公开(公告)号：US20240379336A1

公开(公告)日：2024-11-14

申请号：US18691598

申请日：2022-09-15

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Chang LIU ,  Gordana IVOSEV ,  Hui ZHANG

IPC: H01J49/00

Abstract: Methods and systems for spectral comparison and quality assessment are disclosed. In one example, a method for assessing quality of a mass spectrum (MS) of a sample is provided. The method comprises: predefining one or more features or attributes indicative of the sample quality with reference to a target compound; and calculating a quality score for the MS with respect to the selected features or attributes.

公开(公告)号：US20240339311A1

公开(公告)日：2024-10-10

申请号：US18294386

申请日：2022-08-05

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  David Michael COX ,  Michael JARVIS ,  Chang LIU

IPC: H01J49/00 ,  H01J49/16

CPC classification number: H01J49/0031 ,  H01J49/165

Abstract: A method for measuring a concentration of an analyte in a sample includes: sampling, from a first sample, a first one or more droplets for mass analysis, wherein the first sample includes the sample; performing mass analysis on the first one or more droplets to determine a first intensity of an analyte in the first one or more droplets; sampling, from a second sample, a second one or more droplets for mass analysis, wherein the sec-ond sample includes the sample and a first spike of the analyte; performing mass analysis on the second one or more droplets to determine a second intensity of the analyte in the second one or more droplets; fitting a curve to the first intensity and the second intensity; and based on the fitted curve, calculating an analyte concentration for the sample.

公开(公告)号：US20240326055A1

公开(公告)日：2024-10-03

申请号：US18579231

申请日：2022-07-14

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: B01L3/00 ,  H01J49/04

CPC classification number: B01L3/502784 ,  H01J49/0431 ,  B01L2200/027 ,  B01L2300/0829 ,  B01L2400/0436

Abstract: Methods and systems for handling and/or analyzing samples are provided. In one example, a method comprises: introducing (406), with a liquid handler (322), at least one assisting agent into a sample well (310) of a well plate (312), wherein the sample comprises a sample volume; and ejecting (408), with an acoustic droplet ejector, ADE, (306), a mixture comprising the sample mixed with the at least one assisting agent from the sample well, wherein the at least one assisting agent interacts (406) with an analyte of the sample to limit gel formation at a top surface of the sample volume, prior to the mixture ejection.

公开(公告)号：US20240255473A1

公开(公告)日：2024-08-01

申请号：US18565850

申请日：2022-06-03

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: G01N30/06 ,  G01N30/02 ,  G01N30/72

CPC classification number: G01N30/06 ,  G01N30/7233 ,  G01N2030/027

Abstract: A system for analyzing a sample includes a sample preparation sub-system for preparing at least one sample in a sample vessel and a magnetic bead storage sub-system. A sample intake sub-system receives the at least one sample. A mass spectrometer (MS) is communicatively coupled to the sample intake sub-system. A transfer sub-system includes a tool for moving the sample vessel from the sample preparation sub-system to the sample intake sub-system.

公开(公告)号：US20230405594A1

公开(公告)日：2023-12-21

申请号：US18036485

申请日：2021-11-19

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Chang LIU

IPC: B01L3/00 ,  G01N35/00 ,  B03C1/01 ,  B03C1/28 ,  B03C1/033

CPC classification number: B01L3/502761 ,  G01N35/0098 ,  B03C1/01 ,  B03C1/288 ,  B03C1/0335 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2400/082 ,  B01L2400/043 ,  B01L2300/0877 ,  B03C2201/18

Abstract: A method for processing a fluid sample containing a first target analyte includes introducing a first batch of magnetic particles into a fluid conduit, the fluid conduit having a first open end, a second open end, and a first electromagnetic trap between the first open end and the second open end. The magnetic particles include a first receptor to bind the first target analyte in the fluid sample. The method further includes activating the first electromagnetic trap to trap and mix the magnetic particles within the first electromagnetic trap. A flow of the fluid sample is introduced through the fluid conduit from the first open end to the second open end. Deactivating first electromagnetic trap releases the magnetic particles from the first electromagnetic trap.

公开(公告)号：US20230197428A1

公开(公告)日：2023-06-22

申请号：US17999614

申请日：2021-05-20

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Thomas R. COVEY ,  Chang LIU

IPC: H01J49/04 ,  H01J49/24

CPC classification number: H01J49/0404 ,  H01J49/24 ,  H01J49/044

Abstract: In a sampling system for mass spectrometry, a method and apparatus are set forth for high flow-rate flushing and sample delivery via a sampling probe (10). The sampling system includes a sampling probe (10) having a first fluid conduit (40) with an inlet, a second fluid conduit (42) with an outlet, and a sampling port fluidly connecting the first fluid conduit (40) and second fluid conduit (42). A fluid source (50) is attached to the inlet and a vacuum source (60) is attached to the outlet for causing fluid to flow through the first fluid conduit (40) past the sampling port and exit through the second fluid conduit (42). A cap (90) is provided for selectively closing and opening the sampling port. When the cap is removed, thus when the sampling port is open, sample may be introduced into, and captured by fluid flowing through the sampling port. When the cap is in place, thus when the sampling port is closed, a flushing fluid is supplied for flushing the sampling probe (10).

公开(公告)号：US20170072397A1

公开(公告)日：2017-03-16

申请号：US15309275

申请日：2015-05-06

Applicant: DH Technologies Development PTE Ltd.

Inventor： John Lawrence CAMPBELL ,  Kihwan CHOI ,  Yves LEBLANC ,  Chang LIU ,  Aaron WHEELER

IPC: B01L3/00 ,  G01N35/00 ,  G01N30/16

CPC classification number: B01L3/502792 ,  B01F13/0071 ,  B01F13/0076 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0427 ,  G01N27/44791 ,  G01N30/16 ,  G01N35/00871 ,  G01N2030/162

Abstract: Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in some aspects enable the integration of a digital microfluidic device as a direct, in-line sample processing platform from which a droplet can be transferred to a downstream analyzer.

Abstract translation: 本文描述了利用数字微流体装置处理流体并将液滴从数字微流体装置转移到下游分析器的方法和系统。 根据本教导的方法和系统可以允许从数字微流体装置中取出流体，并且在某些方面，可以将数字微流体装置整合为直接的在线样品处理平台，液滴可从该样品处理平台 转移到下游分析仪。