公开(公告)号：US06945710B2

公开(公告)日：2005-09-20

申请号：US10341477

申请日：2003-01-10

申请人： Wen-Tzung Chen ,  Chien-Cheng Yang ,  Chun-Chieh Chang ,  Chun-Te Lee ,  Chih-Hsien Chang ,  Cheng-Ta Chen ,  Bao-Jen Pong

发明人： Wen-Tzung Chen ,  Chien-Cheng Yang ,  Chun-Chieh Chang ,  Chun-Te Lee ,  Chih-Hsien Chang ,  Cheng-Ta Chen ,  Bao-Jen Pong

IPC分类号： G02B6/42 ,  G02B6/26

CPC分类号： G02B6/4207

摘要： An optical sub-assembly (OSA) module for suppressing optical back-reflection and effectively guiding light from a light source to an optical waveguide is disclosed. The module comprises a light source for emitting light to said optical waveguide and at least one light transmitting element installed between said light source and said optical waveguide. The at least one light transmitting element is arranged to have a configuration for avoiding light to reflect back to the light source and to cause a light beam from said light source to point to said core of said optical waveguide. Thereby, the working distance is increased, and the assembling process of the OSA module is simplified. This new optical design scheme will greatly improve the optical characteristics of an OSA module, increase the optical transceiver propagation distance, and reduce the difficulty of OSA assembly process.

摘要翻译： 公开了一种用于抑制光学背反射并有效地将光从光源引导到光波导的光学子组件（OSA）模块。 该模块包括用于向所述光波导发射光的光源和安装在所述光源和所述光波导之间的至少一个光传输元件。 所述至少一个光传输元件被布置成具有用于避免光反射回光源并使来自所述光源的光束指向所述光波导的所述芯的构造。 因此，工作距离增加，并且简化了OSA模块的组装过程。 这种新的光学设计方案将大大提高OSA模块的光学特性，增加光收发器的传播距离，降低OSA装配过程的难度。

公开(公告)号：US6099386A

公开(公告)日：2000-08-08

申请号：US340404

申请日：1999-06-28

申请人： Pei-Wei Tsai ,  Huan-Jen Tseng ,  Chih-Hsien Chang ,  Yi-Hua Chin

发明人： Pei-Wei Tsai ,  Huan-Jen Tseng ,  Chih-Hsien Chang ,  Yi-Hua Chin

IPC分类号： B24B37/04 ,  B24B49/10 ,  B24B57/02 ,  H01L21/00 ,  B24B29/00

CPC分类号： H01L21/67253 ,  B24B37/04 ,  B24B49/10 ,  B24B57/02

摘要： The present invention provides a control device for maintaining a chemical mechanical polishing (CMP) machine in a wet mode, the CMP machine comprising a polishing pad, a slurry sprinkler for sprinkling liquid or deionized water, and at least one carrier head, the control device comprising a sensor positioned on the CMP machine for sensing the operational status of the slurry sprinkler and generating a corresponding sensing signal; and a control unit electrically connected to the sensor for measuring the time period over which the slurry sprinkler is closed wherein when the measured time period exceeds a predetermined length, the control unit will either send a warning signal or turn on the slurry sprinkler to sprinkle liquid onto the polishing pad according to a predetermined process so as to maintain the polishing pad in a wet mode.

摘要翻译： 本发明提供了一种用于在湿模式下保持化学机械抛光（CMP）机器的控制装置，所述CMP机器包括抛光垫，用于喷洒液体或去离子水的浆料喷洒器，以及至少一个载体头，所述控制装置 包括位于所述CMP机器上的用于感测所述浆料喷洒器的操作状态并产生相应感测信号的传感器; 以及控制单元，电连接到所述传感器，用于测量所述浆料喷洒器关闭的时间段，其中当所测量的时间段超过预定长度时，所述控制单元将发送警告信号或者打开所述浆料喷洒器以喷洒液体 按照预定的处理在抛光垫上，以便将抛光垫保持在湿模式。

公开(公告)号：USD725488S1

公开(公告)日：2015-03-31

申请号：US29494575

申请日：2014-06-23

申请人： Chih-Hsien Chang

设计人： Chih-Hsien Chang

公开(公告)号：US08936399B2

公开(公告)日：2015-01-20

申请号：US13026028

申请日：2011-02-11

申请人： Wen-Tzung Chen ,  Chih-Hsien Chang

发明人： Wen-Tzung Chen ,  Chih-Hsien Chang

IPC分类号： G02B6/36 ,  G02B6/42

CPC分类号： G02B6/4246 ,  G02B6/4263 ,  G02B6/4281 ,  G02B6/4292

摘要： A receptacle-type bi-directional optical module includes an optical connector, a bi-directional optical sub-assembly (BOSA), and a flexible printed circuit board. The bi-directional optical sub-assembly is detachably coupled to the optical connector. The bi-directional optical sub-assembly includes a transmitter end and a receiver end. The flexible printed circuit board includes a board body, a first connection part, and a second connection part. A first end of the board body is electrically connected to a printed circuit board. The first connection part is connected to a second end of the board body for electrically connecting to the transmitter end. The second connection part is connected to the edge of the first connection part for electrically connecting to the receiver end.

摘要翻译： 插座型双向光模块包括光连接器，双向光子组件（BOSA）和柔性印刷电路板。 双向光学子组件可拆卸地联接到光学连接器。 双向光学子组件包括发射器端和接收器端。 柔性印刷电路板包括板主体，第一连接部和第二连接部。 电路板主体的第一端电连接到印刷电路板。 第一连接部分连接到电路板主体的第二端，用于电连接到发射器端。 第二连接部分连接到第一连接部分的边缘，用于电连接到接收器端。

公开(公告)号：US20140377169A1

公开(公告)日：2014-12-25

申请号：US13921217

申请日：2013-06-19

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： B01J19/00 ,  A61K51/12

CPC分类号： B01J19/004 ,  A61K51/1234 ,  C07B59/001

摘要： An automated synthesis device to produce Re-188-BMEDA solution including: a plurality of reagent vials, three-way solenoid valves, gel filtration columns and micro pumps, and a reaction vial, a product vial, a temporary storage vial, a filter membrane, and a waste vial, wherein the plurality of reagent vials include first reagent vial and second reagent vials being connected to the reaction vial through first micro pump, the third reagent vial and fourth reagent vial being connected to the reaction vial through second micro pump, fifth reagent vial being connected to the reaction vial through third micro pump, and sixth reagent vial being connected to the temporary storage vial through fourth micro pump, wherein the reaction vial is connected to the plurality of gel filtration columns through the micro-pump, respectively. The automated synthesis device is operable with program to upgrade yield and avoid contamination.

摘要翻译： 一种用于生产Re-188-BMEDA溶液的自动化合成装置，包括：多个试剂瓶，三通电磁阀，凝胶过滤柱和微型泵，以及反应瓶，产品小瓶，临时储存小瓶，过滤膜 以及废物小瓶，其中所述多个试剂小瓶包括通过第一微泵连接到所述反应小瓶的第一试剂小瓶和第二试剂小瓶，所述第三试剂小瓶和第四试剂小瓶通过第二微泵连接到所述反应小瓶， 第五试剂小瓶通过第三微泵连接到反应小瓶，第六试剂小瓶通过第四微泵连接到临时存储小瓶，其中反应小瓶分别通过微型泵连接到多个凝胶过滤柱 。 自动合成装置可与程序一起操作，以提高产量并避免污染。

公开(公告)号：US08519765B2

公开(公告)日：2013-08-27

申请号：US13228508

申请日：2011-09-09

申请人： Mao-Hsuan Chou ,  Min-Shueh Yuan ,  Chih-Hsien Chang

发明人： Mao-Hsuan Chou ,  Min-Shueh Yuan ,  Chih-Hsien Chang

IPC分类号： H03H11/16

CPC分类号： H03K5/135 ,  H03B19/00 ,  H03L7/099

摘要： A method for signal phase calibration includes providing multiple periodic clock signals, including a reference signal and multiple phase shifted versions of the reference signal. The signals have a common frequency and are shifted from one another by multiples of a phase offset. An edge of a first signal is detected. The first signal is one of multiple phase shifted versions of the reference signal. The edge is a transition from a first logic value to a second logic value. The second logic value of the first signal is compared, upon detection of the edge, to a logic value of a second signal that is one of the first plurality of periodic clock signals other than the first signal. An inversion of the first signal is selectively provided based on an outcome of the comparison.

摘要翻译： 用于信号相位校准的方法包括提供多个周期性时钟信号，包括参考信号和参考信号的多个相移版本。 这些信号具有共同的频率并且相互偏移倍数的相位偏移。 检测到第一信号的边缘。 第一个信号是参考信号的多个相移版本之一。 边缘是从第一逻辑值到第二逻辑值的转换。 第一信号的第二逻辑值在检测到边缘时被比较为除了第一信号之外的第一多个周期性时钟信号之一的第二信号的逻辑值。 基于比较的结果选择性地提供第一信号的反转。

公开(公告)号：US07803350B2

公开(公告)日：2010-09-28

申请号：US11881901

申请日：2007-07-30

申请人： Te-Wei Lee ,  Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shiang-Rong Chang ,  Shyh-Yi Chyi ,  Chih-Hsien Chang ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao

发明人： Te-Wei Lee ,  Chun-Ying Huang ,  Ming-Shiuan Wu ,  Te-Jung Chen ,  Kwo-Ping Chang ,  Shiang-Rong Chang ,  Shyh-Yi Chyi ,  Chih-Hsien Chang ,  Yin-Mao Hsu ,  Kuo-Hsien Fan ,  Wei-Chuan Hsu ,  Ying-Kai Fu ,  Charng-Feng Kao

IPC分类号： A61K51/00 ,  A61K36/14

CPC分类号： A61K51/02 ,  A61K41/009 ,  A61K51/121

摘要： This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i).This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumors.

摘要翻译： 本发明提供一种放射性含砷化合物的制造方法，其特征在于，包括以下工序：（i）对含砷化合物进行中子照射处理，所述含砷化合物选自As2O3，As2S3， As2S2及其组合，使含砷化合物中所含的砷元素转化为放射性砷同位素; 和（ii）从步骤（i）中回收所得产物。 本发明还提供包含治疗有效量的放射性含砷化合物和药学上可接受的载体的药物组合物。 药物组合物可用于治疗肿瘤/癌症如血液恶性肿瘤和实体瘤。

公开(公告)号：US20080259023A1

公开(公告)日：2008-10-23

申请号：US11737349

申请日：2007-04-19

申请人： Chih-Hsien Chang

发明人： Chih-Hsien Chang

IPC分类号： G09G5/00

CPC分类号： G09G5/006 ,  G09G2370/24 ,  H04N19/42 ,  H04N21/23614 ,  H04N21/2365 ,  H04N21/4122 ,  H04N21/4143 ,  H04N21/4307 ,  H04N21/4347 ,  H04N21/4348 ,  H04N21/43607

摘要： A video signal processor encodes a video signal received from the target computer through the computer interface. A peripheral interface controller is coupled to the video signal processor, and transmits the encoded video signal to the console computer in a peripheral interface standard through the console interface. A console module is coupled to the console computer, and decodes the encoded video signal for displaying on the console computer and transmits a manipulation signal to the target computer through the console interface, the peripheral interface controller and the computer interface. A method of making the console computer as a console for managing the target computer is also disclosed.

摘要翻译： 视频信号处理器通过计算机接口对从目标计算机接收的视频信号进行编码。 外围接口控制器耦合到视频信号处理器，并通过控制台接口将经编码的视频信号以外设接口标准传输到控制台计算机。 控制台模块耦合到控制台计算机，并且解码编码的视频信号以在控制台计算机上显示，并通过控制台接口，外围接口控制器和计算机接口将操作信号发送到目标计算机。 还公开了使控制台计算机作为用于管理目标计算机的控制台的方法。

公开(公告)号：US20080226546A1

公开(公告)日：2008-09-18

申请号：US11687650

申请日：2007-03-18

申请人： Te-Wei Lee ,  Ya-Jen Chang ,  Liang-Cheng Chen ,  Chia-Yu Yu ,  Shu-Pei Chiu ,  Shu-Ling Chen ,  Tsai-Yueh Luo ,  Chih-Hsien Chang ,  Gann Ting

发明人： Te-Wei Lee ,  Ya-Jen Chang ,  Liang-Cheng Chen ,  Chia-Yu Yu ,  Shu-Pei Chiu ,  Shu-Ling Chen ,  Tsai-Yueh Luo ,  Chih-Hsien Chang ,  Gann Ting

IPC分类号： A61K51/12 ,  A61K51/00 ,  A61P35/00 ,  A61K51/04

CPC分类号： A61K31/704 ,  A61K47/6911 ,  A61K51/0478 ,  A61K51/1234 ,  A61K2300/00

摘要： This invention is to manufacture a kit for preparation of nano-targeted liposome drugs in combined chemotherapy and radionuclide therapy. It is a kit consisting of three components: (1) A 10 ml vial A which contains BMEDA, gluconate acetate, SnCl2. (2) A 10 ml vial B which contains DSPC, cholesterol, DSPE-PEG, and Doxorubicin(DXR) (or Daunorubicin, Vinolbine). (3) A 10 ml vial C which contains 188ReO4− (or 186ReO4−) solution. The procedure of using the kit is as follows: (1) Remove the contents of the 188ReO4− (or 186ReO4−) solution from vial C. (2) Inject the 188ReO4− (or 186ReO4−) solution into the vial A, and the mixtures react in appropriate temperature. (3) Remove the contents of the 188Re-BMEDA (or 186Re-BMEDA) solution from vial A. (4) Inject the 188Re-BMEDA (or 186Re-BMEDA) solution into the vial B, and the mixtures react in appropriate temperature. The reconstituted solution in the vial B is applied to combine bimodality radiochemotherapy for treatment of tumor and ascites.

摘要翻译： 本发明是在联合化疗和放射性核素治疗中制备用于制备纳米靶向脂质体药物的试剂盒。 它是由三个组分组成的试剂盒：（1）含有BMEDA，葡萄糖酸乙酯，SnCl 2 2的10ml小瓶A. （2）含有DSPC，胆固醇，DSPE-PEG和多柔比星（DXR）（或柔红霉素，维罗非因）的10ml小瓶B。 （3）将含有<！ - SIPO - >反应物（或<！ - SIPO - > ^{- ）解决方案。 使用试剂盒的步骤如下：（1）除去 188 - （或 186 < 来自小瓶C的溶液。（2）注射<！ - SIPO - >反应物 > - （或 186 ）溶液加入到小瓶A中，并且混合物在合适的温度下反应。 （3）从小瓶A中取出 188 Re-BMEDA（或<186> 重BMEDA）溶液的内容物。（4）注入 188 Re-BMEDA）溶液加入小瓶B中，混合物在合适的温度下反应。 将小瓶B中的重构溶液应用于结合双功能放射化学疗法治疗肿瘤和腹水。}

公开(公告)号：USD729072S1

公开(公告)日：2015-05-12

申请号：US29482110

申请日：2014-02-14

申请人： Chih-Hsien Chang

设计人： Chih-Hsien Chang