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    Methods of inhibiting proliferation or immunoglobulin production of B cells using human tumor necrosis factor receptor TR-17 polypeptides
    22.
    发明授权
    Methods of inhibiting proliferation or immunoglobulin production of B cells using human tumor necrosis factor receptor TR-17 polypeptides 有权
    使用人肿瘤坏死因子受体TR-17多肽抑制B细胞增殖或免疫球蛋白产生的方法

    公开(公告)号：US08518389B2

    公开(公告)日：2013-08-27

    申请号：US12336051

    申请日：2008-12-16

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K38/16

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。

    Human Tumor Necrosis Factor TR18 and Methods Based Thereon
    28.
    发明申请
    Human Tumor Necrosis Factor TR18 and Methods Based Thereon 审中-公开
    人类肿瘤坏死因子TR18及其方法

    公开(公告)号：US20080227714A1

    公开(公告)日：2008-09-18

    申请号：US12116717

    申请日：2008-05-07

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K38/16 ,  A61P37/00 ,  A61P35/00

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K14/70578 ,  C07K14/7151

    摘要： The present invention relates to TR18 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR18 protein. TR18 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR18 activity. The invention further relates to methods of treating, preventing, prognosing, or diagnosing an autoimmune disease or condition associated with an autoimmune disease, comprising administering to a patient an effective amount of polypeptides of the invention.

    摘要翻译： 本发明涉及TR18多肽。 特别地，提供编码人TR18蛋白的分离的核酸分子。 还提供TR18多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定TR18活性的激动剂和拮抗剂的筛选方法。 本发明还涉及治疗，预防，预后或诊断与自身免疫性疾病相关的自身免疫性疾病或病症的方法，其包括向患者施用有效量的本发明的多肽。