利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

114 条记录 (耗时 0.031 秒)

    Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue
    21.
    发明授权
    Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue 有权
    用于减少非内膜血管组织区域的矿物质含量的方法和装置

    公开(公告)号：US06755811B1

    公开(公告)日：2004-06-29

    申请号：US09382571

    申请日：1999-08-25

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61M3100

    CPC分类号： A61B17/11 ,  A61B17/08 ,  A61B2017/00778 ,  A61B2017/00893 ,  A61B2017/1107 ,  A61N7/00

    摘要： Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue are provided. In the subject methods, an isolated local environment that includes the region to be demineralized is produced. The pH of the local environment is then reduced to a subphysiologic level, e.g. by flushing with an acidic dissolution fluid, for a period of time sufficient for the mineral content of the region to be reduced. The devices of the subject invention are characterized by comprising a means for producing an isolated local environment that includes a non-intimal region of vascular tissue. Also provided are kits for practicing the subject methods.

    摘要翻译： 提供了用于降低非内膜血管组织区域的矿物质含量的方法和装置。 在主题方法中，产生了包括待软化区域的孤立的局部环境。 然后将局部环境的pH降低至亚生理水平，例如 通过用酸性溶解流体冲洗一段足以减少该区域的矿物质含量的时间。 本发明的装置的特征在于包括用于产生包括血管组织的非内膜区域的分离的局部环境的装置。 还提供了用于实践主题方法的工具包。

    Methods and devices for reducing the mineral content of vascular calcified lesions
    23.
    发明授权
    Methods and devices for reducing the mineral content of vascular calcified lesions 有权
    减少血管钙化病变矿物质含量的方法和装置

    公开(公告)号：US06379345B1

    公开(公告)日：2002-04-30

    申请号：US09353127

    申请日：1999-07-14

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61M3100

    CPC分类号： A61B17/22 ,  A61B2017/22067 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2017/22098

    摘要： Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are systems and kits for practicing the subject methods. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.

    摘要翻译： 提供了至少减少血管钙化病变的矿物质含量的方法和装置，即存在于宿主血管组织上的钙化损伤。 在本方法中，病变的局部环境在亚生物pH下保持足以使损伤的矿物质含量降低的时间，例如， 通过用能够局部增加病变区域中的质子浓度的流体冲洗病变。 还提供了用于实践主题方法的系统和工具包。 本发明的方法和装置特别用于治疗与血管组织上的钙化损伤相关的血管疾病。

    Methods and kits for use in preventing restenosis
    24.
    发明授权
    Methods and kits for use in preventing restenosis 有权
    用于预防再狭窄的方法和试剂盒

    公开(公告)号：US6156350A

    公开(公告)日：2000-12-05

    申请号：US454235

    申请日：1999-12-02

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K33/00 ,  A61K33/14 ,  A61K33/20 ,  A61K33/18

    CPC分类号： A61K33/14 ,  A61K33/00 ,  A61K33/20

    摘要： Methods and kits are provided for at least inhibiting the progression of, if not preventing, restenosis in a host. In the subject methods, a vascular site is contacted, usually flushed, with a solution having a pH that is less than about 4, e.g. a hydrochloric acid. The subject methods find use in applications where the prevention of restenosis is desirable, including angioplasty applications, and may be used in combination with other treatment modalities, e.g. stents, and the like.

    摘要翻译： 提供了方法和试剂盒，用于至少抑制宿主的进展，如果不防止再狭窄。 在本发明的方法中，将血管部位通常用pH低于约4的溶液进行冲洗，通常冲洗。 盐酸。 本发明的方法可用于预防再狭窄的应用，包括血管成形术应用，并且可以与其它治疗方式组合使用。 支架等。

    Storage stable calcium phosphate cements
    25.
    发明授权
    Storage stable calcium phosphate cements 有权
    储存稳定的磷酸钙水泥

    公开(公告)号：US6053970A

    公开(公告)日：2000-04-25

    申请号：US345984

    申请日：1999-06-30

    申请人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

    发明人： Ira C. Ison ,  Mark T. Fulmer ,  Bryan M. Barr ,  Brent R. Constantz

    IPC分类号： A61F2/00 ,  A61L27/12 ,  C04B12/02 ,  C04B20/10 ,  C04B28/34 ,  C04B40/06

    CPC分类号： C04B20/107 ,  A61L27/12 ,  C04B12/025 ,  C04B20/1077 ,  C04B28/34 ,  C04B28/344 ,  C04B40/06 ,  A61F2310/00293 ,  C04B2111/00836 ,  Y10S623/901 ,  Y10T428/2949 ,  Y10T428/2991 ,  Y10T428/2993

    摘要： Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion. Alternatively, a phosphoric acid solution may be rapidly combined with a basic calcium phosphate particle slurry such that partially neutralized acidic calcium phosphate precipitates on the surface of the basic calcium phosphate particles.

    摘要翻译： 提供了两种组分的储存稳定的磷灰石水泥组合物，以及它们的生产方法。 受试者磷灰石水泥的干组分包括至少部分涂覆有部分中和的酸性磷酸钙的碱性钙源颗粒。 通过将碱性钙源颗粒与溶解的酸性磷酸盐在至少部分水性介质中组合来制备主体组合物的干组分，由此碱性钙源颗粒部分地涂覆有部分中和的酸性磷酸钙。 在酸性磷酸盐和碱性钙源之间的反应完成之后，通过从反应混合物中除去可用的水来终止反应。 在第一模式中，主体水泥可以通过在水性溶剂的存在下将酸性磷酸盐源与碱性钙源颗粒机械混合并在完成之前停止酸和碱之间的反应来制备。 或者，磷酸溶液可以与碱性磷酸钙颗粒浆料快速组合，使得部分中和的酸性磷酸钙在碱性磷酸钙颗粒的表面上沉淀。