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    PORATED CELL EJECTION DEVICES
    22.
    发明申请
    PORATED CELL EJECTION DEVICES 有权

    公开(公告)号：US20210179991A1

    公开(公告)日：2021-06-17

    申请号：US16076545

    申请日：2017-06-09

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Viktor SHKOLNIKOV ,  Kenneth WARD

    IPC: C12M3/06 ,  B01L3/02 ,  C12M1/00 ,  C12M1/42 ,  C12N15/87

    Abstract: A microfluidic device may include a microfluidic channel including an electrode placed at opposite ends of the microfluidic channel to create an electrical field within the channel and an ejection device to eject at least one cell porated within the electrical field. A cassette may include a substrate, a die coupled to the substrate, a microfluidic channel defined within the die, the microfluidic channel including a necked portion to receive a cell therein and at least two electrodes each placed at a first and a second end of the microfluidic channel to apply an electric field to the cell above a proration threshold and a cell ejection device to eject the cell from the die.

    MEASURING DEFORMABILITY OF A CELL
    25.
    发明申请
    MEASURING DEFORMABILITY OF A CELL 有权

    公开(公告)号：US20230140317A1

    公开(公告)日：2023-05-04

    申请号：US17912723

    申请日：2020-04-23

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Fausto D'APUZZO ,  Viktor SHKOLNIKOV ,  Alexander GOVYADINOV

    IPC: C12M1/34 ,  C12M3/06

    Abstract: An example method for measuring deformability of a cell, consistent with the present disclosure, includes detecting a single cell of a biologic sample in a cell probing chamber of a microfluidic device. The method includes isolating the cell in the cell probing chamber of the microfluidic device by terminating the flow of the biologic sample through the microfluidic device. The method further includes causing deformation of the cell by introducing ultrasonic waves into the cell probing chamber, and measuring deformability of the cell responsive to the introduction of the ultrasonic waves.

    SORTING A DROPLET INCLUDING A BIOLOGIC SAMPLE
    26.
    发明申请
    SORTING A DROPLET INCLUDING A BIOLOGIC SAMPLE 有权

    公开(公告)号：US20220323958A1

    公开(公告)日：2022-10-13

    申请号：US17634787

    申请日：2019-12-04

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Alexander Govyadinov ,  Viktor SHKOLNIKOV

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/6844

    Abstract: Examples herein involve sorting a droplet including a biologic sample. In a particular example, sorting a droplet including a biologic sample includes generating a droplet including a biologic sample and a pH sensitive surfactant, and heating a nucleic acid molecule in the biologic sample. The pH sensitive surfactant may change the surface tension of the droplet responsive to amplification of the nucleic acid molecule. The droplet may be sorted into one of a plurality of sorting lanes based on the surface tension of the droplet, where a sorting lane among the plurality of sorting lanes is associated with droplets including the amplified nucleic acid molecule. A determination of whether the droplet includes the amplified nucleic acid molecule may be performed by detecting passage of the droplet in one of the plurality of sorting lanes.

    CHIP TO CHIP FLUIDIC INTERCONNECT
    27.
    发明申请
    CHIP TO CHIP FLUIDIC INTERCONNECT 审中-公开

    公开(公告)号：US20200094247A1

    公开(公告)日：2020-03-26

    申请号：US16494856

    申请日：2017-04-21

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Michael W. CUMBIE ,  Viktor SHKOLNIKOV ,  Chien-Hua CHEN

    IPC: B01L3/00 ,  G01N35/00 ,  B01L7/00

    Abstract: A device may include a substrate, a first fluid processing chip, a second fluid processing chip, a tapered channel, and a fluid actuator. The first fluid processing chip may be disposed on the substrate and may process a micro-volume of fluid. The second fluid processing chip may be disposed on the substrate and co-planar with the first fluid processing chip. The second fluid processing chip may process at least a portion of the micro-volume of fluid. The tapered channel may be disposed between the first and second fluid processing chips to transport the at least the portion of the micro-volume of fluid from the first fluid processing chip to the second fluid processing chip. The fluid actuator may be disposed proximate to the tapered channel and may control movement of the at least the portion of the micro-volume of fluid within the tapered channel.

    ENZYMATIC SAMPLE PURIFICATION
    29.
    发明申请
    ENZYMATIC SAMPLE PURIFICATION 审中-公开

    公开(公告)号：US20190003937A1

    公开(公告)日：2019-01-03

    申请号：US15770456

    申请日：2016-02-29

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor SHKOLNIKOV ,  Anita ROGACS

    IPC: G01N1/40 ,  C12Q1/37

    Abstract: An enzymatic purification method involves the introduction of a sample comprising a target analyte and amino acids into a porous matrix of a reaction chamber. The reaction chamber includes first pores and second pores. The first pores contain polypeptide synthesis enzymes that react with the amino acids to form polypeptides. First pores having a first size to be accessible by amino acids but inaccessible by the subsequently formed polypeptides. The second pores have a second size greater than the first size, are in contact with the first pores and form a series extending from within the reaction chamber to a waste chamber. The formed polypeptides are migrated through the series of second pores to the waste chamber. The target analyte of the sample is extracted from the reaction chamber.

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