公开(公告)号：US20210230687A1

公开(公告)日：2021-07-29

申请号：US17228477

申请日：2021-04-12

Applicant: ILLUMINA CAMBRIDGE LIMITED

Inventor： Elena Cressina ,  Antoine Francais ,  Xiaohai Liu

IPC: C12Q1/6869 ,  C07H19/06 ,  C07H21/00 ,  C07H19/16 ,  C07H19/20 ,  C07H19/10 ,  C07H19/073 ,  C07H19/14 ,  C07H21/04 ,  C12Q1/6809 ,  C12Q1/6816

Abstract: The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications.

公开(公告)号：US20190017111A1

公开(公告)日：2019-01-17

申请号：US16033118

申请日：2018-07-11

Applicant: ILLUMINA CAMBRIDGE LIMITED

Inventor： Elena Cressina ,  Antoine Francais ,  Xiaohai Liu

IPC: C12Q1/6869 ,  C12Q1/6809 ,  C12Q1/6816 ,  C07H21/04 ,  C07H19/073 ,  C07H19/14

Abstract: The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications.

公开(公告)号：US20240247311A1

公开(公告)日：2024-07-25

申请号：US18390578

申请日：2023-12-20

Applicant: Illumina, Inc.

Inventor： Cassio Pedroso ,  Adyasha Panigrahi ,  Angelica Mariani ,  Adam Carver ,  Raphaëlle Hours ,  Preeti Chandrachud ,  Antoine Francais ,  Tushar Apsunde ,  Kathryn Hattingh ,  Timothy Beech ,  Daniel Solis ,  Elliot J. Lawrence

IPC: C12Q1/6874 ,  B01J23/44 ,  B01J27/02 ,  B01J31/06 ,  B01J37/16

CPC classification number: C12Q1/6874 ,  B01J23/44 ,  B01J27/02 ,  B01J31/065 ,  B01J37/16

Abstract: The present application relates to palladium catalyst composition and uses in sequencing by synthesis. In particular, the Pd catalyst composition comprises one or more macrocycles (e.g., cyclodextrin or analogs thereof) as additives for improving thermal or oxidative stability of the active Pd(0) species.

公开(公告)号：US20240209015A1

公开(公告)日：2024-06-27

申请号：US18393220

申请日：2023-12-21

Applicant: Illumina, Inc.

Inventor： Antoine Francais ,  Elena Cressina ,  Angelica Mariani ,  Adam Culley ,  Anno Koetje ,  Xiaohai Liu ,  Xiaolin Wu ,  Kathryn Hattingh

IPC: C07H19/073 ,  C07H19/173 ,  C12Q1/6869

CPC classification number: C07H19/073 ,  C07H19/173 ,  C12Q1/6869

Abstract: Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or allyl 3′ blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses of fully functionalized nucleotides containing the 3′ blocking groups for sequencing applications.

公开(公告)号：US20240271206A1

公开(公告)日：2024-08-15

申请号：US18392547

申请日：2023-12-21

Applicant: Illumina, Inc.

Inventor： Antoine Francais ,  Elena Cressina ,  Kathryn Hattingh ,  Angelica Mariani ,  Xiaolin Wu ,  Xiaohai Liu

IPC: C12Q1/6874 ,  B01J23/44 ,  C12Q1/48 ,  C12Q1/6806 ,  C12Q1/6823

CPC classification number: C12Q1/6874 ,  B01J23/44 ,  C12Q1/485 ,  C12Q1/6806 ,  C12Q1/6823 ,  G01N2333/9126

Abstract: Embodiments of the present disclosure relate to nucleotides with 3′ allyl blocking groups. Also provided herein are methods of sequencing using nucleotides with 3′ allyl blocking groups described herein, and sequencing kits.

公开(公告)号：US20240229131A1

公开(公告)日：2024-07-11

申请号：US18390322

申请日：2023-12-20

Applicant: Illumina, Inc.

Inventor： Angelica Mariani ,  Timothy Beech ,  Antoine Francais ,  Adyasha Panigrahi ,  Kathryn Hattingh ,  Elena Cressina

IPC: C12Q1/6874 ,  B01J23/44 ,  B01J31/14 ,  B01J31/24

CPC classification number: C12Q1/6874 ,  B01J23/44 ,  B01J31/146 ,  B01J31/24 ,  B01J2531/824

Abstract: The present application relates to compositions and methods for sequencing by synthesis. A blocking group of a nucleotide may be removed by a transition metal catalyst, the transition metal catalyst activated by a non-reducing ligand and a reducing agent.

公开(公告)号：US20240218443A1

公开(公告)日：2024-07-04

申请号：US18393291

申请日：2023-12-21

Applicant: Illumina, Inc.

Inventor： Angelica Mariani ,  Antoine Francais ,  Frederick James Topping ,  Christopher Winnard ,  Philip Balding ,  Chol Steven Yun ,  Patrizia Iavicoli ,  Kathryn Hattingh ,  Xiaolin Wu ,  Xiaohai Liu

IPC: C12Q1/6874 ,  B01J23/44 ,  C12Q1/48 ,  C12Q1/6806 ,  G01N21/64

CPC classification number: C12Q1/6874 ,  B01J23/44 ,  C12Q1/485 ,  C12Q1/6806 ,  G01N21/6486 ,  G01N2333/9126

Abstract: The present application relates to palladium compositions, methods for sequencing by synthesis using nucleotides with 3′ blocking groups, and sequencing kits, where one or more palladium scavengers were used to improve sequencing metrics such phasing and prephasing values.

公开(公告)号：US20240182963A1

公开(公告)日：2024-06-06

申请号：US18392975

申请日：2023-12-21

Applicant: Illumina, Inc.

Inventor： Antoine Francais ,  Elena Cressina ,  Adam Culley ,  Angelica Mariani ,  Xiaolin Wu ,  Xiaohai Liu ,  Kathryn Hattingh

IPC: C12Q1/6869 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00

CPC classification number: C12Q1/6869 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00

Abstract: Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with 3′ acetal, thiocarbamate or allyl blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses of fully functionalized nucleotides containing the 3′-OH blocking group for sequencing applications.