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公开(公告)号：US20050233379A1
公开(公告)日：2005-10-20
申请号：US11098889
申请日：2005-04-04
IPC分类号： G01N33/566 , A61K38/00 , C07K14/51 , C07K14/675 , C07K14/705 , C07K14/71 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12R1/91 , G01N33/53 , G01N33/567 , G01N33/68 , G01N33/74
CPC分类号： G01N33/6845 , A61K38/00 , C07K14/51 , C07K14/71 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/6887 , G01N33/74 , G01N2500/00 , G01N2500/04
摘要： Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods and compositions for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.
摘要翻译： 公开了（1）核酸序列，氨基酸序列，同源性，结构特征和表征形态发生细胞表面受体，特别是OP-1结合细胞表面受体的各种其他数据; （2）使用重组DNA技术生产受体蛋白，包括其片段的方法; （3）鉴定新型形态发生受体及其编码DNA的方法; （4）鉴定能够调节内源性形态发生物受体水平的化合物的方法和组合物; 和（5）用于鉴定形态发生受体结合类似物的方法和组合物，其可用于设计用于治疗，诊断和实验用途的形态发生激动剂和拮抗剂。
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22.发明授权Activin receptor-like kinase-1 proteins having serine-threonine kinase domains 失效具有丝氨酸 - 苏氨酸激酶结构域的激活素受体样激酶-1蛋白公开(公告)号：US07932351B2
公开(公告)日：2011-04-26
申请号：US11656720
申请日：2007-01-23
摘要： A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-beta-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.
摘要翻译： 已经鉴定了激活素样激酶的新受体家族。 新型蛋白质具有激活素/ TGF-β-I受体功能，并具有相应的诊断/治疗效用。 它们可以具有丝氨酸/苏氨酸激酶结构域，子域VIB中的DFKSRN或DLKSKN序列和/或亚域VIII中的GTKRYM序列。
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23.发明申请Activin receptor-like kinases, proteins having serine threonine kinase domains and their use 失效活化素受体样激酶，具有丝氨酸苏氨酸激酶结构域的蛋白质及其用途公开(公告)号：US20100330657A1
公开(公告)日：2010-12-30
申请号：US11981260
申请日：2007-10-31
摘要： A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-β-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.
摘要翻译： 已经鉴定了激活素样激酶的新受体家族。 新型蛋白质具有激活素/ TGF-β1型受体功能，并具有相应的诊断/治疗效用。 它们可以具有丝氨酸/苏氨酸激酶结构域，子域VIB中的DFKSRN或DLKSKN序列和/或亚域VIII中的GTKRYM序列。
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公开(公告)号：US07276525B2
公开(公告)日：2007-10-02
申请号：US10559155
申请日：2004-06-07
申请人： Kohei Miyazono , Takeshi Imamura , Shingo Maeda
发明人： Kohei Miyazono , Takeshi Imamura , Shingo Maeda
CPC分类号： G01N33/6863 , A61K31/4439 , A61K38/1875 , A61K45/06 , G01N2333/51 , G01N2500/00 , A61K2300/00
摘要： It is an object of the present invention to provide an excellent enhancer for an osteogenesis accelerator that can enhance the activity of BMP as an osteogenesis accelerator. Another object of the present invention is to provide a method of screening for a novel enhancer for an osteogenesis accelerator.The present invention relates to an enhancer for an osteogenesis accelerator, which comprises a compound having a TGF-β selective inhibitory activity as an active ingredient, the enhancer being administered with an osteogenesis accelerator containing BMP as an active ingredient either simultaneously or sequentially, and to a method of screening for an enhancer for an osteogenesis accelerator, comprising using a TGF-β inhibition as a measure for discovering the enhancer.
摘要翻译： 本发明的目的是提供一种成骨促进剂的优异增强剂，其能够增强BMP作为成骨促进剂的活性。 本发明的另一个目的是提供一种筛选用于成骨促进剂的新增强剂的方法。 本发明涉及一种成骨促进剂的增强剂，其包含具有TGF-β选择性抑制活性作为活性成分的化合物，所述增强剂以含有BMP作为活性成分的成骨促进剂同时或依次施用，以及 筛选增强子用于成骨促进剂的方法，包括使用TGF-β抑制作为发现增强子的量度。
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公开(公告)号：US07067260B2
公开(公告)日：2006-06-27
申请号：US09982543
申请日：2001-10-18
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/6845 , A61K38/00 , C07K14/51 , C07K14/71 , G01N33/566 , G01N33/567 , G01N33/68 , G01N33/6887 , G01N33/74 , G01N2500/00 , G01N2500/04
摘要： Disclosed are (1) nucleic acid sequences, amino acid sequences, homologies, structural features and various other data characterizing a morphogen cell surface receptors particularly OP-1-binding cell surface receptors; (2) methods for producing receptor proteins, including fragments thereof, using recombinant DNA technology; (3) methods for identifying novel morphogen receptors and their encoding DNAs; (4) methods and compositions for identifying compounds capable of modulating endogenous morphogen receptor levels; and (5) methods and compositions for identifying morphogen receptor binding analogs useful in the design of morphogen agonists and antagonists for therapeutic, diagnostic and experimental uses.
摘要翻译： 公开了（1）核酸序列，氨基酸序列，同源性，结构特征和表征形态发生细胞表面受体，特别是OP-1结合细胞表面受体的各种其它数据; （2）使用重组DNA技术生产受体蛋白，包括其片段的方法; （3）鉴定新型形态发生受体及其编码DNA的方法; （4）鉴定能够调节内源性形态发生物受体水平的化合物的方法和组合物; 和（5）用于鉴定形态发生受体结合类似物的方法和组合物，其可用于设计用于治疗，诊断和实验用途的形态发生激动剂和拮抗剂。
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公开(公告)号：US06534476B2
公开(公告)日：2003-03-18
申请号：US09923922
申请日：2001-08-07
申请人： Kohei Miyazono , Masahiro Kawabata
发明人： Kohei Miyazono , Masahiro Kawabata
IPC分类号： C07K1400
CPC分类号： C07K14/4703 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
摘要： The invention includes nucleic acids encoding the Smad6 protein, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such nucleic acids, and antibodies relating thereto. Methods and products for using such nucleic acids and polypeptides also are provided.
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27.发明授权Activin like receptor--Isolated kinase proteins ALK-2, ALK-4, ALK-5, and nucleic acid molecules encoding them 有权活化素样受体 - 分离的激酶蛋白ALK-2，ALK-4，ALK-5和编码它们的核酸分子公开(公告)号：US06271365B1
公开(公告)日：2001-08-07
申请号：US09395115
申请日：1999-09-14
IPC分类号： C12N1512
摘要： The invention involves three members of the activin like receptor kinase family, and the nucleic acids encoding these.
摘要翻译： 本发明涉及激活素样受体激酶家族的三个成员和编码它们的核酸。
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28.发明申请Brain Tumor Stem Cell Differentiation Promoter, and Therapeutic Agent for Brain Tumor 审中-公开脑肿瘤干细胞分化启动子和脑肿瘤治疗剂公开(公告)号：US20120039808A1
公开(公告)日：2012-02-16
申请号：US13207846
申请日：2011-08-11
申请人： Kohei Miyazono , Hiroaki Ikushima , Keiji Miyazawa , Tomoki Todo , Yasushi Ino
发明人： Kohei Miyazono , Hiroaki Ikushima , Keiji Miyazawa , Tomoki Todo , Yasushi Ino
IPC分类号： A61K49/00 , A61K31/7088 , A61K31/711 , A61K31/713 , A61P35/00 , C12Q1/02 , C12Q1/68 , C40B30/02 , C07H21/00 , C07H21/02 , G01N33/53
CPC分类号： A61K31/713 , A61K31/4439 , A61K45/06 , C12N15/113 , C12N2310/11 , C12N2310/14
摘要： A promoter for differentiation of brain tumor initiating cells is provided.
摘要翻译： 提供了用于脑肿瘤起始细胞分化的启动子。
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29.发明授权Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use 失效具有丝氨酸/苏氨酸激酶结构域的蛋白质，相应的核酸分子及其用途公开(公告)号：US08012704B2
公开(公告)日：2011-09-06
申请号：US12803779
申请日：2010-07-06
申请人： Kohei Miyazono , Takeshe Imamura , Peter ten Dijke
发明人： Kohei Miyazono , Takeshe Imamura , Peter ten Dijke
IPC分类号： G01N33/53 , C12P21/00 , C07K14/495 , C07K14/71 , C07K16/28
CPC分类号： G01N33/566 , A61K38/00 , C07K14/71 , C07K16/2863 , G01N2333/495
摘要： The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF-β family. The molecule has a role in the phosphorylation of Smad-5 and Smad1, which also act as activators of certain genes. Aspects of the invention relate to this interaction.
摘要翻译： 本发明涉及被称为ALK-1的分子及其作为TGF-β1成员的I型受体的作用。 家庭。 该分子在Smad-5和Smad1的磷酸化中起作用，Smad-5和Smad1也作为某些基因的激活剂。 本发明的方面涉及这种相互作用。
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公开(公告)号：US07592428B1
公开(公告)日：2009-09-22
申请号：US10630555
申请日：2003-07-30
IPC分类号： C07K16/00 , C07K14/00 , A61K39/395
摘要： A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-β-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.
摘要翻译： 已经鉴定了激活素样激酶的新受体家族。 新型蛋白质具有激活素/ TGF-β-I受体功能，并具有相应的诊断/治疗效用。 它们可以具有丝氨酸/苏氨酸激酶结构域，子域VIB中的DFKSRN或DLKSKN序列和/或亚域VIII中的GTKRYM序列。
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