-
公开(公告)号:US08163767B2
公开(公告)日:2012-04-24
申请号:US11995445
申请日:2006-07-13
申请人: Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
发明人: Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
IPC分类号: A61K31/44 , C07D471/14
CPC分类号: C07D471/14 , C07D519/00
摘要: The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要翻译: 本发明涉及式(I)化合物或其盐,其中-R1,-R2,-R3,-R4,-R5,-M-,-X-和-Y =如说明书中所定义,它们 使用as,药物,其制备方法和用于治疗JAK3介导的疾病。
-
公开(公告)号:US20110101659A1
公开(公告)日:2011-05-05
申请号:US12997994
申请日:2009-06-09
申请人: Mitsuo Nogami , Ryuta Kon , Takashi Kasahara , Yutaka Nakajima
发明人: Mitsuo Nogami , Ryuta Kon , Takashi Kasahara , Yutaka Nakajima
IPC分类号: B60R21/20
CPC分类号: B60R21/213 , B60R21/232 , B60R21/2338 , B60R21/237 , B60R2021/23388
摘要: A curtain airbag device for a vehicle having a lightweight, simplified, and inexpensive structure can prevent a curtain airbag from being caught by a pillar garnish when the airbag is deployed and inflated, and can restrict the deployment direction of the airbag. The curtain airbag may have sub-chambers formed therein that are folded together with the curtain airbag, and disposed adjacently thereto. The sub-chambers have a communication path formed therein that communicates with the curtain airbag. The curtain airbag is provided with tab cloth strips for supporting and fixing the curtain airbag. The tab cloth strips have an attachment section formed thereon and an annular binding section that binds together the curtain airbag and the sub-chambers. The binding section is provided with a tearing section to be torn when the curtain airbag is deployed and inflated and an anchoring section anchoring the airbag to the vehicle body side.
摘要翻译: 具有重量轻,结构简单,结构便宜的车辆帘式气囊装置能够防止当气囊展开并膨胀时,帘式气囊被支柱装饰件卡住,并能够限制气囊的展开方向。 帘式气囊可以具有形成在其中的副室,其与帘式气囊一起折叠并且与其邻接设置。 子室具有形成在其中的与帘式气囊连通的连通路径。 帘式气囊具有用于支撑和固定帘式气囊的凸片布条。 标签布条具有形成在其上的附接部分和将帘式气囊和子室结合在一起的环形捆扎部分。 装订部分设置有当帘式气囊展开并充气时要撕裂的撕裂部分,以及将安全气囊锚定到车体侧的锚固部分。
-
公开(公告)号:US20060173674A1
公开(公告)日:2006-08-03
申请号:US11394099
申请日:2006-03-31
申请人: Yutaka Nakajima , Yutaka Suzue , Kevin Gjerstad , Dong-Hui Zhang , Hiroaki Kanokogi , Benjamin Westbrook
发明人: Yutaka Nakajima , Yutaka Suzue , Kevin Gjerstad , Dong-Hui Zhang , Hiroaki Kanokogi , Benjamin Westbrook
IPC分类号: G06F17/27
CPC分类号: G06F17/273 , G06F17/2715 , G06F17/2725 , G06F17/2765
摘要: The sharing of language models is disclosed. In one embodiment, a language model service is provided that is shareable among handlers for input devices. The service includes a pre-processing mode of operation, and a correction mode of operation. In the former mode, the language model service is designed to receive a range within a document from a handler for an input device, and in response provide advice regarding text under consideration by the handler to insert within the document at the range, based on the context of the document within the range. In the latter mode, the language model service is designed to supervise correction over a range of text within a document, in which a number of different handlers for a number of different input devices were initially responsible for insertion of the text, such that the service solicits suggestions from the handlers, and based thereon determines text corrections. The corrections can then be made by the handlers, or by the service.
-
公开(公告)号:US20120034250A1
公开(公告)日:2012-02-09
申请号:US13264008
申请日:2010-04-13
申请人: Shohei Shirakami , Yutaka Nakajima , Jun Maeda , Hiroaki Tominaga , Hiroaki Yamagishi , Takeshi Hondo , Masamichi Inami , Hiroki Morio , Takayuki Inoue , Tsuyoshi Mizutani , Hiroki Ishioka
发明人: Shohei Shirakami , Yutaka Nakajima , Jun Maeda , Hiroaki Tominaga , Hiroaki Yamagishi , Takeshi Hondo , Masamichi Inami , Hiroki Morio , Takayuki Inoue , Tsuyoshi Mizutani , Hiroki Ishioka
IPC分类号: A61K31/437 , A61K31/55 , A61P37/06 , A61K31/541 , A61K31/5377 , A61K31/496 , C07D471/14 , A61K31/497
CPC分类号: C07D471/14 , C07D519/00
摘要: [Problem]The present invention provides a condensed pyrrolopyridine derivative which is useful as an active ingredient for a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases caused by undesirable cytokine signal transduction or diseases caused by abnormal cytokine signal transduction.[Means for Solution]The present inventors have extensively studied a compound having a JAK inhibitory action, and as a result, they have found that a condensed pyrrolopyridine derivative which is the compound of the present invention has an excellent JAK inhibitory action, and is therefore useful as an agent for preventing or treating diseases caused by undesirable cytokine signal transduction or diseases caused by abnormal cytokine signal transduction, thereby completing the present invention.
摘要翻译: 本发明提供可用作药物组合物的活性成分的特别是用于预防或治疗由不良细胞因子信号转导引起的疾病或由异常细胞因子信号转导引起的疾病的药物组合物的缩合吡咯并吡啶衍生物。 [解决方案]本发明人广泛研究了具有JAK抑制作用的化合物,结果发现,作为本发明化合物的缩合吡咯并吡啶衍生物具有优异的JAK抑制作用,因此 可用作预防或治疗由不良细胞因子信号转导引起的疾病或由异常细胞因子信号转导引起的疾病的药剂,从而完成本发明。
-
公开(公告)号:US20110230467A1
公开(公告)日:2011-09-22
申请号:US13130527
申请日:2009-11-20
申请人: Shohei Shirakami , Fumie Takahashi , Yutaka Nakajima , Hirofumi Omura , Naohiro Aoyama , Hiroshi Sasaki , Takeshi Hondo , Hiroaki Tominaga
发明人: Shohei Shirakami , Fumie Takahashi , Yutaka Nakajima , Hirofumi Omura , Naohiro Aoyama , Hiroshi Sasaki , Takeshi Hondo , Hiroaki Tominaga
IPC分类号: A61K31/55 , A61K31/5513 , A61K31/5377 , A61P43/00 , A61K31/497 , A61K31/506 , A61K31/444 , A61K31/4439 , C07D401/14 , C07D413/14 , C07D401/12 , C07D417/14 , C07D409/14 , C07D401/00
CPC分类号: C07D401/12 , C07D213/82 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/10
摘要: [Problem] The present invention provides a 4,6-diaminonicotinamide compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for treating diseases caused by undesirable and/or abnormal cytokine signal transduction.[Means for Solution] The present inventors have extensively studied compounds having a JAK3 inhibitory action, and as a result, they have found that a 4,6-diaminonicotinamide compound which is the compound of the present invention has an excellent JAK3 inhibitory action and is useful as an agent for preventing or treating diseases caused by undesirable and/or abnormal cytokine signal transduction, thereby completing the present invention.
摘要翻译: 本发明提供了可用作药物组合物的活性成分的特征的4,6-二氨基烟酰胺化合物,特别是用于治疗由不希望的和/或异常的细胞因子信号转导引起的疾病的药物组合物。 [解决方案]本发明人广泛研究了具有JAK3抑制作用的化合物,结果发现作为本发明化合物的4,6-二氨基烟酰胺化合物具有优异的JAK3抑制作用, 可用作预防或治疗由不良和/或异常细胞因子信号转导引起的疾病的药剂,从而完成本发明。
-
公开(公告)号:US20110039822A1
公开(公告)日:2011-02-17
申请号:US12914475
申请日:2010-10-28
申请人: Takayuki INOUE , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
发明人: Takayuki INOUE , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
IPC分类号: A61K31/437 , C07D471/04 , C07D471/14 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P17/06 , A61P19/02 , A61P37/00 , A61P37/06
CPC分类号: C07D451/04 , C07D471/04 , C07D471/14 , C07D519/00
摘要: The present invention provides a compound having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases.As a result of studies on a novel condensed heterocyclic derivative, the inventors have found that a compound having a cross-linked structure has an excellent JAK3 inhibition activity, and have completed the present invention.In other words, it is verified that the compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
摘要翻译: 本发明提供具有优异的JAK3抑制活性的化合物,可用作治疗和/或预防各种免疫疾病,包括自身免疫性疾病,炎症性疾病和过敏性疾病的药剂的活性成分。 作为研究新型稠合杂环衍生物的结果,本发明人发现具有交联结构的化合物具有优异的JAK3抑制活性,并且完成了本发明。 换句话说,证实了本发明的化合物对JAK3具有抑制活性,因此可用作治疗或预防由不期望的细胞因子信号传导引起的疾病的药剂的活性成分(例如器官/ 组织移植,自身免疫性疾病,多发性硬化,类风湿性关节炎,牛皮癣,哮喘,特应性皮炎,阿尔茨海默病和动脉粥样硬化疾病)或由异常细胞因子信号传导引起的疾病(例如癌症和白血病)。
-
公开(公告)号:US20100102542A1
公开(公告)日:2010-04-29
申请号:US12522063
申请日:2007-11-28
申请人: Yutaka Nakajima , Ken Tanmachi , Yosuke Shimizu , Eri Kobori
发明人: Yutaka Nakajima , Ken Tanmachi , Yosuke Shimizu , Eri Kobori
IPC分类号: B60R21/16
CPC分类号: B60R21/233 , B60R21/2338 , B60R21/239 , B60R2021/23316 , B60R2021/23382 , B60R2021/2395
摘要: [PROBLEMS] To cushion impact acting on an occupant who is not in a regular position. [MEANS FOR SOLVING PROBLEMS] When an abnormality occurs, an airbag device (1) inflates and expands in front of an occupant and absorbs an impact from the front of a vehicle. An airbag (2) to which gas from an inflator is supplied in an abnormality is provided with a vertical recess (2c) facing the head (Ph) of the occupant (P). The recess (2c) is located at the center, in the right and left direction of the vehicle, of an occupant restriction surface (2b) formed at a position facing the occupant (P) sitting on the seat during inflation and expansion. At least one fixed vent (2ea, 2eb) and at least one variable vent (2fan, 2fb) are provided at each of opposite sidewalls (2da, 2db). The fixed vent (2ea, 2eb) has an invariant opening area, and the variable vents (2fan 2fb) has an opening area variable depending on the sitting position of the occupant (P) during expansion. The recess (2c) and the opposite sidewalls (2da, 2db) are coupled in the airbag (2) by shape control members (3a,3b). [EFFECT] Even an occupant of out of position or an occupant not wearing a seat belt can be received relatively flexibly, and trouble caused on the occupant by the airbag is reduced.
摘要翻译: [问题]缓解对不在正常位置的乘客的影响。 解决问题的手段当发生异常时,气囊装置(1)在乘员前方膨胀膨胀并吸收车辆前方的冲击。 在异常情况下供给来自充气机的气体的气囊(2)设置有面向乘员(P)的头部(Ph)的垂直凹部(2c)。 在充气和膨胀期间,形成在面对乘坐人员(P)的位置的乘员限制面(2b)的凹部(2c)位于车辆的左右方向的中心。 在每个相对的侧壁(2da,2db)处设置至少一个固定排气口(2ea,2eb)和至少一个可变排气口(2fan,2fb)。 固定通风口(2ea,2eb)具有不变的开口面积,并且可变通风口(2fan 2fb)具有根据乘员(P)在展开期间的坐姿可变的开口面积。 凹部(2c)和相对的侧壁(2da,2db)通过形状控制构件(3a,3b)联接在气囊(2)中。 [效果]即使是位置不正确的乘员也不能佩戴座椅安全带的乘客也能够相对灵活地接收,并且能够减轻乘员对乘坐者造成的麻烦。
-
公开(公告)号:US20090264399A1
公开(公告)日:2009-10-22
申请号:US11995445
申请日:2006-07-13
申请人: Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
发明人: Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
IPC分类号: A61K31/437 , C07D471/04 , C07D413/14 , C07D471/14 , A61K31/5377 , A61K31/397 , A61P25/00 , A61P37/06 , A61P35/00 , A61P35/02 , A61P11/06
CPC分类号: C07D471/14 , C07D519/00
摘要: The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要翻译: 本发明涉及式(I)或其盐的化合物,其中-R1,-R2,-R3,-R4,-R5,-M-,-X-和-Y-如说明书中所定义,它们 使用as,药物,其制备方法和用于治疗JAK3介导的疾病。
-
29.
公开(公告)号:US20050090669A1
公开(公告)日:2005-04-28
申请号:US10504990
申请日:2003-03-10
IPC分类号: C07D295/14 , A61K31/18 , A61K31/196 , A61K31/24 , A61K31/245 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/351 , A61K31/381 , A61K31/402 , A61K31/44 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/455 , A61K31/4965 , A61K31/695 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/24 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/04 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P25/00 , A61P25/02 , A61P25/22 , A61P25/24 , A61P27/06 , A61P29/00 , C07C217/74 , C07C219/26 , C07C229/46 , C07C229/50 , C07C229/60 , C07C229/64 , C07C233/54 , C07C233/55 , C07C255/57 , C07C255/59 , C07C271/24 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/35 , C07C311/37 , C07C311/51 , C07C317/44 , C07C321/30 , C07C323/62 , C07D207/26 , C07D207/27 , C07D211/60 , C07D211/62 , C07D213/36 , C07D213/38 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/79 , C07D213/80 , C07D241/24 , C07D307/54 , C07D307/68 , C07D309/12 , C07D309/14 , C07D333/22 , C07D333/32 , C07D333/38 , C07D333/40 , C07D401/04 , C07D405/12 , C07F7/18 , C07D49/14 , C07D43/14 , C07D41/14
CPC分类号: C07D307/54 , C07C219/26 , C07C271/24 , C07C311/08 , C07C311/51 , C07C317/44 , C07C323/62 , C07C2601/14 , C07C2602/10 , C07C2602/12 , C07D207/27 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/79 , C07D213/80 , C07D241/24 , C07D309/12 , C07D309/14 , C07D333/22 , C07D333/32 , C07D333/38 , C07D401/04 , C07D405/12 , C07F7/1804 , Y02P20/55
摘要: The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond, -o-o, —O—CH2—, etc., y is in which Z is bond, —O—(CH2)m— (in which m is 1 to 4), etc., R3 is lower alkanoyl, carboxy, lower alkoxycarbonyl, etc., and R4 is hydrogen, halogen, hydroxy, phenoxy, lower alkyl, lower alkoxy, etc., and n is 0, 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.
摘要翻译: 本发明涉及其中R 1和R 5各自独立地为氢,卤素,低级烷基等的化合物式[I],R 2是氢或氨基 保护基,x为键,-o,-O-CH 2 - 等,y为Z为键,-O-(CH 2/2) 其中m为1至4)等,R 3为低级烷酰基,羧基,低级烷氧基羰基等,R 4为氢, SUP>是氢,卤素,羟基,苯氧基,低级烷基,低级烷氧基等,n是0,1或2,或其盐。 本发明的化合物[I]及其药学上可接受的盐可用于预防和/或治疗呼吸窘迫症或尿失禁。
-
公开(公告)号:US4403832A
公开(公告)日:1983-09-13
申请号:US199978
申请日:1980-10-23
IPC分类号: G02F1/1347 , G04G9/00 , G09F9/35 , G09F9/46 , G02F1/13
CPC分类号: G04G9/0094 , G02F1/1347 , G02F1/13471 , G04G9/0035
摘要: A liquid crystal display device having a structural arrangement that a plurality of liquid crystal layers each for displaying a pattern are piled up and a pair of polarizers are provided above an uppermost liquid crystal layer and below a lowermost liquid crystal layer, is disclosed in which a polarizer is interposed between adjacent liquid crystal layers in such a manner that adjacent ones of the polarizers are different in direction of transmission axis from each other, in order to eliminate a white on black portion caused by an overlap of the patterns and to thereby reduce the area of a display region; or in which a white on black portion caused by an overlap of the patterns is used as a display portion to form a display pattern having a predetermined shape and to open up new possibilities for color display.
摘要翻译: 公开了一种液晶显示装置,其具有堆叠多个用于显示图案的液晶层和一对偏振器的结构布置,其中最上层的液晶层的上方和下方的液晶层的下方, 偏振器以相邻的偏振器彼此不同的方式插入在相邻的液晶层之间,以便消除由图案的重叠引起的黑色部分上的白色,从而减少 显示区域的区域; 或其中由图案重叠引起的白色黑色部分用作显示部分以形成具有预定形状的显示图案,并且开辟了彩色显示的新可能性。
-
-
-
-
-
-
-
-
-