公开(公告)号：US4575046A

公开(公告)日：1986-03-11

申请号：US595839

申请日：1984-04-02

Applicant: Bernd Krause ,  Wayne L. Hoelscher ,  William F. Scroggin

Inventor： Bernd Krause ,  Wayne L. Hoelscher ,  William F. Scroggin

IPC: F16K1/226 ,  F16K1/22

CPC classification number: F16K1/2263 ,  Y10T137/0525 ,  Y10T137/6048 ,  Y10T403/7005

Abstract: A recessed seat retainer for a valve is secured in an annular recess on the face of a valve body by a totally internally disposed key system which does not create an external leak path. An annular keyway is formed in the cylindrical sidewall of a seat retainer. A key extends from the cylindrical sidewall of an annular recess formed in an axial face of the valve body. The key is received in the keyway and locks the retainer against axial dislodgement from the valve body.

Abstract translation: 用于阀的凹座座保持器通过不产生外部泄漏路径的完全内部设置的钥匙系统固定在阀体的表面上的环形凹部中。 环形键槽形成在座椅保持器的圆柱形侧壁中。 钥匙从形成在阀体的轴向面上的环形凹部的圆柱形侧壁延伸。 钥匙被接收在键槽中并锁定保持器以防止阀体的轴向移位。

公开(公告)号：US4418889A

公开(公告)日：1983-12-06

申请号：US244091

申请日：1981-03-16

Applicant: Bernd Krause

Inventor： Bernd Krause

IPC: F16K1/226 ,  F16K5/06 ,  F16K1/22

CPC classification number: F16K5/0673 ,  F16K1/2263 ,  Y10T137/1797 ,  Y10T137/1812

Abstract: A novel seat especially adapted for a butterfly valve is provided which is formed both of metal and "soft" material so as to furnish a "bubble tight" seal in normal operating conditions and a metal-to-metal seal in fire situations. The seat is uniquely constructed and is permanently deformed by the disc or closure member of the valve to form a precise size and configuration corresponding to the size and configuration of the disc.

Abstract translation: 提供一种特别适用于蝶阀的新型座椅，其形成为金属和“柔软”材料，以便在正常操作条件下提供“气泡密封”密封，并在火情况下提供金属对金属密封。 座椅是独特构造的，并且被阀的盘或闭合构件永久变形，以形成对应于盘的尺寸和构造的精确尺寸和构造。

公开(公告)号：US10974201B2

公开(公告)日：2021-04-13

申请号：US13120375

申请日：2009-09-23

Applicant: Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

Inventor： Bernd Krause ,  Markus Neubauer ,  Joachim Loercher

IPC: C12M1/12 ,  B01D67/00 ,  C12N5/00 ,  C12N5/0775 ,  A61L2/02

Abstract: A membrane for cultivating adherent or suspension cells, in particular adherent cells. The membrane permits adhesion and proliferation of the cells due to the irradiation of the wet or dry membrane with gamma or beta rays or an electron beam in a dose of from 12.5 to 175 kGy in the presence of oxygen. The resulting membrane may be used without any pre-treatment with surface-modifying substances. A method for preparing such an irradiated membrane for cultivating adherent or suspension cells. Methods of using such a membrane for cultivating adherent or suspension cells.

公开(公告)号：US08657775B2

公开(公告)日：2014-02-25

申请号：US12585054

申请日：2009-09-01

Applicant: Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

Inventor： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

IPC: A61M1/14 ,  A61M1/18 ,  A61M1/34 ,  B01D61/24 ,  B01D61/28 ,  B01D69/08 ,  B01D63/02

CPC classification number: B01D61/243 ,  A61M1/16 ,  B01D67/0013 ,  B01D69/08 ,  B01D69/12 ,  B01D2325/022 ,  B01D2325/20

Abstract: The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.

Abstract translation: 本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化 血液。 单核细胞是涉及心血管疾病进展的主要循环血细胞。 慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展， 导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

公开(公告)号：US20130205873A1

公开(公告)日：2013-08-15

申请号：US13814125

申请日：2011-08-10

Applicant: Steffen Wagner ,  Philipp Herbst ,  Bernd Krause

Inventor： Steffen Wagner ,  Philipp Herbst ,  Bernd Krause

IPC: G01N15/08

CPC classification number: G01N15/082 ,  B01D65/102 ,  B01D2313/10 ,  G01N15/0826 ,  G01N2015/084

Abstract: A process and a device for testing a hollow fiber membrane filter comprises two compartments separated by a porous membrane. A specific amount of testing liquid is provided via a line from a testing liquid reservoir.

Abstract translation: 用于测试中空纤维膜过滤器的方法和装置包括由多孔膜分离的两个室。 通过来自测试液体储存器的管线提供特定量的测试液体。

公开(公告)号：US08051991B2

公开(公告)日：2011-11-08

申请号：US12307670

申请日：2007-06-25

Applicant: Bernd Krause ,  Markus Hornung ,  Herman Goehl

Inventor： Bernd Krause ,  Markus Hornung ,  Herman Goehl

IPC: B01D63/02 ,  B01D69/08 ,  B01D71/68 ,  B01D61/00

CPC classification number: B01D69/087 ,  A61M1/3496 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D71/44 ,  B01D71/68 ,  B01D2323/12 ,  Y10T428/1376 ,  Y10T428/139

Abstract: A process for manufacturing of an asymmetric hollow fiber membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fiber spinning nozzle, simultaneously extruding a center fluid through the inner bore of the hollow fiber spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% water the centre fluid contains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.

Abstract translation: 一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤出聚合物溶液，同时将中心流体通过中空纤维纺丝喷嘴的内孔挤出成为沉淀物 由此聚合物​​溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％的聚乙烯吡咯烷酮（PVP），55-75重量％的N-烷基 - 2-吡咯烷酮（NAP）和3〜9重量％的水，中心流体含有70〜90重量％的N-烷基-2-吡咯烷酮（NAP）和10〜30重量％的水，沉淀浴中含有0〜 20重量％的N-烷基-2-吡咯烷酮（NAP）和80-100重量％的水。

公开(公告)号：US20110091780A1

公开(公告)日：2011-04-21

申请号：US12580863

申请日：2009-10-16

Applicant: Daniel T. Folmsbee ,  Balasubramanian Lakshmanan ,  John P. Salvador ,  Joe C. Machuca ,  Bernd Krause ,  David R. Savage ,  David A. Arthur ,  Derek R. Lebzelter

Inventor： Daniel T. Folmsbee ,  Balasubramanian Lakshmanan ,  John P. Salvador ,  Joe C. Machuca ,  Bernd Krause ,  David R. Savage ,  David A. Arthur ,  Derek R. Lebzelter

IPC: H01M8/00

CPC classification number: H01M8/04388 ,  H01M8/04126 ,  H01M8/04231 ,  H01M8/0441 ,  H01M8/04492 ,  H01M8/04507 ,  H01M8/04753 ,  H01M8/04828 ,  H01M8/04835 ,  H01M8/04843 ,  H01M2250/20 ,  Y02E60/50 ,  Y02T90/32

Abstract: A method for reconditioning a fuel cell stack. The method includes periodically increasing the relative humidity level of the cathode input airflow to the stack to saturate the cell membrane electrode assemblies to be greater than the relative humidity levels during normal stack operating conditions. The method also includes providing hydrogen to the anode side of the fuel cell stack at system shut down while the membrane electrode assemblies are saturated without stack loads being applied so that the hydrogen crosses the cell membranes to the cathode side and reacts with oxygen to reduce stack contaminants.

Abstract translation: 一种用于再燃燃料电池堆的方法。 该方法包括在正常堆叠操作条件期间周期性地增加阴极输入气流到堆叠的相对湿度水平以使细胞膜电极组件饱和，以使其大于相对湿度水平。 该方法还包括在系统关闭时向燃料电池堆的阳极侧提供氢气，同时膜电极组件饱和而不施加堆叠负载，使得氢气穿过细胞膜至阴极侧并与氧反应以减少堆积 污染物

公开(公告)号：US20100320146A1

公开(公告)日：2010-12-23

申请号：US12680531

申请日：2008-09-26

Applicant: Bernd Krause ,  Markus Hornung ,  Reinhold Deppisch ,  Doris Deppisch ,  Silvia Koch

Inventor： Bernd Krause ,  Markus Hornung ,  Reinhold Deppisch ,  Doris Deppisch ,  Silvia Koch

IPC: B01D71/06 ,  B01D71/68 ,  B01D69/08 ,  B01D61/24 ,  B01J20/00 ,  B01J20/26

CPC classification number: B01D69/02 ,  A61M1/16 ,  A61M1/3496 ,  B01D67/0088

Abstract: The invention relates to hydrophilic membranes which are supplemented or treated with a non-ionic surfactant and processes for preparing such membranes. The membranes are particularly suitable for plasma separation or for haemodialysis and haemodiafiltration, but can also advantageously be used in other applications. Accordingly, the invention is further directed to the use of such membranes for plasma separation, plasma filtration, micro filtration, plasma therapy, haemodialysis and haemodiafiltration or cell filtration applications, respectively. The treated hydrophilic membranes show excellent biocompatibility, such as reduced platelet drop and decreased TAT levels.

Abstract translation: 本发明涉及用非离子表面活性剂补充或处理的亲水膜及其制备方法。 该膜特别适用于血浆分离或用于血液透析和血液透析过滤，但也可有利地用于其它应用。 因此，本发明进一步涉及这种膜用于血浆分离，血浆过滤，微过滤，血浆治疗，血液透析和血液透析或细胞过滤应用。 经处理的亲水膜显示出优异的生物相容性，例如减少血小板降低和降低的TAT水平。

公开(公告)号：US20090283470A1

公开(公告)日：2009-11-19

申请号：US12307678

申请日：2007-06-25

Applicant: Bernd Krause ,  Markus Hornung ,  Herman Goehl

Inventor： Bernd Krause ,  Markus Hornung ,  Herman Goehl

IPC: B01D69/08 ,  B01D67/00 ,  B01D69/02

CPC classification number: B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D69/081 ,  B01D69/085 ,  B01D71/68 ,  B01D2325/022 ,  B01D2325/24 ,  B01D2325/28 ,  B01D2325/36

Abstract: A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simultaneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP) and 60 to 80 wt-% N-alkyl-2-pyrrolidone (NAP), the centre fluid contains 60 to 70 wt-% N-alkyl-2-pyrrolidone (NAP) and 30 to 40 wt-% water, and the precipitation bath contains 70 to 82 wt-% N-alkyl-2-pyrrolidone (NAP) and 18 to 30 wt-% water.

Abstract translation: 一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤出聚合物溶液，同时将中心流体通过中空纤维纺丝喷嘴的内孔挤出成为沉淀物 由此聚合物​​溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％聚乙烯吡咯烷酮（PVP）和60-80重量％N-烷基 - 2-吡咯烷酮（NAP），中心流体含有60〜70重量％的N-烷基-2-吡咯烷酮（NAP）和30〜40重量％的水，沉淀浴含有70〜82重量％的N-烷基 -2-吡咯烷酮（NAP）和18-30wt％水。

公开(公告)号：US20080076012A1

公开(公告)日：2008-03-27

申请号：US11534341

申请日：2006-09-22

Applicant: Sebastian Lienkamp ,  Bernd Krause

Inventor： Sebastian Lienkamp ,  Bernd Krause

IPC: H01M2/00

CPC classification number: H01M8/04992 ,  H01M8/04552 ,  H01M8/04559 ,  H01M8/04649 ,  H01M2008/1095 ,  H01M2250/20 ,  Y02T90/32

Abstract: A method for revising a reference polarization curve of a fuel cell stack that identifies the relationship between the voltage and the current of the stack over time. When the stack is operating at a low load where kinetic voltage losses of the stack dominate, a first adaptation value is revised as the difference between the actual stack voltage and the stack voltage of the reference polarization curve. When the stack is operating at higher loads where ohmic voltage losses of the stack dominate, a second adaptation value is revised as the difference between the actual stack voltage and the stack voltage of the reference polarization curve.

Abstract translation: 一种用于修改燃料电池堆的参考极化曲线的方法，其识别堆叠随时间的电压和电流之间的关系。 当堆栈以堆叠的动态电压损失为主的低负载运行时，第一适配值被修改为实际堆叠电压与参考极化曲线的堆叠电压之间的差值。 当堆栈工作在堆叠的欧姆电压损耗主导的较高负载时，第二适配值被修改为实际堆叠电压和参考极化曲线的堆叠电压之间的差。