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公开(公告)号:US10568628B2
公开(公告)日:2020-02-25
申请号:US15602457
申请日:2017-05-23
申请人: Muffin Incorporated
发明人: Gregory James Hardy , Shaun Davis Gittard , John C. Sigmon, Jr. , William J. Havel , Jeremy T. Newkirk , Neal E. Fearnot , Rita Hadley
摘要: There are shown and described embodiments of a closure device for closing holes in tissue, for example in the right atrial appendage. The closure device in particular embodiments includes first and second mesh closure members and a tether or stem connecting them. Embodiments of a delivery device for the closure device are also described.
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公开(公告)号:US10532193B2
公开(公告)日:2020-01-14
申请号:US15453194
申请日:2017-03-08
申请人: Muffin Incorporated
发明人: Frank J. Fischer, Jr. , James R. Randolph , Neal E. Fearnot , Jimmy L. Taylor, Jr. , Gary B. Shirley
摘要: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
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公开(公告)号:US20190261943A1
公开(公告)日:2019-08-29
申请号:US16174395
申请日:2018-10-30
申请人: Muffin Incorporated
摘要: Described are methods and systems and system components useful for percutaneously delivering or retrieving vascular implant devices, such as filters, utilizing intravenous ultrasound (IVUS) imaging alone or in combination with external (e.g. transabdominal) ultrasound or other imaging technology. Implants deliverable by such systems, such as vena cava or other vascular filters, can have two or more echogenic markers spaced at such a distance that they are separately discernible by IVUS and/or external ultrasound imaging.
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公开(公告)号:US10111645B2
公开(公告)日:2018-10-30
申请号:US13731313
申请日:2012-12-31
申请人: Muffin Incorporated
摘要: Described are methods and systems and system components useful for percutaneously delivering or retrieving vascular implant devices, such as filters, utilizing intravenous ultrasound (IVUS) imaging alone or in combination with external (e.g. transabdominal) ultrasound or other imaging technology. Implants deliverable by such systems, such as vena cava or other vascular filters, can have two or more echogenic markers spaced at such a distance that they are separately discernible by IVUS and/or external ultrasound imaging.
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公开(公告)号:US09931439B2
公开(公告)日:2018-04-03
申请号:US14088606
申请日:2013-11-25
发明人: Neal E. Fearnot , Michael C. Hiles , Jeremy Metz , F. Joseph Obermiller , Andrew J. Kaucher , Steven Charlebois
CPC分类号: A61L27/60 , A61F2/0063 , A61F2/02 , A61F2002/0072 , A61F2210/0076 , A61F2250/0003 , A61F2250/0068 , A61L27/3633 , A61L27/38
摘要: Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. The medical graft materials and devices can have a first outer surface and a second outer surface and can define an internal chamber between the first outer surface and the second outer surface. The medical graft materials and devices can also have at least one region of the graft material interrupting the chamber and surrounded by the chamber. Also described are methods for making and using these medical graft materials and devices.
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公开(公告)号:US20170173309A1
公开(公告)日:2017-06-22
申请号:US15453194
申请日:2017-03-08
申请人: Muffin Incorporated
发明人: Frank J. Fischer, JR. , James R. Randolph , Neal E. Fearnot , Jimmy L. Taylor, JR. , Gary B. Shirley
摘要: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.
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公开(公告)号:US09675323B2
公开(公告)日:2017-06-13
申请号:US14211780
申请日:2014-03-14
申请人: Muffin Incorporated
发明人: Peter S. McKinnis , Yun Zhou , Sarah Robbins , Neal E. Fearnot
CPC分类号: A61B8/4281 , A61B1/00064 , A61B8/0891 , A61B8/12 , A61B8/4272 , A61B8/445 , A61B8/4461 , A61N7/022 , A61N2007/0043 , A61N2007/0082
摘要: There are disclosed embodiments of devices and methods for imaging the inside of a body part, particularly a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a linear motor, a shaft or filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.
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公开(公告)号:US20170144782A1
公开(公告)日:2017-05-25
申请号:US15282001
申请日:2016-09-30
申请人: Muffin Incorporated
发明人: Richard B. Sisken , James Thomas Jones , Charles Leland Baxter , Marc C. Buhrmester , William J. Havel , James D. Purdy , Neal E. Fearnot , Kyle D. Amick
摘要: A filling and sealing system is provided for efficiently filling a series of individual vials with therapeutic liquids. In particular embodiments, the system includes a filling zone or station, a sealing zone or station, an unloading zone or station, and electronic controls.
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公开(公告)号:US09456802B2
公开(公告)日:2016-10-04
申请号:US14051812
申请日:2013-10-11
申请人: Muffin Incorporated
发明人: Yun Zhou , Peter S. McKinnis , Neal E. Fearnot
CPC分类号: A61B8/4461 , A61B8/12 , A61B8/445 , A61B8/4483 , A61B8/4494 , A61B8/483 , F04C2270/041 , G01S15/8943 , G10K11/357
摘要: A system for use with ultrasound procedures including an ultrasound control and/or imaging system which has a microminiature motor, a rotatable reflector and a stationary ultrasound transducer. The transducer may be placed between the motor and the reflector, so as to eliminate the need for placement of wires or other artifact-creating items in the path of ultrasound signals. In particular embodiments, such systems can be incorporated in or retrofitted to commercially standard diagnostic and therapeutic catheters or other housings. Examples can be used in variety of ultrasound procedures, e.g. to perform intravascular ultrasound (IVUS) imaging.
摘要翻译: 一种用于超声波程序的系统,包括具有微型马达,可旋转反射器和固定超声换能器的超声控制和/或成像系统。 传感器可以放置在电动机和反射器之间,以便消除在超声波信号的路径中布置导线或其它造假物品的需要。 在特定实施例中,这样的系统可以并入或改装到商业标准的诊断和治疗导管或其它外壳中。 例子可用于各种超声程序,例如 进行血管内超声(IVUS)成像。
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公开(公告)号:US20160082157A1
公开(公告)日:2016-03-24
申请号:US14835005
申请日:2015-08-25
CPC分类号: A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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