公开(公告)号：US20230035535A1

公开(公告)日：2023-02-02

申请号：US17384376

申请日：2021-07-23

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Anand Samuel JEBAKUMAR

IPC: B01L3/00

Abstract: An example microfluidic device comprises a plurality of fluidic channels and a fluidic multiplexor. The fluidic multiplexor includes a plurality of fluidic micro-valves fluidically coupled to the plurality of fluidic channels, and a plurality of control lines that cross the plurality of fluidic channels proximal to the plurality of fluidic micro-valves.

公开(公告)号：US20210322992A1

公开(公告)日：2021-10-21

申请号：US17268975

申请日：2019-05-06

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Pavel KORNILOVICH ,  Alexander GOVYADINOV

IPC: B01L7/00 ,  B01L3/00 ,  B01L9/00

Abstract: A rapid thermal cycling device can include a microfluidic reaction chamber, a dry reagent, and a heating element. The microfluidic reaction chamber can be defined between a substrate and a cover having an average space therebetween from 4 μm to 150 μm. The dry reagent can be positioned within the microfluidic reaction chamber. The heating element can be thermally coupled to the microfluidic reaction chamber to heat a fluid when introduced therein.

公开(公告)号：US20210322991A1

公开(公告)日：2021-10-21

申请号：US17268971

申请日：2018-12-13

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Diane HAMMERSTAD ,  Alexander GOVYADINOV ,  Brian J. KEEFE ,  Erik D. TORNIAINEN ,  Tyler COCHELL ,  Pavel KORNILOVICH

IPC: B01L7/00 ,  B01L3/00 ,  B01L9/00

Abstract: A rapid thermal cycling device can include a static microfluidic reaction chamber that can be defined between a layered substrate and a cover that can have an average space therebetween from 4 μm to 150 μm. The layered substrate can include a heating element thermally coupled to the static microfluidic reaction chamber to heat a fluid when present therein. The layered substrate, the cover, or both can include a heat diffusing material thermally coupled to the static microfluidic reaction chamber to diffuse heat out from the fluid while remaining in the static microfluidic reaction chamber.

公开(公告)号：US20210190694A1

公开(公告)日：2021-06-24

申请号：US16074298

申请日：2016-04-20

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Ning GE ,  Anita ROGACS ,  Viktor SHKOLNIKOV ,  Alexander GOVYADINOV

IPC: G01N21/65

Abstract: A surface enhanced Raman scattering (SERS) sensor may include a substrate, an electrically conductive layer having a first portion spaced from a second portion by a gap, an electrically resistive layer in contact with and extending between the first portion and the second portion of the electrically conductive layer to form an electrically resistive bridge across the gap that heats the nano fingers in response to electrical current flowing across the bridge from the first portion to the second portion and nano fingers extending upward from the bridge.

公开(公告)号：US20200179924A1

公开(公告)日：2020-06-11

申请号：US16618200

申请日：2017-07-19

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： David P. MARKEL ,  Erik D TORNIAINEN ,  Alexander GOVYADINOV ,  Pavel KORNILOVICH

IPC: B01L3/00

Abstract: One example includes a device that may include a heating element and a molecular binding site. The heating element may heat a fluid volume, interfaced with the heating element, in response to a voltage being applied to the heating element, the heat transforming the fluid volume from a liquid state into a vaporized state to generate fluid motion within the fluid volume. The molecular binding site may be disposed proximate to the heating element, in which a portion of the fluid volume expands when the fluid volume transforms from the liquid state into the vaporized state, the vaporized state of the fluid volume generating the fluid motion within a target fluid that is disposed within the molecular binding site.

公开(公告)号：US20230330675A1

公开(公告)日：2023-10-19

申请号：US17721724

申请日：2022-04-15

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Oumnia El Fajri ,  Richard W. SEAVER ,  Erik D. TORNIAINEN ,  Anand Samuel JEBAKUMAR ,  Pavel KORNILOVICH ,  Alexander GOVYADINOV ,  Carson DENISON

IPC: B01L3/00

CPC classification number: B01L3/502784 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0406

Abstract: An example microfluidic structure can include a first microfluidic channel segment in a first elevation plane, a second microfluidic channel segment in a second elevation plane, and a transverse microfluidic channel segment connecting the first microfluidic channel segment to the second microfluidic channel segment. An interior pillar can be positioned at the transverse microfluidic channel segment. The interior pillar can have a tapered downstream edge. The tapered downstream edge can be angled in the first or second elevation plane at an acute angle. A fluid cross-sectional area can increase in the fluid flow direction along the tapered downstream edge.

公开(公告)号：US20230173497A1

公开(公告)日：2023-06-08

申请号：US17911838

申请日：2020-04-29

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Viktor SHKOLNIKOV ,  Alexander GOVYADINOV

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/686

CPC classification number: B01L7/52 ,  B01L3/502715 ,  C12Q1/686 ,  B01L3/502761 ,  B01L2300/0896 ,  B01L2400/043 ,  B01L2400/0487

Abstract: Examples relate to techniques for performing a nucleic acid amplification reaction. The method includes generating a nucleic acid solution comprising a plurality of nucleic acid molecules, and combining the nucleic acid solution with a plurality of chamber particles. Each chamber particle includes a chamber for receiving the nucleic acid solution, wherein the chamber receives, at most, one of the plurality of nucleic acid molecules. Each chamber particle also includes reagents for causing a polymerase chain reaction within the chamber. The method further includes inducing nucleic acid amplification to generate an amplified nucleic acid, and performing a detection process to detect the presence of the amplified nucleic acid within the chamber.

公开(公告)号：US20230001412A1

公开(公告)日：2023-01-05

申请号：US17782598

申请日：2020-01-21

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Alexander GOVYADINOV ,  Hilary Ely ,  Brett E DAHLGREN ,  Si-lam J. CHOY ,  Erik TORNIAINEN

IPC: B01L3/00 ,  C12Q1/6844 ,  B01L7/00 ,  G01N21/64

Abstract: A microfluidic reaction chamber with a reaction chamber circuit includes a microfluidic reaction chamber to contain a reaction fluid for amplification of nucleic acids, and a reaction chamber circuit disposed within the microfluidic reaction chamber. The microfluidic reaction chamber includes a base wall, a top wall parallel to the base wall and defined in part by a transparent lid, a first side wall, and a second side wall. The reaction chamber circuit is disposed within the microfluidic reaction chamber, and includes a top surface, a bottom surface, a first side wall, and a second side wall. The reaction chamber circuit is in fluidic contact with the reaction fluid and includes a photodetector to detect a fluorescence signal from a labeled fluorescent tag in the reaction fluid.

公开(公告)号：US20220080413A1

公开(公告)日：2022-03-17

申请号：US17415916

申请日：2019-03-08

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Diane R. HAMMERSTAD ,  Alexander GOVYADINOV

IPC: B01L3/00

Abstract: A disposable microfluidic cassette can include a substrate and an engagement feature associated with the substrate to removably join the cassette with a cassette-receiver of an analytical system. A microfluidic network can be carried by the substrate. The microfluidic network can include a fluid inlet, a fluid outlet, and a sample manipulation portion fluidly coupling the fluid inlet to the fluid outlet. An ejector can be associated with the microfluidic network to move fluid out of the disposable microfluidic cassette via the fluid outlet.

公开(公告)号：US20200333238A1

公开(公告)日：2020-10-22

申请号：US16768878

申请日：2018-01-29

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Alexander GOVYADINOV ,  Pavel KORNILOVICH

IPC: G01N15/14 ,  B01L3/00 ,  H01L41/09

Abstract: An example system includes an input channel having a first end and a second end to receive particles through the first end, a sensor to categorize particles in the input channel into one of at least two categories, and at least two output channels Each output channel is coupled to the second end of the input channel to receive particles from the input channel, and each output channel is associated with at least one category of the at least two categories. Each output channel has a corresponding pump operable, based on the categorization of a detected particle in a category associated with a different output channel, to selectively slow, stop, or reverse a flow of particles into the output channel from the input channel.