公开(公告)号：US09772272B2

公开(公告)日：2017-09-26

申请号：US13498615

申请日：2010-09-24

申请人： Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Josephus Arnoldus Hendricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko ,  Kim Van Ommering

发明人： Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Josephus Arnoldus Hendricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko ,  Kim Van Ommering

IPC分类号： G01N15/06 ,  G01N15/14 ,  G01N21/47 ,  G01N21/552 ,  G01N21/64 ,  G01N27/74 ,  G01N33/543 ,  G01N15/02 ,  G01N35/00

CPC分类号： G01N15/0612 ,  G01N15/1434 ,  G01N21/47 ,  G01N21/552 ,  G01N21/648 ,  G01N27/745 ,  G01N33/54333 ,  G01N35/0098 ,  G01N2015/025 ,  G01N2201/0627

摘要： A substance determining apparatus determines a substance within a fluid where particles, which have attached the substance, are bound to a binding surface. A sensing unit is configured to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface and the binding surface, and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit is configured to discriminate between different kinds of binding of the particles bound on the binding surface depending on the generated sensing signal. The binding discrimination unit may be a unit for determining the part of the sensing signal being caused by specifically bound particles and for determining the substance based on this determined part of the sensing signal.

公开(公告)号：US20120202194A1

公开(公告)日：2012-08-09

申请号：US13498615

申请日：2010-09-24

申请人： Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Josephus Arnoldus Hendricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko ,  Kim Van Ommering

发明人： Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Josephus Arnoldus Hendricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko ,  Kim Van Ommering

IPC分类号： G01N21/63 ,  C12M1/34 ,  C12Q1/02 ,  C12Q1/70 ,  G01N33/53 ,  G01N21/64

CPC分类号： G01N15/0612 ,  G01N15/1434 ,  G01N21/47 ,  G01N21/552 ,  G01N21/648 ,  G01N27/745 ,  G01N33/54333 ,  G01N35/0098 ,  G01N2015/025 ,  G01N2201/0627

摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles, which have attached the substance, are bound to a binding surface (30). A sensing unit (33) is adapted to generate a sensing signal being indicative of at least one of i) a distance between the particles bound on the binding surface (30) and the binding surface (30) and ii) an in-plane position of the particles bound on the binding surface. A binding discrimination unit (34) is adapted to discriminate between different kinds of binding of the particles bound on the binding surface (30) depending on the generated sensing signal. The binding discrimination unit (34) is preferentially a unit for determining the part of the sensing signal being caused by specifically bound particles and to determine the substance based on this determined part of the sensing signal.

摘要翻译： 本发明涉及一种用于确定流体内物质的物质确定装置。 具有附着物质的颗粒结合至结合表面（30）。 感测单元（33）适于产生感测信号，该感测信号指示i）结合在装订表面（30）和装订表面（30）上的颗粒之间的距离和ii）平面内位置 的结合表面上的颗粒。 绑定识别单元（34）适于根据产生的感测信号来区分绑定在绑定表面（30）上的粒子的不同种类的绑定。 装订识别单元（34）优选地是用于确定由特定结合的粒子引起的感测信号的部分的单元，并且基于该确定的感测信号的部分来确定物质。

公开(公告)号：US09075052B2

公开(公告)日：2015-07-07

申请号：US13498482

申请日：2010-09-23

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Josephus Arnoldus Henricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Josephus Arnoldus Henricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko

IPC分类号： G01N21/00 ,  G01N33/543 ,  G01N21/47 ,  G01N21/552 ,  G01N21/64 ,  G01R33/12 ,  G01N21/51 ,  G01N21/49 ,  G01N27/72 ,  G01N15/10 ,  G01N15/00

CPC分类号： G01N33/54373 ,  G01N15/10 ,  G01N15/1031 ,  G01N21/47 ,  G01N21/49 ,  G01N21/51 ,  G01N21/552 ,  G01N21/6458 ,  G01N27/72 ,  G01N33/54313 ,  G01N2015/0065 ,  G01N2201/12 ,  G01R33/1269

摘要： A biosensor system for the detection of particles includes a biosensor cartridge having a sensor surface. A biosensor magnet assembly is disposed on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface. The biosensor magnet assembly includes at least two magnetic sub-units separated by a gap. A first optical detection system detects the particles arranged at the same side of the cartridge as the magnet assembly. The magnet assembly and the first optical sensor are disposed such that the optical detection is accomplished through the gap of the magnet assembly.

摘要翻译： 用于检测颗粒的生物传感器系统包括具有传感器表面的生物传感器盒。 生物传感器磁体组件设置在盒的一侧，用于在盒和传感器表面产生有效的磁场。 生物传感器磁体组件包括由间隙分开的至少两个磁性子单元。 第一光学检测系统检测与磁体组件布置在盒的同一侧的颗粒。 磁体组件和第一光学传感器被布置成使得通过磁体组件的间隙实现光学检测。

公开(公告)号：US20120250005A1

公开(公告)日：2012-10-04

申请号：US13498482

申请日：2010-09-23

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Josephus Arnoldus Henricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Josephus Arnoldus Henricus Maria Kahlman ,  Ron Martinus Laurentius Van Lieshout ,  Mikhail Mikhaylovich Ovsyanko

IPC分类号： G01N21/49 ,  G01R33/12

CPC分类号： G01N33/54373 ,  G01N15/10 ,  G01N15/1031 ,  G01N21/47 ,  G01N21/49 ,  G01N21/51 ,  G01N21/552 ,  G01N21/6458 ,  G01N27/72 ,  G01N33/54313 ,  G01N2015/0065 ,  G01N2201/12 ,  G01R33/1269

摘要： The present invention is related to a biosensor system for the detection of particles comprising: a biosensor cartridge comprising a sensor surface, a biosensor magnet assembly on one side of the cartridge for generating a magnetic field effective at the cartridge and the sensor surface, the first biosensor magnet assembly comprising at least two magnetic sub-units separated by a gap, a first optical detection system for detecting the particles arranged at the same side of the cartridge as the magnet assembly, whereas the magnet assembly is designed in a way that the optical detection is accomplished through the gap of the magnet assembly.

摘要翻译： 本发明涉及一种用于检测颗粒的生物传感器系统，包括：生物传感器盒，包括传感器表面，在盒的一侧上的生物传感器磁体组件，用于产生在盒和感测器表面有效的磁场;第一 生物传感器磁体组件，其包括由间隙分隔开的至少两个磁性子单元;第一光学检测系统，用于检测与磁体组件位于盒的同一侧的颗粒，而磁体组件设计成使得光学 通过磁体组件的间隙实现检测。

公开(公告)号：US09339813B2

公开(公告)日：2016-05-17

申请号：US13516060

申请日：2010-12-10

申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Johannes Joseph Hubertina Barbara Schleipen ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Ron Martinus Laurentius Van Lieshout

发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Johannes Joseph Hubertina Barbara Schleipen ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Ron Martinus Laurentius Van Lieshout

IPC分类号： G01N21/17 ,  B01L3/00 ,  G01N21/552 ,  G01N21/84 ,  G01N33/543

CPC分类号： B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N21/552 ,  G01N21/8483 ,  G01N33/54373

摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.

摘要翻译： 本发明涉及一种用于确定流体内物质的物质确定装置。 颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。 根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。 在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。 因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。 因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

公开(公告)号：US20120329039A1

公开(公告)日：2012-12-27

申请号：US13516060

申请日：2010-12-10

申请人： Josephus Arnoldus Henricus Maria Kahlman ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Johannes Joseph Hubertina Barbara Schleipen ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Ron Martinus Laurentius Van Lieshout

发明人： Josephus Arnoldus Henricus Maria Kahlman ,  Joannes Baptist Adrianus Dionisius Van Zon ,  Johannes Joseph Hubertina Barbara Schleipen ,  Derk Jan Wilfred Klunder ,  Toon Hendrik Evers ,  Ron Martinus Laurentius Van Lieshout

IPC分类号： G01N33/566 ,  C12M1/34 ,  C12Q1/70 ,  G01N30/00 ,  G01N33/53

CPC分类号： B01L3/5027 ,  B01L2200/0605 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N21/552 ,  G01N21/8483 ,  G01N33/54373

摘要： The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface (30), wherein a sensing signal is generated depending on the bound particles. Binding events indicating a binding of a particle on the binding surface (30) are determined from the generated sensing signal, and the substance within the fluid is determined based on the determined binding events. During a procedure of determining a substance within a fluid, particles may bind to the binding surface and may leave the binding surface. Therefore, during this procedure a number of binding events can be determined being much larger than the number of bound particles. The determination of the substance within the fluid can therefore be based on a very large amount of data, thereby increasing the accuracy of determining the substance within the fluid.

摘要翻译： 本发明涉及一种用于确定流体内物质的物质确定装置。 颗粒附着物质并结合到结合表面（30），其中根据结合的颗粒产生感测信号。 根据产生的感测信号确定指示结合表面（30）上的颗粒结合的结合事件，并且基于所确定的结合事件确定流体内的物质。 在确定流体内的物质的过程中，颗粒可能结合到结合表面并且可能离开结合表面。 因此，在此过程中，可以确定许多结合事件比结合粒子的数量大得多。 因此，流体内的物质的测定可以基于非常大量的数据，从而提高确定流体内物质的准确性。

公开(公告)号：US08390817B2

公开(公告)日：2013-03-05

申请号：US12810867

申请日：2008-12-18

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Hendricus Maria Kahlman

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Hendricus Maria Kahlman

IPC分类号： G01N21/55 ,  G01N21/00

CPC分类号： G01N21/552

摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.

摘要翻译： 本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。 所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。 该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

公开(公告)号：US20130114076A1

公开(公告)日：2013-05-09

申请号：US13809304

申请日：2011-07-05

申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Albert Hendrik Jan Immink ,  Menno William Jose Prins ,  Derk Jan Wilfred Klunder

发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Albert Hendrik Jan Immink ,  Menno William Jose Prins ,  Derk Jan Wilfred Klunder

IPC分类号： G01N21/01

CPC分类号： G01N21/01 ,  A61B5/0059 ,  B01L3/508 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0822 ,  B01L2300/0887 ,  B01L2400/043 ,  G01N21/552 ,  G01N21/648 ,  G01N21/7703

摘要： The invention relates to a cartridge (110) and an examination apparatus (100) for optical examinations of a sample. The cartridge (110) comprises a transparent bottom layer (113) that is of substantially uniform thickness and a top layer (111, 112) comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a C roll-to-roll process. The bottom layer (113) is provided with structures like gratings (115) that allow the incoupling or outcoupling of light.

摘要翻译： 本发明涉及用于样品光学检查的盒（110）和检查装置（100）。 盒（110）包括具有基本均匀厚度的透明底层（113）和包括样品室（SC）的顶层（111,112）。 底层和顶层优选层压在彼此上，例如以C卷对卷方法。 底层（113）设置有允许光耦合或耦合的光栅（115）的结构。

公开(公告)号：US20120040475A1

公开(公告)日：2012-02-16

申请号：US13201927

申请日：2010-02-08

申请人： Dominique Maria Bruls ,  Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Dominique Maria Bruls ,  Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01N21/55

CPC分类号： G01N21/552 ,  G01N21/274 ,  G01N33/54373

摘要： The present invention relates to a sensing device (100) for detecting a target substance (2) in an investigation region (113). The sensing device (100) comprises a sensing surface (112) with an investigation region (113) and a reference region (120) thereon. The sensing device (100) further comprises a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing an improved correction of light reflected at the investigation region (113).

摘要翻译： 本发明涉及一种用于在调查区域（113）中检测目标物质（2）的感测装置（100）。 感测装置（100）包括其上具有调查区域（113）和参考区域（120）的感测表面（112）。 感测装置（100）还包括位于参考区域（120）处的参考元件（121）。 参考元件（121）适于屏蔽参考区域（120）与目标物质（2），使得在全内反射条件下在参考区域（120）处反射的光线不会受到目标物质的存在或不存在的影响 （2）。 这允许独立于目标物质（2）的存在或不存在来测量在参考区域（120）处反射的光的特性（通常为强度）。 反射光的测量特性可用于对在调查区域（113）反射的光进行改进的校正。

公开(公告)号：US09804089B2

公开(公告)日：2017-10-31

申请号：US13201927

申请日：2010-02-08

申请人： Dominique Maria Bruls ,  Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen

发明人： Dominique Maria Bruls ,  Toon Hendrik Evers ,  Johannes Joseph Hubertina Barbara Schleipen

IPC分类号： G01N21/552 ,  G01N33/543 ,  G01N21/27

CPC分类号： G01N21/552 ,  G01N21/274 ,  G01N33/54373

摘要： A sensing device (100) detects a target substance (2) in an investigation region (113). The sensing device (100) includes a sensing surface (112) with an investigation region (113) and a reference region (120). The sensing device (100) further includes a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing a correction of light reflected at the investigation region (113).