公开(公告)号：US07622027B1

公开(公告)日：2009-11-24

申请号：US11214279

申请日：2005-08-29

Applicant: Brian T. Cunningham

Inventor： Brian T. Cunningham

IPC: G01N27/453

CPC classification number: G01N27/453

Abstract: The invention provides methods of detecting, purifying, quantifying, and separating molecules using an electrophoresis adapted biosensor.

Abstract translation: 本发明提供使用电泳适配生物传感器检测，纯化，定量和分离分子的方法。

公开(公告)号：US07615339B2

公开(公告)日：2009-11-10

申请号：US11485867

申请日：2006-07-13

Applicant: Brian T. Cunningham ,  Jean Qiu

Inventor： Brian T. Cunningham ,  Jean Qiu

IPC: C12Q1/00

CPC classification number: B01L3/5085 ,  G01N21/253 ,  G01N21/4788 ,  G01N33/54373 ,  G02B5/1809 ,  Y10S435/808

Abstract: The invention provides methods for fabricating calorimetric resonant reflection biosensors.

Abstract translation: 本发明提供了制造比色共振反射生物传感器的方法。

公开(公告)号：US07521769B2

公开(公告)日：2009-04-21

申请号：US11177707

申请日：2005-07-08

Applicant: Brian T. Cunningham

Inventor： Brian T. Cunningham

IPC: H01L23/00

CPC classification number: G01N21/00 ,  B82Y15/00 ,  G01N21/4788 ,  G01N21/55 ,  G01N2021/7776

Abstract: The invention provides sensor compositions and method of making sensors.

公开(公告)号：US20080240543A1

公开(公告)日：2008-10-02

申请号：US12077809

申请日：2008-03-20

Applicant: Wolfgang Ernst Gustav Budach ,  Dieter Neuschafer ,  Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

Inventor： Wolfgang Ernst Gustav Budach ,  Dieter Neuschafer ,  Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

IPC: G06K9/00

CPC classification number: G01N33/54373 ,  B01L3/5085 ,  G01N21/4788 ,  G01N21/552 ,  G01N21/554 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N21/7743

Abstract: Calibration and normalization methods for a grating-based sensor design are disclosed. The sensor may be constructed in a manner optimized for both label-free and luminescence, e.g. fluorescence, amplification detection in a single device. Such a sensor, based on grating or another periodical structure with appropriate coating, dramatically increases the diversity of applications and allows realizing novel concepts that provide qualitative and quantitative information/data for each location or capture element in the sensor surface. The invention takes advantage of these different modes to carry out a quality control (QC) step and a calibration of each individual location of the sensor. Thus, the assay data can be flagged according to their quality and local density variations, batch variations and variations in the printed deposition of probes or the materials to the surface can be compensated.

Abstract translation: 公开了基于光栅的传感器设计的校准和归一化方法。 传感器可以以针对无标记和发光两者而优化的方式来构造。 荧光，放大检测在单个器件中。 这种基于光栅或具有适当涂层的周期性结构的传感器显着地增加了应用的多样性，并且实现了为传感器表面中的每个位置或捕获元件提供定性和定量的信息/数据的新概念。 本发明利用这些不同的模式来执行传感器的每个单独位置的质量控制（QC）步骤和校准。 因此，可以根据其质量和局部密度变化标记测定数据，可以补偿探针的印刷沉积或表面的材料的批量变化和变化。

公开(公告)号：US07312090B2

公开(公告)日：2007-12-25

申请号：US11508512

申请日：2006-08-22

Applicant: Bo Lin ,  Jane Pepper ,  Brian T. Cunningham ,  John Gerstenmaier ,  Peter Li ,  Jean Qiu ,  Homer Pien

Inventor： Bo Lin ,  Jane Pepper ,  Brian T. Cunningham ,  John Gerstenmaier ,  Peter Li ,  Jean Qiu ,  Homer Pien

IPC: G01N33/543

CPC classification number: G01N21/774 ,  B01J2219/00315 ,  B01J2219/00511 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0829 ,  C40B60/12 ,  G01N21/253 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G02B5/008 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809 ,  Y10S436/81

Abstract: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

公开(公告)号：US07300803B2

公开(公告)日：2007-11-27

申请号：US11508597

申请日：2006-08-22

Applicant: Bo Lin ,  Jane Pepper ,  Brian T. Cunningham ,  John Gerstenmaier ,  Peter Li ,  Jean Qiu ,  Homer Pien

Inventor： Bo Lin ,  Jane Pepper ,  Brian T. Cunningham ,  John Gerstenmaier ,  Peter Li ,  Jean Qiu ,  Homer Pien

IPC: G01N33/543

CPC classification number: G01N33/54373 ,  B01J2219/00315 ,  B01J2219/00454 ,  B01J2219/00511 ,  B01J2219/00545 ,  B01J2219/00662 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  G01N21/253 ,  G01N21/4788 ,  G01N21/78 ,  Y10S436/805 ,  Y10S436/809 ,  Y10S436/81

Abstract: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.

Abstract translation: 提供了检测生物分子相互作用的方法。 不需要使用标签，并且可以以高通量的方式执行方法。 本发明还涉及光学器件。

公开(公告)号：US07298477B1

公开(公告)日：2007-11-20

申请号：US11506639

申请日：2006-08-18

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US07266990B2

公开(公告)日：2007-09-11

申请号：US11357911

申请日：2006-02-17

Applicant: Brian T. Cunningham ,  John R. Williams

Inventor： Brian T. Cunningham ,  John R. Williams

IPC: G01N29/02

CPC classification number: G01N29/022 ,  G01N29/22 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106 ,  Y10T29/42 ,  Y10T29/49007

Abstract: A method for manufacturing a flexural plate wave sensor includes the steps of depositing an etch-stop layer over a substrate, depositing a membrane layer over the etch stop layer, depositing a piezoelectric layer over the membrane layer, forming a transducer on the piezoelectric layer, etching a cavity through the substrate, the cavity having substantially parallel interior walls, and removing the portion of the etch stop layer between the cavity and the membrane layer to expose a portion of the membrane layer.

Abstract translation: 制造弯曲板波传感器的方法包括以下步骤：在衬底上沉积蚀刻停止层，在蚀刻停止层上沉积膜层，在膜层上沉积压电层，在压电层上形成换能器， 通过衬底蚀刻空腔，空腔具有基本上平行的内壁，并且去除腔和膜层之间的蚀刻停止层的部分以暴露膜层的一部分。

公开(公告)号：US07171844B2

公开(公告)日：2007-02-06

申请号：US11352610

申请日：2006-02-13

Applicant: Brian T. Cunningham ,  John R. Williams

Inventor： Brian T. Cunningham ,  John R. Williams

IPC: G01N5/04 ,  G01N25/08

CPC classification number: G01N29/4436 ,  G01N5/04 ,  G01N5/045 ,  G01N29/022 ,  G01N29/228 ,  G01N2291/014 ,  G01N2291/0212 ,  G01N2291/0228 ,  G01N2291/0256 ,  G01N2291/02845 ,  G01N2291/0427

Abstract: An apparatus for measuring the mass of a substance includes a sensor having a membrane layer, the membrane for receiving the substance thereon, an oscillator device for driving the membrane at a reference resonant frequency, a frequency detection device for determining a change in the reference resonant frequency caused by the presence of the substance on the membrane, and a mass determining device for determining the mass of the substance, the change in the reference resonant frequency being indicative of the mass of the substance.

Abstract translation: 用于测量物质质量的装置包括具有膜层的传感器，用于在其上接收物质的膜，用于以参考共振频率驱动膜的振荡器装置，用于确定参考共振的变化的频率检测装置 由物质在膜上的存在引起的频率，以及用于确定物质质量的质量确定装置，参考共振频率的变化指示物质的质量。

公开(公告)号：US07153702B2

公开(公告)日：2006-12-26

申请号：US10237641

申请日：2002-09-09

Applicant: Bo Lin ,  Jane Pepper ,  Brian T. Cunningham ,  John Gerstenmaier ,  Peter Li ,  Jean Qiu ,  Homer Pien

Inventor： Bo Lin ,  Jane Pepper ,  Brian T. Cunningham ,  John Gerstenmaier ,  Peter Li ,  Jean Qiu ,  Homer Pien

IPC: G01N33/543

CPC classification number: G01N21/774 ,  B01J2219/00315 ,  B01J2219/00511 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0829 ,  C40B60/12 ,  G01N21/253 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G02B5/008 ,  G02B5/1809 ,  Y10S436/805 ,  Y10S436/809 ,  Y10S436/81

Abstract: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.