公开(公告)号：US06772781B2

公开(公告)日：2004-08-10

申请号：US09764424

申请日：2001-01-19

申请人： Dean L. Doty ,  Yan Xu ,  Stephen Chesters ,  Ben R. Hall ,  Roger Q. Petton ,  Thomas P. Ross ,  Charles A. White ,  Reginald Wynne

发明人： Dean L. Doty ,  Yan Xu ,  Stephen Chesters ,  Ben R. Hall ,  Roger Q. Petton ,  Thomas P. Ross ,  Charles A. White ,  Reginald Wynne

IPC分类号： E03B100

CPC分类号： G05D11/138 ,  G05D11/132 ,  Y10T137/0329 ,  Y10T137/0363 ,  Y10T137/2509 ,  Y10T137/87249 ,  Y10T137/87692

摘要： Provided are apparatuses and methods for mixing gases. The apparatuses are suitable for use in the manufacture of an electronic device. The apparatuses include a gas mixing manifold. A first, bulk gas source is connected to introduce a flow of a first gas to the manifold. A second gas source is connected to introduce a flow of a second gas to the manifold. The first and second gases are mixed in the manifold, thereby forming a gas mixture. A conduit is connected to one or more point of use for introducing a flow of the gas mixture thereto. The present invention is particularly applicable in the semiconductor manufacturing industry.

摘要翻译： 提供了用于混合气体的装置和方法。 这些装置适用于制造电子装置。 这些装置包括气体混合歧管。 连接第一体积气体源以将第一气体的流动引入歧管。 第二气体源被连接以将第二气体的流动引入歧管。 第一和第二气体在歧管中混合，从而形成气体混合物。 导管连接到一个或多个使用点以将气体混合物的流引入其中。 本发明特别适用于半导体制造业。

公开(公告)号：US5519842A

公开(公告)日：1996-05-21

申请号：US23560

申请日：1993-02-26

申请人： Deif N. Atallah ,  Yan Xu

发明人： Deif N. Atallah ,  Yan Xu

IPC分类号： G06F9/34 ,  G06F12/04 ,  G06F13/00

CPC分类号： G06F12/04 ,  G06F9/34

摘要： A system which is able to perform unaligned big endian and little endian accesses to memory with little or no added overhead to the system. In the preferred embodiment, the processor operates in little endian data format. The memory, however, can store data in big endian and little endian format in different memory regions. If an unaligned access is to be performed, the access requires translation to corresponding aligned memory accesses. However, if the processor operates in little endian format and accesses are to memory which store according big endian format, special code is required to perform proper translation of accesses. When the address generation unit of the processor detects an unaligned memory access, an unaligned signal is set which causes a microassist to initiate a microflow to execute microcode which performs the necessary translations for unaligned accesses. The address generation unit also sends the address to be access to the memory region table which maintains information regarding each memory region, including whether the region is big endian or little endian. The state bit indicative of the data format is logically combined with the unaligned access signal to generate an output which sets the state of the flag. The flag is then accessed by the microcode to determine the translation routine to process the memory access.

摘要翻译： 能够对系统执行不重要的大端和小端访问的系统，很少或没有额外的开销。 在优选实施例中，处理器以小的数据格式进行操作。 然而，存储器可以在不同的存储器区域中存储大端和小端格式的数据。 如果要执行未对齐的访问，则访问需要转换为对应的对齐的存储器访问。 然而，如果处理器以小的端格式操作，并且访问是根据大端格式存储的存储器，则需要特殊代码来执行适当的访问转换。 当处理器的地址生成单元检测到未对齐的存储器访问时，设置未对齐的信号，其使微辅助器发起微流以执行对未对齐访问执行必要的转换的微代码。 地址生成单元还将要访问的地址发送到维护关于每个存储区域的信息的存储器区域表，包括该区域是大端还是小端。 指示数据格式的状态位与未对准的访问信号逻辑组合以产生设置标志状态的输出。 然后，该标记由微码访问以确定翻译程序来处理存储器访问。

公开(公告)号：USD975453S1

公开(公告)日：2023-01-17

申请号：US29720975

申请日：2020-01-16

申请人： Yan Xu

设计人： Yan Xu

公开(公告)号：USD964049S1

公开(公告)日：2022-09-20

申请号：US29720979

申请日：2020-01-16

申请人： Yan Xu

设计人： Yan Xu

公开(公告)号：US10323247B2

公开(公告)日：2019-06-18

申请号：US15995134

申请日：2018-06-01

申请人： Xiaowei Yu ,  Yan Xu

发明人： Xiaowei Yu ,  Yan Xu

IPC分类号： C12N9/20 ,  C12N15/00 ,  C12N1/20 ,  C12P21/06 ,  C12P21/04 ,  C12N1/14 ,  C07H21/04 ,  C07K1/00 ,  C12N15/62 ,  C07K14/38 ,  C12N15/81 ,  C12N9/50

摘要： The invention discloses a method for improving the extracellular expression level of a foreign protein by means of phospholipase fusion expression. Four proteins, PLA2, MBP, CBD and SUMO, are used as a fusion tag to construct a fusion gene. Compared with an original protein MOH without any fusion tag, the extracellular expression level and enzymatic activity of all the four fusion proteins are increased to some degree. Among them, the fusion protein using PLA2 as the fusion tag has the highest expression level, which is 7.4 times higher than that of the original protein. Compared with other fusion tags, PLA2 has a low molecular weight and the fusion protein having PLA2 as the fusion tag has the highest expression level (up to 12 g·L−1 in a 7 L fermentation tank for high-density fermentation). It is shown that the secretory expression of a foreign protein can be effectively increased by using PLA2 as a fusion tag.

公开(公告)号：US10091495B2

公开(公告)日：2018-10-02

申请号：US14654804

申请日：2012-12-24

申请人： Jianping Song ,  Lin Du ,  Yan Xu

发明人： Jianping Song ,  Lin Du ,  Yan Xu

IPC分类号： H04N21/43 ,  H04N13/30 ,  H04N13/04 ,  H04N5/45 ,  H04N21/431 ,  H04N21/81 ,  H04N13/00

摘要： One aspect of the disclosed invention relates to a stereoscopic display apparatus comprising: a stereo image acquisition unit configured to acquire a first stereo image for a first image and a second stereo image for a second image; a border generation unit configured to generate a border for separating the first image from the second image; and a displaying unit configured to combine the second stereo image and the generated border with the first stereo image and display the combined stereo images.

公开(公告)号：US10023882B1

公开(公告)日：2018-07-17

申请号：US15641268

申请日：2017-07-04

申请人： Rongzhen Zhang ,  Yan Xu ,  Yaohui Li

发明人： Rongzhen Zhang ,  Yan Xu ,  Yaohui Li

IPC分类号： C12N9/02 ,  C12P7/02 ,  C12N11/18 ,  C12P7/22 ,  C12N9/04 ,  C12P17/12

摘要： Provided are novel hetero-oligomers of (S)-carbonyl reductases and their application in catalyzing the reduction of polyphenyl ketones. Also provided are recombinant strains expressing hetero-oligomers of SCR/SCR2 or SCR2/SCR3, which can catalyze the reduction of polyphenyl ketones. The hetero-oligomer of SCR/SCR2 is capable of catalyzing 2,4-dichlorobenzophenone, 2-naphthalenone and [(E)-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic acid methyl ester (Keto Easter M) with a specific activity of 4.55 U/mg, 2.43 U/mg and 0.86 U/mg, respectively. The hetero-oligomer of SCR2/SCR3 is capable of catalyzing 2,4-dichlorobenzophenone and [(E)-2-[3-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic acid methyl ester (Keto Easter M) with a specific activity of 4.42 U/mg and 1.21 U/mg, respectively. No catalyzing activities for reducing polyphenyl ketones were detected in the naturally existing homo-oligomers of SCR, SCR2 or SCR3, which can catalyze the reduction of monobenzoic cyclic compounds. The invention expands the substrate spectrum of natural (S)-carbonyl reductases (SCR, SCR2 and SCR3) and provides a novel type of oxidoreductases for catalyzing the reduction of polyphenyl ketones.

公开(公告)号：US09624288B2

公开(公告)日：2017-04-18

申请号：US14650859

申请日：2013-12-09

申请人： Yan Xu ,  Pei Tang ,  Tommy Tillman

发明人： Yan Xu ,  Pei Tang ,  Tommy S. Tillman

IPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/195 ,  C07K14/27 ,  A61K38/16 ,  A61K38/17 ,  B82Y5/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K38/164 ,  A61K38/177 ,  B82Y5/00 ,  C07K14/195 ,  C07K14/27 ,  C07K2319/00 ,  C07K2319/03

摘要： Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed. The use of these compositions and nanoparticles, such as for the treatment of pain, cystic fibrosis and asthma, is also disclosed.

公开(公告)号：US20150266926A1

公开(公告)日：2015-09-24

申请号：US14412497

申请日：2011-12-19

申请人： Xun Xu ,  Yan Xu

发明人： Xun Xu ,  Yan Xu

IPC分类号： C07K14/00

CPC分类号： C07K14/001 ,  A61K38/00 ,  C07K14/4705

摘要： The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.

摘要翻译： 本发明提供富含亮氨酸并用于预防和抑制炎症的多肽及其应用。 本发明还提供了制备多肽的方法和含有多肽的药物组合物。 多肽的优点包括：分子量小，以渗透各种眼组织屏障; 水溶性高，以至于在中性眼泪，房水和玻璃体液中具有高溶解性; 和简单的合成，从而具有较低的制备成本。

公开(公告)号：US08802895B2

公开(公告)日：2014-08-12

申请号：US12906315

申请日：2010-10-18

申请人： Bin Su ,  Aimin Zhou ,  Yan Xu

发明人： Bin Su ,  Aimin Zhou ,  Yan Xu

IPC分类号： C07C303/00

CPC分类号： C07C311/08 ,  C07C2601/08 ,  C07D261/18 ,  C07D307/68 ,  C07D317/60 ,  C07D333/38

摘要： The invention provides a compound of formula (I), a pharmaceutical composition thereof, a method of preparing a medicament for the treatment of a cancer, and a method of treating cancers. The invention exhibits merits against cancers such as significantly higher potency and effectiveness over a broader range of cancers. In formula (I), Ra is a benzyl group with alkyl and/or alkoxy; Rb is selected from H and alkyl groups; Rf is an alkyl; and R3 is selected from a substituted phenyl, a heterocyclic group, and wherein Rc is selected from a fused ring, fused rings, and any bivalent cyclic group.

摘要翻译： 本发明提供式（I）化合物，其药物组合物，制备用于治疗癌症的药物的方法和治疗癌症的方法。 本发明表现出对癌症的优点，例如在更广泛的癌症上显着更高的效力和有效性。 在式（I）中，R a为具有烷基和/或烷氧基的苄基; Rb选自H和烷基; Rf是烷基; 并且R 3选自取代的苯基，杂环基，并且其中R c选自稠环，稠环和任何二价环状基团。