-
公开(公告)号：US07108816B2
公开(公告)日：2006-09-19
申请号：US10266275
申请日：2002-10-08
IPC分类号： B29C47/06
CPC分类号： H01L51/5256
摘要： This invention relates to a method of manufacture of a barrier, especially for electronic display devices, comprising the step of co-extruding a melt of at least one inorganic material with a melt of at least one organic material, wherein the at least one inorganic material and the at least one organic material are co-extruded as a continuous sheet.
摘要翻译： 本发明涉及一种制造屏障的方法，特别是用于电子显示装置的方法，包括将至少一种无机材料的熔体与至少一种有机材料的熔体共挤出的步骤，其中至少一种无机材料 并且所述至少一种有机材料作为连续片共挤出。
-
公开(公告)号：US5845035A
公开(公告)日：1998-12-01
申请号：US903112
申请日：1997-07-30
IPC分类号： G02B6/00 , F21V8/00 , G02B5/30 , G02B27/28 , G02F1/1335 , G02F1/13357 , G02B6/10
CPC分类号： G02B6/0056 , G02B5/3083 , G02B6/0068 , G02F1/133536 , G02F1/13362 , G02F2001/13355
摘要： The invention relates to an illumination system comprising an optical waveguide of an optically transparent material having an exit surface and a plurality of end faces, and a light source whose light is coupled into the waveguide via at least one end face of the waveguide. The waveguide further comprises polarizing means for polarizing the light emitted by the light source. The waveguide comprises at least two layers, of which one layer comprises an optically anisotropic material having refractive indices n.sub.e and n.sub.o and the other layer comprises an optically isotropic material having a refractive index n.sub.i, in which one of the refractive indices n.sub.e or n.sub.o is equal to n.sub.i. For the refractive indices, n.sub.e or n.sub.o should be equal or substantially equal to n.sub.i in order that polarization separation occurs at the interface between the isotropic and the anisotropic material. The invention also relates to a flat-panel picture display device including such an illumination system.
摘要翻译： 本发明涉及一种包括具有出射表面和多个端面的光学透明材料的光波导的照明系统，以及其光通过波导的至少一个端面耦合到波导中的光源。 波导还包括用于使由光源发射的光偏振的偏振装置。 波导包括至少两层，其中一层包括具有折射率为ne和no的光学各向异性材料，另一层包括具有折射率为ni的折射率为n或者折射率之一的折射率为ni的光学各向同性材料 到ni 对于折射率，ne或no应等于或基本上等于ni，以便在各向同性材料和各向异性材料之间的界面处发生极化分离。 本发明还涉及包括这种照明系统的平板图像显示装置。
-
公开(公告)号：US09291284B2
公开(公告)日：2016-03-22
申请号：US13980586
申请日：2012-01-20
CPC分类号： F16K51/00 , B01L3/502738 , B01L2300/0874 , B01L2300/0887 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/794
摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
摘要翻译： 本发明涉及用于生物传感器的微型阀，微流体装置，这种装置的使用以及微流体元件。 生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。 该传感器可以用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。
-
公开(公告)号：US08618508B2
公开(公告)日：2013-12-31
申请号：US13119897
申请日：2009-09-21
申请人： Reinhold Wimberger-Friedl , Jeroen Hans Nieuwenhuis , Johannes Joseph Hubertina Barbara Schleipen
发明人： Reinhold Wimberger-Friedl , Jeroen Hans Nieuwenhuis , Johannes Joseph Hubertina Barbara Schleipen
CPC分类号： G01N21/6428 , G01N21/648
摘要： A detection system combining an excitation radiation source providing excitation radiation to an analysis region of a sample within a substrate having a detection surface, a detector for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads within the sample to the substrate surface. The detection radiation is collected from the detection surface of the substrate to give an enhanced surface specificity.
摘要翻译： 一种检测系统，其将激发辐射源组合到具有检测表面的基底内的样品的分析区域，用于检测从包括由激发产生的样品的检测表面的分析区域收集的辐射的检测器，以及 磁体布置在样品的分析区域下方，并且相对于激发辐射源和光耦合装置固定，用于将样品内的磁珠吸引到基底表面。 从衬底的检测表面收集检测辐射以提供增强的表面特异性。
-
公开(公告)号：US20120165219A1
公开(公告)日：2012-06-28
申请号：US13393255
申请日：2010-08-26
申请人： Pieter Jan Van Der Zaag , Harma Feitsma , Jacob Marinus Jan Den Toonder , Reinhold Wimberger-Friedl
发明人： Pieter Jan Van Der Zaag , Harma Feitsma , Jacob Marinus Jan Den Toonder , Reinhold Wimberger-Friedl
CPC分类号： C12Q1/6834 , C12Q2537/149 , C12Q2527/107
摘要： The present invention relates to a device for the specific selection of target molecules, comprising: (a) at least one reaction zone comprising a microarray, wherein the microarray comprises a substrate, on which one or more species of capture molecules are immobilized, comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone; (b) at least one non-reaction zone comprising one or more temperature control and/or regulating units for controlling and/or regulating the temperature within the zone, which is in fluid connection with the reaction zone; and (c) at least one transportation means capable of generating and/or regulating a fluid flow between said reaction zone (a) and said non-reaction zone comprising one or more temperature control and/or regulating units (b). The present invention further relates to a device for the specific selection of target molecules wherein the immobilized capture molecules are organized in the microarray in the form of spots, elongated spots and/or lines. In a further aspect the present invention relates to a method of specifically selecting target molecules, comprising the introducing a medium to such a device, performing interaction reactions in a reaction zone, transporting not interacted or not bound target molecules to a zone allowing reactivation of the target molecules and performing additional interaction reactions with the reactivated target molecules at the reaction zone, as well as the use of such a device for specifically selecting target molecules, e.g. for target enrichment also referred to as microarray based genome selection (MGS) in the literature.
摘要翻译： 本发明涉及用于特异性选择靶分子的装置，其包括：（a）包含微阵列的至少一个反应区，其中所述微阵列包含其上固定有一种或多种捕获分子的底物，其包含一个 或更多温度控制和/或调节单元，用于控制和/或调节该区域内的温度; （b）至少一个非反应区，包括一个或多个温度控制和/或调节单元，用于控制和/或调节与反应区流体连通的区域内的温度; 和（c）能够产生和/或调节所述反应区（a）和包括一个或多个温度控制和/或调节单元（b）的所述非反应区之间的流体流动的至少一个输送装置。 本发明还涉及用于特异性选择靶分子的装置，其中固定的捕获分子以斑点，细长斑点和/或线的形式组织在微阵列中。 在另一方面，本发明涉及一种特异性选择靶分子的方法，包括向这种装置中引入培养基，在反应区中进行相互作用反应，将不相互作用或不结合的靶分子传输到允许重新激活 目标分子，并在反应区域与再活化的靶分子进行额外的相互作用反应，以及使用这种用于特异性选择靶分子的装置，例如 对于目标富集，文献中也称为基于微阵列的基因组选择（MGS）。
-
公开(公告)号：US20120156765A1
公开(公告)日：2012-06-21
申请号：US13393097
申请日：2010-08-25
CPC分类号： B01L3/502715 , B01L3/502753 , B01L2200/027 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , Y10T29/4998
摘要： The invention relates to a fluid filtering device comprising a filter (2) for filtering a fluid and a substrate (3) comprising a collecting structure (4) for collecting the filtered fluid from the filter (2). An adhesive (5) holds the filter (2) in place with respect to the collecting structure (4). The filter (2), the substrate (3) with the collecting structure (4) and the adhesive (5) are arranged such that the collecting structure (4) contacts the filter (2) and the filter (2) is attached to the substrate (3) by the adhesive (5). The collecting structure is very close to the filter and the adhesive ensures that the collecting structure remains very close to the filter. The filtered fluid can therefore be collected very efficiently and very fast. The fluid filtering device is preferentially used for filtering blood in a biosensing device.
摘要翻译： 本发明涉及一种流体过滤装置，其包括用于过滤流体的过滤器（2）和包括用于从过滤器（2）收集过滤流体的收集结构（4）的基底（3）。 粘合剂（5）将过滤器（2）相对于收集结构（4）保持在适当的位置。 过滤器（2），具有收集结构（4）的基板（3）和粘合剂（5）被布置成使得收集结构（4）接触过滤器（2），并且过滤器（2）附接到 基材（3）由粘合剂（5）。 收集结构非常接近过滤器，并且粘合剂确保收集结构保持非常接近过滤器。 因此，可以非常有效和非常快地收集过滤的流体。 流体过滤装置优选用于过滤生物传感装置中的血液。
-
公开(公告)号：US20120115246A1
公开(公告)日：2012-05-10
申请号：US13262942
申请日：2010-04-09
CPC分类号： B01L3/50273 , B01L3/5027 , B01L3/502746 , B01L2300/0627 , B01L2300/0825 , B01L2300/0877 , B01L2300/0887 , B01L2400/0406
摘要： The invention relates to a microfluidic device for performing detection of a substance in a liquid sample, wherein a cavity (24) is formed above a sensor surface area (22) of a sensor (18), said cavity (24) extending at the first side of a base plate (10) from a first area (32), where the cavity overlaps a first lateral channel part (30), to a second area (34), where the cavity overlaps a second lateral channel part (36); the second lateral channel part (36) comprising a lateral channel part formed by a porous capillary suction structure (13). The cavity (24) forms a flow path (42) from the first lateral channel part (30) along the sensor surface area (22) to the second lateral channel part (36); further, the invention relates to a method of detecting a target molecule in a liquid sample.
摘要翻译： 本发明涉及一种用于执行液体样品中物质检测的微流体装置，其中在传感器（18）的传感器表面区域（22）的上方形成空腔（24），所述空腔（24）在第一 来自第一区域（32）的基板（10）的侧面，其中空腔与第一横向通道部分（30）重叠，到第二区域（34），其中空腔与第二横向通道部分（36）重叠; 所述第二横向通道部分（36）包括由多孔毛细管抽吸结构（13）形成的侧向通道部分。 空腔（24）沿着传感器表面区域（22）从第一横向通道部分（30）形成到第二横向通道部分（36）的流动路径（42）。 此外，本发明涉及一种检测液体样品中的靶分子的方法。
-
公开(公告)号：US20120100630A1
公开(公告)日：2012-04-26
申请号：US13265569
申请日：2010-04-16
CPC分类号： B01F13/0059 , B01F5/0683 , B01F5/0688 , B01F11/0071 , Y10T436/25 , Y10T436/2575
摘要： The invention relates to a micro fluidics system (1) comprising: a closed, expandable volume (35) for mixing a fluid; a flexible membrane (40) for allowing mixing in the closed, expandable volume (35), characterized in that the micro fluidics system (1) further comprises: a surface (5) comprising at least one channel (20, 20a, 20b, 20c, 20d) for fluidically coupling a first side (10) of the surface (5) to the closed, expandable volume (35) on a second side (15) of the surface (5), the channel (20, 20a, 20b, 20c, 20d) comprising a first channel opening (25) fluidically coupling the first side (10) of the surface (5) to the channel (20, 20a, 20b, 20c, 20d) and a second channel opening (30) fluidically coupling the channel (20, 20a, 20b, 20c, 20d) to the closed, expandable volume (35), the expandable volume (35) being defined by the flexible membrane (40) closing the second channel opening (30) when there is no fluid in the expandable volume (35). The invention further relates to a method for using such a microfluidics system (1).
摘要翻译： 本发明涉及一种微流体系统（1），其包括：用于混合流体的封闭的可膨胀体积（35） 柔性膜（40），用于允许在封闭的可膨胀体积（35）中进行混合，其特征在于，微流体系统（1）还包括：表面（5），包括至少一个通道（20,20a，20b，20c ，20d），用于将所述表面（5）的第一侧（10）与所述表面（5）的第二侧（15）上的所述封闭的可膨胀体积（35）流体耦合，所述通道（20,20a，20b， 包括将表面（5）的第一侧（10）流体耦合到通道（20,20a，20b，20c，20d）的第一通道开口（25）和与流体连接的第二通道开口（30） 所述通道（20,20a，20b，20c，20d）到所述封闭的可膨胀容积（35），所述可膨胀容积（35）由所述柔性膜（40）限定，当不存在时，所述柔性膜（40）封闭所述第二通道开口 可膨胀体积（35）中的流体。 本发明还涉及一种使用这种微流体系统（1）的方法。
-
公开(公告)号：US20080271799A1
公开(公告)日：2008-11-06
申请号：US12067302
申请日：2006-09-19
申请人： Reinhold Wimberger-Friedl , Rifat Ata Mustafa Hikmet , Ties Van Bommel , Jacob Marinus Jan Den Toomder , Melike Yavuz
发明人： Reinhold Wimberger-Friedl , Rifat Ata Mustafa Hikmet , Ties Van Bommel , Jacob Marinus Jan Den Toomder , Melike Yavuz
CPC分类号： F15C3/04 , B01L3/502738 , B01L2200/12 , B01L2400/0487 , B01L2400/0633 , B01L2400/0638 , Y10T137/2191 , Y10T137/2202 , Y10T137/2213
摘要： The invention relates to a microfluidic regulating device, comprising a first layer having a first microfluidic channel defined therein, a second layer having a second microfluidic channel defined therein, a fluid flow regulating layer disposed between the first and the second microfluidic channel, which layer comprises a movable valve member which in open position allows fluid communication between the first and second channel and in closed position seals against a valve seat, whereby at least part of the valve member and of the valve seat is magnetic. The device is able to store small quantities of liquids at microfluidic cartridges and access these on demand in a well controlled and simple way.
摘要翻译： 本发明涉及一种微流体调节装置，其包括具有限定在其中的第一微流体通道的第一层，其中限定有第二微流体通道的第二层，设置在第一和第二微流体通道之间的流体流动调节层，该层包括 处于打开位置的可移动阀构件允许第一和第二通道之间的流体连通并且在关闭位置中密封抵靠阀座，由此阀构件和阀座的至少一部分是磁性的。 该设备能够在微流控盒中储存少量液体，并以良好控制和简单的方式随时访问。
-
公开(公告)号：US20080227188A1
公开(公告)日：2008-09-18
申请号：US12088941
申请日：2006-09-25
IPC分类号： G01N21/05
CPC分类号： G01N21/05 , G01N21/645 , G01N33/543 , G01N33/54366 , G01N2021/0346
摘要： The matching of refractive index of a nanoporous membrane with an analyte solution used with the membrane for use in a sensor is described. Scattering of the excitation and/or emitted light is reduced by matching the refractive indices. This improves efficiency when the porous translucent membrane is used in flow-through or flow-over sensors such as biosensors.
摘要翻译： 描述了纳米多孔膜的折射率与用于传感器的膜使用的分析物溶液的匹配。 通过匹配折射率来减少激发和/或发射光的散射。 当多孔半透膜用于流过或流过传感器（例如生物传感器）时，这提高了效率。
-
-
-
-
-
-
-
-
-
搜索结果
54 条记录 (耗时 0.032 秒)
