公开(公告)号：US20120028312A1

公开(公告)日：2012-02-02

申请号：US13196710

申请日：2011-08-02

申请人： Lance P. Ford ,  David Brown

发明人： Lance P. Ford ,  David Brown

IPC分类号： C12P19/34 ,  C12N9/12 ,  C12N9/22

CPC分类号： C12N15/1135 ,  C12N9/22 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2330/30 ,  C12Y301/26003

摘要： The present invention concerns methods and compositions involving RNase III and polypeptides containing RNase III domains to generate RNA capable of triggering RNA-mediated interference (RNAi) in a cell. In some embodiments, the RNase III is from a prokaryote. RNase III activity will cleave a double-stranded RNA molecule into short RNA molecules that may trigger or mediate RNAi (siRNA). Compositions of the invention include kits that include an RNase III domain-containing polypeptide. The present invention further concerns methods using polypeptides with RNase III activity for generating RNA molecules that effect RNAi, including the generation of a number of RNA molecules to the same target.

摘要翻译： 本发明涉及包含RNase III和含有RNase III结构域的多肽的方法和组合物以产生能够触发细胞中RNA介导的干扰（RNAi）的RNA。 在一些实施方案中，RNA酶III来自原核生物。 RNA酶III活性将双链RNA分子切割成可以引发或介导RNAi（siRNA）的短RNA分子。 本发明的组合物包括包含含有RNase III结构域的多肽的试剂盒。 本发明还涉及使用具有RNase III活性的多肽来产生影响RNAi的RNA分子的方法，包括向同一靶标产生大量RNA分子。

公开(公告)号：US20110248567A1

公开(公告)日：2011-10-13

申请号：US12757884

申请日：2010-04-09

申请人： David Brown ,  Norman J. Weigert ,  Gery J. Kissel ,  George D. Bellino ,  David B. Ouwerkerk ,  Christopher P. Lawrence

发明人： David Brown ,  Norman J. Weigert ,  Gery J. Kissel ,  George D. Bellino ,  David B. Ouwerkerk ,  Christopher P. Lawrence

IPC分类号： H02J3/32 ,  H02J7/00

CPC分类号： H02J3/18 ,  H02J7/045 ,  H02J13/002 ,  H02J13/0055 ,  H02J13/0075 ,  Y02B70/3266 ,  Y02E40/30 ,  Y02E40/74 ,  Y02P80/11 ,  Y04S10/22 ,  Y04S20/242 ,  Y10T307/359 ,  Y10T307/527

摘要： A charging system of the present invention is connectable to a power grid having a monitoring device. The monitoring device monitors the power delivered to a plurality of loads and determines a power factor and a power factor correction value associated with the loads. The power factor correction value indicates the difference between the power factor and unity. The charging system includes an electrical device, a charger in communication with the electrical device, a charging controller, a power factor correction circuit, a communication device, and a controller. The communication device of the charger receives a data signal from the monitoring device indicative of the power factor correction value associated with the plurality of loads. The power factor correction circuit is configured to communicate an input current to and from the power grid, which adjusts the power factor of the associated loads to about unity.

摘要翻译： 本发明的充电系统可连接到具有监控装置的电网。 监视装置监视传送到多个负载的功率，并确定与负载相关联的功率因数和功率因数校正值。 功率因数校正值表示功率因数和功率因数之间的差异。 充电系统包括电气设备，与电气设备通信的充电器，充电控制器，功率因数校正电路，通信设备和控制器。 充电器的通信装置从监视装置接收指示与多个负载相关联的功率因数校正值的数据信号。 功率因数校正电路被配置为将输入电流传送到电网和从电网传送，其将相关联的负载的功率因数调整到大约一个一个。

公开(公告)号：US07772982B2

公开(公告)日：2010-08-10

申请号：US11800103

申请日：2007-05-04

申请人： Jeffrey A Feibelman ,  David Brown

发明人： Jeffrey A Feibelman ,  David Brown

IPC分类号： G08B13/14

CPC分类号： E05B73/0017 ,  G08B13/2434

摘要： An anti-theft tag includes a body that carries an EAS sensor, a shrinkable sleeve disposed about the outside of the body, an adhesive material disposed on the body between the body and the sleeve, and a sleeve holder extending from the body. The sleeve holder is constructed and arranged to hold the sleeve on the body such that a portion of the sleeve and the body define an aperture configured to receive an elongate article, such as an arm from a pair of eyeglasses. In use, once the anti-theft tag is disposed on the article, an assembler shrinks the sleeve to secure the anti-theft tag to the arm. In such a configuration, the sleeve and adhesive material holds the body of the anti-theft tag against the arm, thereby limiting the ability for a thief to remove the anti-theft tag from the elongate article by twisting or rotating the anti-theft tag relative to the article.

摘要翻译： 防盗标签包括承载EAS传感器的主体，围绕主体外侧设置的可收缩套筒，设置在主体和套筒之间的主体上的粘合材料以及从主体延伸的套筒保持架。 套筒保持器被构造和布置成将套筒保持在主体上，使得套筒和主体的一部分限定了一个孔，该孔构造成从一对眼镜接收诸如臂的细长物品。 在使用中，一旦将防盗标签设置在物品上，装配商收缩套筒以将防盗标签固定到手臂上。 在这种构造中，套筒和粘合剂材料将防盗标签的主体抵靠在手臂上，从而通过扭转或旋转防盗标签来限制小偷从细长制品中移除防盗标签的能力 相对于文章。

公开(公告)号：US20100152284A1

公开(公告)日：2010-06-17

申请号：US12447624

申请日：2007-10-30

申请人： David Brown ,  Alan James Husband ,  Ann M. Turnley

发明人： David Brown ,  Alan James Husband ,  Ann M. Turnley

IPC分类号： A61K31/352 ,  C07D311/58 ,  A61P35/00 ,  A61P25/02

CPC分类号： A61K31/352 ,  C07D311/36 ,  C07D311/58 ,  C07D311/64

摘要： Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.

摘要翻译： 本文提供了治疗或预防神经病，神经病相关病症的方法，其中所述神经病或神经病相关病症是用至少一种化学治疗剂诱导或以其他方式与受试者相关的，所述方法包括施用有效量 的式（I）的异黄酮化合物。 还提供了治疗神经损伤的方法。 还提供了式（I）的异黄酮化合物在治疗神经病变，神经病变相关病症和神经损伤中的用途。

公开(公告)号：US07738606B2

公开(公告)日：2010-06-15

申请号：US11088357

申请日：2005-03-24

申请人： Ian Williamson ,  David Brown

发明人： Ian Williamson ,  David Brown

IPC分类号： H04L1/02

CPC分类号： H04B1/7085

摘要： A receiver utilizes an array of complex accumulation registers to form an image of the average chip shape or, as appropriate, chip edge shape, of the received signal over a specified period of time as a time series of complex power measurements. The receiver divides the length of the chip into a plurality of ranges, or bins, and, as appropriate, extends the bins to cover additional chips or portions thereof. When a sample is taken, the receiver enables the respective registers that are associated with the corresponding bin or bins, and the respective registers then accumulates the associated power measurement. The receiver uses the accumulated measurements from selected registers and/or selected groups of registers, to produce the correlation values that are needed to perform one or more correlation techniques and/or one or more multipath mitigation techniques. As appropriate, the sizes and/or starting points of the bins, and/or the selections of the bins for the various groupings may be altered, to change the spacings, locations, and so forth to which correlation values correspond.

摘要翻译： 接收机利用复数累加寄存器的阵列来形成平均码片形状的图像，或者在适当的时候，在指定的时间段内形成接收信号的码片边缘形状，作为复杂功率测量的时间序列。 接收器将芯片的长度划分成多个范围或箱，并且适当地，扩展箱以覆盖附加的芯片或其部分。 当采样时，接收机启用与相应的箱或箱相关联的相应寄存器，并且相应的寄存器然后累积关联的功率测量。 接收机使用来自所选择的寄存器和/或所选择的寄存器组的累积测量值来产生执行一个或多个相关技术和/或一个或多个多径抑制技术所需的相关值。 适当地，可以改变箱的尺寸和/或起点，和/或用于各种组的箱的选择，以改变相关值对应的间隔，位置等。

公开(公告)号：US20100137277A1

公开(公告)日：2010-06-03

申请号：US12522724

申请日：2008-01-11

申请人： Thomas Antonsson ,  Peter Bach ,  David Brown ,  Ruth Bylund ,  Fabrizio Giordanetto ,  Johan Johansson

发明人： Thomas Antonsson ,  Peter Bach ,  David Brown ,  Ruth Bylund ,  Fabrizio Giordanetto ,  Johan Johansson

IPC分类号： A61K31/397 ,  C07D401/04 ,  A61K31/4545 ,  A61P7/02 ,  A61K31/4439

CPC分类号： C07D401/04 ,  C07D413/14

摘要： The present invention relates to certain new pyridin analogues of Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

摘要翻译： 本发明涉及式（I）的某些新的吡啶类似物，用于制备这些化合物的方法，其作为P2Y12抑制剂和抗血栓形成剂的用途，其作为心血管疾病中的药物的用途以及含有它们的药物组合物。

公开(公告)号：US07716398B2

公开(公告)日：2010-05-11

申请号：US12004500

申请日：2007-12-20

申请人： David Brown

发明人： David Brown

IPC分类号： G06F3/00 ,  G11C7/10

CPC分类号： H04J3/047

摘要： A buffer includes a plurality of serial inputs, a plurality of de-serializers, each coupled to a respective input, a plurality n of buffers and a media access controller having inputs coupled to the plurality of de-serializers, data outputs coupled to the buffers, and two control outputs coupled to respective buffers for buffering input data at a clock rate one-nth that of the input data. Preferably the buffer is a bifurcate buffer. In operation, serial packets are received on a port. They must be converted to parallel data for processing by conventional CMOS logic, however there are limits serial to parallel conversion ratio. This buffer describe circumvents theses limits.

摘要翻译： 缓冲器包括多个串行输入，多个解串器，每个耦合到相应的输入，多个n个缓冲器以及具有耦合到多个解串器的输入的媒体访问控制器，耦合到缓冲器的数据输出 以及耦合到相应缓冲器的两个控制输出，用于以输入数据的输入数据的1/0的时钟速率缓冲输入数据。 优选地，缓冲液是分叉缓冲液。 在操作中，端口上接收到串行数据包。 它们必须转换为并行数据，以便通过常规CMOS逻辑进行处理，但串行到并行转换比率有限制。 这个缓冲区描述了这些限制。

公开(公告)号：US07714721B1

公开(公告)日：2010-05-11

申请号：US12014287

申请日：2008-01-15

申请人： Jeffrey Feibelman ,  David Brown

发明人： Jeffrey Feibelman ,  David Brown

IPC分类号： G08B13/14

CPC分类号： G09F3/14 ,  G08B13/2434 ,  G09F3/0329 ,  G09F3/0335

摘要： An anti-theft tag deterring theft of a ring is provided. The anti-theft tag includes an elongated housing for accommodating an EAS marker, a product support member that locks into the housing and which supports the ring, and a flexible, tear resistant strap for securing the ring to the support member, the strap being disposed at least partially within the housing during use. In one embodiment, the support member includes an arcuate seat portion for supporting a circular shank portion of the ring, and a locking member that locks into a corresponding cavity in the housing. In use, the tear resistant strap extends over the ring shank, and the strap ends are received within the cavity of the housing to protect the strap from unauthorized removal by a consumer.

摘要翻译： 提供防盗环的防盗标签。 防盗标签包括用于容纳EAS标记的细长壳体，锁定到壳体中并且支撑环的产品支撑构件以及用于将环固定到支撑构件的柔性防撕裂带，所述带被设置 在使用期间至少部分地在壳体内。 在一个实施例中，支撑构件包括用于支撑环的圆形柄部分的弓形座部分，以及锁定在壳体中的对应空腔中的锁定构件。 在使用中，防撕裂带延伸到环形柄上，并且带端部容纳在壳体的空腔内，以保护带免遭消费者的非法移除。

公开(公告)号：US20100071446A1

公开(公告)日：2010-03-25

申请号：US12563046

申请日：2009-09-18

申请人： David Brown

发明人： David Brown

IPC分类号： G01N13/04 ,  G01N1/10

CPC分类号： G01N13/04 ,  G01N1/4055 ,  G01N2001/4061

摘要： A solute concentration measurement device is disclosed. The device may comprise a filter membrane, an exchange chamber, a sensing chamber, a separator, and a sensor. The device may be configured to be placed in fluid communication with a sample solution containing a solute and a solvent. The filter membrane may provide selective fluid communication between the solution and the exchange chamber. The separator may separate the exchange chamber from the sensing chamber and cause a change in a condition of the sensing chamber corresponding to a change of a condition of the exchange chamber. The sensor may sense the condition pertaining to the sensing chamber and calculate the concentration of the sample solution corresponding to this change.

摘要翻译： 公开了一种溶质浓度测定装置。 该装置可以包括过滤膜，交换室，感测室，分离器和传感器。 该装置可以被配置为与含有溶质和溶剂的样品溶液流体连通。 过滤膜可以在溶液和交换室之间提供选择性的流体连通。 分离器可以将交换室与感测室分开，并且使得感应室的状态改变对应于交换室的状态的改变。 传感器可以感测与感测室相关的状态，并计算与该变化相对应的样品溶液的浓度。

公开(公告)号：US20080026951A1

公开(公告)日：2008-01-31

申请号：US11837495

申请日：2007-08-11

申请人： David Brown ,  Rick Conrad ,  Eric Devroe ,  Marianna Goldrick ,  Kerri Keiger ,  Emmanuel Labourier ,  Ivonne Moon ,  Patricia Powers ,  Jeffrey Shelton ,  Jaclyn Shingara

发明人： David Brown ,  Rick Conrad ,  Eric Devroe ,  Marianna Goldrick ,  Kerri Keiger ,  Emmanuel Labourier ,  Ivonne Moon ,  Patricia Powers ,  Jeffrey Shelton ,  Jaclyn Shingara

IPC分类号： C40B30/04

CPC分类号： C12Q1/6806 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/3517 ,  C12N2310/3519 ,  C12N2320/10 ,  C12P19/34 ,  C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2565/501 ,  C12Q2525/207

摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.

摘要翻译： 本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。 此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。