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公开(公告)号：US20050208002A1
公开(公告)日：2005-09-22
申请号：US10506335
申请日：2003-03-06
申请人： Eiko Kato , Eiji Ogata , Tadashi Yoneda , Jiro Takata
发明人： Eiko Kato , Eiji Ogata , Tadashi Yoneda , Jiro Takata
IPC分类号： A61K8/67 , A61K31/355 , A61Q19/02 , A61K7/135
CPC分类号： A61K31/355 , A61K8/678 , A61Q19/02
摘要： A preparation for external use on skin which comprises an active ingredient exhibiting superior effects of preventing pigmentation or eliminating pigments formed in the skin, and has a high level of safety, and in particular, a cosmetic composition exhibiting superior so-called whitening effects, are provided. The whitening cosmetic composition comprises a tocopherol alkylglycine ester and/or a salt thereof.
摘要翻译： 皮肤外用的制剂，其特征在于，具有表现出优异的防止色素沉着的作用的活性成分或消除皮肤中形成的颜料，并且具有高水平的安全性，特别是具有优异的所谓的美白效果的化妆品组合物。 提供。 美白化妆品组合物包含生育酚烷基甘氨酸酯和/或其盐。
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2.发明申请公开(公告)号：US20070140998A1
公开(公告)日：2007-06-21
申请号：US10575624
申请日：2004-10-13
申请人： Eiko Kato , Tadashi Yoneda , Eiji Ogata
发明人： Eiko Kato , Tadashi Yoneda , Eiji Ogata
IPC分类号： A61K8/55
CPC分类号： A61K8/345 , A61K8/602 , A61K8/676 , A61K2800/52 , A61Q19/00 , C07D307/62 , C07F9/65515
摘要： An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.
摘要翻译： 本发明的皮肤外用剂含有抗坏血酸-2-磷酸酯和多元醇的高级脂肪酸酯的盐。 根据本发明，即使使用抗坏血酸-2-磷酸酯的高级脂肪酸酯的特定盐制备皮肤外用剂，也可以防止浊度或时间的沉淀发生，从而提高稳定性。 因此，本发明对于皮肤外用的所有试剂，特别是化妆品是有用的。
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3.发明授权公开(公告)号：US08278350B2
公开(公告)日：2012-10-02
申请号：US10575624
申请日：2004-10-13
申请人： Eiko Kato , Tadashi Yoneda , Eiji Ogata
发明人： Eiko Kato , Tadashi Yoneda , Eiji Ogata
IPC分类号： A61K31/375 , C07D307/62
CPC分类号： A61K8/345 , A61K8/602 , A61K8/676 , A61K2800/52 , A61Q19/00 , C07D307/62 , C07F9/65515
摘要： An agent for skin external use of the invention contains a salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester and a polyhydric alcohol. According to the present invention, occurrence of turbidity or precipitation with time can be prevented to enhance stability even when the agent for skin external use is prepared using a specific salt of higher fatty acid ester of ascorbic acid-2-phosphoric acid ester. Therefore, the present invention is useful for all agents for skin external use, particularly cosmetics.
摘要翻译： 本发明的皮肤外用剂含有抗坏血酸-2-磷酸酯和多元醇的高级脂肪酸酯的盐。 根据本发明，即使使用抗坏血酸-2-磷酸酯的高级脂肪酸酯的特定盐制备皮肤外用剂，也可以防止浊度或时间的沉淀发生，从而提高稳定性。 因此，本发明对于皮肤外用的所有试剂，特别是化妆品是有用的。
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4.发明申请Fungicidal and/or bactericidal composition, production process thereof and sterilization method using the composition 审中-公开杀真菌和/或杀菌组合物，其制备方法和使用该组合物的灭菌方法公开(公告)号：US20050032677A1
公开(公告)日：2005-02-10
申请号：US10486327
申请日：2002-08-09
申请人： Eiichi Kitakuni , Tadashi Yoneda , Toshi Tsuzuki , Eiji Ogata
发明人： Eiichi Kitakuni , Tadashi Yoneda , Toshi Tsuzuki , Eiji Ogata
IPC分类号： A01N43/713 , A01N43/72 , A01N63/00 , A01N63/02
摘要： The present invention relates to a fungicidal and/or bactericidal composition comprising a combination of iturin and surfactin which are a cyclic peptide produced by a mircoorganism, preferably a microorganism belonging to the genus Bacillus, with an amphipathic organic material having a hydrocarbon chain, its production process and sterilization method using the same. The fungicidal and/or bactericidal composition of the present invention is highly safe to human body or environment, is free of generation of resistant bacteria even on repeated use and has a wide sterilization spectrum.
摘要翻译： 本发明涉及杀真菌和/或杀菌组合物，其包含由微生物产生的环状肽，优选属于芽孢杆菌属的微生物和具有烃链的两亲性有机材料产生的环肽的组合，其生产 过程和灭菌方法使用相同。 本发明的杀真菌剂和/或杀菌剂组合物对人体或环境高度安全，甚至在重复使用时也不会产生耐药性细菌，并具有广泛的杀菌谱。
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公开(公告)号：US07011969B2
公开(公告)日：2006-03-14
申请号：US10381698
申请日：2001-09-28
申请人： Tadashi Yoneda , Yoshiaki Miyota , Kazuo Furuya , Toshi Tsuzuki
发明人： Tadashi Yoneda , Yoshiaki Miyota , Kazuo Furuya , Toshi Tsuzuki
IPC分类号： C12N1/20
摘要： A process for producing Surfactin, comprising culturing a microorganism of the genus Bacillus in a liquid culture medium containing flour of beans such as soybean or an extract thereof as a nitrogen source and accumulating Surfactin in the culture broth, and a microorganism of the genus Bacillus which have an activity to produce a crude Surfactin in a concentration of from 8 to 50 g/L on culturing for 20 to 90 hours.
摘要翻译： 一种生产枯草芽孢杆菌素的方法，包括在含有诸如大豆或其提取物的豆的面粉的液体培养基中培养芽孢杆菌属的微生物作为氮源并在培养肉汤中积累枯草芽孢杆菌素和芽孢杆菌属的微生物 具有在培养20〜90小时时产生浓度为8〜50g / L的粗的枯草菌素的活性。
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6.发明授权Method of producing &agr;-halo-&agr;,&bgr;-saturated carbonyl compounds from the corresponding &agr;,&bgr;-unsaturated compounds 失效从相应的α，β-不饱和化合物生产α-卤代-α，β-饱和羰基化合物的方法公开(公告)号：US06379935B1
公开(公告)日：2002-04-30
申请号：US09369144
申请日：1999-08-05
IPC分类号： C12P1710
摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an a-halocarbonyl compound having an &agr;, &bgr;-carbon-carbon double bond.
摘要翻译： 一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于 醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属 ，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。 假单胞菌属 伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。
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7.发明申请Oil-in-Water Emulsified Composition, and External Preparation for Skin and Cosmetics Using the Composition 审中-公开水包油乳化组合物，以及使用组合物的皮肤和化妆品的外部制剂公开(公告)号：US20080311234A1
公开(公告)日：2008-12-18
申请号：US10593692
申请日：2005-03-22
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
摘要： An oil-in-water emulsified composition suitable for external preparation for skin and cosmetic product, which comprised 0.1 to 5% by mass of (A) lipopeptide compound derived from a microorganism such as surfactin and its analogous compound, 0.05 to 1.5% by mass of (B) xanthan gum, 25 to 70% by mass of (C) oil component and (D) water, free from non-ionic surfactants and acrylic water-soluble polymers, and is excellent in feeling upon use, moisture retention, emollient property and stability as well as environmental suitability and safety for living organisms, and external preparation for skin and cosmetic product using the composition.
摘要翻译： 一种适用于皮肤和化妆品外用剂的水包油乳化组合物，其含有0.1〜5质量％的（A）衍生自微生物如表面活性素及其类似化合物的脂肽化合物，0.05〜1.5质量％ 的（B）黄原胶，25〜70质量％的（C）油成分和（D）水，不含非离子表面活性剂和丙烯酸类水溶性聚合物，使用感好，保湿性，润肤性 性质和稳定性以及生物体的环境适应性和安全性，以及使用该组合物的皮肤和化妆品的外用制剂。
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8.发明授权Microorganisms useful in a method of producing &agr;-halo-&agr;, &bgr;-saturated carbonyl compounds 失效用于生产α-卤代-α，β-饱和羰基化合物的方法的微生物公开(公告)号：US06645752B2
公开(公告)日：2003-11-11
申请号：US09962252
申请日：2001-09-26
IPC分类号： C12N112
摘要： A method of producing an &agr;-halo-&agr;,&bgr;-saturated carbonyl compound from an &agr;-halocarbonyl compound having an &agr;,&bgr;-carbon-carbon double bond by reducing said &agr;,&bgr;-carbon-carbon double bond using a microorganism belonging to any one of the genera Acetobacter, Actinomyces, Acinetobacter, Agrobacterium, Aeromonas, Alcaligenes, Arthrobacter, Azotobacter, Bacillus, Brevibacterium, Burkholderia, Cellulomonas, Corynebacterium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Gluconobacter, Halobacteium, Halococccus, Klebsiella, Lactobacillus, Microbacterium, Micrococcus, Micropolyspora, Mycobacterium, Nocardia, Pseudomonas, Pseudonocardia, Rhodococcus, Rhodobacter, Serratia, Staphylococcus, Streptococcus and Streptomyces, Xanthomonas, or a microbial product thereof. Pseudomonas sp. SD810, SD811 and SD812, Burkholderia sp. SD 816, and mutants thereof having an activity of reducing the &agr;,&bgr;-carbon-carbon double bond of an &agr;-halocarbonyl compound having an &agr;,&bgr;-carbon-carbon double bond.
摘要翻译： 一种由具有α，β-碳 - 碳双键的α-卤代羰基化合物生产α-卤代-α，β-饱和羰基化合物的方法，通过使用属于 醋杆菌属，放线菌属，不动杆菌属，农杆菌属，气单胞菌属，产碱杆菌属，节杆菌属，固氮菌属，芽孢杆菌属，短杆菌属，伯克霍尔德杆菌属，丝杆菌属，棒状杆菌属，肠杆菌属，肠球菌属，棒状杆菌属，黄杆菌属，葡萄球菌属，卤杆菌属，卤杆菌属，克雷伯菌属，乳杆菌属，微杆菌属 ，微球菌，微孢子虫，分枝杆菌，诺卡氏菌，假单胞菌属，假诺卡氏菌属，红球菌属，红细菌属，沙雷氏菌属，葡萄球菌属，链球菌属和链霉菌属，黄单胞菌属或其微生物产物。 假单胞菌属 伯克霍尔德氏菌属SD810，SD811和SD812 SD 816及其具有降低具有α，β-碳 - 碳双键的α-卤代羰基化合物的α，β-碳 - 碳双键活性的突变体。
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9.发明授权Catalyst for hydrolyzing cellulose or hemicellulose and method for producing sugar-containing solution employing same 有权用于水解纤维素或半纤维素的催化剂及其制备使用其的含糖溶液的方法公开(公告)号：US09144785B2
公开(公告)日：2015-09-29
申请号：US13498285
申请日：2010-08-05
IPC分类号： B01J31/02 , C13K1/02 , B01J21/18 , B01J23/40 , B01J23/46 , B01J35/00 , B01J35/02 , B01J35/10 , B01J37/00 , B01J37/08 , B01J21/06 , B01J29/03 , B01J29/04
CPC分类号： B01J21/18 , A23V2002/00 , B01J21/063 , B01J21/066 , B01J23/40 , B01J23/462 , B01J29/0325 , B01J29/043 , B01J35/002 , B01J35/023 , B01J35/1023 , B01J35/1028 , B01J35/1047 , B01J35/1061 , B01J37/0018 , B01J37/084 , C13K1/02 , A23V2250/5108
摘要： Disclosed are: a novel catalyst for the hydrolysis of cellulose, which does not require the use of a large quantity of sulfuric acid for the preparation thereof and from which sulfuric acid cannot be eluted; a novel catalyst for the hydrolysis of cellulose, which is not changed in structure even in hot water and therefore does not undergo the deterioration in activity; and a process for producing a cellulose hydrolysate, mainly including glucose, using any one of the aforementioned catalysts. Specifically disclosed are: a catalyst for the hydrolysis of cellulose, which comprises a porous carbon material having a specific surface area of 800 to 2500 m2/g inclusive and a phenolic hydroxy group content of 100 to 700 mmol/kg inclusive, such as a porous carbon material having such a structure that carbon is filled in pores of mesoporous silica that is used as a template; and a catalyst for the hydrolysis of cellulose or hemicellulose, which comprises the aforementioned porous carbon material and a transition metal belonging to Group 8 to Group 11 and supported on the porous carbon material.
摘要翻译： 公开了一种用于纤维素水解的新型催化剂，其不需要使用大量的硫酸来制备，硫酸不能被洗脱; 用于水解纤维素的新型催化剂，即使在热水中结构也不改变，因此不会发生活性降低; 以及使用上述任一种催化剂生产主要包括葡萄糖的纤维素水解产物的方法。 具体公开的是：纤维素水解用催化剂，其含有比表面积为800〜2500m2 / g，含有酚类羟基含量为100〜700mmol / kg的多孔碳材料，例如多孔碳 具有碳被填充在作为模板的介孔二氧化硅的孔中的结构的碳材料; 以及用于水解纤维素或半纤维素的催化剂，其包含上述多孔碳材料和属于第8族至第11族的过渡金属并负载在多孔碳材料上。
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10.发明申请EMULSIFIED SKIN EXTERNAL PREPARATION AND METHOD FOR STABILIZING THE SKIN EXTERNAL PREPARATION 审中-公开用于稳定皮肤外用制剂的乳化皮肤外用制剂和方法公开(公告)号：US20100152139A1
公开(公告)日：2010-06-17
申请号：US11996887
申请日：2006-07-24
申请人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
发明人： Tadashi Yoneda , Naoko Ito , Kazuo Furuya
CPC分类号： A61K8/676 , A61K8/375 , A61K31/375 , A61K2800/522 , A61Q19/00
摘要： An emulsified skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is provided, and the decomposition and consequent decrease of the salt are prevented and thereby the stability of the preparation is enhanced. A method for stabilizing the skin external preparation containing a salt of a higher fatty acid ester of ascorbic acid-2-phosphate is provided. The emulsified skin external preparation includes 0.03 to 25% by mass of a salt of a higher fatty acid ester of ascorbic acid-2-phosphate (A), and 0.05 to 25% by mass of a glycerin mono fatty acid ester (B), the higher fatty acid ester of ascorbic acid-2-phosphate being represented by Formula (1): . . . (1) wherein R is a higher fatty acid residue.
摘要翻译： 提供了含有抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐的乳化皮肤外用剂，防止了盐的分解和随之而来的降低，从而提高了制剂的稳定性。 提供了一种稳定皮肤外用制剂的方法，其含有抗坏血酸-2-磷酸酯的高级脂肪酸酯的盐。 乳化皮肤外用剂含有0.03〜25质量％的抗坏血酸-2-磷酸（A）的高级脂肪酸酯的盐和0.05〜25质量％的甘油单脂肪酸酯（B）， 抗坏血酸-2-磷酸的高级脂肪酸酯由式（1）表示：。 。 。 （1）其中R是高级脂肪酸残基。
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