SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION
    21.
    发明申请
    SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION 审中-公开
    用于监测心脏病发作,病变和形态学以及可能引起心脏病毒或调节心肌细胞功能的药物代谢筛选的系统和方法

    公开(公告)号:US20110039294A1

    公开(公告)日:2011-02-17

    申请号:US12774709

    申请日:2010-05-05

    IPC分类号: C12Q1/02 C12M1/34

    CPC分类号: G01N33/48735

    摘要: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.

    摘要翻译: 提供了用于进行细胞的细胞外记录的装置和方法,例如可兴奋细胞,心肌细胞和心肌细胞前体细胞。 示例性装置包括形成或提供为一个或多个孔的基底的非导电基底; 记录电极,其位于所述阱内的所述衬底上,其中当将细胞样品添加到所述装置时,所述记录电极可接近细胞; 以及位于无细胞区域内的阱内的参比电极,当将细胞样品添加到器件时,无细胞区域表征为不与细胞接触,从而防止细胞与参比电极之间的接触。

    Method, system and apparatus for message interworking
    24.
    发明授权
    Method, system and apparatus for message interworking 有权
    消息互通的方法,系统和装置

    公开(公告)号:US08799373B2

    公开(公告)日:2014-08-05

    申请号:US12704348

    申请日:2010-02-11

    摘要: A method for message interworking, a Session Initiation System messaging server, an interworking gateway and a system for message interworking are disclosed. The method for message interworking includes: receiving, by an SIP messaging server, an SIP message, and routing the SIP message to a recipient; receiving an SIP response to the SIP message; sending the SIP message to an interworking gateway when it is determined that message interworking is required, so that the interworking gateway may perform a protocol conversion on the SIP message and send the converted non-SIP message to a corresponding non-SIP messaging system, or, so that the interworking gateway may establish a session between the interworking gateway itself and a sender terminal, receive an SIP session message via the established session, perform a protocol conversion on the SIP session message and then send the converted non-SIP message to a corresponding non-SIP messaging system.

    摘要翻译: 公开了一种消息互通方法,会话发起系统消息传递服务器,互通网关和消息互通系统。 消息互通方法包括:由SIP消息收发服务器接收SIP消息,并将SIP消息路由给接收者; 接收对SIP消息的SIP响应; 当确定需要消息互通时,将SIP消息发送到互通网关,使得互通网关可以对SIP消息执行协议转换,并将转换的非SIP消息发送到对应的非SIP消息系统,或者 ,使得互通网关可以在互通网关本身和发送者终端之间建立会话,经由建立的会话接收SIP会话消息,对SIP会话消息执行协议转换,然后将转换的非SIP消息发送到 相应的非SIP消息系统。

    Anodized substrate layer with solid lubricant
    26.
    发明授权
    Anodized substrate layer with solid lubricant 有权
    具有固体润滑剂的阳极氧化基材层

    公开(公告)号:US08226809B2

    公开(公告)日:2012-07-24

    申请号:US11330507

    申请日:2006-01-12

    IPC分类号: C25D5/02

    CPC分类号: C25D9/08 C25D11/02 C25D11/20

    摘要: An anodized layer on a metallic substrate is treated in a manner to directly electrodeposit a metal sulfide solid lubricant material represented by MS2, where M is Mo, W or other suitable metal, in pores of the anodized layer without any subsequent thermal and/or chemical treatment being needed.

    摘要翻译: 处理金属基底上的阳极氧化层,以直接电化沉积由阳离子化层的孔中的由MS2表示的金属硫化物固体润滑剂材料(其中M是Mo,W或其它合适的金属),而没有任何后续的热和/或化学 需要治疗

    Method and system for precise-clock synchronization, and device for precise-clock frequency/time synchronization
    28.
    发明授权
    Method and system for precise-clock synchronization, and device for precise-clock frequency/time synchronization 有权
    精确时钟同步的方法和系统,以及用于精确时钟频率/时间同步的设备

    公开(公告)号:US07916758B2

    公开(公告)日:2011-03-29

    申请号:US12904754

    申请日:2010-10-14

    IPC分类号: H04J3/06

    摘要: A precise-clock synchronization method and system and a precise-clock frequency/time synchronization device are provided. In the embodiments of the present invention, two time stamp engines are provided at a slave clock side. A relative time stamp engine provides a relative arrival time stamp. An absolute time stamp engine provides an absolute arrival time stamp. The frequency/time synchronization is calculated by using different time stamps obtained from different time stamp engines, so the frequency synchronization and time synchronization of the master clock and the slave clock may be separately accomplished, and one synchronization function may be enabled or disabled. Therefore, the frequency synchronization and time synchronization of the master clock and the slave clock do not interfere with each other, thus greatly reducing the occupied link bandwidth resources.

    摘要翻译: 提供精确时钟同步方法和系统以及精确时钟频率/时间同步装置。 在本发明的实施例中,在从时钟侧提供两个时间戳引擎。 相对时间戳引擎提供相对到达时间戳。 绝对时间戳引擎提供绝对到达时间戳。 通过使用从不同的时间戳引擎获得的不同的时间标记来计算频率/时间同步,因此可以分别实现主时钟和从时钟的频率同步和时间同步,并且可以启用或禁用一个同步功能。 因此,主时钟和从时钟的频率同步和时间同步不会相互干扰,从而大大减少了占用的链路带宽资源。

    Method and device for improving clock stability
    29.
    发明申请
    Method and device for improving clock stability 有权
    提高时钟稳定性的方法和装置

    公开(公告)号:US20110058576A1

    公开(公告)日:2011-03-10

    申请号:US12938123

    申请日:2010-11-02

    IPC分类号: H04J3/00

    摘要: A method and device for improving clock stability are provided. The method includes: determining whether a difference between a current sender timestamp (ST) and a current receiver timestamp (RT) is a mutated value; pre-processing the ST and RT, if the difference between the ST and RT is a mutated value; acquiring a service clock according to the pre-processed ST and RT; and sending time division multiplex (TDM) data according to the service clock.. Through the embodiments of the present disclosure, a packet delay variance (PDV) may be smoothed, the impairment of the PDV on clock recovery may be reduced, the quality of the clock recovery may be improved, and the problem of clock synchronization may be solved through the mutation processing on the timestamps.

    摘要翻译: 提供了一种用于提高时钟稳定性的方法和装置。 该方法包括:确定当前发送者时间戳(ST)和当前接收者时间戳(RT)之间的差异是否是突变值; 如果ST和RT之间的差异是突变值,则预处理ST和RT; 根据预处理的ST和RT获取服务时钟; 并根据业务时钟发送时分复用(TDM)数据。通过本公开的实施例,可以平滑分组延迟方差(PDV),可以减少时钟恢复上的PDV的损耗, 可以提高时钟恢复,并且可以通过对时间戳的突变处理来解决时钟同步的问题。