公开(公告)号：US20250066474A1

公开(公告)日：2025-02-27

申请号：US18946033

申请日：2024-11-13

Applicant: Janssen Biotech, Inc.

Inventor： Kyle J. Bednar ,  Naresh Kumar ,  Sanjaya Singh ,  Danlin Yang ,  Rajkumar Ganesan

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46

Abstract: Provided herein are multispecific antibodies, that bind to CD79b and CD22, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20250043019A1

公开(公告)日：2025-02-06

申请号：US18811332

申请日：2024-08-21

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  Anna Kuchnio ,  Cassandra L. Lowenstein ,  Ulrike Philippar ,  Sanjaya Singh ,  Nele Vloemans ,  Danlin Yang

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: Provided herein are multispecific antibodies, including trispecific antibodies that bind to CD79b, CD20 and CD3, and bispecific antibodies that bind to CD79b and CD3, and multispecific antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided multispecific antibodies or multispecific antigen-binding fragments, cells expressing the provided multispecific antibodies or multispecific antigen-binding fragments, as well as associated vectors and detectably labeled multispecific antibodies or multispecific antigen-binding fragments. In addition, methods of producing and using the provided multispecific antibodies and multispecific antigen-binding fragments are described. Further provided herein are isolated antibodies that bind to CD79b and antigen-binding fragments thereof. Also described are related polynucleotides capable of encoding the provided CD79b-specific antibodies or antigen-binding fragments, cells expressing the provided CD79b-specific antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled CD79b-specific antibodies or antigen-binding fragments. In addition, methods of producing and using the provided CD79b-specific antibodies and antigen-binding fragments are described.

公开(公告)号：US12180278B2

公开(公告)日：2024-12-31

申请号：US17702042

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Kyle J. Bednar ,  Naresh Kumar ,  Sanjaya Singh ,  Danlin Yang ,  Rajkumar Ganesan

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46

Abstract: Provided herein are multispecific antibodies, that bind to CD79b and CD22, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US12084501B2

公开(公告)日：2024-09-10

申请号：US17701764

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Adam Zwolak ,  Raymond Brittingham ,  Scott R. Brodeur ,  Rajkumar Ganesan ,  Sherry Lynn La Porte ,  Jinquan Luo ,  Fang Yi ,  Colleen M. Kane ,  Triveni K. Bhatt

IPC: C07K16/28 ,  C07K16/46 ,  C12N15/85 ,  A61K39/00

CPC classification number: C07K16/2809 ,  C07K16/468 ,  C12N15/85 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622

Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US12077592B2

公开(公告)日：2024-09-03

申请号：US16743188

申请日：2020-01-15

Applicant: Janssen Biotech, Inc.

Inventor： Ricardo Attar ,  Rajkumar Ganesan ,  Francois Gaudet ,  Bradley J. Heidrich ,  Carmen Baca Jones ,  John Lee ,  Yingzhe Li ,  Sanjaya Singh ,  Sathya Venkataramani

IPC: C07K16/28 ,  A61K9/00 ,  A61P35/00 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K9/0019 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US12071466B2

公开(公告)日：2024-08-27

申请号：US16936719

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Raymond Brittingham ,  Rajkumar Ganesan ,  Sherry La Porte ,  John T. Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Sanjaya Singh ,  Degang Song ,  Sathyadevi Venkataramani ,  Fang Yi ,  Yonghong Zhao

IPC: A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/40

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70517 ,  C07K14/70596 ,  C07K16/40 ,  A61K38/00 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US20240124583A1

公开(公告)日：2024-04-18

申请号：US18397711

申请日：2023-12-27

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  John Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Degang Song ,  Raymond Brittingham ,  Sathyadevi Venkataramani ,  Sanjaya Singh ,  Yonghong Zhao ,  Fang Yi ,  Sherry Lynn LaPorte

IPC: C07K16/28 ,  C07K16/34

CPC classification number: C07K16/2809 ,  C07K16/34 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/565

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

公开(公告)号：US11639396B2

公开(公告)日：2023-05-02

申请号：US17672471

申请日：2022-02-15

Applicant: Janssen Biotech, Inc.

Inventor： Sanjaya Singh ,  Rajkumar Ganesan ,  Jun Chen ,  Iqbal S. Grewal

IPC: C07K16/42 ,  G01N33/68

Abstract: Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.

公开(公告)号：US20230040715A1

公开(公告)日：2023-02-09

申请号：US17701764

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Adam Zwolak ,  Raymond Brittingham ,  Scott R. Brodeur ,  Rajkumar Ganesan ,  Sherry Lynn La Porte ,  Jinquan Luo ,  Fang Yi ,  Colleen M. Kane ,  Triveni K. Bhatt

IPC: C07K16/28 ,  C07K16/46 ,  C12N15/85

Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20210214440A1

公开(公告)日：2021-07-15

申请号：US17125162

申请日：2020-12-17

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  Sanjaya Singh ,  Iqbal S. Grewal ,  Michael Riis Hansen

IPC: C07K16/28 ,  B01D15/00

Abstract: An isolated molecule, comprising: a first antigen binding domain and a second antigen binding domain, wherein the first antigen binding domain specifically binds CD8 and the second antigen binding domain specifically binds a T cell receptor (TCR) complex.