公开(公告)号：US08618508B2

公开(公告)日：2013-12-31

申请号：US13119897

申请日：2009-09-21

申请人： Reinhold Wimberger-Friedl ,  Jeroen Hans Nieuwenhuis ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Reinhold Wimberger-Friedl ,  Jeroen Hans Nieuwenhuis ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01J1/42 ,  G01J1/58 ,  G21K5/00

CPC分类号： G01N21/6428 ,  G01N21/648

摘要： A detection system combining an excitation radiation source providing excitation radiation to an analysis region of a sample within a substrate having a detection surface, a detector for detecting radiation collected from the analysis region comprising the detection surface of the sample resulting from the excitation, and a magnet arrangement beneath the analysis region of the sample, and stationary with respect to the excitation radiation source and light coupling arrangement, for attracting magnetic beads within the sample to the substrate surface. The detection radiation is collected from the detection surface of the substrate to give an enhanced surface specificity.

摘要翻译： 一种检测系统，其将激发辐射源组合到具有检测表面的基底内的样品的分析区域，用于检测从包括由激发产生的样品的检测表面的分析区域收集的辐射的检测器，以及 磁体布置在样品的分析区域下方，并且相对于激发辐射源和光耦合装置固定，用于将样品内的磁珠吸引到基底表面。 从衬底的检测表面收集检测辐射以提供增强的表面特异性。

公开(公告)号：US20130134293A1

公开(公告)日：2013-05-30

申请号：US13581696

申请日：2011-02-24

申请人： Jacobus Hermanus Maria Neijzen ,  Jacobus Maria Antonius Van Den Eerenbeemd ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Jacobus Hermanus Maria Neijzen ,  Jacobus Maria Antonius Van Den Eerenbeemd ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01J1/42

CPC分类号： G01J1/42 ,  G01J3/02 ,  G01J3/0262 ,  G01J3/10 ,  G01N21/255

摘要： The invention relates to a sensor device (100) in which the spatial distribution of an input light (L1) emission from a light emitting area (121, 122) of a light source (120) can selectively be changed. The input light is propagated through an optical system (110) to produce some output light (L2). Changes of the input light are taken into account when the detected output light (L2) is evaluated. Thus it is for example possible to detect and/or eliminate optical disturbances occurring in the optical path outside an object region (3). The light source (120) may particularly comprise a plurality of a light emitting segments (121, 122) that can selectively be switched on or off.

摘要翻译： 本发明涉及一种传感器装置（100），其中从光源（120）的发光区域（121,122）发射的输入光（L1）的空间分布可以选择性地改变。 输入光通过光学系统（110）传播以产生一些输出光（L2）。 当检测到的输出光（L2）被评估时，会考虑输入光的变化。 因此，例如可能检测和/或消除在物体区域（3）外部的光路中出现的光学干扰。 光源（120）可以特别地包括可以选择性地打开或关闭的多个发光段（121,122）。

公开(公告)号：US08390817B2

公开(公告)日：2013-03-05

申请号：US12810867

申请日：2008-12-18

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Hendricus Maria Kahlman

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Hendricus Maria Kahlman

IPC分类号： G01N21/55 ,  G01N21/00

CPC分类号： G01N21/552

摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.

摘要翻译： 本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。 所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。 该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

公开(公告)号：US20120329039A1

公开(公告)日：2012-12-27

申请号：US13516060

申请日：2010-12-10

申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Johannes Joseph Hubertina Barbara Schleipen ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Ron Martinus Laurentius Van Lieshout

发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Johannes Joseph Hubertina Barbara Schleipen ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Ron Martinus Laurentius Van Lieshout

IPC分类号： G01N33/566 ,  C12M1/34 ,  C12Q1/70 ,  G01N30/00 ,  G01N33/53

CPC分类号： B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N21/552 ,  G01N21/8483 ,  G01N33/54373

摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.

摘要翻译： 本发明涉及一种用于确定流体内物质的物质确定装置。 颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。 根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。 在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。 因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。 因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

公开(公告)号：US20120202194A1

公开(公告)日：2012-08-09

申请号：US13498615

申请日：2010-09-24

申请人： Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Josephus Arnoldus Hendricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko ,  Kim Van Ommering

发明人： Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Josephus Arnoldus Hendricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko ,  Kim Van Ommering

IPC分类号： G01N21/63 ,  C12M1/34 ,  C12Q1/02 ,  C12Q1/70 ,  G01N33/53 ,  G01N21/64

CPC分类号： G01N15/0612 ,  G01N15/1434 ,  G01N21/47 ,  G01N21/552 ,  G01N21/648 ,  G01N27/745 ,  G01N33/54333 ,  G01N35/0098 ,  G01N2015/025 ,  G01N2201/0627

摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.

摘要翻译： 本发明涉及一种用于确定流体内物质的物质确定装置。 具有附着物质的颗粒结合至结合表面（30）。 感测单元（33）适于产生感测信号，该感测信号指示i）结合在装订表面（30）和装订表面（30）上的颗粒之间的距离和ii）平面内位置 的结合表面上的颗粒。 绑定识别单元（34）适于根据产生的感测信号来区分绑定在绑定表面（30）上的粒子的不同种类的绑定。 装订识别单元（34）优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元，并且基于该确定的感测信号的部分来确定物质。

公开(公告)号：US07221492B2

公开(公告)日：2007-05-22

申请号：US10523384

申请日：2003-08-04

申请人： Nobuyoshi Mori ,  Katsuya Yagi ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Johannes Joseph Hubertina Barbara Schleipen ,  Marco Andreas Jacobus Van As

发明人： Nobuyoshi Mori ,  Katsuya Yagi ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Johannes Joseph Hubertina Barbara Schleipen ,  Marco Andreas Jacobus Van As

IPC分类号： G02B26/08

CPC分类号： G11B7/1374 ,  G11B7/121

摘要： An optical scanning device (1) for scanning an information layer (4) of an optical record carrier (2), the device (1) comprising a radiation source (11) for generating a radiation beam (12, 15, 20) and an objective system (18) for converging the radiation beam on the information layer, the information layer being covered by a transparent layer (3) of thickness td and refractive index nd. The objective system comprises a lens having a protection device projecting away from the lens towards the optical record carrier such that the distance between the protection device and the optical record carrier is less than the free working distance. The lens satisfies the condition: where D is the entrance pupil diameter, FWD is the free working distance, and D, FWD, t and td are all expressed in millimeters and where FWD+td/nd

摘要翻译： 一种用于扫描光学记录载体（2）的信息层（4）的光学扫描装置（1），所述装置（1）包括用于产生辐射束（12,15,20）的辐射源（11）和 目标系统（18），用于将辐射束会聚在信息层上，信息层被厚度为td的透明层（3）和折射率nd覆盖。 物镜系统包括具有保护装置的透镜，该保护装置从透镜朝向光学记录载体突出，使得保护装置与光学记录载体之间的距离小于自由工作距离。 透镜满足条件：其中D是入射光瞳直径，FWD是自由工作距离，D，FWD，t和td都以毫米表示，其中FWD + td / nd <0.51。

公开(公告)号：US09658219B2

公开(公告)日：2017-05-23

申请号：US12518164

申请日：2007-12-10

申请人： Coen Adrianus Verschuren ,  Dominique Maria Bruls ,  Albert Hendrik Jan Immink ,  Femke Karina De Theije ,  Thea Van Der Wijk ,  Alexander Marc Van Der Lee ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Coen Adrianus Verschuren ,  Dominique Maria Bruls ,  Albert Hendrik Jan Immink ,  Femke Karina De Theije ,  Thea Van Der Wijk ,  Alexander Marc Van Der Lee ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01N21/552 ,  G01N21/64 ,  G01N33/543 ,  G01N27/74 ,  G01N21/39

CPC分类号： G01N33/543 ,  G01N21/552 ,  G01N21/553 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/648 ,  G01N27/745 ,  G01N33/54306 ,  G01N33/54386 ,  Y10S436/00

摘要： A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.

公开(公告)号：US20120250005A1

公开(公告)日：2012-10-04

申请号：US13498482

申请日：2010-09-23

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Josephus Arnoldus Henricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Josephus Arnoldus Henricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko

IPC分类号： G01N21/49 ,  G01R33/12

CPC分类号： G01N33/54373 ,  G01N15/10 ,  G01N15/1031 ,  G01N21/47 ,  G01N21/49 ,  G01N21/51 ,  G01N21/552 ,  G01N21/6458 ,  G01N27/72 ,  G01N33/54313 ,  G01N2015/0065 ,  G01N2201/12 ,  G01R33/1269

摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface, a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic sub-units separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.

摘要翻译： 本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一 生物传感器磁体组件，其包括由间隙分隔开的至少两个磁性子单元;第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学 通过磁体组件的间隙实现检测。

公开(公告)号：US08228506B2

公开(公告)日：2012-07-24

申请号：US12670148

申请日：2008-07-17

申请人： Dominique Maria Bruls ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Dominique Maria Bruls ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01B9/02 ,  G01N21/00 ,  G01N21/55

CPC分类号： G01N21/552 ,  G01N21/648 ,  G01N27/745 ,  G01N2201/064 ,  G01N2201/0691 ,  G01N2201/0696

摘要： A microelectronic sensor device and a method for making optical examinations at a carrier for the detection of magnetic particles, for example, at a contact surface of the carrier by frustrated total internal reflection (FTIR), include a light source with a laser modulator for emitting an input light beam into the carrier. The input light beam is modulated such that optical interferences with reflections of the input light beam from the entrance window, or from other components of the carrier, are reduced or minimized. This can be achieved by a pulsed on/off modulation in which the first relaxation minimum of a currently emitted pulse (PN) coincides in the light source with the first relaxation maximum of a reflected pulse (PN-1′). By reducing the effect of interferences, the setup is less prone to disturbances from dimensional variations that are induced by thermal extension, for example.

摘要翻译： 微电子传感器装置和用于在载体处用于检测磁性颗粒的光学检查的方法，例如通过沮丧的全内反射（FTIR）在载体的接触表面处，包括具有用于发射的激光调制器的光源 输入光束进入载体。 输入光束被调制成使得来自入口窗口的输入光束或者来自载体的其它部件的反射的光学干涉被减小或最小化。 这可以通过脉冲开/关调制来实现，其中当前发射的脉冲（PN）的第一弛豫最小值在光源中与反射脉冲（PN-1'）的第一弛豫最大值重合。 通过减少干扰的影响，例如，该设置不容易受到由热延伸引起的尺寸变化的干扰。

公开(公告)号：US20120170042A1

公开(公告)日：2012-07-05

申请号：US13395932

申请日：2010-09-13

申请人： Josephus Arnoldus Hendrcus Maria Kahlman ,  Theodorus Petru Henricus Gerardus Jansen ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Josephus Arnoldus Hendrcus Maria Kahlman ,  Theodorus Petru Henricus Gerardus Jansen ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01N21/59

CPC分类号： G01N21/8483

摘要： The invention relates to a sensing system for sensing a substance in a fluid. The sensing system comprises a sensing site (132) at which the substance is to be sensed and a reference site (131). A signal generation unit generates a sensing signal by sensing the sensing site (132) and a reference signal by sensing the reference site (131). The reference signal is used for normalizing the sensing signal, wherein the sensing site (132) and the reference site (131) are arranged such that a drift variation of the normalized sensing signal is within a noise variation of the normalized sensing signal. This improves the accuracy of the normalized sensing signal.

摘要翻译： 本发明涉及用于感测流体中的物质的感测系统。 感测系统包括感测部位（132），物体被检测到的感测部位（132）和参考部位（131）。 信号生成单元通过感测检测位置（132）和感测参考位置（131）的参考信号来生成感测信号。 参考信号用于归一化感测信号，其中感测位置（132）和参考位置（131）被布置成使得归一化感测信号的漂移变化在归一化感测信号的噪声变化之内。 这提高了归一化感测信号的精度。