin B. Spahr
CPC classification number: H01M10/48 , H01M2/164 , H01M2/1686 , H01M10/4285
Abstract: Light is transmitted from a light source through or from a separator of a battery cell and received by one or more light detectors. The light that is normally transmitted through the separator is scattered, absorbed, wavelength-shifted or otherwise distorted by an impending fault in the vicinity of or within the separator. The change in light due to the impending fault is measured by a detector and a signal from the detector is processed to identify the impending fault so that a warning can be generated indicative of the impending fault. In particular, the separator and a battery cell electrolyte can be selected to provide waveguide properties.
Abstract translation: 光从光源通过电池单元的隔板传送，并由一个或多个光检测器接收。 通常通过分离器传播的光被分离器附近或内部即将发生的故障散射，吸收，波长偏移或以其它方式扭曲。 由于即将发生的故障引起的光的变化由检测器测量，并且来自检测器的信号被处理以识别即将发生的故障，使得可以产生指示即将发生的故障的警告。 特别地，可以选择分离器和电池单体电解质以提供波导特性。
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公开(公告)号：US20150155605A1
公开(公告)日：2015-06-04
申请号：US14414984
申请日：2013-08-09
Applicant: Battelle Memorial Institute
Inventor： James E. Dvorsky , Steven M. Risser , James H. Saunders , C. Alexander Morrow , David W. Nippa
CPC classification number: H01M10/48 , G01R1/07 , G01R31/382 , G01R31/396 , H01M2/14 , H01M2/1606 , H01M2/1653 , H01M2/1666
Abstract: Light is transmitted through or from a separator of a battery cell or scattered within a battery cell and received by one or more light detectors. The light that is normally transmitted through the separator is scattered, absorbed, wavelength-shifted or otherwise distorted by an impending fault in the vicinity of or within the separator. The change in light due to the impending fault is measured by a detector and a signal from the detector is processed to identify the impending fault so that a warning can be generated indicative of the impending fault.
Abstract translation: 光通过电池单元的分离器或从电池单元的分离器传播，或者散布在电池单元内并由一个或多个光检测器接收。 通常通过分离器传播的光被分离器附近或内部即将发生的故障散射，吸收，波长偏移或以其它方式扭曲。 由于即将发生的故障引起的光的变化由检测器测量，并且来自检测器的信号被处理以识别即将发生的故障，使得可以产生指示即将发生的故障的警告。
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公开(公告)号：US20140324022A1
公开(公告)日：2014-10-30
申请号：US14356859
申请日：2012-11-07
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Eric C. Scribben , Steven M. Risser , Amy M. Heintz , Jeffrey L. Ellis , John D. Clay , Timothy M. Blum
IPC: A61M5/20
CPC classification number: A61M5/20 , A61M5/19 , A61M5/204 , A61M5/2448 , A61M5/284 , A61M5/286 , A61M5/3134 , A61M5/31596 , A61M2005/247 , A61M2005/3128 , A61M2005/31598 , A61M2202/07 , A61M2206/18
Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.
Abstract translation: 核心环形流动用于使皮下递送粘性流体，例如蛋白质治疗剂型。 高粘度流体被低粘度流体包围，低粘度流体润滑高粘度流体的通道。 这允许使用在相对减少的注射力下降低注射时间的具有较高浓度和较高粘度的蛋白质制剂。 这里描述了提供芯环形流的注射装置的几个不同实施例。
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公开(公告)号：US20230020138A1
公开(公告)日：2023-01-19
申请号：US17945486
申请日：2022-09-15
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Chad E. Bouton , Gaurav Sharma , Andrew Sweeney , Amy M. Heintz , Stephanie Kute , Nicholas Annetta , Thomas D. Haubert , Steven M. Risser , Jeffrey Friend , John Bartholomew , Rachel Thurston , Alexander C. Morrow , George Brand , Jeffrey Ellis , Matthew Mowrer , Raymond Zaborski
Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.
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