公开(公告)号：US20100310531A1

公开(公告)日：2010-12-09

申请号：US12795195

申请日：2010-06-07

Applicant: Joseph Wagner ,  Randell Young ,  David Fink

Inventor： Joseph Wagner ,  Randell Young ,  David Fink

IPC: A61K35/12 ,  C07K7/06 ,  C12N5/0789 ,  C07K7/08 ,  C12N5/074 ,  C12N5/0775 ,  A61P9/00

CPC classification number: A61K35/28 ,  A61K47/543 ,  A61K47/64

Abstract: Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.

Abstract translation: 本发明的实施方案涉及包含治疗细胞和涂覆治疗细胞的多种靶向复合物的涂覆细胞，并且每种所述靶向复合物包含归巢分子，脂质部分和具有约1至约10个 氨基酸，并将归巢分子与脂质部分共价连接，并且其中脂质部分非共价连接到治疗细胞上。 在一些实施方案中，治疗性细胞是干细胞。 本发明的实施方案涉及涂覆治疗细胞的方法。 本发明的实施方案涉及治疗脉管系统疾病的方法。

公开(公告)号：US20100280468A1

公开(公告)日：2010-11-04

申请号：US12686813

申请日：2010-01-13

Applicant: Kurt Haggstrom ,  David Fink ,  Katja Grundmeier

Inventor： Kurt Haggstrom ,  David Fink ,  Katja Grundmeier

IPC: A61M1/00

CPC classification number: A61M1/0027 ,  A61F13/00063 ,  A61F13/00068 ,  A61F13/0209 ,  A61F13/0216 ,  A61M1/0031 ,  A61M1/0088 ,  A61M27/00 ,  A61M39/24 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/587 ,  A61M2205/6081 ,  A61M2205/8206

Abstract: A wound dressing apparatus includes a wound dressing member dimensioned for positioning relative to a wound bed. The wound dressing member including an internal vacuum reservoir and has a port in communication with the vacuum reservoir for applying subatmospheric pressure to the vacuum reservoir to facilitate removal of fluid from the wound bed. The wound dressing member includes a visual pressure indicator associated therewith for indicating a level of pressure within the vacuum reservoir. The visual pressure indicator includes color indicia having a plurality of colors corresponding to a condition of the pressure within the vacuum reservoir. The wound dressing member includes a lower absorbent member positionable adjacent the wound bed and an upper member which at least partially defines the vacuum reservoir. At least one of the top member and the lower absorbent member has the visual pressure indicator mounted thereto.

Abstract translation: 一种伤口敷料装置包括用于相对于伤口床定位的伤口敷料构件。 所述伤口敷料构件包括内部真空容器，并且具有与所述真空容器连通的端口，用于向所述真空容器施加低于大气压的压力，以便于从所述伤口床移除流体。 伤口敷料构件包括与其相关联的视觉压力指示器，用于指示真空容器内的压力水平。 视觉压力指示器包括具有对应于真空容器内的压力状态的多种颜色的颜色标记。 所述伤口敷料构件包括可邻近所述伤口床定位的下部吸收体，以及至少部分限定所述真空容器的上部构件。 顶部构件和下部吸收构件中的至少一个具有安装在其上的视觉压力指示器。

公开(公告)号：US07699823B2

公开(公告)日：2010-04-20

申请号：US11516925

申请日：2006-09-06

Applicant: Kurt Haggstrom ,  David Fink ,  Katja Grundmeier

Inventor： Kurt Haggstrom ,  David Fink ,  Katja Grundmeier

IPC: A61M1/00

CPC classification number: A61M1/0027 ,  A61F13/00063 ,  A61F13/00068 ,  A61F13/0209 ,  A61F13/0216 ,  A61M1/0031 ,  A61M1/0088 ,  A61M27/00 ,  A61M39/24 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/587 ,  A61M2205/6081 ,  A61M2205/8206

Abstract: A wound dressing apparatus includes a wound dressing member dimensioned for positioning relative to a wound bed. The wound dressing member including an internal vacuum reservoir and has a port in communication with the vacuum reservoir for applying subatmospheric pressure to the vacuum reservoir to facilitate removal of fluid from the wound bed. The wound dressing member includes a visual pressure indicator associated therewith for indicating a level of pressure within the vacuum reservoir. The visual pressure indicator includes color indicia having a plurality of colors corresponding to a condition of the pressure within the vacuum reservoir. The wound dressing member includes a lower absorbent member positionable adjacent the wound bed and an upper member which at least partially defines the vacuum reservoir. At least one of the top member and the lower absorbent member has the visual pressure indicator mounted thereto. The preferred visual pressure indicator includes an electronic position sensor. The visual pressure indicator further includes circuit means and visible alarm means. The circuit means is adapted to actuate the visible alarm means when the position sensor detects a relative positioning of the top member of the wound dressing member to provide a visual indication of the condition of the subatmospheric pressure within the vacuum reservoir.

Abstract translation: 一种伤口敷料装置包括用于相对于伤口床定位的伤口敷料构件。 所述伤口敷料构件包括内部真空容器，并且具有与所述真空容器连通的端口，用于向所述真空容器施加低于大气压的压力，以便于从所述伤口床移除流体。 伤口敷料构件包括与其相关联的视觉压力指示器，用于指示真空容器内的压力水平。 视觉压力指示器包括具有对应于真空容器内的压力状态的多种颜色的颜色标记。 所述伤口敷料构件包括可邻近所述伤口床定位的下部吸收体，以及至少部分限定所述真空容器的上部构件。 顶部构件和下部吸收构件中的至少一个具有安装在其上的视觉压力指示器。 优选的视觉压力指示器包括电子位置传感器。 视觉压力指示器还包括电路装置和可见报警装置。 当位置传感器检测到伤口敷料构件的顶部构件的相对定位以提供在真空容器内的低于大气压的状况的视觉指示时，电路装置适于致动可见警报装置。

公开(公告)号：US20090199231A1

公开(公告)日：2009-08-06

申请号：US12380073

申请日：2009-02-23

Applicant: Yossi Tsuria ,  Stephanie Wald ,  Gadi Tirosh ,  Ezra Darshan ,  David Richardson ,  David Fink ,  Moshe Shlissel ,  Menachem Vinokurov ,  Reuven Wachtfogel ,  Eli Jacobs ,  Einat Cohen ,  Ian Bastable

Inventor： Yossi Tsuria ,  Stephanie Wald ,  Gadi Tirosh ,  Ezra Darshan ,  David Richardson ,  David Fink ,  Moshe Shlissel ,  Menachem Vinokurov ,  Reuven Wachtfogel ,  Eli Jacobs ,  Einat Cohen ,  Ian Bastable

IPC: H04N7/025 ,  H04N7/173

CPC classification number: H04N21/466 ,  H04N5/76 ,  H04N9/8205 ,  H04N9/8227 ,  H04N9/8233 ,  H04N21/26291 ,  H04N21/4331 ,  H04N21/4334 ,  H04N21/4335 ,  H04N21/4532 ,  H04N21/454 ,  H04N21/458 ,  H04N21/812 ,  H04N21/8456 ,  H04N21/8545

Abstract: Methods and apparatus for managing, implementing and using interactive applications and content that are digitally recorded and viewed in real-time and/or a time-shifted moded are provided. The interactive applications may be associated with television programs or may be unrelated thereto, and may be transmitted together with television programs or separately therefrom. Interactive applications that are employed in a time-shifted mode can be matched to current conditions and interactive content may be updated to include current data. Users may view and manipulate highlights of television programs and receive alerts of occurrence of real-time events during viewing of recorded material. Additional manipulations of interactive applications and content are also enabled. Related apparatus and methods are also described.

Abstract translation: 提供了用于管理，实现和使用实时和/或时移模式数字记录和观看的交互式应用和内容的方法和装置。 交互式应用可以与电视节目相关联或者可以与电视节目无关，并且可以与电视节目一起发送或者与电视节目分开地传送。 以时移模式采用的交互式应用程序可以与当前条件匹配，交互式内容可能会被更新为包含当前数据。 用户可以查看和操纵电视节目的亮点，并在观看录制资料期间收到实时事件发生的警报。 还启用了交互式应用程序和内容的其他操作。 还描述了相关装置和方法。

公开(公告)号：US20070299112A1

公开(公告)日：2007-12-27

申请号：US11674349

申请日：2007-02-13

Applicant: David Fink ,  Yulin Chiang ,  Nicola Collar

Inventor： David Fink ,  Yulin Chiang ,  Nicola Collar

IPC: A61K31/426 ,  A61K31/407 ,  A61K31/4436 ,  A61P25/24 ,  C07D401/14 ,  C07D487/04 ,  C07D513/04

CPC classification number: C07D495/04 ,  C07D513/04

Abstract: The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) and a method for the preparation of compounds of formula (I) or formula (II) are also disclosed and claimed.

Abstract translation: 本发明公开并要求具有式（I）和式（II）的化合物作为人酪蛋白激酶Iepsilon的抑制剂以及使用所述化合物治疗中枢神经系统疾病和病症（包括情绪障碍和睡眠障碍）的方法。 还公开并要求保护包含式（I）或式（II）化合物的药物组合物和制备式（I）或式（II）化合物的方法。

公开(公告)号：US20070161641A1

公开(公告)日：2007-07-12

申请号：US11714047

申请日：2007-03-05

Applicant: James Hendrix ,  Horst Hemmerle ,  Matthias Urmann ,  Gregory Shutske ,  Joseph Strupczewski ,  Kenneth Bordeau ,  John Jurcak ,  Thaddeus Nieduzak ,  Sharon Jackson ,  Paul Angell ,  James Carey ,  George Lee ,  David Fink ,  Jean-Francois Sabuco ,  Yulin Chiang ,  Nicola Collar

Inventor： James Hendrix ,  Horst Hemmerle ,  Matthias Urmann ,  Gregory Shutske ,  Joseph Strupczewski ,  Kenneth Bordeau ,  John Jurcak ,  Thaddeus Nieduzak ,  Sharon Jackson ,  Paul Angell ,  James Carey ,  George Lee ,  David Fink ,  Jean-Francois Sabuco ,  Yulin Chiang ,  Nicola Collar

IPC: A61K31/498 ,  A61K31/497 ,  A61K31/496

CPC classification number: A61K31/496 ,  C07D209/08 ,  C07D213/74 ,  C07D215/40 ,  C07D231/12 ,  C07D233/56 ,  C07D239/42 ,  C07D241/04 ,  C07D241/20 ,  C07D249/08 ,  C07D261/20 ,  C07D295/14 ,  C07D295/155 ,  C07D307/66 ,  C07D307/68 ,  C07D317/58 ,  C07D333/58 ,  C07D333/66 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D471/06 ,  C07D495/04 ,  C07D498/04

Abstract: The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine D3 receptors. In another aspect, the invention relates is to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D3 receptors.

Abstract translation: 本发明涉及显示与多巴胺D 3受体的选择性结合的杂环取代的羰基衍生物。 另一方面，本发明涉及在需要这种治疗的患者中治疗与多巴胺D 3 N 3受体活性相关的中枢神经系统障碍的方法，包括向受试者施用治疗有效量的 所述化合物用于缓解这种病症。 可能用这些化合物治疗的中枢神经系统疾病包括心理障碍，物质依赖性，物质滥用，运动障碍（例如帕金森病，帕金森综合征，神经灵敏诱导的迟发性运动障碍，杜氏杜勒氏综合征和亨廷顿病），痴呆，焦虑 疾病，睡眠障碍，昼夜节律紊乱和情绪障碍。 本发明还涉及制备本文所述化合物的方法以及制备和使用化合物作为多巴胺D 3受体的显像剂的方法。

公开(公告)号：US20050131012A1

公开(公告)日：2005-06-16

申请号：US11001533

申请日：2004-12-01

Applicant: William Metz ,  Frank Halley ,  Gilles Dutruc-Rosset ,  Yong Choi-Sledeski ,  Gregory Bernard Poli ,  David Fink ,  Gilles Doerflinger ,  Bao-Guo Huang ,  Ann Gelormini ,  Juan Gamboa ,  Andrew Giovanni ,  Joachim Roehr ,  Joseph Tsay ,  Fernando Camacho ,  William Hurst ,  Stephen Harnish ,  Yulin Chiang

Inventor： William Metz ,  Frank Halley ,  Gilles Dutruc-Rosset ,  Yong Choi-Sledeski ,  Gregory Bernard Poli ,  David Fink ,  Gilles Doerflinger ,  Bao-Guo Huang ,  Ann Gelormini ,  Juan Gamboa ,  Andrew Giovanni ,  Joachim Roehr ,  Joseph Tsay ,  Fernando Camacho ,  William Hurst ,  Stephen Harnish ,  Yulin Chiang

IPC: A61K31/437 ,  C07D471/04 ,  C07D471/02 ,  A61K31/4745

CPC classification number: C07D471/04

Abstract: The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.

Abstract translation: 本发明公开并要求作为人酪蛋白激酶IF抑制剂的式（I）化合物，以及使用所述式（I）化合物治疗中枢神经系统疾病和病症（包括情绪障碍和睡眠障碍）的方法。 还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。

公开(公告)号：US5774546A

公开(公告)日：1998-06-30

申请号：US780501

申请日：1997-01-08

Applicant: Doron Handelman ,  Moshe Kranc ,  David Fink ,  Arnold Zucker ,  Perry Smith ,  Gerson Bar-on

Inventor： Doron Handelman ,  Moshe Kranc ,  David Fink ,  Arnold Zucker ,  Perry Smith ,  Gerson Bar-on

IPC: G06K19/00 ,  G06F21/10 ,  G06K7/00 ,  G07C9/00 ,  G07F7/10 ,  H04N5/445 ,  H04N7/16 ,  H04N21/418 ,  H04N21/4405 ,  H04N21/4545 ,  H04N21/4623 ,  H04L9/00 ,  H04N7/167 ,  G06F7/04

CPC classification number: G07F7/1008 ,  G06K7/0004 ,  G06K7/0034 ,  G06Q20/341 ,  G06Q20/346 ,  G06Q20/3578 ,  G06Q20/35785 ,  G07C9/00119 ,  H04N21/4181 ,  H04N21/4405 ,  H04N21/4623 ,  H04N7/163 ,  H04N5/445

Abstract: A data access system is provided including a processor, an IC card reader and writer coupled to the processor and including an IC card receptacle, and an IC card which is insertable into the IC card receptacle and which has a memory which includes video data to be accessed by the processor. The processor includes security level data determining the level of encryption of said video data. In another embodiment of the invention, one IC card with two separate integrated circuits embodied within is provided, each of the separate integrated circuits being separately accessible by an IC card reader and writer.

Abstract translation: 提供了一种数据访问系统，包括处理器，耦合到处理器的IC卡读取器和写入器，并且包括IC卡插座和可插入到IC卡插座中的IC卡，并且具有包括视频数据的存储器 由处理器访问。 处理器包括确定所述视频数据的加密级别的安全级数据。 在本发明的另一个实施例中，提供了具有体现在其内的两个单独的集成电路的一个IC卡，每个单独的集成电路可由IC卡读写器单独访问。

公开(公告)号：US5666412A

公开(公告)日：1997-09-09

申请号：US375995

申请日：1995-01-20

Applicant: Doron Handelman ,  Moshe Kranc ,  David Fink ,  Arnold Zucker ,  Perry Smith ,  Gerson Bar-On

Inventor： Doron Handelman ,  Moshe Kranc ,  David Fink ,  Arnold Zucker ,  Perry Smith ,  Gerson Bar-On

IPC: G06K19/00 ,  G06F21/10 ,  G06K7/00 ,  G07C9/00 ,  G07F7/10 ,  H04N5/445 ,  H04N7/16 ,  H04N21/418 ,  H04N21/4405 ,  H04N21/4545 ,  H04N21/4623 ,  H04L9/00 ,  H04N7/167 ,  G06F7/04

CPC classification number: G07F7/1008 ,  G06K7/0004 ,  G06K7/0034 ,  G06Q20/341 ,  G06Q20/346 ,  G06Q20/3578 ,  G06Q20/35785 ,  G07C9/00119 ,  H04N21/4181 ,  H04N21/4405 ,  H04N21/4623 ,  H04N7/163 ,  H04N5/445

Abstract: A CATV system including a CATV network and apparatus for transmitting over the CATV network information to a multiplicity of subscriber units, each including a CATV decoder and an IC card reader and writer coupled to the CATV decoder, the IC card reader and writer includes two separate IC card receptacles, such that IC cards inserted into the two separate IC card receptacles are separately accessed by the IC card reader and writer.

Abstract translation: 一种CATV系统，包括CATV网络和用于通过CATV网络信息传输到多个用户单元的装置，每个用户单元包括耦合到CATV解码器的CATV解码器和IC卡读写器，IC卡读写器包括两个分开的 IC卡插座，插入到两个分开的IC卡插座中的IC卡被IC卡读写器单独访问。

公开(公告)号：US5283795A

公开(公告)日：1994-02-01

申请号：US871877

申请日：1992-04-21

Applicant: David Fink

Inventor： David Fink

IPC: H01S3/08 ,  H01S3/1055 ,  H01S3/13

CPC classification number: H01S3/08009 ,  H01S2301/08 ,  H01S3/08068 ,  H01S3/1055

Abstract: The present invention provides various embodiments of laser systems for generating "chirp" signals. In the broadest sense, a diffraction grating is placed within a laser cavity on the face of a carrier and the motion of the carrier in its own plane causes the laser to chirp. Typically, the diffraction grating is placed in the end-reflector position of the optical path of the resonant cavity associated with the laser. By putting the diffraction grating on the outer peripheral rim of a wheel and rotating the wheel, a sequence of either up-chirp or down-chirp signals can be generated continuously. Similarly, the desired "chirped" signals can be generated by using a diffraction grating oriented radially on the face of a rotating wheel. The system also contemplates the simultaneous generation of both an up-chirp signal of one polarization and a down-chirp signal of an orthogonal polarization by using a pair of lasers and a single wheel carrying the diffraction grating on either its outer peripheral rim or its face disposed in the end-reflector positions of the lasers for simultaneously generating both the up-chirp and down-chirp signals. An optical system including a reflective mirror, a one-half waveplate, and a polarizing beamsplitter are provided at the output of the two laser system for combining the up-chirp signal and down-chirp signal for simultaneous outputting.

Abstract translation: 本发明提供了用于产生“啁啾”信号的激光系统的各种实施例。 在最广泛的意义上，衍射光栅被放置在载体表面上的激光腔内，并且载体在其自身平面中的运动导致激光器啁啾。 通常，衍射光栅被放置在与激光器相关联的谐振腔的光路的端反射器位置。 通过将衍射光栅放置在车轮的外周边缘并旋转车轮，可以连续生成上升啁啾或下降线性调频信号的序列。 类似地，可以通过使用在旋转轮的表面上径向定向的衍射光栅来产生期望的“啁啾”信号。 该系统还考虑通过使用一对激光器和在其外周缘或其表面上承载衍射光栅的单个轮轮来同时产生一个极化的向上啁啾信号和正交偏振的向下啁啾信号 设置在激光器的端反射器位置，以同时产生上啁啾和下啁啾信号。 在两个激光系统的输出处提供包括反射镜，一半波片和偏振分束器的光学系统，用于组合用于同时输出的上升线性调频脉冲信号和下拉线性调频信号。