-
公开(公告)号:US09075052B2
公开(公告)日:2015-07-07
申请号:US13498482
申请日:2010-09-23
申请人: Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人: Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
IPC分类号: G01N21/00 , G01N33/543 , G01N21/47 , G01N21/552 , G01N21/64 , G01R33/12 , G01N21/51 , G01N21/49 , G01N27/72 , G01N15/10 , G01N15/00
CPC分类号: G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要: A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译: 用于检测颗粒的生物传感器系统包括具有传感器表面的生物传感器盒。 生物传感器磁体组件设置在盒的一侧,用于在盒和传感器表面产生有效的磁场。 生物传感器磁体组件包括由间隙分开的至少两个磁性子单元。 第一光学检测系统检测与磁体组件布置在盒的同一侧的颗粒。 磁体组件和第一光学传感器被布置成使得通过磁体组件的间隙实现光学检测。
-
公开(公告)号:US20120250005A1
公开(公告)日:2012-10-04
申请号:US13498482
申请日:2010-09-23
申请人: Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
发明人: Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Josephus Arnoldus Henricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko
CPC分类号: G01N33/54373 , G01N15/10 , G01N15/1031 , G01N21/47 , G01N21/49 , G01N21/51 , G01N21/552 , G01N21/6458 , G01N27/72 , G01N33/54313 , G01N2015/0065 , G01N2201/12 , G01R33/1269
摘要: The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface, a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic sub-units separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.
摘要翻译: 本发明涉及一种用于检测颗粒的生物传感器系统,包括:生物传感器盒,包括传感器表面,在盒的一侧上的生物传感器磁体组件,用于产生在盒和感测器表面有效的磁场;第一 生物传感器磁体组件,其包括由间隙分隔开的至少两个磁性子单元;第一光学检测系统,用于检测与磁体组件位于盒的同一侧的颗粒,而磁体组件设计成使得光学 通过磁体组件的间隙实现检测。
-
公开(公告)号:US09339813B2
公开(公告)日:2016-05-17
申请号:US13516060
申请日:2010-12-10
申请人: Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人: Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号: G01N21/17 , B01L3/00 , G01N21/552 , G01N21/84 , G01N33/543
CPC分类号: B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要: The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译: 本发明涉及一种用于确定流体内物质的物质确定装置。 颗粒附着物质并结合到结合表面(30),其中根据结合的颗粒产生感测信号。 根据产生的感测信号确定指示结合表面(30)上的颗粒结合的结合事件,并且基于所确定的结合事件确定流体内的物质。 在确定流体内的物质的过程中,颗粒可能结合到结合表面并且可能离开结合表面。 因此,在此过程中,可以确定许多结合事件比结合粒子的数量大得多。 因此,流体内的物质的测定可以基于非常大量的数据,从而提高确定流体内物质的准确性。
-
公开(公告)号:US20120329039A1
公开(公告)日:2012-12-27
申请号:US13516060
申请日:2010-12-10
申请人: Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
发明人: Josephus Arnoldus Henricus Maria Kahlman , Joannes Baptist Adrianus Dionisius Van Zon , Johannes Joseph Hubertina Barbara Schleipen , Derk Jan Wilfred Klunder , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout
IPC分类号: G01N33/566 , C12M1/34 , C12Q1/70 , G01N30/00 , G01N33/53
CPC分类号: B01L3/5027 , B01L2200/0605 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N21/552 , G01N21/8483 , G01N33/54373
摘要: The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.
摘要翻译: 本发明涉及一种用于确定流体内物质的物质确定装置。 颗粒附着物质并结合到结合表面(30),其中根据结合的颗粒产生感测信号。 根据产生的感测信号确定指示结合表面(30)上的颗粒结合的结合事件,并且基于所确定的结合事件确定流体内的物质。 在确定流体内的物质的过程中,颗粒可能结合到结合表面并且可能离开结合表面。 因此,在此过程中,可以确定许多结合事件比结合粒子的数量大得多。 因此,流体内的物质的测定可以基于非常大量的数据,从而提高确定流体内物质的准确性。
-
公开(公告)号:US09772272B2
公开(公告)日:2017-09-26
申请号:US13498615
申请日:2010-09-24
申请人: Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人: Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
IPC分类号: G01N15/06 , G01N15/14 , G01N21/47 , G01N21/552 , G01N21/64 , G01N27/74 , G01N33/543 , G01N15/02 , G01N35/00
CPC分类号: G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要: A substance determining apparatus determines a substance within a fluid where particles, which have attached the substance, are bound to a binding surface. A sensing unit is configured to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface and the binding surface, and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit is configured to discriminate between different kinds of binding of the particles bound on the binding surface depending on the generated sensing signal. The binding discrimination unit may be a unit for determining the part of the sensing signal being caused by specifically bound particles and for determining the substance based on this determined part of the sensing signal.
-
公开(公告)号:US20120202194A1
公开(公告)日:2012-08-09
申请号:US13498615
申请日:2010-09-24
申请人: Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
发明人: Toon Hendrik Evers , Johannes Joseph Hubertina Barbara Schleipen , Joannes Baptist Adrianus Dionisius Van Zon , Derk Jan Wilfred Klunder , Josephus Arnoldus Hendricus Maria Kahlman , Ron Martinus Laurentius Van Lieshout , Mikhail Mikhaylovich Ovsyanko , Kim Van Ommering
CPC分类号: G01N15/0612 , G01N15/1434 , G01N21/47 , G01N21/552 , G01N21/648 , G01N27/745 , G01N33/54333 , G01N35/0098 , G01N2015/025 , G01N2201/0627
摘要: The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.
摘要翻译: 本发明涉及一种用于确定流体内物质的物质确定装置。 具有附着物质的颗粒结合至结合表面(30)。 感测单元(33)适于产生感测信号,该感测信号指示i)结合在装订表面(30)和装订表面(30)上的颗粒之间的距离和ii)平面内位置 的结合表面上的颗粒。 绑定识别单元(34)适于根据产生的感测信号来区分绑定在绑定表面(30)上的粒子的不同种类的绑定。 装订识别单元(34)优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元,并且基于该确定的感测信号的部分来确定物质。
-
公开(公告)号:US09612239B2
公开(公告)日:2017-04-04
申请号:US14001566
申请日:2012-02-27
申请人: Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
发明人: Joannes Baptist Adrianus Dionisius Van Zon , Toon Hendrik Evers , Ron Martinus Laurentius Van Lieshout , Wilhelmina Maria Hardeman , Derk Jan Wilfred Klunder
IPC分类号: G01N21/17 , G01N33/543 , G01N21/552 , G01N21/64 , G01N21/77 , G01N27/74
CPC分类号: G01N33/54326 , G01N21/552 , G01N21/648 , G01N21/7703 , G01N27/745
摘要: The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.
-
公开(公告)号:US20130141726A1
公开(公告)日:2013-06-06
申请号:US13695828
申请日:2011-04-26
IPC分类号: G01N21/55
CPC分类号: G01N21/55 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/04 , B01L2200/0684 , B01L2200/143 , B01L2300/025 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/0677 , G01N21/274 , G01N21/552 , G01N21/553 , G01N21/648 , G01N21/65 , G01N21/76 , G01N29/022 , G01N29/30 , G01N2021/0346 , G01N2021/7723 , G01N2201/0221 , G01N2291/0255 , G01N2291/0256 , Y10T29/49826
摘要: The invention relates to a sensing device (1) for detecting a substance (3) in a fluid (6), wherein the sensing device (1) comprises a sensing region (2) for being used for generating a sensing signal depending on the substance, a reference region (4) for being used for providing a reference signal, and a reference element (5) covering the reference region (4). The reference element (5) is adapted to shield the reference region (4) from the substance (3) and to allow the fluid (6) to penetrate the reference element (5). This reduces the influence of the reference signal by the substance (3) and, since the reference element (5) is adapted to allow the fluid (6) to penetrate the reference element (5), differences regarding properties of the fluid (6) at the sensing region (2) and of the reference element (5) at the reference region (4) can be reduced. This reduction leads to an improved reference signal, which can be used, for example, for correcting the sensing signal.
摘要翻译: 本发明涉及一种用于检测流体(6)中的物质(3)的感测装置(1),其中感测装置(1)包括感测区域(2),用于根据物质产生感测信号 ,用于提供参考信号的参考区域(4)和覆盖参考区域(4)的参考元件(5)。 参考元件(5)适于屏蔽参考区域(4)与物质(3)并允许流体(6)穿透参考元件(5)。 这样减少了物质(3)的参考信号的影响,并且由于参考元件(5)适于允许流体(6)穿透参考元件(5),所以关于流体(6)的性质的差异, 可以减小在参考区域(4)处的感测区域(2)和参考元件(5)。 这种减少导致改进的参考信号,其可以用于例如用于校正感测信号。
-
-
-
-
-
-
-