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公开(公告)号：US20090262361A1
公开(公告)日：2009-10-22
申请号：US12492985
申请日：2009-06-26
CPC分类号： A61B5/6852 , A61B5/0066 , A61B2017/00057 , A61B2017/00061 , A61B2017/22001 , G01N21/4795 , G01N2021/4742 , G02B6/0008 , G02B6/262
摘要： A catheter device for an optical coherence tomography apparatus is configured to enhance the resolution of the cross-sectional image in the azimuthal direction. The catheter device includes a drive shaft driven to rotate in a catheter sheath, an optical fiber in the drive shaft and driven to rotate with the drive shaft, and an optical component attached to a distal portion of the optical fiber. The catheter device emits light, transmitted in the optical fiber, into a body cavity through the optical component. A surface on the optical path of the optical component is a curved surface facing the drive shaft direction or the azimuthal direction to ensure that, when light emitted from the optical component is radiated into the body cavity via the catheter sheath, the difference between the diameter of the radiated light in the drive axis direction and the azimuthal direction is reduced.
摘要翻译： 用于光学相干断层摄影装置的导管装置被配置为增强方位角方向上横截面图像的分辨率。 导管装置包括被驱动以在导管护套中旋转的驱动轴，驱动轴中的光纤并被驱动以与驱动轴一起旋转，以及附接到光纤的远端部分的光学部件。 该导管装置通过光学部件将在光纤中传输的光发射到体腔内。 光学部件的光路上的表面是面向驱动轴方向或方位方向的弯曲表面，以确保当从光学部件发射的光通过导管护套辐射到体腔时，直径 的辐射光在驱动轴方向和方位角方向上减小。
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公开(公告)号：US07482427B2
公开(公告)日：2009-01-27
申请号：US11064039
申请日：2005-02-22
申请人： Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
发明人： Paul O. Zamora , Louis A. Pena , Xinhua Lin , Kazuyuki Takahashi
CPC分类号： C07K14/4705 , A61K31/727 , A61K38/00 , A61K38/1875 , A61K47/64 , A61L27/34 , C07H21/04 , C07K14/475 , C07K14/503 , C07K14/51 , C07K2319/00 , C08L89/00
摘要： Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
摘要翻译： 式I和式II的本发明的化合物在说明书中公开，其中所述化合物是骨形态发生蛋白活性的调节剂。 化合物是具有非生长因子肝素结合区的合成肽，接头和与骨形态发生蛋白的受体特异性结合的序列。 公开了本发明化合物在治疗骨损伤，退行性关节疾病和增强骨形成中的用途。
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公开(公告)号：US20080234445A1
公开(公告)日：2008-09-25
申请号：US12064343
申请日：2007-05-22
CPC分类号： C08G64/307
摘要： The object of the present invention is to provide a production method of a high molecular weight aromatic polycarbonate containing a reduced amount of a high melting point product, and having less thermal history received and excellent hue by a melt process. The present invention relates to a production method of an aromatic polycarbonate, characterized in that in producing an aromatic polycarbonate using an aromatic dihydroxy compound and a carbonic diester as raw materials and using plural reactors, a molten reactant temperature T1 (° C.) in at least one reactor A and a molten reactant temperature T2 (° C.) in a reactor B subsequent to the reactor A are satisfied with the relationship of T2
摘要翻译： 本发明的目的是提供一种高分子量芳族聚碳酸酯的制造方法，该方法含有低熔点产物，并且具有较少的热历史记录和通过熔融加工具有优异的色调。 本发明涉及一种芳族聚碳酸酯的制造方法，其特征在于，在使用芳香族二羟基化合物和碳酸二酯作为原料制造使用多个反应器的芳香族聚碳酸酯时，将熔融反应物温度T1（℃） 反应器A之后的反应器B中的至少一个反应器A和熔融反应物温度T2（℃）满足T2
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24.发明申请公开(公告)号：US20070153645A1
公开(公告)日：2007-07-05
申请号：US10579797
申请日：2005-09-26
申请人： Atsuo Kikuchi , Kazuyuki Takahashi
发明人： Atsuo Kikuchi , Kazuyuki Takahashi
IPC分类号： G11B7/00
CPC分类号： G11B7/1374 , G11B7/1376 , G11B7/13922 , G11B7/22
摘要： An optical pickup is provided which is capable of minimizing an astigmatism thereof with a simple configuration. The optical pickup 6 includes a collimate lens 16 for transferring optical beams outputted from a laser diode 11 to parallel light, and an objective lens 18 for collecting the optical beams transferred to parallel light with the collimate lens 16 and applying the optical beams to an optical disk 50, wherein mounting angles of the collimate lens 16 and the objective lens 18 are adjusted so that astigmatisms of the collimate lens 16 and the objective lens 18 may be offset by each other. Thus the astigmatism of the optical pickup 6 can be minimized with a simple configuration without need for separately providing means of correcting aberration.
摘要翻译： 提供一种能够以简单的配置使其散光最小化的光学拾取器。 光学拾取器6包括用于将从激光二极管11输出的光束传送到平行光的准直透镜16和用于收集被准直透镜16转移到平行光的光束的物镜18，并将光束施加到光学 盘50，其中调整准直透镜16和物镜18的安装角度，使得准直透镜16和物镜18的像散可能彼此抵消。 因此，可以通过简单的配置使光拾取器6的像散最小化，而不需要单独提供校正像差的装置。
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公开(公告)号：US20060199764A1
公开(公告)日：2006-09-07
申请号：US11361565
申请日：2006-02-23
申请人： Paul Zamora , Louis Pena , Xinhua Lin , Kazuyuki Takahashi
发明人： Paul Zamora , Louis Pena , Xinhua Lin , Kazuyuki Takahashi
摘要： The present invention provides a fibroblast growth factor heparin-binding analog of the formula: where R1, R2, R3, R4, R5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
摘要翻译： 本发明提供了下式的成纤维细胞生长因子肝素结合类似物：其中R 1，R 2，R 3，R SUB > 4，R 5，X，Y和Z如上所定义，药物组合物，包衣组合物和包括上述配方的成纤维细胞生长因子肝素结合类似物的医疗装置和方法 及其用途。
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公开(公告)号：US06546622B2
公开(公告)日：2003-04-15
申请号：US09808980
申请日：2001-03-16
申请人： Masahiro Iba , Hisashi Wakako , Kazuhisa Sato , Haruhiko Murata , Kazuyuki Takahashi , Kenzo Kawaguchi
发明人： Masahiro Iba , Hisashi Wakako , Kazuhisa Sato , Haruhiko Murata , Kazuyuki Takahashi , Kenzo Kawaguchi
IPC分类号： H05K302
CPC分类号： H01L23/5383 , H01L2224/16225 , H05K1/0266 , H05K3/28 , H05K3/381 , H05K3/4602 , H05K3/4644 , H05K2203/107 , H05K2203/122 , H05K2203/161 , Y10T29/49124 , Y10T29/49126 , Y10T29/49128 , Y10T29/49144 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158
摘要： A printed-wiring substrate 1 includes internal dielectric resin layers 12 and 14. A main-surface-side external dielectric resin layer 13 is formed on the internal dielectric resin layer 12 such that the surface thereof serves as a substrate main-surface 1A. A back-surface-side external dielectric resin layer 15 is formed on the internal dielectric resin layer 14 such that the surface thereof serves as a substrate back-surface 1B. A surface 12A of the main-surface-side internal dielectric resin layer 12 and a surface 14A of the back-surface-side internal dielectric resin layer 14 are roughened. The substrate main-surface 1A and the substrate back-surface 1B are roughened such that surface roughness thereof is lower than that of the surfaces 12A and 14A.
摘要翻译： 印刷布线基板1包括内部电介质树脂层12和14.主表面侧外部电介质树脂层13形成在内部电介质树脂层12上，使得其表面用作基板主表面1A。 在内部电介质树脂层14上形成背面侧外部电介质树脂层15，使其表面作为基板背面1B。 主表面侧内部电介质树脂层12的表面12A和背面侧内部电介质树脂层14的表面14A被粗糙化。 基板主表面1A和基板背面1B被粗糙化，使得表面粗糙度低于表面12A和14A的表面粗糙度。
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公开(公告)号：US5828498A
公开(公告)日：1998-10-27
申请号：US967212
申请日：1997-10-29
CPC分类号： G02B23/243
摘要： An objective lens for an endoscope includes a front lens of negative power, an aperture stop, and a rear lens group of positive power in this order from the object side. At least one surface of the front lens group and/or the rear lens group is a compound aspherical lens made of a glass lens and a transparent layer applied to the glass lens surface. A surface of the transparent layer farther from the glass lens is an aspherical surface. The refractive index n of the glass lens to which the transparent layer is applied is more than 1.65 (n>1.65).
摘要翻译： 内窥镜用物镜从物体侧开始依次具有负电源用前透镜，孔径光阑以及正功率后透镜组。 前透镜组和/或后透镜组的至少一个表面是由玻璃透镜和施加到玻璃透镜表面的透明层制成的复合非球面透镜。 离玻璃透镜更远的透明层的表面是非球面。 施加透明层的玻璃透镜的折射率n大于1.65（n> 1.65）。
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公开(公告)号：US5724190A
公开(公告)日：1998-03-03
申请号：US587983
申请日：1996-01-17
CPC分类号： G02B9/12 , G02B23/243
摘要： An objective lens for an endoscope includes a first lens group having one negative lens, a second lens group having at least one positive lens, and a third lens group including a positive lens. The objective lens satisfies the following relationship: .theta..sub.g,d
摘要翻译： 用于内窥镜的物镜包括具有一个负透镜的第一透镜组，具有至少一个正透镜的第二透镜组和包括正透镜的第三透镜组。 物镜满足以下关系：theta g，d <-2.223×10 -3。 nu d + 1.365其中theta g，d =（ng-nd）/（nF-nC），ng表示第一透镜组在g线处的玻璃材料的折射率，nd表示玻璃的折射率 d线上的第一透镜组的材料，nF表示第一透镜组在F线处的玻璃材料的折射率，n C表示第一透镜组在C字形的玻璃材料的折射率， 线，nu d表示第一透镜组的玻璃材料的阿贝数。
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公开(公告)号：US5620955A
公开(公告)日：1997-04-15
申请号：US168390
申请日：1993-12-17
摘要： Bombesin is an amphibian peptide that has a structure closely related to that of several mammalian peptides, including Gastrin Releasing Peptide (GRP) and Neuromedins B and C. Bombesin, GRP and related peptides exert their in vivo effects by binding to specific receptors present on cells of the gastrointestinal tract, the central nervous system, and tumors. The invention relates to novel bombesin derivatives which act as bombesin receptor antagonists by blocking the binding of bombesin, GRP or related peptides to cellular receptors. By blocking the binding of bombesin, GRP and related peptides to cellular receptors on cancer cells, these antagonists inhibit the growth of tumor cells that respond to the growth-promoting action of bombesin. These antagonists are expected to block the binding of bombesin, GRP or related peptides to similar receptors on cells in the gastrointestinal tract or the central nervous system. Thus, these antagonists have therapeutic use in the treatment or prevention of conditions mediated by bombesin, GRP or related peptides, including cancer and gastrointestinal disorders such as peptic ulcer, pancreatitis, and feeding disorders.
摘要翻译： 轰炸蛋白是具有与几种哺乳动物肽密切相关的结构的两栖动物肽，包括胃泌素释放肽（GRP）和神经介肽B和C.Bombesin，GRP和相关肽通过结合存在于细胞上的特异性受体发挥其体内作用 的胃肠道，中枢神经系统和肿瘤。 本发明涉及通过阻断bombesin，GRP或相关肽与细胞受体的结合而作为铃蟾肽受体拮抗剂的新型bombesin衍生物。 通过阻断bombesin，GRP和相关肽与癌细胞上的细胞受体的结合，这些拮抗剂抑制响应bombesin生长促进作用的肿瘤细胞的生长。 预期这些拮抗剂可阻断bombesin，GRP或相关肽与胃肠道或中枢神经系统细胞中相似受体的结合。 因此，这些拮抗剂具有治疗或预防由bombesin，GRP或相关肽介导的病症的治疗用途，包括癌症和消化道疾病如消化性溃疡，胰腺炎和进食障碍。
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公开(公告)号：US5342687A
公开(公告)日：1994-08-30
申请号：US960676
申请日：1992-10-13
申请人： Yoshio Iwai , Kazuyuki Takahashi , Takeshi Hirota , Tomoji Abe , Isao Imanishi
发明人： Yoshio Iwai , Kazuyuki Takahashi , Takeshi Hirota , Tomoji Abe , Isao Imanishi
IPC分类号： B65D63/10 , B65D63/12 , B65D81/34 , D01F1/10 , D01F6/88 , D01F6/90 , D01F6/92 , B32B5/16 , B65D77/10
CPC分类号： B65D81/3461 , B65D63/12 , Y10T24/15 , Y10T24/153 , Y10T24/157 , Y10T428/24479 , Y10T428/2495 , Y10T428/2982 , Y10T428/31623 , Y10T428/31786 , Y10T428/31913
摘要： A non-metallic coreless twist-tie is formed by melting polymeric material, extruding the material in an elongated form, cooling the material, then drawing the material at a rate of more than about 2.5 times. The tie can include glass beads. The polymer is preferably formed from polymeric resin having a degree of crystallization of about 10% to 60% at a crystallized temperature range of about 100.degree. C. to 250.degree. C. and can also include a quantity of fine glass beads. The resulting tie can be twisted and untwisted many times without breakage, is suitable for use in microwave ovens and is simpler to construct than multicomponent ties.
摘要翻译： 通过熔化聚合材料，将材料挤压成细长形式，冷却材料，然后以大于约2.5倍的速率拉伸材料，形成非金属无芯扭绞带。 领带可以包括玻璃珠。 聚合物优选在约100℃至250℃的结晶温度范围内由结晶度为约10％至60％的聚合物树脂形成，并且还可以包括一定量的细玻璃珠。 所得到的领带可以扭曲和解捻多次而不破裂，适用于微波炉，并且比多组分连接件更容易构造。
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