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87 条记录 (耗时 0.129 秒)

    Antibodies to IL-6 and use thereof
    25.
    发明授权
    Antibodies to IL-6 and use thereof 有权
    IL-6抗体及其用途

    公开(公告)号：US07935340B2

    公开(公告)日：2011-05-03

    申请号：US12153612

    申请日：2008-05-21

    申请人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

    发明人： Leon Garcia-Martinez ,  Anne Elisabeth Carvalho Jensen ,  Katie Olson ,  Ben Dutzar ,  Ethan Ojala ,  Brian Kovacevich ,  John Latham ,  Jeffrey T. L. Smith

    IPC分类号： A61K39/395 ,  C07K16/24 ,  C12P21/08

    CPC分类号： C07K16/248 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/94

    摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.

    摘要翻译： 本发明涉及对IL-6具有结合特异性的抗体及其片段。 本发明的另一个实施方案涉及本文所述的抗体及其结合片段，其包含本文所述的VH，VL和CDR多肽的序列，以及编码它们的多核苷酸。 本发明还涉及抗IL-6抗体及其与一个或多个功能或可检测部分缀合的结合片段的缀合物。 本发明还考虑制备所述抗IL-6抗体及其结合片段的方法。 本发明的实施方案还涉及抗IL-6抗体及其结合片段用于诊断，评估和治疗与IL-6相关的疾病和病症的用途。 这些抗体可以结合可溶性IL-6，细胞表面表达的IL-6，IL-6 / IL-6R中的至少一种和/或阻止IL-6和IL-6R的结合，IL-6 / IL -6R和gp130，或者形成IL-6 / IL-6R / gp130多聚体，从而抑制与前述任何相关的生物学作用。

    Antibodies specific for sclerostin
    27.
    发明授权
    Antibodies specific for sclerostin 有权
    针对硬皮蛋白的特异性抗体

    公开(公告)号：US07578999B2

    公开(公告)日：2009-08-25

    申请号：US11399210

    申请日：2006-04-05

    申请人： David G. Winkler ,  Jiye Shi ,  John Latham

    发明人： David G. Winkler ,  Jiye Shi ,  John Latham

    IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18

    CPC分类号： C07K16/22 ,  A01K2217/05 ,  A01K2217/075 ,  A61K48/00 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2319/00 ,  C12N2799/021 ,  G01N33/6872 ,  G01N2333/495 ,  G01N2500/04 ,  G01N2800/108

    摘要： A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

    摘要翻译： 公开了一种新型的TGF-β结合蛋白类或家族。 还公开了用于选择用于增加骨矿化的分子的测定法和利用这种分子的方法。 特别地，提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。

    Antibodies specific for sclerostin and methods of screening and use therefor
    28.
    发明授权
    Antibodies specific for sclerostin and methods of screening and use therefor 有权
    针对硬皮蛋白的特异性抗体及其筛选和使用方法

    公开(公告)号：US07381409B2

    公开(公告)日：2008-06-03

    申请号：US10868497

    申请日：2004-06-15

    申请人： David G. Winkler ,  Jiye Shi ,  John Latham

    发明人： David G. Winkler ,  Jiye Shi ,  John Latham

    IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

    CPC分类号： C07K16/22 ,  A61K47/643 ,  A61K47/646 ,  C07K14/475 ,  C07K14/51 ,  C07K16/18 ,  C07K2317/76 ,  G01N33/6854 ,  G01N2333/4704

    摘要： Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

    摘要翻译： 提供了与特异性结合TGF-β结合蛋白的抗体相关的组合物和方法。 这些方法和组合物涉及通过干扰TGF-β结合蛋白质硬化蛋白和TGF-β超家族成员，特别是骨形态发生蛋白之间的相互作用来改变骨矿物质密度。 增加骨矿物质密度在低骨矿物质密度代表骨质减少症，骨质疏松症和骨折等疾病和病症中具有应用价值。

    Aptamers specific for biomolecules and methods of making
    29.
    发明授权
    Aptamers specific for biomolecules and methods of making 失效
    适用于生物分子和制备方法

    公开(公告)号：US5756291A

    公开(公告)日：1998-05-26

    申请号：US484192

    申请日：1995-06-07

    申请人： Linda Griffin ,  Glenn Albrecht ,  John Latham ,  Lawrence Leung ,  Eric Vermaas ,  John J. Toole

    发明人： Linda Griffin ,  Glenn Albrecht ,  John Latham ,  Lawrence Leung ,  Eric Vermaas ,  John J. Toole

    IPC分类号： C12N9/74 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C07K1/14

    CPC分类号： C12N9/6429 ,  C12Q1/6811 ,  C12Y304/21005

    摘要： A method for identifying oligomer sequences, optionally comprising modified base, which specifically bind target molecules such as serum proteins, kinins, eicosanoids and extracellular proteins is described. The method is used to generate aptamers that bind to serum Factor X, PDGF, FGF, ICAM, VCAM, E-selectin, thrombin, bradykinin, PGF2 and cell surface molecules. The technique involves complexation of the target molecule with a mixture of oligonucleotides containing random sequences and sequences which serve as primer for PCR under conditions wherein a complex is formed with the specifically binding sequences, but not with the other members of the oligonucleotide mixture. The complex is then separated from uncomplexed oligonucleotides and the complexed members of the oligonucleotide mixture are recovered from the separated complex using the polymerase chain reaction. The recovered oligonucleotides may be sequenced, and successive rounds of selection using complexation, separation, amplification and recovery can be employed. The oligonucleotides can be used for therapeutic and diagnostic purposes and for generating secondary aptamers.

    摘要翻译： 描述了用于鉴定特异性结合靶分子如血清蛋白，激肽，类花生酸和细胞外蛋白质的寡核苷酸序列的任选包含修饰的碱基的方法。 该方法用于产生与血清因子X，PDGF，FGF，ICAM，VCAM，E-选择蛋白，凝血酶，缓激肽，PGF2和细胞表面分子结合的适体。 该技术涉及将靶分子与含有随机序列和序列的寡核苷酸的混合物络合，所述随机序列和序列用作PCR引物的条件，其中用特异性结合序列形成复合物，但不与寡核苷酸混合物的其它成员形成。 然后将复合物与未络合的寡核苷酸分离，并使用聚合酶链反应从分离的复合物中回收寡核苷酸混合物的络合成员。 可以对回收的寡核苷酸进行测序，并且可以使用使用络合，分离，扩增和回收的连续轮次选择。 寡核苷酸可用于治疗和诊断目的并用于产生次级适体。