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公开(公告)号：US20060211050A1
公开(公告)日：2006-09-21
申请号：US11442747
申请日：2006-05-30
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01001
摘要： The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-2 gene has been introduced or disrupted. The invention still further provides isolated COE-2 proteins, fusion proteins, antigenic peptides and anti-COE-2 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：US06664373B1
公开(公告)日：2003-12-16
申请号：US09561763
申请日：2000-04-28
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK gene has been introduced or disrupted. The invention still further provides isolated TWIK proteins, fusion proteins, antigenic peptides and anti-TWIK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TWIK核酸分子，其编码参与钾通道介导的活性的蛋白质。 本发明还提供了反义核酸分子，含有TWIK核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏TWIK基因的非人类转基因动物。 本发明还进一步提供了分离的TWIK蛋白，融合蛋白，抗原肽和抗TWIK抗体。 还提供了利用本发明组合物的诊断方法。
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23.发明申请NOVEL 15571, 2465, 14266, 2882, 52871, 8203 AND 16852 MOLECULES AND USES THEREFOR 审中-公开新型15571,2245,14266,2882,52871,8203和16852分子及其用途公开(公告)号：US20110171205A1
公开(公告)日：2011-07-14
申请号：US13012890
申请日：2011-01-25
申请人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
发明人： Martin R. Hodge , Clare M. Lloyd , Nadine S. Weich , Jose M. Lora , David White , Maria A. Glucksmann , Keith E. Robison , Inmaculada Silos-Santiago , Andrew D.J. Goodearl , Rory A.J. Curtis
IPC分类号： A61K39/395 , C07H21/04 , C12N5/00 , C07K14/00 , C07K16/18 , C12P21/02 , C12Q1/68 , G01N33/53 , A61K38/17 , A61K31/7088 , C12N15/11 , C12N1/21 , A61P25/00 , A61P19/02 , A61P25/28 , A61P25/16 , A61P25/18 , A61P9/00 , A61P9/04 , A61P35/00 , A61P3/10 , A61P15/02
CPC分类号： C07K14/47 , C07K16/286 , G01N33/6893 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2800/122 , G01N2800/24
摘要： The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15571, 2465, 14266, 2882, 52871, 8203 or 16852 gene has been introduced or disrupted. The invention still further provides isolated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 proteins, fusion proteins, antigenic peptides and anti-15571, 2465, 14266, 2882, 52871, 8203 or 16852 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为15571,2465,14266,2882,52871,8203或16852核酸分子。 本发明还提供反义核酸分子，含有15571,2465,14266,2882,52871,8203或16852核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中15571， 2465,14266,2882,52871,8203或16852基因已被引入或破坏。 本发明还进一步提供了分离的15571,2465,14266,2882,52871,8203或16852蛋白，融合蛋白，抗原肽和抗15571,2465,14266,2882,52871,8203或16852抗体。 还提供了利用本发明组合物的诊断和治疗方法。
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公开(公告)号：US07517659B2
公开(公告)日：2009-04-14
申请号：US10701013
申请日：2003-11-04
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides isolated nucleic acids molecules, designated TWIK nucleic acid molecules, which encode proteins involved in potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK gene has been introduced or disrupted. The invention still further provides isolated TWIK proteins, fusion proteins, antigenic peptides and anti-TWIK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为TWIK核酸分子，其编码参与钾通道介导的活性的蛋白质。 本发明还提供了反义核酸分子，含有TWIK核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏TWIK基因的非人类转基因动物。 本发明还进一步提供了分离的TWIK蛋白，融合蛋白，抗原肽和抗TWIK抗体。 还提供了利用本发明组合物的诊断方法。
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25.发明申请Methods and compositions for the treatment and diagnosis of pain disorders using 9805, 2047, 46566, 57749, 577, 20739, 57145, 1465, 1587, 2146, 2207, 32838, 336 or 52908 审中-公开使用9805,2047,46566,57749,577,20739,57145,1465,1587,2166,2207,32838,336或52908来治疗和诊断疼痛障碍的方法和组合物公开(公告)号：US20070179102A1
公开(公告)日：2007-08-02
申请号：US11232776
申请日：2005-09-22
IPC分类号： A61K48/00 , C12Q1/68 , G01N33/567
CPC分类号： G01N33/6896 , G01N2500/10 , G01N2800/2842
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of pain disorders. The invention further provides methods for identifying a compound capable of treating a pain disorder. In addition, the invention provides a method for treating a subject having a pain disorder, e.g., a pain disorder characterized by aberrant 9805, 2047, 46566, 57749, 577, 20739, 57145, 1465, 1587, 2146, 2207, 32838, 336 and 52908 polypeptide activity or aberrant 9805, 2047, 46566, 57749, 577, 20739, 57145, 1465, 1587, 2146, 2207, 32838, 336 and 52908 nucleic acid expression.
摘要翻译： 本发明涉及用于治疗和诊断疼痛障碍的方法和组合物。 本发明还提供了鉴定能够治疗疼痛障碍的化合物的方法。 此外，本发明提供了治疗患有疼痛障碍的受试者的方法，例如以异常9805,2047,46566,57749,577,20739,57145,1465,1587,2146,2207,32838,336为特征的疼痛病症 和52908多肽活性或异常9805,2047,46566,57749,577,20739,57145,1465,1587,2166,2207,32838,336和52908核酸表达。
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26.发明授权Method of identifying a compound capable of treating a pain or a painful disorder 失效鉴定能够治疗疼痛或疼痛障碍的化合物的方法公开(公告)号：US07169751B2
公开(公告)日：2007-01-30
申请号：US10768158
申请日：2004-01-30
IPC分类号： G01N33/15 , G01N33/483 , A61K38/16
CPC分类号： G01N33/6893 , C07K16/286 , G01N2333/68
摘要： We claim a methods for identifying a compound capable of treating a pain or a painful disorder state comprising combining the test compound with the polypeptide of SEQ ID NO:2, and detecting binding of said test compound to said polypeptide thereby identifying a compound that binds to said polypeptide.
摘要翻译： 我们要求一种用于鉴定能够治疗疼痛或疼痛障碍状态的化合物的方法，包括将测试化合物与SEQ ID NO：2的多肽组合，并检测所述测试化合物与所述多肽的结合，从而鉴定与 所述多肽。
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公开(公告)号：US20060100152A1
公开(公告)日：2006-05-11
申请号：US11312958
申请日：2005-12-20
CPC分类号： G01N33/5008 , A61K31/00 , C12Q1/6883 , C12Q2600/158 , G01N33/502 , G01N33/5041 , G01N33/5058 , G01N33/68 , G01N2500/04
摘要： The present invention relates to methods for the diagnosis and treatment of pain or painful disorders. Specifically, the present invention identifies the differential expression of 9949, 14230, 760, 62553, 12216, 17719, 41897, 47174, 33408, 10002, 16209, 314, 636, 27410, 33260, 619, 15985, 69112, 2158, 224, 615, 44373, 95431, 22245, 2387, 16658, 55054, 16314, 1613, 1675, 9569 and 13424 genes in tissues relating to pain sensation, relative to their expression in normal, or non-painful disease states, and/or in response to manipulations relevant to pain. The present invention describes methods for the diagnostic evaluation and prognosis of various pain disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating pain or painful disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of pain and painful disorders.
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28.发明申请Methods and compositions for the treatment and diagnosis of pain disorders using 46566 审中-公开使用46566治疗和诊断疼痛障碍的方法和组合物公开(公告)号：US20050255518A1
公开(公告)日：2005-11-17
申请号：US11183624
申请日：2005-07-18
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P43/00 , C12N5/06 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/68 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N2500/00
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of pain disorders, including, but not limited to, inflammatory pain, chronic pain and/or neuropathic pain. The invention further provides methods for identifying a compound capable of treating a pain disorder or modulating pain and/or inflammation response. The invention further provides a method for modulating pain and/or inflammation in a subject. In addition, the invention provides a method for treating a subject having a pain disorder characterized by aberrant 46566 polypeptide activity or aberrant 46566 nucleic acid expression.
摘要翻译： 本发明涉及用于治疗和诊断疼痛障碍的方法和组合物，包括但不限于炎性疼痛，慢性疼痛和/或神经性疼痛。 本发明还提供了鉴定能够治疗疼痛障碍或调节疼痛和/或炎症反应的化合物的方法。 本发明还提供了调节受试者的疼痛和/或炎症的方法。 此外，本发明提供了一种治疗患有以异常46566多肽活性或异常46566核酸表达为特征的疼痛病症的受试者的方法。
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公开(公告)号：US06573057B2
公开(公告)日：2003-06-03
申请号：US10000273
申请日：2001-11-02
IPC分类号： G01M3353
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6872
摘要： The invention relates to OCT-3 polypeptides, nucleic acid molecules encoding OCT-3, and uses thereof. OCT-3 is a protein that is expressed in the plasma membrane of biological cells, across which it regulates the transport of organic molecules.
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