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公开(公告)号：US20210313033A1
公开(公告)日：2021-10-07
申请号：US17265780
申请日：2019-09-30
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Hanish Lakhani , Swapnil Puranik , Nishu Garg , Hemalatha J
Abstract: A monitoring system comprises a manufacture system with capability to manufacture a plurality of biopharmaceutical products, at least one image capture device arranged to capture a scene comprising the manufacture system, and a processing element connected to said at least one image capture device and arranged to process images captured by said at least one image capture device to track operator interactions and/or a result of operator interactions within the scene. The processing element is further is arranged to compare a predefined workflow process scheme relating to the selected biopharmaceutical product to at least a part of the tracked operator interactions with the manufacture system and/or to at least a part of the result of the tracked operator interactions with the manufacture system, and determine whether at least one pre-set criterion set by the workflow process scheme is fulfilled based on the comparison.
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公开(公告)号：US20210062923A1
公开(公告)日：2021-03-04
申请号：US16981114
申请日：2019-03-21
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
IPC: F16K7/04 , F16K7/12 , F16K31/12 , F16K31/122 , F16K31/126
Abstract: A method for controlling at least one valve provided to a tube in a bioprocess flow system, said method comprising the steps of: —controlling the at least one valve to be in a first state, which is an open state when a flow through the tube should be allowed; —controlling the at least one valve to be in a second state during some parts of a process run in the system, said second state is a closed state were a first closing force is provided; and—controlling the at least one valve to be in a third state during some parts of a process run in the system, said third state is a closed state were a second closing force is provided which is a higher force than the first closing force.
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公开(公告)号：US12264306B2
公开(公告)日：2025-04-01
申请号：US17296711
申请日：2019-12-10
Applicant: Cytiva Sweden AB
Inventor： Bjorn Olovsson , Andreas Lundin , Klaus Gebauer , Tim Francois , Kerstin Erickson
IPC: C12M1/00
Abstract: A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold (12; 112; 212; 312) comprising: ⋅o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ⋅o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ⋅—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is prevented between the first end (18) and the second end (20) of this fluid connection tube (14).
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公开(公告)号：US20240425799A1
公开(公告)日：2024-12-26
申请号：US18824731
申请日：2024-09-04
Applicant: Cytiva Sweden AB
Inventor： Victor Jose , Andreas Axen , Klaus Gebauer , Veena B N Rao , Patric Fricking , Hanish Lakhani
Abstract: A bio-processing system (100) is presented. The bio-processing system (100) includes one or more bio-processing units (110-114), one or more process supporting devices (116, 118), one or more sensors (120-132), and a bio-processing workflow controller (104) wirelessly coupled to at least one of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-132). The bio-processing workflow controller (104) includes a processor (202) configured to create a reconfigurable bio-processing workflow, and where the reconfigurable bio-processing workflow is representative of an arrangement of one or more of the one or more bio-processing units (110-114), the one or more process supporting devices (116, 118), and the one or more sensors (120-132) to perform at least one bio-processing operation.
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25.发明授权公开(公告)号：US11867330B2
公开(公告)日：2024-01-09
申请号：US17056510
申请日：2019-05-29
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer
CPC classification number: F16L35/00 , A61M39/165 , F16L2201/10 , F16L2201/44 , F16L2201/60 , F16L2201/80
Abstract: A connector for forming a substantially aseptic connection is provided, said connector having a connector member a coupling end with a coupling element for engaging a similar coupling element on a similar connector to form a seal. A method for connecting and disconnecting two such connectors is also provided.
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Patent Agency Ranking
公开(公告)号：US20230221241A1
公开(公告)日：2023-07-13
申请号：US17997644
申请日：2021-06-10
Applicant: CYTIVA SWEDEN AB
Inventor： Hanno Ehring , Klaus Gebauer
CPC classification number: G01N21/05 , G01N21/15 , G01N2021/052 , G01N2201/0245
Abstract: Disclosed is an optical flow cell (100, 300) and a method (400) for bioprocessing applications. The optical flow cell (100, 300) comprises a fluid inlet (102, 302), a fluid outlet (104, 304), and a fluid flow channel (106, 306) provided between said fluid inlet (102, 302) and said fluid outlet (104, 304). The optical flow cell (100, 300) also comprises an output optical waveguide (108, 308) configured to emit light into said fluid flow channel (106, 306), and a collector optical waveguide (110, 310) configured to collect light from said fluid flow channel (106, 306). An optical pathlength adjuster (120, 320) for varying the optical pathlength (130, 330) between said output optical waveguide (108, 308) and said collector optical waveguide (110, 310) is also provided.
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公开(公告)号：US20230093940A1
公开(公告)日：2023-03-30
申请号：US18062481
申请日：2022-12-06
Applicant: Cytiva Sweden AB
Inventor： Andreas Castan , Klaus Gebauer
IPC: C12M1/00 , C12N5/07 , C12M3/06 , C12M3/00 , C12M1/06 , C12N5/071 , C12N1/20 , C12N5/04 , C12N1/16
Abstract: The invention discloses a bioreactor with a vessel defining an inner volume, agitation means and at least one addition tube, wherein a delivery orifice in the addition tube is located within the inner volume and a check valve is arranged in proximity of the delivery orifice for allowing flow of a fluid in the direction from the addition tube into the inner volume of the vessel and blocking flow in the reverse direction.
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公开(公告)号：US11525111B2
公开(公告)日：2022-12-13
申请号：US16586272
申请日：2019-09-27
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Andreas Castan , Camilla Estmer-Nilsson , Thomas Falkman , Anders Wilen , Michael Miller , Ralph Stankowski
Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.
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公开(公告)号：US20220317099A1
公开(公告)日：2022-10-06
申请号：US17742230
申请日：2022-05-11
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Jan Kranse , Mats Lundkvist
Abstract: A fluid distributor unit comprising a channel system where one or more inlet channels (2) starting on an inlet side (3) of the distributor unit branch out successively into several channels (6) ending on the other side of the distributor unit, called the outlet side (4), characterised in that said distributor unit is provided in one single body (1) by free form fabrication.
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公开(公告)号：US11360057B2
公开(公告)日：2022-06-14
申请号：US16708291
申请日：2019-12-09
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Jan Kranse , Mats Lundkvist
Abstract: A fluid distributor unit comprising a channel system where one or more inlet channels (2) starting on an inlet side (3) of the distributor unit branch out successively into several channels (6) ending on the other side of the distributor unit, called the outlet side (4), characterised in that said distributor unit is provided in one single body (1) by free form fabrication.
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