公开(公告)号：US11285273B2

公开(公告)日：2022-03-29

申请号：US16577364

申请日：2019-09-20

Applicant: BAYER HEALTHCARE LLC

Inventor： Kevin Cowan ,  Michael Spohn ,  Michael McDermott

IPC: A61M5/36 ,  A61M5/00 ,  A61M5/145 ,  A61M5/315 ,  G01F23/02 ,  A61M5/31 ,  A61M5/44

Abstract: A fluid injection system and a fluid verification system for confirming that a syringe, containing a fluid for injection, is fully filled with fluid and neither has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within a syringe.

公开(公告)号：US11083882B2

公开(公告)日：2021-08-10

申请号：US15778367

申请日：2016-11-23

Applicant: BAYER HEALTHCARE LLC

Inventor： Matthew Schrauder ,  Brian Cain ,  Michael Cousley ,  Kevin Cowan ,  Michael Spohn

IPC: A61M39/10 ,  A61M5/28

Abstract: A connector assembly may include a body and a fluid fitting, the fluid fitting configured for releasably engaging a syringe nozzle, at least one deflectable locking arm connected to the body and radially deflectable relative to the distal end, the proximal end of the at least one deflectable locking arm configured for deflecting in a radial direction relative to the distal end to releasably engage the syringe nozzle, and at least one locking element disposed on the at least one deflectable locking arm, the at least one locking element movable with movement of the at least one deflectable locking arm between a first position where the at least one locking element is released from an engagement portion of the syringe nozzle and a second position where the at least one locking element is engaged with the engagement portion of the syringe nozzle.

公开(公告)号：US11007118B2

公开(公告)日：2021-05-18

申请号：US15778350

申请日：2016-11-23

Applicant: BAYER HEALTHCARE LLC

Inventor： Kevin Cowan ,  James A. Dedig ,  Michael Spohn ,  Michael McDermott ,  Matthew McGee

IPC: A61M5/30 ,  A61J1/20 ,  A61J1/14 ,  A61M37/00 ,  A61M5/32 ,  B67D7/60 ,  B65D5/72

Abstract: A fill adapter for delivery of a medical liquid to a container has a body with a distal end, a proximal end, and a central bore extending between the distal end and the proximal end along a longitudinal axis. The central bore has an angled portion at the proximal end of the body such that a diameter of the central portion increases at the angled portion in a direction from the distal end to the proximal end. The fill adapter further has a flow controller disposed within the central bore at a distal end of the angled portion such that a gap is formed between an outer surface of the flow controller and an inner surface of the central bore. The flow controller is shaped to direct liquid flowing through the central bore to flow through the gap and along the angled portion of the central bore under a Coandă effect.

公开(公告)号：US10933190B2

公开(公告)日：2021-03-02

申请号：US15568505

申请日：2016-04-22

Applicant: BAYER HEALTHCARE LLC

Inventor： David Berry ,  Kevin Cowan ,  Martin Gibler ,  Benjamin Krupp ,  Vince Delbrugge ,  Michael Spohn

IPC: A61M5/145 ,  A61M5/148 ,  A61M5/00

Abstract: A rolling diaphragm syringe includes a proximal end having an end wall, a distal end having an open-ended discharge neck, a sidewall extending along a longitudinal axis, and a piston engagement portion protruding proximally from a central portion of the end wall and configured for engagement with a piston of a fluid injector. The piston engagement portion has a stem with a first end attached to the end wall, a second end extending proximally from the first end, and at least one protrusion that protrudes radially outward. The sidewall is flexible and rolls upon itself when acted upon by the piston such that an outer surface of the sidewall is folded in a radially inward direction as the piston is advanced from the proximal end to the distal end, and unfolded in a radially outward direction as the piston is retracted from the distal end to the proximal end.

公开(公告)号：US10898638B2

公开(公告)日：2021-01-26

申请号：US16081202

申请日：2017-03-03

Applicant: BAYER HEALTHCARE LLC

Inventor： Michael Spohn ,  Ralph Schriver ,  Arthur E. Uber, III ,  Ronald Heller ,  Kevin Cowan ,  Barry Tucker ,  Edward Rhinehart ,  Timothy Newing

IPC: A61M5/14 ,  A61M5/145 ,  A61M5/00 ,  A61M5/142

Abstract: A method of maintaining an overall flow rate during a sequential delivery of at least two fluids to a patient's blood vessel includes delivering at least a first fluid into the patient's blood vessel at a first flow rate, delivering at least a second fluid into the patient's blood vessel at a second flow rate, and adjusting at least one of a first flow profile of the first flow rate and a second flow profile of the second flow rate to dampen a transient increase in the overall flow rate during a transition between delivering one of the first fluid and the second fluid to delivering the other of the first fluid and the second fluid.

公开(公告)号：US12201802B2

公开(公告)日：2025-01-21

申请号：US18051950

申请日：2022-11-02

Applicant: BAYER HEALTHCARE LLC

Inventor： John Haury ,  Michael Swantner ,  Richard Sokolov ,  Benjamin James Cullen ,  Alison Ruth Von Moger ,  Ernesto Hueso Monis ,  Kamman Law ,  Mark Silivio Profaca ,  Patrick Spence ,  Michael Spohn ,  Justin Angert ,  Brian Cain

IPC: A61M39/10 ,  A61M5/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/145 ,  A61M5/168 ,  A61M5/19 ,  A61M5/31 ,  A61M39/24 ,  A61J3/00

Abstract: A multi-fluid injector system having a powered injector having a housing enclosing at least one reciprocally operable piston is described. The injector system includes a multi-use disposable set (MUDS) connectable to the powered fluid injector. The MUDS has at least one syringe having a proximal end and a distal end and a plunger reciprocally movable by the at least one piston element within a syringe interior between the proximal end and the distal end; a manifold in fluid communication with the distal end of the at least one syringe; at least one valve in fluid communication with the syringe interior, the at least one valve operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior; and at least one connection port in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. The injector system further includes a coupling mechanism for operating the at least one valve between the filling position and the delivery position. Various features of the MUDS assembly and methods of interaction between the injector system and the MUDS assembly are also described.

公开(公告)号：US20240408371A1

公开(公告)日：2024-12-12

申请号：US18809744

申请日：2024-08-20

Applicant: BAYER HEALTHCARE LLC

Inventor： Kevin Cowan ,  James Dedig ,  Michael Spohn ,  John Haury

IPC: A61M39/10 ,  A61M39/00 ,  A61M39/24

Abstract: A fluid mixing device for mixing a first injection fluid and a second injection fluid includes a first fluid inlet, a second fluid inlet, a mixing chamber in fluid communication with the first and second fluid inlets, and an outlet port in fluid communication with the mixing chamber. The first fluid inlet is configured to conduct the first injection fluid in a first direction and has a first redirecting surface. The second fluid inlet is configured to conduct the second injection fluid in a second direction along a different axis from the first direction and has a second redirecting surface. The mixing chamber is configured to mix the first injection fluid and the second fluid together. The mixture of the first injection fluid and the second injection fluid exits the fluid mixing device via the outlet port.

公开(公告)号：US12077338B2

公开(公告)日：2024-09-03

申请号：US17625814

申请日：2020-07-14

Applicant: BAYER HEALTHCARE LLC

Inventor： Michael Spohn ,  Kevin Cowan ,  David Berry

IPC: B65D1/02 ,  B29C49/06 ,  B29C49/42 ,  B29C49/64 ,  B29C49/66 ,  B29C71/00 ,  B29C71/04 ,  B29K67/00 ,  B29L31/00

CPC classification number: B65D1/0207 ,  B29C49/06 ,  B29C49/4273 ,  B29C49/6605 ,  B29C71/0063 ,  B29C71/04 ,  B29K2067/003 ,  B29K2995/0043 ,  B29L2031/7158 ,  B29L2031/7544 ,  B65D2203/06

Abstract: A fluid container having a proximal end having an end wall, a distal end having an open-ended neck, and a sidewall extending between the proximal end and the distal end along a longitudinal axis is described. A localized crystallinity of a polymeric material of the fluid container of at least a first region of the fluid container is greater than a crystallinity of a polymeric material of the fluid container of at least a second region. Examples of fluid containers include medical fluid containers, such as medical bottles and syringes, including rolling diaphragm-type syringes, and commercial beverage containers Articles of manufacturer formed form a polymeric material and having regions with increased localized polymeric crystallinity are also described.

公开(公告)号：US12023475B2

公开(公告)日：2024-07-02

申请号：US17704280

申请日：2022-03-25

Applicant: Bayer Healthcare LLC

Inventor： Kevin Cowan ,  Michael Spohn ,  Michael McDermott

IPC: A61M5/36 ,  A61M5/00 ,  A61M5/145 ,  A61M5/31 ,  A61M5/315 ,  A61M5/44 ,  G01F23/02

CPC classification number: A61M5/365 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/315 ,  G01F23/02 ,  A61M5/3134 ,  A61M5/31511 ,  A61M5/445 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3331 ,  A61M2205/3362 ,  A61M2205/3368 ,  A61M2205/505 ,  A61M2205/587 ,  A61M2205/6018 ,  A61M2205/6063 ,  A61M2205/6072 ,  A61M2205/6081

Abstract: A fluid injection system and a fluid verification system for determining the operating status of the fluid injection system, for example by confirming that a fluid reservoir, containing a fluid for injection, is fully filled with fluid and has free space (i.e., air) near the distal end thereof when the syringe is provided in an upright position nor contains air bubbles. Imaging processing techniques, methods, and systems are also provided to determine various injection parameters and to verify the type and certain properties of fluid that is present within the fluid reservoir.

公开(公告)号：US11826541B2

公开(公告)日：2023-11-28

申请号：US16621809

申请日：2018-09-12

Applicant: BAYER HEALTHCARE LLC

Inventor： Kevin Cowan ,  Michael Spohn ,  Barry Tucker ,  Matthew Walker ,  James Dedig ,  James Fentress ,  Joseph Ranaletta

IPC: A61M5/00 ,  A61M5/20 ,  A61M5/31 ,  A61M5/315 ,  B65B3/00 ,  B65B7/28 ,  A61M5/145 ,  A61M39/24

CPC classification number: A61M5/007 ,  A61M5/204 ,  A61M5/3134 ,  A61M5/31515 ,  B65B3/003 ,  B65B7/28 ,  A61M2005/14553 ,  A61M2005/3104 ,  A61M2005/3114 ,  A61M2039/2486 ,  A61M2039/2493 ,  A61M2205/3334 ,  A61M2209/045

Abstract: A cap for intake and delivery of a fluid from a syringe is described. The cap includes an outer cap assembly comprising a fluid inlet path and a fluid outlet path and an inner cap assembly configured for insertion into a fluid nozzle of the syringe and to provide selective fluid communication between an interior of a syringe and the fluid inlet path or the fluid outlet path. The outer cap assembly is slidable relative to the inner cap assembly between a first filling position, where the interior of the syringe is in fluid communication with the fluid inlet path, and a second delivery position, where the interior of the syringe is in fluid communication with the fluid outlet path. Syringes including the cap are also described.