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207 条记录 (耗时 0.049 秒)

    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    22.
    发明授权
    Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 失效
    氨基甲酸氨基甲酸烷基酯前药，合成和使用方法

    公开(公告)号：US07749985B2

    公开(公告)日：2010-07-06

    申请号：US12506961

    申请日：2009-07-21

    申请人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    发明人： Mark A. Gallop ,  Feng Xu ,  Thu Phan ,  Usha Dilip ,  Ge Peng

    IPC分类号： A61K31/66 ,  C07F9/02

    CPC分类号： C07F9/301

    摘要： Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

    摘要翻译： 3-氨基丙基次膦酸的氨基甲酸烷基酯氨基甲酸酯前药及其类似物，3-氨基丙基次膦酸及其类似物的制备酰氨基烷基氨基甲酸酯前药的方法及其类似物，使用3-氨基丙基次膦酸及其类似物的酰氨基烷基氨基甲酸酯前药的方法和包含酰氨基烷基氨基甲酸酯前药3 - 氨基丙基次膦酸及其类似物用于治疗疾病或病症如轻度认知障碍，与阿尔茨海默氏病相关的认知障碍阿尔茨海默氏病，抑郁症，焦虑和癫痫。 还公开了适用于口服给药和缓释口服剂型的3-氨基丙基次膦酸的氨基氧基烷基氨基甲酸酯前药及其类似物。

    Aromatic prodrugs of propofol, compositions and uses thereof
    25.
    发明授权
    Aromatic prodrugs of propofol, compositions and uses thereof 失效
    丙泊酚的芳族前药，其组合物和用途

    公开(公告)号：US07576127B2

    公开(公告)日：2009-08-18

    申请号：US11507968

    申请日：2006-08-21

    申请人： Mark A. Gallop ,  Feng Xu

    发明人： Mark A. Gallop ,  Feng Xu

    IPC分类号： A61K31/265 ,  A61K31/235

    CPC分类号： C07C271/28

    摘要： Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.

    摘要翻译： 丙泊酚的前药，制备丙泊酚前药的方法，丙泊酚前药的药物组合物和使用异丙酚前药的方法及其药物组合物治疗或预防疾病或病症如偏头痛头痛和化疗后或术后手术恶心 和呕吐。

    Methods of reducing the inhibitory effect of a redox active metal ion on the enzymatic hydrolysis of cellulosic material
    28.
    发明申请
    Methods of reducing the inhibitory effect of a redox active metal ion on the enzymatic hydrolysis of cellulosic material 审中-公开
    降低氧化还原活性金属离子对纤维素材料酶水解的抑制作用的方法

    公开(公告)号：US20090130707A1

    公开(公告)日：2009-05-21

    申请号：US12263268

    申请日：2008-10-31

    申请人： Feng Xu

    发明人： Feng Xu

    IPC分类号： C12P1/00

    CPC分类号： C12P7/10 ,  C12P19/02 ,  Y02E50/16

    摘要： The present invention relates to methods of producing a cellulosic material reduced in a redox active metal cation having a redox potential (Eo) in the range of about −0.4 to about 1.2 volts, comprising treating the cellulosic material with an effective amount of a chelator to reduce the inhibitory effect of the redox active metal cation on enzymatically degrading or converting the cellulosic material and alternatively also treating the cellulosic material with an effective amount of an oxidant when the redox active metal cation has a low valence state to convert the redox active metal cation to a high valence state to preferentially chelate the redox active metal cation. The present invention also relates to methods for degrading or converting a cellulosic material and to methods of producing a fermentation product.

    摘要翻译： 本发明涉及减少氧化还原电位（Eo）在约-0.4至约1.2伏范围内的氧化还原活性金属阳离子还原的纤维素材料的方法，包括用有效量的螯合剂处理纤维素材料至 降低氧化还原活性金属阳离子对酶促降解或转化纤维素材料的抑制作用，或者当氧化还原活性金属阳离子具有低价态以转化氧化还原活性金属阳离子时，用有效量的氧化剂处理纤维素材料 以高价态优先螯合氧化还原活性金属阳离子。 本发明还涉及降解或转化纤维素材料的方法以及生产发酵产物的方法。

    Isomerization catalyst and process
    29.
    发明授权
    Isomerization catalyst and process 有权
    异构化催化剂和工艺

    公开(公告)号：US07414007B2

    公开(公告)日：2008-08-19

    申请号：US11304521

    申请日：2005-12-15

    申请人： Ralph D. Gillespie ,  Feng Xu

    发明人： Ralph D. Gillespie ,  Feng Xu

    IPC分类号： B01J27/00 ,  B01J27/188 ,  B01J27/185 ,  B01J23/00

    CPC分类号： B01J27/188 ,  B01J23/6527 ,  B01J27/1856

    摘要： A catalyst and process is disclosed to selectively upgrade a paraffinic feedstock to obtain an isoparaffin-rich product for blending into gasoline. The catalyst comprises a support of a tungstated oxide or hydroxide of a Group IVB (IUPAC 4) metal, a phosphorus component, and at least one platinum-group metal component which is preferably platinum. The catalyst has a structure other than a hetropoly anion structure.

    摘要翻译： 公开了一种催化剂和方法，用于选择性地升级链烷烃原料以获得用于混合成汽油的富含异链烷烃的产物。 该催化剂包含钨IVB（IUPAC 4）金属，磷成分和至少一种优选为铂的铂族金属成分的钨酸氧化物或氢氧化物的载体。 催化剂具有除了全反式阴离子结构以外的结构。