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    NOVEL PROCESS FOR THE MANUFACTURE OF METHYL LIMONITRILE
    21.
    发明申请
    NOVEL PROCESS FOR THE MANUFACTURE OF METHYL LIMONITRILE 有权
    用于制造甲基硫酸钠的新工艺

    公开(公告)号：US20150031597A1

    公开(公告)日：2015-01-29

    申请号：US14378551

    申请日：2013-02-11

    Applicant: DSM IP ASSETS B.V.

    Inventor： Raphael Beumer ,  Werner Bonrath ,  Silke Dorn ,  Angela Wildermann

    IPC: C11B9/00

    CPC classification number: C11B9/0023 ,  C07C253/30 ,  C07C255/07

    Abstract: The present invention is directed to a process for the manufacture of methyl limonitrile comprising a mixture of 3,7-dimethyl-2,6-nonadiene nitrile, 3,7-dimethyl-3,6-nonadiene nitrile and 7-methyl-3-methylene-6-nonene nitrile comprising the following steps: a) reacting 6-methyl-5-octen-2-one with cyano acetic acid and removing carbon dioxide and water, wherein the reaction and the removal of carbon dioxide and water are performed in the presence of a base and a co-base in an organic solvent, wherein the base is pyridine, wherein the co-base is 1,4-diamino butane, and wherein the organic solvent is a solvent which forms a heteroazeotrop with water; b) removing the solvent and pyridine of the reaction mixture obtained after having performed step a) or step c) by distillation to obtain a reaction mixture; c) isomerizing the reaction mixture obtained after having performed step a) or step b) to obtain an isomerized reaction mixture; whereby step b) can be performed before or after step c).

    Abstract translation: 本发明涉及一种制备甲基有限公司的方法，该方法包括3,7-二甲基-2,6-壬二烯腈，3,7-二甲基-3,6-壬二烯腈和7-甲基-3- 亚甲基-6-壬烯腈包括以下步骤：a）使6-甲基-5-辛烯-2-酮与氰基乙酸反应并除去二氧化碳和水，其中二氧化碳和水的反应和除去在 在有机溶剂中存在碱和共碱，其中所述碱为吡啶，其中所述共碱为1,4-二氨基丁烷，并且其中所述有机溶剂是与水形成杂合性的溶剂; b）在通过蒸馏进行步骤a）或步骤c）之后，除去反应混合物中的溶剂和吡啶，得到反应混合物; c）使进行步骤a）或步骤b）后得到的反应混合物异构化得到异构化反应混合物; 由此步骤b）可以在步骤c）之前或之后进行。

    Regioselective hydroxylation of isophorone
    22.
    发明授权
    Regioselective hydroxylation of isophorone 有权

    公开(公告)号：US12077801B2

    公开(公告)日：2024-09-03

    申请号：US16500497

    申请日：2018-04-06

    Applicant: DSM IP Assets B.V.

    Inventor： Werner Bonrath ,  Martin Schürmann ,  Michele Tavanti ,  Fabio Parmeggiani ,  Nicholas Turner ,  Andrea Mattevi ,  Jose Ruben Casstellanos

    IPC: C12P7/26 ,  C12N9/02

    CPC classification number: C12P7/26 ,  C12N9/0081 ,  C12Y114/15006

    Abstract: The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of α-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.

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