公开(公告)号：US20150177179A1

公开(公告)日：2015-06-25

申请号：US14138368

申请日：2013-12-23

Applicant: GOOGLE INC.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: G01N27/327 ,  B05D3/00

CPC classification number: C12Q1/006 ,  G01N3/50

Abstract: An analyte sensor and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a sensing membrane having a crosslinked network with an embedded analyte sensing component. In another aspect, the analyte sensor includes a protective membrane adjacent to the surface of the sensing membrane. The protective membrane can be a crosslinked, hydrophilic copolymer having methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have hydrophilic side chains, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks. A method for making the analyte sensor is also disclosed.

Abstract translation: 公开了分析物传感器和用于制造分析物传感器的方法。 在一个方面，分析物传感器包括具有嵌入分析物感测部件的交联网络的感测膜。 在另一方面，分析物传感器包括与感测膜的表面相邻的保护膜。 保护膜可以是具有甲基丙烯酸酯衍生的第一个甲基丙烯酸酯单元的主链，第二个甲基丙烯酸酯衍生的单元和第三个甲基丙烯酸酯单元的交联的亲水共聚物。 第一和第二甲基丙烯酸酯衍生单元具有亲水侧链，并且不同主链中的第三甲基丙烯酸酯衍生单元通过亲水性交联连接。 还公开了制备分析物传感器的方法。

公开(公告)号：US20150177177A1

公开(公告)日：2015-06-25

申请号：US14138379

申请日：2013-12-23

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: G01N27/327 ,  A61L2/20

CPC classification number: A61L2/206 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/682 ,  A61B5/6821 ,  C12Q1/006

Abstract: Analyte sensors capable of undergoing sterilization with ethylene oxide are provided. The analyte sensors can include one or more polymer membranes having a nucleophilic group.

Abstract translation: 提供能够与环氧乙烷进行灭菌的分析物传感器。 分析物传感器可以包括具有亲核基团的一个或多个聚合物膜。

公开(公告)号：US08979271B2

公开(公告)日：2015-03-17

申请号：US13626542

申请日：2012-09-25

Applicant: Google Inc.

Inventor： Nathan Pletcher ,  Zenghe Liu ,  Brian Otis

IPC: G02C7/00 ,  G02C7/04

CPC classification number: G02C7/04 ,  A61B5/01 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/20 ,  A61B5/6803 ,  A61B5/6821 ,  A61B5/7203 ,  A61B5/7221

Abstract: Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information.

Abstract translation: 提供了使用隐形眼镜传感器的装置，系统和方法。 在一些方面，隐形眼镜包括基底和电路。 电路可以包括：设置在基底上或内部的一个或多个传感器，其感测与隐形眼镜的佩戴者相关联的特征; 以及设置在基板上或内部的补偿电路，耦合到传感器并输出信息以调节传感器的输出。 补偿电路可以包括：感测传感器的温度的温度分量; 以及通信部件，其输出表示所述传感器的温度的信息，并且接收与调整所述传感器的输出相关联的信息。 在其他方面，隐形眼镜包括感测隐形眼镜佩戴者体温或身体外部的环境温度的电路。 可以基于该信息执行传感器融合和/或校准。

公开(公告)号：US20140194706A1

公开(公告)日：2014-07-10

申请号：US14030756

申请日：2013-09-18

Applicant: Google Inc.

Inventor： Zenghe Liu ,  James Etzkorn

IPC: A61B5/145

CPC classification number: A61B5/14507 ,  A61B5/14532 ,  A61B5/6821

Abstract: Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid.

Abstract translation: 使用具有感测泪液中的分析物的一个或多个传感器的隐形眼镜的装置，系统和方法以及收集泪液的一个或多个凹部。 在一些方面，隐形眼镜包括形成隐形眼镜的主体的至少一部分的基底和形成在基底内的凹陷，构造成当佩戴隐形眼镜时收集泪液。 隐形眼镜还包括布置在基底内的至少一个传感器，其配置成感测所收集的泪液中分析物的存在。

公开(公告)号：US20140107447A1

公开(公告)日：2014-04-17

申请号：US13650248

申请日：2012-10-12

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Brian Otis

IPC: A61B5/1495 ,  A61B5/1477

CPC classification number: A61B5/1495 ,  A61B5/0004 ,  A61B5/0026 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6821 ,  A61B5/683

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.

公开(公告)号：US09320460B2

公开(公告)日：2016-04-26

申请号：US14030756

申请日：2013-09-18

Applicant: Google Inc.

Inventor： Zenghe Liu ,  James Etzkorn

IPC: A61B5/00 ,  A61B5/05 ,  A61B5/145

CPC classification number: A61B5/14507 ,  A61B5/14532 ,  A61B5/6821

Abstract: Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid.

Abstract translation: 使用具有感测泪液中的分析物的一个或多个传感器的隐形眼镜的装置，系统和方法以及收集泪液的一个或多个凹部。 在一些方面，隐形眼镜包括形成隐形眼镜的主体的至少一部分的基底和形成在基底内的凹陷，构造成当佩戴隐形眼镜时收集泪液。 隐形眼镜还包括布置在基底内的至少一个传感器，其配置成感测所收集的泪液中分析物的存在。

公开(公告)号：US20150173658A1

公开(公告)日：2015-06-25

申请号：US14136895

申请日：2013-12-20

Applicant: Google Inc.

Inventor： Zenghe Liu ,  Huanfen Yao

IPC: A61B5/145 ,  A61B5/1477 ,  A61B5/053

CPC classification number: A61B5/14507 ,  A61B3/101 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/1468 ,  A61B5/6821 ,  A61B2560/0219 ,  A61B2562/028 ,  A61B2562/12

Abstract: Disclosed herein is a fluid conductivity sensor that can be used to obtain in-vivo measurements of conductivity of biological fluid samples, for example, to determine osmolarity. The conductivity sensor can be disposed on a substrate that is at least partially embedded within a polymeric material of a body-mountable device. The conductivity sensor can include a frame having a trench formed therein that defines a fluid sample cell. First and second electrodes can be formed on sidewalls of the trench, such that the first and second electrodes are on opposite sides of the fluid sample cell. A controller in the body-mountable device can operate the sensor by applying a voltage to the electrodes and measuring a current through a fluid occupying the fluid sample cell. The body-mountable device may indicate the current measurements wirelessly using an antenna.

Abstract translation: 本文公开了一种流体电导率传感器，其可用于获得生物流体样品的导电性的体内测量，例如以确定渗透压。 电导率传感器可以设置在至少部分地嵌入在可体内安装的装置的聚合物材料中的基底上。 电导率传感器可以包括其中形成有沟槽的框架，其限定流体样本池。 第一和第二电极可以形成在沟槽的侧壁上，使得第一和第二电极在流体样品池的相对侧上。 身体安装装置中的控制器可以通过向电极施加电压并测量通过占据流体样品池的流体的电流来操作传感器。 身体安装设备可以使用天线无线地指示当前测量。

公开(公告)号：US20150173602A1

公开(公告)日：2015-06-25

申请号：US14139865

申请日：2013-12-23

Applicant: Google Inc.

Inventor： Daniel Patrick Barrows ,  Zenghe Liu ,  Jeffrey George Linherdt ,  James Etzkorn

IPC: A61B3/10 ,  A61B5/1477

CPC classification number: A61B3/101 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/6821 ,  A61B2560/0214 ,  A61B2562/12 ,  G02C7/04

Abstract: Molded electronic structures configured for use in body-mountable devices and methods for embedding molded electronic structures in a body-mountable device are described. An example method may include molding an electronic structure to have first curvature corresponding to a first radius of curvature. The electronic structure may include an antenna, a sensor, and an electronic device. The example method may also include adhering the molded electronic structure to a first polymer layer. The example method may additionally include forming a second polymer layer over the molded electronic structure adhered to the first polymer layer.

Abstract translation: 描述了构造成用于体内安装的装置中的模制电子结构和用于将模制的电子结构嵌入体内安装的装置中的方法。 示例性方法可以包括将电子结构模制成具有对应于第一曲率半径的第一曲率。 电子结构可以包括天线，传感器和电子设备。 该示例性方法还可以包括将模制的电子结构粘附到第一聚合物层。 该示例性方法可以另外包括在粘附到第一聚合物层上的模制电子结构上形成第二聚合物层。

公开(公告)号：US09055902B2

公开(公告)日：2015-06-16

申请号：US14031299

申请日：2013-09-19

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/1486 ,  G01N27/327

CPC classification number: A61B5/1468 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/6821 ,  A61B5/6867 ,  G01N27/3271 ,  G02C7/04

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.

Abstract translation: 一种可眼睛安装的装置包括嵌入聚合物材料中的电化学传感器，其被配置用于安装到眼睛的表面。 电化学传感器包括工作电极，参比电极和选择性地与分析物反应以产生与可眼睛安装的装置暴露于的流体中的分析物的浓度相关的传感器测量的试剂。 工作电极可具有至少一个小于25微米的尺寸。 参考电极可以具有比工作电极的面积大至少五倍的面积。 聚合物材料的一部分可围绕工作电极和参考电极，使得在工作电极和参比电极之间输送的电流通过透明聚合材料的至少部分环绕的部分。

公开(公告)号：US20150159190A1

公开(公告)日：2015-06-11

申请号：US14098806

申请日：2013-12-06

Applicant: Google Inc.

Inventor： Zenghe Liu

IPC: C12Q1/00 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1486

CPC classification number: C12Q1/006 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6821 ,  C12Q1/002

Abstract: An analyte sensor for measuring physiological parameters, a method for making the analyte sensor, and method of measuring a level of an analyte in a subject are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The crosslinked, hydrophilic copolymer has methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have side chains that can be the same or different, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks. The crosslinked, hydrophilic copolymer has an analyte permeability that is substantially temperature independent. The analyte sensor generates signals that are substantially temperature independent over a range of temperatures.

Abstract translation: 公开了一种用于测量生理参数的分析物传感器，用于制备分析物传感器的方法和测量受试者中分析物水平的方法。 一方面，分析物传感器包括与电极表面接触的交联的亲水共聚物和嵌入交联的亲水共聚物内的分析物感测组分。 交联的亲水共聚物具有衍生自第一甲基丙烯酸酯单元，第二甲基丙烯酸酯衍生单元和第三甲基丙烯酸酯衍生单元的甲基丙烯酸酯衍生的主链。 第一和第二甲基丙烯酸酯衍生单元具有可以相同或不同的侧链，并且不同主链中的第三甲基丙烯酸酯衍生单元通过亲水性交联连接。 交联的亲水共聚物具有基本上独立于温度的分析物渗透性。 分析物传感器产生在温度范围内基本上独立于温度的信号。