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公开(公告)号：US08022763B2
公开(公告)日：2011-09-20
申请号：US11790384
申请日：2007-04-25
申请人： Hiroaki Maeda , Takashi Ono , Yousuke Okazaki , Hirotake Honda , Hiroyuki Ezuka
发明人： Hiroaki Maeda , Takashi Ono , Yousuke Okazaki , Hirotake Honda , Hiroyuki Ezuka
IPC分类号： H03F21/00
CPC分类号： H03F1/3247 , H03F2201/3233 , H04B1/0466 , H04B2001/0416
摘要： An amplifier failure detection apparatus for a radio transmitter that has a function for compensating for amplifier distortion of the radio transmitter and a function for determining amplifier failure has occurred by detecting that the gain of an amplifier has dropped a set level or more, in which: a gain-detection unit detects the gain of the amplifier; an alarm-detection-level-generation unit, which has a table for storing alarm-detection levels that correspond to input-amplitude levels, generates an alarm-detection level that corresponds to an input-amplitude level; and a comparison unit compares the gain detected by the gain-detection unit with the alarm-detection level, and generates an alarm based on the comparison results.
摘要翻译： 通过检测放大器的增益已经下降了设定值以上，已经发生了具有补偿无线电发射机的放大器失真的功能的放大器故障检测装置和用于确定放大器故障的功能，其中： 增益检测单元检测放大器的增益; 具有用于存储对应于输入幅度电平的报警检测电平的表的报警检测电平生成单元生成与输入幅度电平对应的报警检测电平; 并且比较单元将由增益检测单元检测到的增益与报警检测水平进行比较，并且基于比较结果生成报警。
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22.发明授权Protein highly producing recombinant animal cell, method for preparing the same, and method for mass-producing protein using the same 有权蛋白质高产重组动物细胞，其制备方法，以及使用该蛋白质大量生产蛋白质的方法公开(公告)号：US07829306B2
公开(公告)日：2010-11-09
申请号：US10576978
申请日：2004-10-21
CPC分类号： C12P21/02 , C12N2510/02
摘要： A gene encoding a production amount-potentiating factor is introduced into an animal cell to transform the cell. Alternatively, a protein production gene and the gene encoding the production amount-potentiating factor are introduced into the animal cell to transform the cell. Herein, as the production amount potentiating factor, there is used a factor having caspase activity inhibiting activity and/or protein biosynthesis activity potentiating action, for example, baculovirus P35. Further, the animal cell is cultured by a culturing method under a condition that apoptosis is not induced, so that a protein is mass-produced.
摘要翻译： 将编码产生量增加因子的基因导入动物细胞以转化细胞。 或者，将蛋白质生产基因和编码产生量增强因子的基因导入动物细胞以转化细胞。 这里，作为生产量增强因子，使用具有半胱天冬酶活性抑制活性和/或蛋白质生物合成活性增强作用的因子，例如杆状病毒P35。 此外，通过培养方法在不诱导细胞凋亡的条件下培养动物细胞，从而大量生产蛋白质。
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公开(公告)号：US20100240329A1
公开(公告)日：2010-09-23
申请号：US12721064
申请日：2010-03-10
CPC分类号： H03F1/0288 , H03F1/0222 , H03F1/3247 , H03F2201/3233
摘要： An amplifying device includes an amplifier including a first amplifying element with a drain voltage thereof being controlled, and a second amplifying element, the amplifier amplifying a transmission signal with the first and second amplifying elements, synthesizing the transmission signals amplified by the first and second amplifying elements, and outputting the synthesized transmission signal; a distortion compensator part which performs distortion compensation on the input signal in accordance with a compensation coefficient derived from a difference between a input signal and a feedback signal generated from a portion of a signal output from the amplifier; and a controller part which controls the drain voltage of the first amplifying element in response to a result of a comparison between a power level of the input signal prior to the distortion compensation operation by the distortion compensator part and a threshold value.
摘要翻译： 一种放大装置，包括：放大器，包括其漏极电压被控制的第一放大元件;以及第二放大元件，放大器利用第一和第二放大元件放大发送信号，合成由第一和第二放大器放大的发送信号 并输出合成的发送信号; 失真补偿部，其根据从输入信号和从放大器输出的信号的一部分产生的反馈信号之间的差导出的补偿系数，对输入信号进行失真补偿; 以及控制器部分，其响应于在失真补偿器部分的失真补偿操作之前的输入信号的功率电平与阈值之间的比较的结果来控制第一放大元件的漏极电压。
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24.发明申请Process For Producing Recombinant Fibrinogen Highly Producing Cell and Highly Producing Cell 有权生产重组纤维蛋白原高产细胞和高产细胞的方法公开(公告)号：US20100151522A1
公开(公告)日：2010-06-17
申请号：US10566266
申请日：2004-07-28
申请人： Reiko Matsuyama , Hiroaki Maeda
发明人： Reiko Matsuyama , Hiroaki Maeda
CPC分类号： C07K14/75
摘要： When genes encoding three kinds of proteins constituting fibrinogen, an α chain (or variant of α chain), a β chain and a γ chain (or variant of γ chain) are incorporated into an animal cell, a constitutional ratio of respective genes is such that a γ chain (and/or variant of γ chain) gene is an equal amount to a 1000-fold amount relative to an α chain (and/or variant of α chain) gene and a β chain gene and, further, by using a baculovirus P35 gene, a recombinant fibrinogen highly producing cell is prepared.
摘要翻译： 当编码构成纤维蛋白原的三种蛋白质的基因，α链（或α链的变体），a＆bgr; 链和γ链（或γ链的变体）并入动物细胞中，各基因的构成比例使得γ链（和/或γ链的变体）基因等于1000倍 相对于α链（和/或α链的变体）基因和bgr的量; 链基因，并且通过使用杆状病毒P35基因，制备重组纤维蛋白原高产细胞。
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公开(公告)号：US07598349B2
公开(公告)日：2009-10-06
申请号：US11185859
申请日：2005-07-21
IPC分类号： C07K16/00
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.
摘要翻译： 本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有在硒蛋白P的C末端由103个氨基酸残基组成的氨基酸序列，或者具有所述氨基酸序列与一个或多个 其中缺少，取代或添加的几个氨基酸残基，或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列 的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。 本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。
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公开(公告)号：US20090075865A1
公开(公告)日：2009-03-19
申请号：US12081991
申请日：2008-04-24
CPC分类号： A61K38/1709
摘要： A novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, comprising as an active ingredient selenoprotein P and/or a peptide fragment or a series of peptide fragments derived from said protein is provided. The novel medicament for treating neurodegenerative diseases, especially for ameliorating dyskinesia, according to the present invention is suitably applicable to diseases with decrease in motor function.
摘要翻译： 提供了用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物，其包含作为活性成分的硒蛋白P和/或肽片段或一系列源自所述蛋白质的肽片段。 根据本发明的用于治疗神经变性疾病，特别是用于改善运动障碍的新型药物适用于运动功能降低的疾病。
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公开(公告)号：US20070285158A1
公开(公告)日：2007-12-13
申请号：US11790982
申请日：2007-04-30
申请人： Akira Seino , Hiroaki Maeda , Takashi Ono , Yousuke Okazaki
发明人： Akira Seino , Hiroaki Maeda , Takashi Ono , Yousuke Okazaki
CPC分类号： H03F1/0288 , H03F1/52 , H03F2200/207 , H03F2200/465 , H03F2200/471
摘要： The present invention provides an amplifier unit including a carrier amplifier biased for Class A or Class AB operation; a peak amplifier biased for Class B or Class C operation, wherein an input signal is input to the carrier amplifier and the peak amplifier, and wherein output signals from the carrier amplifier and the peak amplifier are synthesized to output therefrom; a comparator configured to compare a gate bias voltage of a transistor device in the peak amplifier with a predetermined threshold voltage and output a first output signal; and a failure detection circuit configured to output a second output signal indicating presence or absence of failure, based on the first output signal received from the comparator.
摘要翻译： 本发明提供一种放大器单元，其包括偏置用于A类或AB类操作的载波放大器; 偏置用于B类或C类工作的峰值放大器，其中输入信号被输入到载波放大器和峰值放大器，并且其中来自载波放大器和峰值放大器的输出信号被合成以从其输出; 比较器，用于将所述峰值放大器中的晶体管器件的栅极偏置电压与预定阈值电压进行比较，并输出第一输出信号; 以及故障检测电路，被配置为基于从所述比较器接收的所述第一输出信号，输出指示故障有无的第二输出信号。
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公开(公告)号：US07199097B1
公开(公告)日：2007-04-03
申请号：US09856199
申请日：1999-11-12
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.
摘要翻译： 本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有在硒蛋白P的C末端由103个氨基酸残基组成的氨基酸序列，或者具有所述氨基酸序列与一个或多个 其中缺少，取代或添加的几个氨基酸残基，或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列 的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。 本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。
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29.发明申请Peptide having cytotoxicity inhibitory activity and method of screening these peptide having cytotoxicity inhibitory activity 失效具有细胞毒性抑制活性的肽和筛选具有细胞毒性抑制活性的肽的方法公开(公告)号：US20050143311A1
公开(公告)日：2005-06-30
申请号：US10477101
申请日：2002-05-10
申请人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
发明人： Masaki Hirashima , Takeshi Naruse , Hiroaki Maeda , Chikateru Nozaki , Takeshi Goto , Katsuhiko Akiyama , Wataru Hattori
CPC分类号： C07K14/4747 , C07K14/47 , G01N33/5014
摘要： A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.
摘要翻译： 含有一种或多种硒代半胱氨酸的肽片段或一系列肽片段，其毒性低于硒代胱氨酸并且具有细胞毒性抑制活性。 根据本发明的肽片段或一系列肽片段优选具有来自硒蛋白P的C末端的第260至第362位氨基酸残基的氨基酸序列，或其中具有一个或几个氨基酸残基的所述氨基酸序列是 缺失，取代或添加，或上述氨基酸序列中的任一个的部分序列，或包含作为上述氨基酸序列之一的氨基酸序列。 还提供了具有细胞毒性抑制活性的肽片段的筛选方法。
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公开(公告)号：US06518045B1
公开(公告)日：2003-02-11
申请号：US09302495
申请日：1999-04-30
IPC分类号： C12P2104
摘要： A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinant DNA, a transformant which is transformed with said expression vector, a process for preparing said protein by culturing said transformant, and an antibody against said protein are provided. The novel feline cytokine protein of the present invention is a heterologous dimer comprising FLAF p35 and FLAF p40 and can be used for treating feline infectious diseases such as feline herpes virus type 1 (FHV-1) or feline calicivirus (FCV).
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