公开(公告)号：US5241121A

公开(公告)日：1993-08-31

申请号：US904887

申请日：1992-06-25

申请人： Eiji Ogata ,  Nobuyuki Nate ,  Kazuo Hamano

发明人： Eiji Ogata ,  Nobuyuki Nate ,  Kazuo Hamano

IPC分类号： C07C315/00 ,  C07C315/04 ,  C07C317/22

CPC分类号： C07C315/00 ,  C07C315/04

摘要： A process for preparing 4,4'-dihydroxydiphenylsulfone, the process including heating 4,4'-dihydroxydiphenylsulfone and 2,4'-dihydroxydiphenylsulfone in the presence of an acid catalyst to isomerize the 2,4'-dihydroxydiphenylsulfone into 4,4'-dihydroxydiphenylsulfone, the process being characterized in that a suspension of 4,4'-dihydroxydiphenylsulfone and 2,4'-dihydroxydiphenylsulfone in a liquid dispersing medium is heated for isomerization while the liquid portion is distilled off or a crystal mixture of 4,4'-dihydroxydiphenylsulfone and 2,4'-dihydroxydiphenylsulfone is heated for isomerization to produce 4,4'-dihydroxydiphenylsulfone in the form of crystal powder.

摘要翻译： 一种制备4,4'-二羟基二苯砜的方法，该方法包括在酸催化剂存在下加热4,4'-二羟基二苯砜和2,4'-二羟基二苯砜，使2,4'-二羟基二苯砜异构化成4,4'-二羟基二苯砜， 二氢二苯基砜，其特征在于将4,4'-二羟基二苯基砜和2,4'-二羟基二苯基砜在液体分散介质中的悬浮液加热异构化，同时蒸馏掉液体部分或4,4'-二羟基二苯基砜的结晶混合物， 二羟基二苯砜和2,4'-二羟基二苯砜加热异构化，生成结晶粉末形式的4,4'-二羟基二苯砜。

公开(公告)号：US4162270A

公开(公告)日：1979-07-24

申请号：US896611

申请日：1978-04-14

申请人： Eiji Ogata ,  Koji Ono ,  Shoji Nakagaki

发明人： Eiji Ogata ,  Koji Ono ,  Shoji Nakagaki

IPC分类号： C07C315/00 ,  C07C317/22 ,  C07C147/10

CPC分类号： C07C315/00

摘要： In a process for producing 4,4'-dihydroxydiphenylsulfone by reacting phenol with sulfuric acid in the presence of a solvent, an improvement which comprises using at least a member selected from the group consisting of chlorobenzene, dichlorobenzene, trichlorobenzene, chlorotoluene, diethylbenzene, xylene, decalin, tetralin and tetrachloroethane as the solvent and removing said solvent progressively and finally substantially completely from the mixture while maintaining the reaction mixture at a temperature of about 160.degree. to about 200.degree. C. to effect precipitation of 4,4'-dihydroxydiphenylsulfone and isomerization of 2,4'-dihydroxydiphenylsulfone to 4,4'-dihydroxydiphenylsulfone.

摘要翻译： 在溶剂存在下，通过苯酚与硫酸反应生产4,4'-二羟基二苯砜的方法，包括使用至少一种选自氯苯，二氯苯，三氯苯，氯甲苯，二乙苯，二甲苯 ，十氢化萘，四氢化萘和四氯乙烷作为溶剂，并逐渐地并最终基本上完全从混合物中除去所述溶剂，同时将反应混合物保持在约160℃至约200℃的温度，以实现4,4'-二羟基二苯砜和 2,4'-二羟基二苯砜异构化为4,4'-二羟基二苯砜。

公开(公告)号：US08278350B2

公开(公告)日：2012-10-02

申请号：US10575624

申请日：2004-10-13

申请人： Eiko Kato ,  Tadashi Yoneda ,  Eiji Ogata

发明人： Eiko Kato ,  Tadashi Yoneda ,  Eiji Ogata

IPC分类号： A61K31/375 ,  C07D307/62

CPC分类号： A61K8/345 ,  A61K8/602 ,  A61K8/676 ,  A61K2800/52 ,  A61Q19/00 ,  C07D307/62 ,  C07F9/65515

摘要： An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.

摘要翻译： 本发明的皮肤外用剂含有抗坏血酸-2-磷酸酯和多元醇的高级脂肪酸酯的盐。 根据本发明，即使使用抗坏血酸-2-磷酸酯的高级脂肪酸酯的特定盐制备皮肤外用剂，也可以防止浊度或时间的沉淀发生，从而提高稳定性。 因此，本发明对于皮肤外用的所有试剂，特别是化妆品是有用的。

公开(公告)号：US20060100178A1

公开(公告)日：2006-05-11

申请号：US11304577

申请日：2005-12-16

申请人： Eiko Masatsuji ,  Toshi Tsuzuki ,  Shinobu Ito ,  Eiji Ogata

发明人： Eiko Masatsuji ,  Toshi Tsuzuki ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K31/665

CPC分类号： A61K8/27 ,  A61K8/671 ,  A61K8/676 ,  A61K31/315 ,  A61K31/375 ,  A61K31/555 ,  A61K33/30 ,  A61K45/06 ,  A61K2800/75 ,  A61Q19/00 ,  A61K2300/00

摘要： A dermal agent for preventing or treating acne, comprising an ascorbic acid derivative which liberates in vivo ascorbic acid, and a zinc salt or comprising a zinc salt of the ascorbic acid-2-phosphate, and a composition comprising tretinoin and an ascorbic acid derivative or a salt thereof, relieving in the irritation of tretinoin by using the dermal agent and tretinoin in combination.

摘要翻译： 一种用于预防或治疗痤疮的真皮剂，其包含在体内抗坏血酸中释放的抗坏血酸衍生物，以及锌盐或包含抗坏血酸-2-磷酸锌的锌盐，以及包含维甲酸和抗坏血酸衍生物的组合物，或 其盐，通过组合使用真皮剂和维甲酸来缓解维A酸的刺激。

公开(公告)号：US20050272956A1

公开(公告)日：2005-12-08

申请号：US10529074

申请日：2003-09-22

申请人： Eiji Ogata ,  Fumio Oi ,  Norio Yanase ,  Nobuyuki Nate

发明人： Eiji Ogata ,  Fumio Oi ,  Norio Yanase ,  Nobuyuki Nate

IPC分类号： C07C315/00 ,  C07C315/06 ,  C07C317/22

CPC分类号： C07C315/00 ,  C07C315/06 ,  C07C317/22

摘要： The present invention provides a process for producing 4,4′-dihydroxydiphenylsulfone of very high purity. In particular, the present invention provides a process for producing 4,4′-dihydroxydiphenylsulfone of high purity comprising the steps of subjecting phenol in combination with a sulfonating agent or phenolsulfonic acid to a dehydration reaction in the presence of an aromatic nonpolar solvent while suspending the resulting dihydroxydiphenylsulfone therein, mixing the reaction suspension with a polar solvent to at least partially dissolve the dihydroxydiphenylsulfone, and precipitating 4,4′-dihydroxydiphenylsulfone.

摘要翻译： 本发明提供了一种制备非常高纯度的4,4'-二羟基二苯砜的方法。 特别地，本发明提供了一种制备高纯度的4,4'-二羟基二苯基砜的方法，包括以下步骤：在芳族非极性溶剂的存在下使苯酚与磺化剂或苯酚磺酸组合进行脱水反应，同时使 将反应悬浮液与极性溶剂混合至少部分溶解二羟基二苯基砜，并沉淀出4,4'-二羟基二苯基砜。

公开(公告)号：US20050220733A1

公开(公告)日：2005-10-06

申请号：US10513371

申请日：2003-05-07

申请人： Toshi Tsuzuki ,  Eiko Kato ,  Eiji Ogata ,  Hiroshi Ikeno

发明人： Toshi Tsuzuki ,  Eiko Kato ,  Eiji Ogata ,  Hiroshi Ikeno

IPC分类号： A61K8/67 ,  A61Q19/02 ,  A61Q19/04 ,  A61K7/135

CPC分类号： A61K8/676 ,  A61K8/678 ,  A61Q19/02 ,  A61Q19/04

摘要： The invention relates to skin whitening external preparations which contain tocopherol phosphate and/or a salt thereof as an active ingredient capable of prevention and/or removal of skin pigmentation, cosmetics including the skin whitening external preparation and cosmetic cares using the cosmetic. The skin whitening external preparations have excellent skin whitening effects and are readily producible so that they can find wide use for the purpose of skin whitening.

摘要翻译： 本发明涉及含有生育酚磷酸酯和/或其盐作为能够预防和/或去除皮肤色素沉积的化妆品的皮肤美白外用制剂，包括皮肤美白外用剂的化妆品和使用该化妆品的化妆品护理。 皮肤美白外用制剂具有优异的皮肤美白效果，并且易于生产，使得它们可以广泛用于皮肤美白的目的。

公开(公告)号：US06299912B1

公开(公告)日：2001-10-09

申请号：US09556460

申请日：2000-04-24

申请人： Shinobu Ito ,  Kuniaki Shimbo ,  Eiji Ogata

发明人： Shinobu Ito ,  Kuniaki Shimbo ,  Eiji Ogata

IPC分类号： A23K100

CPC分类号： A23K50/80 ,  A23K20/174 ,  A23K20/189 ,  A23K50/00 ,  A23K50/10 ,  A23K50/40 ,  A23K50/75 ,  Y10S426/805 ,  Y10S426/807

摘要： A preparation for administration to animals, comprising a sparingly soluble L-ascorbic acid-2-phosphoric ester salt having a solubility in water of 10 wt % or less, the solubility being a value obtained by placing 100 g of purified water in a 200 ml-volume beaker, stirring the water while keeping the temperature at 20° C., adding 0.1 g of the L-ascorbic acid-2-phosphoric ester salt every 5 minutes by taking care not to cause gelation, and 30 minutes after the addition of L-ascorbic acid-2-phosphoric ester salt when the undissolved L-ascorbic acid-2-phosphoric ester salt is observed visually in the aqueous solution, determining the amount in weight percentage of L-ascorbic acid-2-phosphoric ester salt added based on water, and a method for feeding animals, using the preparation.

摘要翻译： 一种用于给予动物的制剂，其包含在水中的溶解度为10重量％以下的微溶L-抗坏血酸-2-磷酸酯盐，其溶解度为将100g纯化水放入200ml 在保持温度为20℃的同时搅拌水，每5分钟加入0.1g L-抗坏血酸-2-磷酸酯盐，注意不引起凝胶化，加入后30分钟 在水溶液中观察未溶解的L-抗坏血酸-2-磷酸酯盐时，测定L-抗坏血酸-2-磷酸酯盐的重量百分比量 在水上，以及饲养动物的方法。

公开(公告)号：US5965750A

公开(公告)日：1999-10-12

申请号：US849052

申请日：1997-05-29

申请人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

发明人： Yutaka Oonishi ,  Tsutomu Nozawa ,  Takami Ooe ,  Keisuke Mano ,  Naoaki Misu ,  Yohei Kurata ,  Shinobu Ito ,  Eiji Ogata

IPC分类号： A61K8/02 ,  A61K8/67 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q5/02 ,  A61Q7/00 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/10 ,  C07F9/655 ,  G01N30/02 ,  G01N30/88 ,  G01N33/82 ,  C07F9/06

CPC分类号： G01N33/82 ,  A61K8/0212 ,  A61K8/678 ,  A61Q19/00 ,  C07F9/65522 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q11/00 ,  A61Q19/10 ,  A61Q5/02 ,  A61Q7/00 ,  G01N2030/884 ,  G01N30/02 ,  Y10S514/846

摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

公开(公告)号：US5937790A

公开(公告)日：1999-08-17

申请号：US993714

申请日：1997-12-18

申请人： Shinobu Ito ,  Eiji Ogata ,  Masahiro Yamada

发明人： Shinobu Ito ,  Eiji Ogata ,  Masahiro Yamada

IPC分类号： A61K31/70 ,  A01K29/00 ,  A23K1/165 ,  A23K1/17

CPC分类号： A61K31/70

摘要： An anti-stress agent for animals for reducing the growth inhibition or mortality of animals and a method of reducing stress using a feed composition having blended therein the anti-stress agent. The anti-stress agent for animals comprises one or more substances selected from L-ascorbic acid-2-phosphoric acid, a salt thereof and an L-ascorbic acid-2-glucoside, as an active ingredient, for inhibiting the increase of blood plasma lactate dehydrogenase (LDH), malate dehydrogenase (MDH) and aspartate aminotransferase (AspAT) and for inhibiting the increase of stress proteins in blood, which occur when animals are placed under stress. Also disclosed is a feed composition comprising the anti-stress agent, and a method of reducing the stress of animals by supplying the same as feed.

摘要翻译： 用于降低动物的生长抑制或死亡率的动物的抗应激剂和使用其中混合有抗应激剂的饲料组合物来降低应激的方法。 用于动物的抗应激剂包含选自L-抗坏血酸-2-磷酸，其盐和L-抗坏血酸-2-葡萄糖苷作为活性成分的一种或多种物质，用于抑制血浆中的增加 乳酸脱氢酶（LDH），苹果酸脱氢酶（MDH）和天冬氨酸氨基转移酶（AspAT），并用于抑制动物在压力下发生的血液中应激蛋白的增加。 还公开了包含抗应激剂的饲料组合物，以及通过将饲料作为饲料供应来减少动物的压力的方法。

公开(公告)号：US5596128A

公开(公告)日：1997-01-21

申请号：US300844

申请日：1994-09-06

申请人： Eiji Ogata ,  Norio Yanase ,  Takayuki Kitahara

发明人： Eiji Ogata ,  Norio Yanase ,  Takayuki Kitahara

IPC分类号： C07B45/02 ,  C07C303/04 ,  C07C309/30 ,  C07C309/35 ,  C07C309/43 ,  C07C309/45 ,  C07C309/46 ,  C07C309/50 ,  C08F8/36 ,  C07C303/02

CPC分类号： C07C303/04 ,  C07B45/02 ,  C08F8/34 ,  C07C2103/24

摘要： A sulfonating agent represented by the general formula ##STR1## wherein the groups R.sup.1 are the same or different and are each a lower alkyl group having 1 to 3 carbon atoms, n is an integer of 3, 4 or 5, m is an integer of 1 or 2, and n+m.ltoreq.6, and a process for sulfonating an aromatic compound with use of the sulfonating agent.

摘要翻译： 由通式表示的磺化剂，其中基团R 1相同或不同，并且各自是具有1至3个碳原子的低级烷基，n是3,4或5的整数，m是 1或2，n + m 6，以及使用磺化剂磺化芳族化合物的方法。