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Patent Agency Ranking
公开(公告)号：US11307133B2
公开(公告)日：2022-04-19
申请号：US16957101
申请日：2018-12-19
Applicant: IMEC VZW
Inventor： Chengxun Liu , Dries Vercruysse , Niels Verellen , Abdulkadir Yurt
Abstract: A device (110) for illuminating a particle comprises: a light waveguide (112; 412a, 412b; 512a, 512b) arranged on a substrate (114); an output coupler (118) configured to output a light beam (150; 450a, 450b; 550a, 550b) forming a sheet-like shape having a cross-section which has an extension in a first direction being larger than a size of a particle; and a fluidic channel (116; 416; 516) arranged on the substrate (114) for guiding a flow of particles along a longitudinal direction of the fluidic channel (116; 416; 516); wherein the sheet-like shape of the light beam (150; 450a, 450b; 550a, 550b) is arranged within the fluidic channel (116; 416; 516) and the first direction of the cross-section of the light beam (150; 450a, 450b; 550a, 550b) forms an angle to the longitudinal direction of the fluidic channel (116; 416; 516). A system (100) for imaging the particle comprises the device, an array (130; 430a, 430b; 530) of light-detecting elements (132; 432a, 432b; 532); and a lens (120) to converge light towards the array (130; 430a, 430b; 530) such that each light-detecting element (132; 432a, 432b; 532) detects light originating from a corresponding position in the fluidic channel (116; 416; 516).
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公开(公告)号：US11207683B2
公开(公告)日：2021-12-28
申请号：US16322820
申请日：2017-07-28
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
Inventor： Shengping Mao , Erik Sohn , Xavier Rottenberg , Chengxun Liu
Abstract: At least one embodiment relates to a focusing arrangement for focusing particles or cells in a flow. The arrangement includes at least one channel for guiding the flow. The channel includes (i) at least one particle confinement structure having particle flow boundaries and (ii) at least one acoustic confinement structure having acoustic field boundaries adapted for confining acoustic fields. The acoustic field boundaries may be different from the particle flow boundaries, and the at least one acoustic confinement structure may be arranged with regard to the channel to at least partially confine acoustic fields in the channel.
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公开(公告)号：US20190336974A1
公开(公告)日：2019-11-07
申请号：US16473821
申请日：2017-12-26
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
Inventor： Koen Johannes Hubertus Gerardus de Wijs , Chengxun Liu
Abstract: Disclosed herein are microfluidic actuators for selecting objects in a fluid stream comprising a plurality of objects. In some embodiments, the actuator comprises an object detection means adapted for, upon arrival of an object, identifying whether an object is an object of interest. It further comprises a heater adapted for generating a jet flow for deflecting an object of interest from the fluid stream and a controller for activating the heater as function of the detection of an object of interest using a nucleation signal. The controller is adapted for obtaining temperature information of the heater and for adjusting a nucleation signal for the heater taking into account the obtained temperature information. Also disclosed are microfluidic systems and diagnostic devices comprising the microfluidic actuators of the disclosure, as well as methods of use thereof.
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公开(公告)号：US20190201901A1
公开(公告)日：2019-07-04
申请号：US16322820
申请日：2017-07-28
Applicant: IMEC VZW , Katholieke Universiteit Leuven, KU LEUVEN R&D
Inventor： Shengping Mao , Erik Sohn , Xavier Rottenberg , Chengxun Liu
CPC classification number: B01L3/502761 , A61M1/3678 , A61M2205/0244 , B01L3/502746 , B01L2200/0652 , B01L2300/0816 , B01L2300/168 , B01L2400/0436 , B01L2400/0439 , B01L2400/086 , B01L2400/088 , G01N15/1404 , G01N29/222 , G01N2015/0053 , G01N2015/0065 , G01N2015/142
Abstract: At least one embodiment relates to a focusing arrangement for focusing particles or cells in a flow. The arrangement includes at least one channel for guiding the flow. The channel includes (i) at least one particle confinement structure having particle flow boundaries and (ii) at least one acoustic confinement structure having acoustic field boundaries adapted for confining acoustic fields. The acoustic field boundaries may be different from the particle flow boundaries, and the at least one acoustic confinement structure may be arranged with regard to the channel to at least partially confine acoustic fields in the channel.
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公开(公告)号：US20160370279A1
公开(公告)日：2016-12-22
申请号：US15179484
申请日：2016-06-10
Applicant: IMEC VZW
Inventor： Richard Min , Liesbet Lagae , Chengxun Liu , Chengjun Huang
CPC classification number: G01N15/1031 , B01L3/502715 , B01L3/502761 , B01L2200/0652 , B01L2300/06 , B01L2300/0864 , B01L2300/12 , B01L2400/043 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1056 , G01N35/0098 , G01N2015/1081 , G01N2015/149
Abstract: A microfluidic magnetic selector comprises a microfluidic channel comprising at least one bifurcation, forming a selection portion of the selector and splitting the microfluidic channel into a main channel and at least one selection channel; at least one magnetic flux concentrator for concentrating a magnetic flux at the level of the bifurcation, and means for generating a magnetic field within the magnetic flux concentrator, and a controller for controlling magnetic pulses through the magnetic flux concentrator.
Abstract translation: 微流体磁选择器包括包含至少一个分叉的微流体通道，形成选择器的选择部分并将微流体通道分成主通道和至少一个选择通道; 用于将磁通集中在分叉水平的至少一个磁通集中器，以及用于在磁通量集中器内产生磁场的装置，以及用于控制通过磁通量集中器的磁脉冲的控制器。
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