公开(公告)号：US11718637B2

公开(公告)日：2023-08-08

申请号：US17207161

申请日：2021-03-19

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Richard L. Mackman ,  Devan Naduthambi ,  Neil H. Squires

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/16 ,  A61P31/18 ,  A61K31/7076 ,  A61K45/06 ,  C07H19/20

CPC classification number: C07H19/16 ,  A61K31/7076 ,  A61K45/06 ,  A61P31/18 ,  C07H19/20

Abstract: The present disclosure provides prodrugs of 4′-C-substituted-2-halo-2′-deoxyadenoside nucleosides, and compositions, methods, and kits thereof. Such compounds can be useful for treating viral infections including, but not limited to, human immunodeficiency virus.

公开(公告)号：US20220119426A1

公开(公告)日：2022-04-21

申请号：US17394630

申请日：2021-08-05

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Devan Naduthambi ,  Neil H. Squires

IPC: C07F9/36

Abstract: Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed. In particular, prodrugs of phosphonamide nucleotide analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.

公开(公告)号：US20250002513A1

公开(公告)日：2025-01-02

申请号：US18673168

申请日：2024-05-23

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC: C07F9/6561 ,  A61K45/06

Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US12116380B2

公开(公告)日：2024-10-15

申请号：US17820183

申请日：2022-08-16

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Michael O. Clarke ,  Deeba Ensan ,  Rao V. Kalla ,  Richard L Mackman ,  Jagadeesh N. Manda ,  Devan Naduthambi ,  Dustin S. Siegel

IPC: C07F9/09 ,  A61K31/706 ,  A61P31/14

CPC classification number: C07F9/095 ,  A61P31/14

Abstract: Phospholipid compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical formulations of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20240287109A1

公开(公告)日：2024-08-29

申请号：US18544561

申请日：2023-12-19

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Rao V. Kalla ,  Dmitry Koltun ,  Richard L. Mackman ,  Thao D. Perry ,  Dustin S. Siegel ,  Scott P. Simonovich

IPC: C07F9/6561 ,  A61K45/06

CPC classification number: C07F9/6561 ,  A61K45/06

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20240279186A1

公开(公告)日：2024-08-22

申请号：US18428316

申请日：2024-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:






or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20240174704A1

公开(公告)日：2024-05-30

申请号：US18354362

申请日：2023-07-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: C07F9/6561 ,  A61P31/14

CPC classification number: C07F9/6561 ,  A61P31/14

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US11919869B2

公开(公告)日：2024-03-05

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20230183189A1

公开(公告)日：2023-06-15

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20220356196A1

公开(公告)日：2022-11-10

申请号：US17176497

申请日：2021-02-16

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Byoung-kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  David Sperandio ,  Hai Yang ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.