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    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS
    21.
    发明申请
    INTEGRATED SENSOR ARRAYS FOR BIOLOGICAL AND CHEMICAL ANALYSIS 审中-公开
    用于生物和化学分析的集成传感器阵列

    公开(公告)号：US20150197797A1

    公开(公告)日：2015-07-16

    申请号：US14599948

    申请日：2015-01-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan M. ROTHBERG ,  James BUSTILLO ,  Mark James MILGREW ,  Jonathan SCHULTZ ,  David MARRAN ,  Todd REARICK ,  Kim L. JOHNSON

    IPC: C12Q1/68 ,  G01N27/414

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

    Abstract: An apparatus comprising a chemical field effect transistor array in a circuit-supporting substrate is disclosed. The transistor array has disposed on its surface an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid. The transistor array has a pitch of 10 μm or less and a sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region.

    Abstract translation: 公开了一种在电路支撑衬底中包括化学场效应晶体管阵列的装置。 晶体管阵列在其表面上设置有能够从样品流体中保留化学或生物样品的样品保持区阵列。 晶体管阵列具有10μm或更小的间距，并且样品保持区位于至少一个化学场效应晶体管上，该化学场效应晶体管被配置为产生与该样品中的化学或生物样品的特征相关的至少一个输出信号 - 区域。

    Windowed Sequencing
    22.
    发明申请
    Windowed Sequencing 审中-公开
    窗口排序

    公开(公告)号：US20140336063A1

    公开(公告)日：2014-11-13

    申请号：US13891023

    申请日：2013-05-09

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd REARICK ,  Mark James MILGREW ,  Jonathan SCHULTZ ,  Chris PAPALIAS ,  Kim L. JOHNSON

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  G16B30/00

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.

    Abstract translation: 在一个实现中，描述了一种方法。 该方法包括确定传感器阵列的传感器的操作特性。 该方法还包括基于组中的传感器的操作特性来选择阵列中的一组传感器。 该方法还包括使得能够读出所选择的组中的传感器。 所述方法还包括接收来自所述使能的传感器的输出信号，所述输出信号指示在所述传感器阵列的传感器附近发生的化学反应。

    METHODS AND APPARATUS FOR MEASURING ANALYTES
    23.
    发明申请
    METHODS AND APPARATUS FOR MEASURING ANALYTES 有权
    测量分析仪的方法和装置

    公开(公告)号：US20140324376A1

    公开(公告)日：2014-10-30

    申请号：US14330756

    申请日：2014-07-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd REARICK ,  Melville DAVEY ,  Mark BEAUCHEMIN

    IPC: G01N27/416

    CPC classification number: G01N27/4165 ,  G01N27/4145 ,  G06F19/22

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor may can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    Abstract translation: 提供了一种方法，计算机程序产品和系统来校准具有多个传感器的传感器阵列。 该方法可以包括将参考电极的电压从第一电压扫描到第二电压，其中参考电极与传感器阵列流体连通。 可以在第一和第二电压内的一个或多个电压监视多个传感器中的每一个的输出电压。 可以在一个或多个电压中的每一个处计算多个传感器的总体平均增益。 此外，可以确定传感器的采集窗口。 采集窗口可以包括在特定参考电极电压下提供最大总平均增益的传感器的最大分布。

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    24.
    发明申请
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 有权
    用于分析合成数据的模型

    公开(公告)号：US20130303384A1

    公开(公告)日：2013-11-14

    申请号：US13892116

    申请日：2013-05-10

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd REARICK

    IPC: G06F19/12 ,  C12Q1/68

    CPC classification number: G06F19/12 ,  C12Q1/6874 ,  G06F19/20 ,  G06F19/22 ,  C12Q2537/165 ,  C12Q2563/113 ,  C12Q2563/116

    Abstract: A method of modeling a background signal when sequencing a polynucleotide strand using sequencing-by-synthesis includes: flowing a series of nucleotide flows onto a reactor array having multiple reaction confinement regions, one or more copies of the polynucleotide strand being located in a loaded reaction confinement region of the reactor array, the loaded reaction confinement region being located in a vicinity of one or more neighboring reaction confinement regions that may or may not be loaded; receiving output signals from the reactor array; and modeling a background signal for the loaded reaction confinement region using the received output signals and a model adapted to account at least for an exchange of ions between the one or more neighboring reaction confinement regions and a headspace adjacent the loaded reaction confinement region and the one or more neighboring reaction confinement regions.

    Abstract translation: 使用逐个合成序列测序多核苷酸链的模拟背景信号的方法包括：将一系列核苷酸流流动到具有多个反应限制区的反应器阵列上，多核苷酸链的一个或多个拷贝位于负载反应中 反应器阵列的约束区域，负载的反应限制区域位于一个或多个相邻反应限制区域附近，该区域可能被加载或不被加载; 从反应器阵列接收输出信号; 以及使用所接收的输出信号对负载的反应限制区域的背景信号进行建模，以及适于至少考虑一个或多个相邻反应限制区域之间的离子交换和邻近负载的反应限制区域的顶部空间的模型， 或更多相邻的反应限制区域。

    APPARATUSES, METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA FOR FLUID POTENTIAL ARTIFACT CORRECTION IN REAGENT DELIVERY SYSTEMS
    25.
    发明申请
    APPARATUSES, METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA FOR FLUID POTENTIAL ARTIFACT CORRECTION IN REAGENT DELIVERY SYSTEMS 审中-公开

    公开(公告)号：US20200041444A1

    公开(公告)日：2020-02-06

    申请号：US16362367

    申请日：2019-03-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Chiu Tai Andrew WONG ,  Todd REARICK ,  John DONOHUE

    IPC: G01N27/414 ,  G16B30/00

    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    28.
    发明申请
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 审中-公开

    公开(公告)号：US20190156918A1

    公开(公告)日：2019-05-23

    申请号：US16195068

    申请日：2018-11-19

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd REARICK ,  Jonathan SCHULTZ

    IPC: G16B40/00 ,  C12Q1/6869

    Abstract: Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled.

    METHODS AND APPARATUS FOR MEASURING ANALYTES
    30.
    发明申请
    METHODS AND APPARATUS FOR MEASURING ANALYTES 审中-公开

    公开(公告)号：US20180313786A1

    公开(公告)日：2018-11-01

    申请号：US15920387

    申请日：2018-03-13

    Applicant: Life Technologies Corporation

    Inventor： Todd REARICK ,  Melville DAVEY ,  Mark BEAUCHEMIN

    IPC: G01N27/416 ,  G01N27/414 ,  G06F19/22

    CPC classification number: G01N27/4165 ,  G01N27/4145 ,  G16B30/00

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. The method can include sweeping a voltage of a reference electrode from a first voltage to a second voltage, where the reference electrode is in fluid communication with the sensor array. The output voltage of each of the plurality of sensors can be monitored at one or more voltages within the first and second voltages. An overall average gain of the plurality of sensors can be calculated at each of the one or more voltages. Further, an acquisition window for the sensor array can be determined. The acquisition window can include a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

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