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公开(公告)号：US11040033B2
公开(公告)日：2021-06-22
申请号：US15999548
申请日：2018-08-20
发明人： Mark J. Bartlett , Britton Kenneth Corkey , Jennifer Leigh Cosman , Kristyna M. Elbel , Elfatih Elzein , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Eric Q. Parkhill , Thao Perry
IPC分类号： A61K31/4745 , A61P35/00 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K35/17 , A61K35/26 , A61K45/06 , C07D471/04 , C07D487/04 , A61K31/437 , A61K39/395 , C07K16/28
摘要： Compounds having the following Formula I and/or Formula II and methods of their use and preparation are disclosed:
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公开(公告)号：US20200031801A1
公开(公告)日：2020-01-30
申请号：US16502453
申请日：2019-07-03
发明人： Mark J. Bartlett , Britton Kenneth Corkey , Jennifer Leigh Cosman , Elfatih Elzein , Xiaofen Li
IPC分类号： C07D401/14 , C07D403/04 , C07D401/04 , C07D413/04 , C07D209/34 , C07D263/58
摘要： Compounds having the following Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use and preparation are disclosed:
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公开(公告)号：US20190192504A1
公开(公告)日：2019-06-27
申请号：US15999548
申请日：2018-08-20
发明人： Mark J. Bartlett , Britton Kenneth Corkey , Jennifer Leigh Cosman , Kristyna M, Elbel , Elfatih Elzein , Rao V. Kalla , Dmitry Koltun , Xiaofen Li , Eric Q Parkhill , Thao Perry
IPC分类号： A61K31/4745 , A61K31/5025 , A61K31/4985 , A61K31/506 , A61K45/06 , C07K16/28 , A61K39/395 , A61K31/519 , A61K35/26 , C07D471/04
CPC分类号： A61K31/4745 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K35/26 , A61K39/3955 , A61K45/06 , A61P35/00 , C07D471/04 , C07D487/04 , C07K16/2827 , C07K2317/24
摘要： Compounds having the following Formula I and/or Formula II and methods of their use and preparation are disclosed:
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公开(公告)号：US09951065B2
公开(公告)日：2018-04-24
申请号：US15153527
申请日：2016-05-12
发明人： Mark J. Bartlett , Julian Andrew Codelli , Britton Kenneth Corkey , Jennifer Leigh Cosman , Kristyna Elbel , Jennifer Alissa Loyer-Drew , David Sperandio , Joshua Van Veldhuizen , Hai Yang , Suet Chung Yeung
IPC分类号： C07D235/06 , C07D235/24 , C07D295/125 , C07D401/12 , C07D471/04 , A61K45/06 , C07D235/08 , A61K31/4184 , A61K31/5377 , A61K31/454 , A61K31/437 , A61K31/506 , A61K31/497 , A61K31/55 , A61K31/541 , A61K31/439 , C07D405/12 , C07D405/14 , C07D471/08 , A61K31/553 , C07D235/30 , C07D235/14 , C07D401/04 , C07D235/12 , A61K31/444 , A61K31/4545 , A61K31/538 , A61K31/5386 , A61K31/438 , C07D403/12 , A61K31/4439 , C07D413/12 , A61K31/496 , C07D487/04 , A61K31/4725 , C07D235/28 , C07D235/16 , C07D409/12
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/438 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D235/28 , C07D235/30 , C07D295/125 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D471/08 , C07D487/04
摘要： The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R1, R2a, R2b, Rn, Rm, and Rt are as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.
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公开(公告)号：US20240287061A1
公开(公告)日：2024-08-29
申请号：US18543272
申请日：2023-12-18
发明人： Gayatri Balan , Mark J. Bartlett , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Jennifer L. Cosman Ellis , Rao V. Kalla , Zachary A. Kasun , Musong Kim , Seung H. Lee , Jennifer R. Lo , Jennifer A. Loyer-Drew , Scott A. Mitchell , Thao D. Perry , Gary B. Phillips , Patrick J. Salvo , Sundaramoorthi Swaminathan , Joshua J. Van Veldhuizen , Suet C. Yeung , Jeff Zablocki
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20240279186A1
公开(公告)日：2024-08-22
申请号：US18428316
申请日：2024-01-31
发明人： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel , Kyle C. Tamshen , Hai Yang
IPC分类号： C07D247/00
CPC分类号： C07D247/00
摘要： Provided herein is A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.-
公开(公告)号：US20240150359A1
公开(公告)日：2024-05-09
申请号：US18237152
申请日：2023-08-23
发明人： Mark J. Bartlett , Daniel H. Byun , Yifan Deng , Jennifer L. Cosman Ellis , Rao V. Kalla , Richard L. Mackman , Dustin S. Siegel , Xianhuang Zeng
IPC分类号： C07D487/04 , A61K9/00 , A61K45/06 , A61P31/14 , C07D519/00 , C07F9/6561
CPC分类号： C07D487/04 , A61K9/0053 , A61K45/06 , A61P31/14 , C07D519/00 , C07F9/6561
摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20240116928A1
公开(公告)日：2024-04-11
申请号：US18344560
申请日：2023-06-29
发明人： Mark J. Bartlett , Gregory F. Chin , Jennifer L. Cosman Ellis , Richard L. Mackman , Michael R. Mish
IPC分类号： C07D471/04 , C07D401/14
CPC分类号： C07D471/04 , C07D401/14
摘要： There is provided a compound of Formula (I):
or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of wherein the various substituents are defined herein,-
公开(公告)号：US11919869B2
公开(公告)日：2024-03-05
申请号：US18050404
申请日：2022-10-27
发明人： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Richard L Mackman , Michael R. Mish , Dustin S. Siegel , Kyle C. Tamshen , Hai Yang
IPC分类号： C07D247/00
CPC分类号： C07D247/00
摘要： Provided herein is A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.-
公开(公告)号：US11845755B2
公开(公告)日：2023-12-19
申请号：US18117913
申请日：2023-03-06
发明人： Mark J. Bartlett , Daniel H. Byun , Yifan Deng , Jennifer L. Cosman Ellis , Rao V. Kalla , Richard L. Mackman , Dustin S. Siegel , Xianhuang Zeng
IPC分类号： A61K31/53 , A61P31/14 , C07D487/04 , A61K45/06 , A61K9/00
CPC分类号： C07D487/04 , A61K9/0053 , A61K45/06 , A61P31/14
摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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